5-Hydroxydopamine (BioDeep_00000027413)

   

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


5-(2-Aminoethyl)benzene-1,2,3-triol

化学式: C8H11NO3 (169.0738896)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 5.5%

分子结构信息

SMILES: C(CN)c1cc(c(c(c1)O)O)O
InChI: InChI=1S/C8H11NO3/c9-2-1-5-3-6(10)8(12)7(11)4-5/h3-4,10-12H,1-2,9H2

描述信息

5-Hydroxydopamine is a naturally occurring amine in human urine. 5-Hydroxydopamine concentration in urine of DOPA treated Parkinsons patients was significantly higher than inpatients not treated or normal controls. (PMID 8255370) [HMDB]
5-Hydroxydopamine is a naturally occurring amine in human urine. 5-Hydroxydopamine concentration in urine of DOPA treated Parkinsons patients was significantly higher than inpatients not treated or normal controls. (PMID 8255370).

同义名列表

8 个代谢物同义名

5-(2-Aminoethyl)benzene-1,2,3-triol; 5-(2-Aminoethyl)1,2,3-benzenetriol; 3,4,5-Trihydroxyphenylethylamine; 5-Hydroxydopamine hydrochloride; 5-Hydroxydopamine hydrobromide; 3,4,5-Trihydroxyphenethylamine; 5-(2-Aminoethyl)-pyrogallol; 5-Hydroxydopamine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guangjun Nie, Yuanlin Cao, Baolu Zhao. Protective effects of green tea polyphenols and their major component, (-)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells. Redox report : communications in free radical research. 2002; 7(3):171-7. doi: 10.1179/135100002125000424. [PMID: 12189048]
  • Y Kawai, E Senba. Spontaneous synaptogenesis in ex vivo sympathetic ganglion and the blockade by serum treatment. The Journal of comparative neurology. 2000 Sep; 424(4):670-8. doi: 10.1002/1096-9861(20000904)424:4<670::aid-cne8>3.0.co;2-e. [PMID: 10931488]
  • E Kienzl, L Puchinger, K Jellinger, W Linert, H Stachelberger, R F Jameson. The role of transition metals in the pathogenesis of Parkinson's disease. Journal of the neurological sciences. 1995 Dec; 134 Suppl(?):69-78. doi: 10.1016/0022-510x(95)00210-s. [PMID: 8847547]
  • K Jellinger, L Linert, E Kienzl, E Herlinger, M B Youdim. Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease. Journal of neural transmission. Supplementum. 1995; 46(?):297-314. doi: NULL. [PMID: 8821067]
  • R Andrew, D G Watson, S A Best, J M Midgley, H Wenlong, R K Petty. The determination of hydroxydopamines and other trace amines in the urine of parkinsonian patients and normal controls. Neurochemical research. 1993 Nov; 18(11):1175-7. doi: 10.1007/bf00978370. [PMID: 8255370]
  • J Y Jew. Histofluorescence and ultrastructural observations of small intensely fluorescent (SIF) cells in the superior sympathetic ganglion of the guinea pig. Cell and tissue research. 1985; 241(3):529-38. doi: 10.1007/bf00214572. [PMID: 4028138]
  • M Wallace, G Singer, J Finlay, S Gibson. The effect of 6-OHDA lesions of the nucleus accumbens septum on schedule-induced drinking, wheelrunning and corticosterone levels in the rat. Pharmacology, biochemistry, and behavior. 1983 Jan; 18(1):129-36. doi: 10.1016/0091-3057(83)90262-9. [PMID: 6828531]
  • H Jeikowski, D Drenckhahn. Evidence for exclusive adrenergic innervation of feather muscles (mm. pennati) in the chicken. Histochemical studies and experiments with 5-hydroxydopamine. Cell and tissue research. 1981; 221(1):157-68. doi: 10.1007/bf00216578. [PMID: 7317941]