5alpha-Cholestanol (BioDeep_00000027667)

 

Secondary id: BioDeep_00000398233, BioDeep_00000405399, BioDeep_00000596861, BioDeep_00000636700, BioDeep_00000867765, BioDeep_00001873911

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


(1S,2S,5S,7S,10R,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-ol

化学式: C27H48O (388.37049579999996)
中文名称: 5α-胆甾烷-3β-醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.48%

分子结构信息

SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CCC4C3(CCC(C4)O)C)C
InChI: InChI=1S/C27H48O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h18-25,28H,6-17H2,1-5H3/t19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1

描述信息

5alpha-Cholestanol, also known as cholestanol or dihydrocholesterol, belongs to the class of organic compounds known as cholesterols and derivatives. Cholesterols and derivatives are compounds containing a 3-hydroxylated cholestane core. Thus, 5alpha-cholestanol is considered to be a sterol lipid molecule. 5alpha-Cholestanol is a very hydrophobic molecule, practically insoluble in water, and relatively neutral. 5alpha-Cholestanol is a potentially toxic compound.
5alpha-Cholestanol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter.
5α-Cholestan-3β-ol is a derivitized steroid compound.
5α-Cholestan-3β-ol is a derivitized steroid compound.

同义名列表

36 个代谢物同义名

(1S,2S,5S,7S,10R,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-ol; Cholestanol, (3alpha, 5beta)-isomer; (3beta,5alpha)-Cholestan-3-ol; 5 alpha-Cholestan-3 alpha-ol; 5 alpha Cholestan 3 alpha ol; 5 beta-Cholestan-3 alpha-ol; beta-Cholestan-3 beta-ol, 5; 5 alpha-Cholestan-3 beta-ol; 5 alpha Cholestan 3 beta ol; beta-Ol, 5 beta-cholestan-3; 5 beta Cholestan 3 beta ol; 5 beta-Cholestan-3 beta-ol; 3b-Hydroxy-5a-cholestane; (3b,5a)-Cholestan-3-ol; (3Β,5α)-cholestan-3-ol; 5a-Dihydrocholesterol; 3b-Hydroxycholestane; Dihydrocholesterin; 5a-Cholestan-3b-ol; 5alpha-Cholestanol; Dihydrocholesterol; beta-Cholestanol; beta Cholestanol; Cholestan-3b-ol; Epicholestanol; 5b-cholestanol; Cholestan-3-ol; 5Α-cholestanol; Cholestan 3 ol; 5a-Cholestanol; Cholestanol; coprosterol; Coprostanol; Zymostanol; NSC 18188; 5α-Cholestan-3β-ol



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

41 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yun-Yuan Tian, Lin-Lin Bi, Wen-Wen Chen, Shu-Xian Zheng, Yu Cao, Yan-Hua Xie, Hai-Feng Tang, Yun-Yang Lu, Si-Wang Wang. Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata. Fitoterapia. 2024 Jun; 175(?):105881. doi: 10.1016/j.fitote.2024.105881. [PMID: 38438054]
  • Adrián Cortés-Martín, Carlos E Iglesias-Aguirre, Alicia Marín, María Romo-Vaquero, Fernando Vallejo, Juan Carlos Espín, María Victoria Selma. Urolithin A production drives the effects of pomegranate on the gut microbial metabolism of bile acids and cholesterol in mild dyslipidaemic overweight and obese individuals. Food & function. 2024 Mar; 15(5):2422-2432. doi: 10.1039/d3fo05014a. [PMID: 38329279]
  • Muhammed Köroğlu, Mustafa Karakaplan, Enes Gündüz, Betül Kesriklioğlu, Emre Ergen, Okan Aslantürk, Zeynep Maraş Özdemir. Cerebrotendinous Xanthomatosis patients with late diagnosed in single orthopedic clinic: two novel variants in the CYP27A1 gene. Orphanet journal of rare diseases. 2024 Feb; 19(1):53. doi: 10.1186/s13023-024-03082-4. [PMID: 38336741]
  • Yan Li, Yuanjue Wu, Yanyan Ge, Shanshan Huang, Yang Yang, Zhen Zhang, Ningning Cui, Junan Yan, Yonggang Li, Ping Luo, Liping Hao, Guoping Xiong, Xuefeng Yang. Pregnancy Cholesterol Metabolism Markers and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study. Nutrients. 2023 Aug; 15(17):. doi: 10.3390/nu15173809. [PMID: 37686841]
  • Laura Stanasila, Pedro Marques-Vidal. Serum Phytosterols Are Not Associated with Inflammatory Markers in Two Cross-Sectional, Swiss Population-Based Studies (The CoLaus PsyCoLaus Study). Nutrients. 2022 Jun; 14(12):. doi: 10.3390/nu14122500. [PMID: 35745232]
  • María José Contreras, María Elena Arias, Mauricio Silva, Paulina Cabrera, Ricardo Felmer. Effect of cholestanol and cholesterol-loaded cyclodextrin on stallion sperm function and capacitation post-cryopreservation. Theriogenology. 2022 Jun; 189(?):1-10. doi: 10.1016/j.theriogenology.2022.06.005. [PMID: 35714521]
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  • Monica Gelzo, Maria Donata Di Taranto, Concetta Sica, Antonio Boscia, Francesco Papagni, Giuliana Fortunato, Gaetano Corso, Antonio Dello Russo. Age-related changes of cholestanol and lathosterol plasma concentrations: an explorative study. Lipids in health and disease. 2019 Dec; 18(1):235. doi: 10.1186/s12944-019-1176-3. [PMID: 31888647]
  • Benjamin L Stottrup, Juan TigreLazo, Vision B Bagonza, Joan C Kunz, Joseph A Zasadzinski. Comparison of Line Tension Measurement Methods for Lipid Monolayers at Liquid-Liquid Coexistence. Langmuir : the ACS journal of surfaces and colloids. 2019 12; 35(48):16053-16061. doi: 10.1021/acs.langmuir.9b01696. [PMID: 31343892]
  • Daniele Mandia, Annabelle Chaussenot, Gérard Besson, Foudil Lamari, Giovanni Castelnovo, Jonathan Curot, Fanny Duval, Philippe Giral, Jean-Michel Lecerf, Dominique Roland, Heloise Pierdet, Claire Douillard, Yann Nadjar. Cholic acid as a treatment for cerebrotendinous xanthomatosis in adults. Journal of neurology. 2019 Aug; 266(8):2043-2050. doi: 10.1007/s00415-019-09377-y. [PMID: 31115677]
  • Joon Hee Lee, Kyunghoon Lee, Sun Hee Jun, Sang Hoon Song, Choong Ho Shin, Junghan Song. A Multiplex Phytosterol Assay Utilizing Gas Chromatography-Mass Spectrometry for Diagnosis of Inherited Lipid Storage Disorders. Annals of laboratory medicine. 2019 Jul; 39(4):411-413. doi: 10.3343/alm.2019.39.4.411. [PMID: 30809990]
  • Maite M Schroor, Henriette P Sennels, Jan Fahrenkrug, Henrik L Jørgensen, Jogchum Plat, Ronald P Mensink. Diurnal Variation of Markers for Cholesterol Synthesis, Cholesterol Absorption, and Bile Acid Synthesis: A Systematic Review and the Bispebjerg Study of Diurnal Variations. Nutrients. 2019 Jun; 11(7):. doi: 10.3390/nu11071439. [PMID: 31247945]
  • Dieter Lütjohann, Ingemar Björkhem, Silvia Friedrichs, Anja Kerksiek, Anita Lövgren-Sandblom, Wolf-Jochen Geilenkeuser, Robert Ahrends, Isabel Andrade, Diana Ansorena, Iciar Astiasarán, Lucía Baila-Rueda, Bianca Barriuso, Susen Becker, Lionel Bretillon, Richard W Browne, Claudio Caccia, Uta Ceglarek, Ana Cenarro, Peter J Crick, Günter Fauler, Guadalupe Garcia-Llatas, Robert Gray, William J Griffiths, Helena Gylling, Scott Harding, Christin Helmschrodt, Luigi Iuliano, Hans-Gerd Janssen, Peter Jones, Leena Kaipiainen, Frank Kannenberg, María Jesús Lagarda, Valerio Leoni, Ana Maria Lottenberg, Dylan S MacKay, Silke Matysik, Jeff McDonald, Maria Menendez-Carreño, Semone B Myrie, Valéria Sutti Nunes, Richard E Ostlund, Eliana Polisecki, Fernando Ramos, Todd C Rideout, Ernst J Schaefer, Gerd Schmitz, Yuqin Wang, Chiara Zerbinati, Ulf Diczfalusy, Hans-Frieder Schött. First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography-Urgent need for harmonisation of analytical methods. The Journal of steroid biochemistry and molecular biology. 2019 06; 190(?):115-125. doi: 10.1016/j.jsbmb.2019.03.025. [PMID: 30940596]
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