Ubiquinol-10 (BioDeep_00000027479)

 

Secondary id: BioDeep_00001871541

human metabolite Endogenous


代谢物信息卡片


2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylbenzene-1,4-diol

化学式: C59H92O4 (864.6995231999999)
中文名称: 泛醇
谱图信息: 最多检出来源 Viridiplantae(plant) 1.71%

分子结构信息

SMILES: CC(=CCC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/CC/C(=C/Cc1c(C)c(c(c(c1O)OC)OC)O)/C)/C)/C)/C)/C)/C)/C)/C)/C)C
InChI: InChI=1S/C59H92O4/c1-44(2)24-15-25-45(3)26-16-27-46(4)28-17-29-47(5)30-18-31-48(6)32-19-33-49(7)34-20-35-50(8)36-21-37-51(9)38-22-39-52(10)40-23-41-53(11)42-43-55-54(12)56(60)58(62-13)59(63-14)57(55)61/h24,26,28,30,32,34,36,38,40,42,60-61H,15-23,25,27,29,31,33,35,37,39,41,43H2,1-14H3/b45-26+,46-28+,47-30+,48-32+,49-34+,50-36+,51-38+,52-40+,53-42+

描述信息

Ubiquinol-10 is a benzoquinol and is the reduced product of ubiquinone also called coenzyme Q10.The reduction of ubiquinone to ubiquinol occurs in Complexes I&II in the electron transfer chain. The Q cycle is a process that occurs in cytochrome b[, a component of Complex III in the electron transport chain,and that converts ubiquinol to ubiquinone in a cyclic fashion. When ubiquinol binds to cytochrome b, the pKa of the phenolic group decreases so that the proton ionizes and the phenoxide anion is formed (Wikipedia). Ubiquinol-10, the reduced form of ubiquinone-10, efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as alpha-tocopherol, which is considered the best lipid-soluble antioxidant in humans. The number of radicals scavenged by each molecule of ubiquinol-10 is 1.1 under certain experimental conditions. In contrast to alpha-tocopherol, ubiquinol-10 is not recycled by ascorbate. However, it is known that ubiquinol-10 can be recycled by electron transport carriers present in various biomembranes and possibly by some enzymes. It is shown that ubiquinol-10 spares alpha-tocopherol when both antioxidants are present in the same liposomal membranes and that ubiquinol-10, like alpha-tocopherol, does not interact with reduced glutathione.It is suggested that ubiquinol-10 is an important physiological lipid-soluble antioxidant. [PMID: 2352956].
Ubiquinol-10 is a benzoquinol and is the reduced product of ubiquinone also called coenzyme Q10.The reduction of ubiquinone to ubiquinol occurs in Complexes I&II in the electron transfer chain. The Q cycle is a process that occurs in cytochrome b[, a component of Complex III in the electron transport chain,and that converts ubiquinol to ubiquinone in a cyclic fashion. When ubiquinol binds to cytochrome b, the pKa of the phenolic group decreases so that the proton ionizes and the phenoxide anion is formed (from wiki)
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同义名列表

18 个代谢物同义名

2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylbenzene-1,4-diol; Ubiquinol 6 (ubiquinol 30); Ubiquinone hydroquinone; Coenzyme Q10, reduced; Reduced coenzyme Q10; Coenzyme Q10-H2; CoQ(,10)H(,2); Ubiquinol(10); ubiquinol-10; Ubiquinol 50; Ubiquinol 1; Ubiquinol 9; Ubiquinol 7; Ubiquinol 0; Ubiquinols; ubiquinol; CoQH(,2); CoQ10h2



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(4)

PlantCyc(3)

代谢反应

100 个相关的代谢反应过程信息。

Reactome(72)

BioCyc(4)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(20)

COVID-19 Disease Map(1)

PathBank(2)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Walaa A El-Sabbagh, Noha A Fadel, Rania M El-Hazek, Ahmed H Osman, Laila A Ramadan. Ubiquinol attenuates γ-radiation induced coronary and aortic changes via PDGF/p38 MAPK/ICAM-1 related pathway. Scientific reports. 2023 12; 13(1):22959. doi: 10.1038/s41598-023-50218-w. [PMID: 38151557]
  • Eglal I Amer, Mervat Z El-Azzouni, Rana T El-Bannan, Thanaa I Shalaby, Samar N El-Achy, Maha M Gomaa. Schistosomiasis mansoni: A new therapeutic target for ubiquinol, a natural inhibitor of neutral magnesium-dependent sphingomyelinase in murine model. Acta tropica. 2022 Feb; 226(?):106231. doi: 10.1016/j.actatropica.2021.106231. [PMID: 34785184]
  • Paula da Fonseca-Pereira, Phuong Anh Pham, João Henrique F Cavalcanti, Rebeca P Omena-Garcia, Jessica A S Barros, Laise Rosado-Souza, José G Vallarino, Marek Mutwil, Tamar Avin-Wittenberg, Adriano Nunes-Nesi, Alisdair R Fernie, Wagner L Araújo. The Arabidopsis electron-transfer flavoprotein:ubiquinone oxidoreductase is required during normal seed development and germination. The Plant journal : for cell and molecular biology. 2022 01; 109(1):196-214. doi: 10.1111/tpj.15566. [PMID: 34741366]
  • Youssef W Naguib, Sanjib Saha, Jessica M Skeie, Timothy Acri, Kareem Ebeid, Somaya Abdel-Rahman, Sandeep Kesh, Gregory A Schmidt, Darryl Y Nishimura, Jeffrey A Banas, Min Zhu, Mark A Greiner, Aliasger K Salem. Solubilized ubiquinol for preserving corneal function. Biomaterials. 2021 08; 275(?):120842. doi: 10.1016/j.biomaterials.2021.120842. [PMID: 34087583]
  • Mathias J Holmberg, Lars W Andersen, Ari Moskowitz, Katherine M Berg, Michael N Cocchi, Maureen Chase, Xiaowen Liu, Duncan M Kuhn, Anne V Grossestreuer, Anne Kirstine Hoeyer-Nielsen, Hans Kirkegaard, Michael W Donnino. Ubiquinol (reduced coenzyme Q10) as a metabolic resuscitator in post-cardiac arrest: A randomized, double-blind, placebo-controlled trial. Resuscitation. 2021 05; 162(?):388-395. doi: 10.1016/j.resuscitation.2021.01.041. [PMID: 33577964]
  • Agustin J Ruiz, Ahmed Tibary, Robert A Heaton, Iain P Hargreaves, Desmond P Leadon, Warwick M Bayly. Effects of Feeding Coenzyme Q10-Ubiquinol on Plasma Coenzyme Q10 Concentrations and Semen Quality in Stallions. Journal of equine veterinary science. 2021 01; 96(?):103303. doi: 10.1016/j.jevs.2020.103303. [PMID: 33349408]
  • Francesca Cateni, Marina Zacchigna, Giuseppe Procida. Synthesis and controlled drug delivery studies of a novel Ubiquinol-Polyethylene glycol-Vitamin E adduct. Bioorganic chemistry. 2020 12; 105(?):104329. doi: 10.1016/j.bioorg.2020.104329. [PMID: 33068813]
  • Luke Young, Alicia Rosell-Hidalgo, Daniel Ken Inaoka, Fei Xu, Mary Albury, Benjamin May, Kiyoshi Kita, Anthony L Moore. Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase. Biochimica et biophysica acta. Bioenergetics. 2020 10; 1861(10):148247. doi: 10.1016/j.bbabio.2020.148247. [PMID: 32565080]
  • Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S McElroy, Marie Werner, Hermon Kihshen, Colleen R Reczek, Samuel E Weinberg, Peng Gao, Elizabeth M Steinert, Raul Piseaux, G R Scott Budinger, Navdeep S Chandel. Mitochondrial ubiquinol oxidation is necessary for tumour growth. Nature. 2020 09; 585(7824):288-292. doi: 10.1038/s41586-020-2475-6. [PMID: 32641834]
  • Patrick Orlando, Jacopo Sabbatinelli, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Phiwayinkosi Vusi Dludla, Alberto Molardi, Francesco Nicolini, Luca Tiano. Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects. Aging. 2020 07; 12(15):15514-15531. doi: 10.18632/aging.103742. [PMID: 32741773]
  • Louise Injarabian, Marc Scherlinger, Anne Devin, Stéphane Ransac, Jens Lykkesfeldt, Benoit S Marteyn. Ascorbate maintains a low plasma oxygen level. Scientific reports. 2020 06; 10(1):10659. doi: 10.1038/s41598-020-67778-w. [PMID: 32606354]
  • Kei Mizuno, Akihiro T Sasaki, Kyosuke Watanabe, Yasuyoshi Watanabe. Ubiquinol-10 Intake Is Effective in Relieving Mild Fatigue in Healthy Individuals. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061640. [PMID: 32498248]
  • Jacopo Sabbatinelli, Patrick Orlando, Roberta Galeazzi, Sonia Silvestri, Ilenia Cirilli, Fabio Marcheggiani, Phiwayinkosi V Dludla, Angelica Giuliani, Anna Rita Bonfigli, Laura Mazzanti, Fabiola Olivieri, Roberto Antonicelli, Luca Tiano. Ubiquinol Ameliorates Endothelial Dysfunction in Subjects with Mild-to-Moderate Dyslipidemia: A Randomized Clinical Trial. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041098. [PMID: 32326664]
  • Enyong Dai, Wenlong Zhang, Dan Cong, Rui Kang, Jing Wang, Daolin Tang. AIFM2 blocks ferroptosis independent of ubiquinol metabolism. Biochemical and biophysical research communications. 2020 03; 523(4):966-971. doi: 10.1016/j.bbrc.2020.01.066. [PMID: 31964528]
  • Zehua Song, Yangfeng Hu, Bogdan I Iorga, Cindy Vallières, Nicholas Fisher, Brigitte Meunier. Mutational analysis of the Qi-site proton pathway in yeast cytochrome bc1 complex. Biochemical and biophysical research communications. 2020 03; 523(3):615-619. doi: 10.1016/j.bbrc.2019.12.102. [PMID: 31941609]
  • T N Fedorova, V S Gusakov, A A Devyatov, O A Muzichuk, A V Lopachev, M A Belousova, S L Stvolinskii, O V Povarova, M V Gulyaev, O S Medvedev, V A Tutelyan. [Neuroprotective mechanisms of the ubiquinol action in experimental focal ischemia]. Biomeditsinskaia khimiia. 2020 Feb; 66(2):145-150. doi: 10.18097/pbmc20206602145. [PMID: 32420895]
  • Anna Gvozdjáková, Jarmila Kucharská, Branislav Kura, Ol'ga Vančová, Zuzana Rausová, Zuzana Sumbalová, Ol'ga Uličná, Ján Slezák. A new insight into the molecular hydrogen effect on coenzyme Q and mitochondrial function of rats. Canadian journal of physiology and pharmacology. 2020 Jan; 98(1):29-34. doi: 10.1139/cjpp-2019-0281. [PMID: 31536712]
  • Huan-Chieh Chen, Chi-Chang Huang, Tien-Jen Lin, Mei-Chich Hsu, Yi-Ju Hsu. Ubiquinol Supplementation Alters Exercise Induced Fatigue by Increasing Lipid Utilization in Mice. Nutrients. 2019 Oct; 11(11):. doi: 10.3390/nu11112550. [PMID: 31652711]
  • Tomoo Shiba, Daniel Ken Inaoka, Gen Takahashi, Chiaki Tsuge, Yasutoshi Kido, Luke Young, Satoshi Ueda, Emmanuel Oluwadare Balogun, Takeshi Nara, Teruki Honma, Akiko Tanaka, Masayuki Inoue, Hiroyuki Saimoto, Shigeharu Harada, Anthony L Moore, Kiyoshi Kita. Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase. Biochimica et biophysica acta. Bioenergetics. 2019 05; 1860(5):375-382. doi: 10.1016/j.bbabio.2019.03.008. [PMID: 30910528]
  • Guillermo López-Lluch, Jesús Del Pozo-Cruz, Ana Sánchez-Cuesta, Ana Belén Cortés-Rodríguez, Plácido Navas. Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Nutrition (Burbank, Los Angeles County, Calif.). 2019 01; 57(?):133-140. doi: 10.1016/j.nut.2018.05.020. [PMID: 30153575]
  • Sho Suzuki, Takuji Gotoda, Chika Kusano, Hisatomo Ikehara, Yo Miyakoshi, Kenji Fujii. Effect of Ubiquinol Intake on Defecation Frequency and Stool Form: A Prospective, Double-Blinded, Randomized Control Study. Journal of medicinal food. 2019 Jan; 22(1):81-86. doi: 10.1089/jmf.2018.4233. [PMID: 30192695]
  • Patrick Orlando, Sonia Silvestri, Roberta Galeazzi, Roberto Antonicelli, Fabio Marcheggiani, Ilenia Cirilli, Tiziana Bacchetti, Luca Tiano. Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes. Redox report : communications in free radical research. 2018 Dec; 23(1):136-145. doi: 10.1080/13510002.2018.1472924. [PMID: 29734881]
  • Ying Zhang, Jin Liu, Xiao-Qiang Chen, C-Y Oliver Chen. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food & function. 2018 Nov; 9(11):5653-5659. doi: 10.1039/c8fo00971f. [PMID: 30302465]
  • Fong-Lin Chen, Po-Sheng Chang, Yi-Chin Lin, Ping-Ting Lin. A Pilot Clinical Study of Liquid Ubiquinol Supplementation on Cardiac Function in Pediatric Dilated Cardiomyopathy. Nutrients. 2018 Nov; 10(11):. doi: 10.3390/nu10111697. [PMID: 30405022]
  • Javier Frontiñán-Rubio, Francisco J Sancho-Bielsa, Juan R Peinado, Frank M LaFerla, Lydia Giménez-Llort, Mario Durán-Prado, Francisco J Alcain. Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease. Molecular and cellular neurosciences. 2018 10; 92(?):67-81. doi: 10.1016/j.mcn.2018.06.005. [PMID: 29953929]
  • Chi-Hua Yen, Ying-Ju Chu, Bor-Jen Lee, Yi-Chin Lin, Ping-Ting Lin. Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial. The British journal of nutrition. 2018 07; 120(1):57-63. doi: 10.1017/s0007114518001241. [PMID: 29936921]
  • A V Kalatanova, V G Makarov, N M Faustova, Ya I Gushchin, M N Makarova. [Evaluation of the cardioprotective effect of ubiquinol on the model of reperfusion injury of rat myocardium]. Biomeditsinskaia khimiia. 2018 Mar; 64(2):188-194. doi: 10.18097/pbmc20186402188. [PMID: 29723149]
  • Ryan A West, Oran G O'Doherty, Trevor Askwith, John Atack, Paul Beswick, Jamie Laverick, Michael Paradowski, Lewis E Pennicott, Srinivasa P S Rao, Gareth Williams, Simon E Ward. African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European journal of medicinal chemistry. 2017 Dec; 141(?):676-689. doi: 10.1016/j.ejmech.2017.09.067. [PMID: 29107420]
  • Jun Mitsui, Ken Koguchi, Toshimitsu Momose, Miwako Takahashi, Takashi Matsukawa, Tsutomu Yasuda, Shin-Ichi Tokushige, Hiroyuki Ishiura, Jun Goto, Shigeaki Nakazaki, Tomoyoshi Kondo, Hidefumi Ito, Yorihiro Yamamoto, Shoji Tsuji. Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations. Cerebellum (London, England). 2017 06; 16(3):664-672. doi: 10.1007/s12311-017-0846-9. [PMID: 28150130]
  • Xiehuang Sheng, Chao Shan, Jianbiao Liu, Jintong Yang, Bin Sun, Dezhan Chen. Theoretical insights into the mechanism of ferroptosis suppression via inactivation of a lipid peroxide radical by liproxstatin-1. Physical chemistry chemical physics : PCCP. 2017 May; 19(20):13153-13159. doi: 10.1039/c7cp00804j. [PMID: 28489094]
  • Alvaro Sarmiento, Javier Diaz-Castro, Mario Pulido-Moran, Jorge Moreno-Fernandez, Naroa Kajarabille, Ignacio Chirosa, Isabel M Guisado, Luis Javier Chirosa, Rafael Guisado, Julio J Ochoa. Short-term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. BioFactors (Oxford, England). 2016 Nov; 42(6):612-622. doi: 10.1002/biof.1297. [PMID: 27193497]
  • Tatyana I Rokitskaya, Michael P Murphy, Vladimir P Skulachev, Yuri N Antonenko. Ubiquinol and plastoquinol triphenylphosphonium conjugates can carry electrons through phospholipid membranes. Bioelectrochemistry (Amsterdam, Netherlands). 2016 Oct; 111(?):23-30. doi: 10.1016/j.bioelechem.2016.04.009. [PMID: 27182824]
  • Rafał Pietras, Marcin Sarewicz, Artur Osyczka. Distinct properties of semiquinone species detected at the ubiquinol oxidation Qo site of cytochrome bc1 and their mechanistic implications. Journal of the Royal Society, Interface. 2016 05; 13(118):. doi: 10.1098/rsif.2016.0133. [PMID: 27194483]
  • Alexandra Fischer, Simone Onur, Petra Niklowitz, Thomas Menke, Matthias Laudes, Frank Döring. Coenzyme Q10 redox state predicts the concentration of c-reactive protein in a large caucasian cohort. BioFactors (Oxford, England). 2016 May; 42(3):268-76. doi: 10.1002/biof.1269. [PMID: 26910885]
  • Alexey V Lokhmatikov, Natalia Voskoboynikova, Dmitry A Cherepanov, Maxim V Skulachev, Heinz-Jürgen Steinhoff, Vladimir P Skulachev, Armen Y Mulkidjanian. Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?. Oxidative medicine and cellular longevity. 2016; 2016(?):8679469. doi: 10.1155/2016/8679469. [PMID: 27313834]
  • Thomas Grenier-Larouche, Anne Galinier, Louis Casteilla, André C Carpentier, André Tchernof. Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and lipid peroxidation in obese women. Journal of lipid research. 2015 Oct; 56(10):1985-92. doi: 10.1194/jlr.p058578. [PMID: 26239051]
  • Michael W Donnino, Sharri J Mortensen, Lars W Andersen, Maureen Chase, Katherine M Berg, Julia Balkema, Jeejabai Radhakrishnan, Raúl J Gazmuri, Xiaowen Liu, Michael N Cocchi. Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial. Critical care (London, England). 2015 Jul; 19(?):275. doi: 10.1186/s13054-015-0989-3. [PMID: 26130237]
  • Djurre H de Jong, Nicoletta Liguori, Tom van den Berg, Clement Arnarez, Xavier Periole, Siewert J Marrink. Atomistic and Coarse Grain Topologies for the Cofactors Associated with the Photosystem II Core Complex. The journal of physical chemistry. B. 2015 Jun; 119(25):7791-803. doi: 10.1021/acs.jpcb.5b00809. [PMID: 26053327]
  • Yvonne Y Clark, Loren E Wold, Laura A Szalacha, Donna O McCarthy. Ubiquinol reduces muscle wasting but not fatigue in tumor-bearing mice. Biological research for nursing. 2015 May; 17(3):321-9. doi: 10.1177/1099800414543822. [PMID: 25230747]
  • Maria Andrea Desbats, Giada Lunardi, Mara Doimo, Eva Trevisson, Leonardo Salviati. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency. Journal of inherited metabolic disease. 2015 Jan; 38(1):145-56. doi: 10.1007/s10545-014-9749-9. [PMID: 25091424]
  • Simone Onur, Petra Niklowitz, Gunnar Jacobs, Wolfgang Lieb, Thomas Menke, Frank Döring. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. BioFactors (Oxford, England). 2015 Jan; 41(1):35-43. doi: 10.1002/biof.1198. [PMID: 25728634]
  • Catherine Elliott, Luke Young, Ben May, Julia Shearman, Mary S Albury, Yasutoshi Kido, Kiyoshi Kita, Anthony L Moore. Purification and characterisation of recombinant DNA encoding the alternative oxidase from Sauromatum guttatum. Mitochondrion. 2014 Nov; 19 Pt B(?):261-8. doi: 10.1016/j.mito.2014.03.002. [PMID: 24632469]
  • A V Lokhmatikov, N E Voskoboynikova, D A Cherepanov, N V Sumbatyan, G A Korshunova, M V Skulachev, H-J Steinhoff, V P Skulachev, A Y Mulkidjanian. Prevention of peroxidation of cardiolipin liposomes by quinol-based antioxidants. Biochemistry. Biokhimiia. 2014 Oct; 79(10):1081-100. doi: 10.1134/s0006297914100101. [PMID: 25519067]
  • Simone Onur, Petra Niklowitz, Gunnar Jacobs, Ute Nöthlings, Wolfgang Lieb, Thomas Menke, Frank Döring. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC research notes. 2014 Jul; 7(?):427. doi: 10.1186/1756-0500-7-427. [PMID: 24996614]
  • Paul Bennetts, Qiuhua Shen, Amanda R Thimmesch, Francisco J Diaz, Richard L Clancy, Janet D Pierce. Effects of ubiquinol with fluid resuscitation following haemorrhagic shock on rat lungs, diaphragm, heart and kidneys. Experimental physiology. 2014 Jul; 99(7):1007-15. doi: 10.1113/expphysiol.2014.078600. [PMID: 24860150]
  • Luke Young, Benjamin May, Alice Pendlebury-Watt, Julia Shearman, Catherine Elliott, Mary S Albury, Tomoo Shiba, Daniel Ken Inaoka, Shigeharu Harada, Kiyoshi Kita, Anthony L Moore. Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis. Biochimica et biophysica acta. 2014 Jul; 1837(7):1219-25. doi: 10.1016/j.bbabio.2014.01.027. [PMID: 24530866]
  • W Peerapanyasut, K Thamprasert, O Wongmekiat. Ubiquinol supplementation protects against renal ischemia and reperfusion injury in rats. Free radical research. 2014 Feb; 48(2):180-9. doi: 10.3109/10715762.2013.858148. [PMID: 24151980]
  • Taichi Inagaki, Takeshi Yamamoto. Critical role of deep hydrogen tunneling to accelerate the antioxidant reaction of ubiquinol and vitamin E. The journal of physical chemistry. B. 2014 Jan; 118(4):937-50. doi: 10.1021/jp410263f. [PMID: 24367903]
  • Anna Gvozdjáková, Jarmila Kucharská, Daniela Ostatníková, Katarína Babinská, Dalibor Nakládal, Fred L Crane. Ubiquinol improves symptoms in children with autism. Oxidative medicine and cellular longevity. 2014; 2014(?):798957. doi: 10.1155/2014/798957. [PMID: 24707344]
  • Jinfeng Qu, Li Ma, Junhua Zhang, Steffen Jockusch, Ilyas Washington. Dietary chlorophyll metabolites catalyze the photoreduction of plasma ubiquinone. Photochemistry and photobiology. 2013 Mar; 89(2):310-3. doi: 10.1111/j.1751-1097.2012.01230.x. [PMID: 22928808]
  • Jacopo Lucchetti, Marianna Marino, Simonetta Papa, Massimo Tortarolo, Giovanna Guiso, Silvia Pozzi, Valentina Bonetto, Silvio Caccia, Ettore Beghi, Caterina Bendotti, Marco Gobbi. A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10. PloS one. 2013; 8(7):e69540. doi: 10.1371/journal.pone.0069540. [PMID: 23936040]
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