Mizoribine (BioDeep_00000027335)

 

Secondary id: BioDeep_00000600352

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide

化学式: C9H13N3O6 (259.08043180000004)
中文名称: 咪唑立兵, 咪唑立宾
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 8%

分子结构信息

SMILES: C1=NC(=C(N1C2C(C(C(O2)CO)O)O)O)C(=O)N
InChI: InChI=1S/C9H13N3O6/c10-7(16)4-8(17)12(2-11-4)9-6(15)5(14)3(1-13)18-9/h2-3,5-6,9,13-15,17H,1H2,(H2,10,16)/t3-,5-,6-,9-/m1/s1

描述信息

Mizoribine belongs to the family of 1-Ribosyl-imidazolecarboxamides. These are organic compounds containing the imidazole ring linked to a ribose ring through a 1-2 bond.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant[1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively[2].
Mizoribine (NSC 289637), an imidazole nucleoside, inhibits HCV RNA replication with IC50 of approximately 100 μM for anti-HCV activity. Immunosuppressant[1]. Mizoribine, an IMPDH inhibitor, inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively[2].

同义名列表

7 个代谢物同义名

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide; Mizoribine 5-monophosphate; mizoribine; NSC289637; Bredinin; NSC 289637; HE 69



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ping Li, Dongrui Cheng, Jiqiu Wen, Xuefeng Ni, Kenan Xie, Xue Li, Jinsong Chen. Conversion from mycophenolate mofetil to mizoribine in the early stages of BK polyomavirus infection could improve kidney allograft prognosis: a single-center study from China. BMC nephrology. 2021 10; 22(1):328. doi: 10.1186/s12882-021-02527-3. [PMID: 34600511]
  • Xichao Wang, Miaomiao Zhang, Wenyu Zhang, Ying Liu, Yingying Han, Wenxiu Chang. Effect of mizoribine pulse therapy in adult membranous nephropathy. International urology and nephrology. 2021 Apr; 53(4):725-731. doi: 10.1007/s11255-020-02680-y. [PMID: 33159256]
  • Hikaru Sugimoto, Shiho Matsuno, Noriko Yamanaka, Wako Yumura, Mitsuyo Itabashi, Takashi Takei. Low-dose corticosteroid with mizoribine might be an effective therapy for elderly-onset ISKDC grade VI IgA vasculitis. CEN case reports. 2021 02; 10(1):46-52. doi: 10.1007/s13730-020-00513-6. [PMID: 32754805]
  • Rui Dai, Jingjie Li, Jingjing Wu, Qian Fu, Jiajia Yan, Guoping Zhong, Changxi Wang, Xiao Chen, Pan Chen. Genetic and clinical determinants of mizoribine pharmacokinetics in renal transplant recipients. European journal of clinical pharmacology. 2021 Jan; 77(1):45-53. doi: 10.1007/s00228-020-02936-7. [PMID: 32803290]
  • Shuichiro Fujinaga, Akira Mizutani. Should rituximab be administered before cyclophosphamide as a first-line steroid-sparing agent to young children with steroid-dependent nephrotic syndrome?. Clinical and experimental nephrology. 2020 Dec; 24(12):1187-1188. doi: 10.1007/s10157-020-01938-0. [PMID: 32728924]
  • Hrvoje Jakovac. COVID-19 and hypertension: is the HSP60 culprit for the severe course and worse outcome?. American journal of physiology. Heart and circulatory physiology. 2020 10; 319(4):H793-H796. doi: 10.1152/ajpheart.00506.2020. [PMID: 32886002]
  • Patrizia Natale, Suetonia C Palmer, Marinella Ruospo, Valeria M Saglimbene, Jonathan C Craig, Mariacristina Vecchio, Joshua A Samuels, Donald A Molony, Francesco Paolo Schena, Giovanni Fm Strippoli. Immunosuppressive agents for treating IgA nephropathy. The Cochrane database of systematic reviews. 2020 03; 3(?):CD003965. doi: 10.1002/14651858.cd003965.pub3. [PMID: 32162319]
  • Zhiguo Peng, Wanhua Xian, Huaibin Sun, Engang Li, Lina Geng, Jun Tian. Efficacy and Safety of a Quadruple Regimen Compared with Triple Regimens in Patients with Mycophenolic Acid-Related Gastrointestinal Complications After Renal Transplantation: A Short-Term Single-Center Study. Annals of transplantation. 2020 Feb; 25(?):e919875. doi: 10.12659/aot.919875. [PMID: 32107364]
  • Keisuke Sugimoto, Takuji Enya, Kohei Miyazaki, Tomoki Miyazawa, Tsukasa Takemura, Mitsuru Okada. Membranoproliferative glomerulonephritis related to a streptococcal infection in a girl with IgA deficiency: a case report. BMC nephrology. 2020 02; 21(1):68. doi: 10.1186/s12882-020-01735-7. [PMID: 32103732]
  • Yuki Ikeda, Kenichi Fukunari, Saori Uchiumi, Yuki Awanami, Akiko Kanaya, Keiichiro Matsumoto, Makoto Fukuda, Tsuyoshi Takashima, Motoaki Miyazono, Yuji Ikeda. A case of anti-neutrophil cytoplasmic antibody-associated vasculitis with anti-glomerular basement membrane antibodies that was successfully treated with mizoribine as a safe and effective remission maintenance therapy with prednisolone and plasma exchange. CEN case reports. 2020 02; 9(1):42-47. doi: 10.1007/s13730-019-00423-2. [PMID: 31612361]
  • Dongyeol Lee, Hee Yeoun Kim, Jin Ho Lee, Yong Hun Sin, Joong Kyung Kim, Joon Seok Oh. Long-term Survival Analysis of Kidney Transplant Recipients Receiving Mizoribine as a Maintenance Immunosuppressant: A Single-Center Study. Transplantation proceedings. 2019 Oct; 51(8):2637-2642. doi: 10.1016/j.transproceed.2019.03.060. [PMID: 31349984]
  • Tomomi Kondoh, Yohei Ikezumi, Katsuyuki Yokoi, Yoko Nakajima, Yuji Matsumoto, Masahiro Kaneko, Hiroya Hasegawa, Takeshi Yamada, Naonori Kumagai, Tetsuya Ito, Tetsushi Yoshikawa. Assessment of factors associated with mizoribine responsiveness in children with steroid-dependent nephrotic syndrome. Clinical and experimental nephrology. 2019 Sep; 23(9):1154-1160. doi: 10.1007/s10157-019-01754-1. [PMID: 31187341]
  • Yuka Kurokawa, Kiyomi Koike, Yusuke Kaida, Sakuya Ito, Hirotane Chiba, Kengo Urae, Tomofumi Moriyama, Nao Nakamura, Tetsurou Imai, Ryo Shibata, Takuma Hazama, Daisuke Wakasugi, Seiya Okuda, Kei Fukami. Effectiveness of cryofiltration and mizoribine combination with oral steroid therapy in a patient with membranoproliferative glomerulonephritis due to essential cryoglobulinemia. CEN case reports. 2019 08; 8(3):205-211. doi: 10.1007/s13730-019-00394-4. [PMID: 30927247]
  • Yi Shi, Hang Liu, Xin-Guo Chen, Zhong-Yang Shen. Efficacy and Safety of Mizoribine Combined With Tacrolimus in Living Donor Kidney Transplant Recipients: 3-Year Results by a Chinese Single Center Study. Transplantation proceedings. 2019 Jun; 51(5):1337-1342. doi: 10.1016/j.transproceed.2019.03.014. [PMID: 31155174]
  • Yi Shi, Hang Liu, Xin-Guo Chen, Zhong-Yang Shen. Hyperuricemia in Living Donor Kidney Transplantation Patients During Mizoribine Administration Caused Mainly by Changes in Kidney Function. Transplantation proceedings. 2019 Jun; 51(5):1392-1396. doi: 10.1016/j.transproceed.2019.01.133. [PMID: 31155176]
  • Zheng-Kun Xia, Yuan-Fu Gao, Li-Ping Rong, Xi-Qiang Dang, Qian Shen, Xiao-Yun Jiang, Zhu-Wen Yi, Hong Xu. Usefulness of mizoribine administration in children with frequently relapsing nephrotic syndrome, and the relationship between pharmacokinetic parameters and efficacy: a multicenter prospective cohort study in China. World journal of pediatrics : WJP. 2019 Jun; 15(3):262-269. doi: 10.1007/s12519-019-00241-7. [PMID: 30864060]
  • Pan Chen, Xuan Xu, Longshan Liu, Jingjing Wu, Jingjie Li, Qian Fu, Jie Chen, Changxi Wang. Prediction of mizoribine pharmacokinetic parameters by serum creatinine in renal transplant recipients. European journal of clinical pharmacology. 2019 Mar; 75(3):363-369. doi: 10.1007/s00228-018-2584-4. [PMID: 30386911]
  • X Yuan, C Chen, Y Zheng, C Wang. Conversion From Mycophenolates to Mizoribine Is Associated With Lower BK Virus Load in Kidney Transplant Recipients: A Prospective Study. Transplantation proceedings. 2018 Dec; 50(10):3356-3360. doi: 10.1016/j.transproceed.2018.01.059. [PMID: 30577207]
  • Akiko Mii, Akira Shimizu, Daisuke Takada, Shuichi Tsuruoka. Proliferative glomerulonephritis with unusual microlamellar organized deposits related to monoclonal immunoglobulin G3 (IgG3) kappa. CEN case reports. 2018 11; 7(2):320-324. doi: 10.1007/s13730-018-0351-0. [PMID: 29987665]
  • Yuko Shima, Koichi Nakanishi, Yoshitsugu Kaku, Kenji Ishikura, Hiroshi Hataya, Takeshi Matsuyama, Masataka Honda, Mayumi Sako, Kandai Nozu, Ryojiro Tanaka, Kazumoto Iijima, Norishige Yoshikawa. Combination therapy with or without warfarin and dipyridamole for severe childhood IgA nephropathy: an RCT. Pediatric nephrology (Berlin, Germany). 2018 11; 33(11):2103-2112. doi: 10.1007/s00467-018-4011-6. [PMID: 29987456]
  • Ayumi Ishiwatari, Mariko Endo, Sachiko Wakai. Ruptured renal artery in microscopic polyangiitis: a case report and literature review. CEN case reports. 2018 11; 7(2):301-306. doi: 10.1007/s13730-018-0347-9. [PMID: 29951966]
  • L Liu, B Ren, H Zhang, J Li, Q Fu, J Jiang, S Deng, J Qiu, G Chen, J Fei, L Chen, C Wang. Population Pharmacokinetic Analysis of Mizoribine in Chinese Renal Transplant Recipients. Transplantation proceedings. 2018 Oct; 50(8):2392-2397. doi: 10.1016/j.transproceed.2018.03.030. [PMID: 30316364]
  • Keisuke Oda, Nobuhiro Mori, Masayoshi Okumi, Miyuki Furusawa, Masashi Ishiguro, Kazuyuki Inoue, Satoshi Shuto, Kohei Unagami, Hideki Ishida, Kazunari Tanabe, Teruo Murakami. Uptake and metabolism of mizoribine, an immunosuppressant, in L5178Y-R mouse lymphoma cells in vitro and peripheral blood mononuclear cells of rats and kidney transplant recipients in vivo. Drug metabolism and pharmacokinetics. 2018 Oct; 33(5):232-239. doi: 10.1016/j.dmpk.2018.08.007. [PMID: 30241694]
  • Yasumori Izumi, Kenjiro Nakaoka, Masatsugu Kamata, Nozomi Iwanaga, Shunsuke Imadachi, Hirokazu Kurohama, Masahiro Ito, Kiyoshi Migita. Steroid-resistant protein-losing gastroenteropathy complicated with Sjögren's syndrome successfully treated with mizoribine. Modern rheumatology. 2018 Jul; 28(4):716-720. doi: 10.3109/14397595.2016.1145570. [PMID: 26872871]
  • Y Maruyama, T Sadahira, Y Mitsui, K Wada, R Tanimoto, S Nishimura, Y Kobayashi, T Watanabe, Y Nasu, M Araki. Acute Inflammatory Syndrome Paradoxically Induced by De Novo Purine Inhibitors Synthesis Before Renal Transplantation: A Case Report and Review of the Literature. Transplantation proceedings. 2018 Apr; 50(3):895-897. doi: 10.1016/j.transproceed.2017.12.030. [PMID: 29571743]
  • Yukihiko Kawasaki, Ryo Maeda, Shinichiro Ohara, Kazuhide Suyama, Mitsuaki Hosoya. Serum IgA/C3 and glomerular C3 staining predict severity of IgA nephropathy. Pediatrics international : official journal of the Japan Pediatric Society. 2018 Feb; 60(2):162-167. doi: 10.1111/ped.13461. [PMID: 29178575]
  • Tsukasa Nishioka, Norio Yoshimura, Hidetaka Ushigome, Yoshihiko Watarai, Kenji Nishimura, Kiyokazu Akioka, Nobuyuki Nakamura, Mutsushi Kawakita, Kenji Yuzawa, Tatsuya Nakatani. High-dose mizoribine combined with calcineurin inhibitor (cyclosporine or tacrolimus), basiliximab and corticosteroids for renal transplantation: A Japanese multicenter study. International journal of urology : official journal of the Japanese Urological Association. 2018 02; 25(2):141-145. doi: 10.1111/iju.13476. [PMID: 29068092]
  • Tsutomu Takeuchi, Kenya Okada, Hisao Yoshida, Nobuyuki Yagi. Post-marketing surveillance study of the long-term use of mizoribine for the treatment of lupus nephritis: 2-Year results. Modern rheumatology. 2018 Jan; 28(1):85-94. doi: 10.1080/14397595.2017.1349573. [PMID: 28722500]
  • Takao Saito, Masayuki Iwano, Koichi Matsumoto, Tetsuya Mitarai, Hitoshi Yokoyama, Noriaki Yorioka, Shinichi Nishi, Ashio Yoshimura, Hiroshi Sato, Satoru Ogahara, Yoshie Sasatomi, Yasufumi Kataoka, Shiro Ueda, Akio Koyama, Shoichi Maruyama, Masaomi Nangaku, Enyu Imai, Seiichi Matsuo, Yasuhiko Tomino. Mizoribine therapy combined with steroids and mizoribine blood concentration monitoring for idiopathic membranous nephropathy with steroid-resistant nephrotic syndrome. Clinical and experimental nephrology. 2017 Dec; 21(6):961-970. doi: 10.1007/s10157-016-1340-2. [PMID: 27783276]
  • Jumpei Hasegawa, Shuji Hatakeyama, Sachiko Wakai, Kazuya Omoto, Masayoshi Okumi, Kazunari Tanabe, Makiko Mieno, Hiroki Shirakawa. Preemptive anti-cytomegalovirus therapy in high-risk (donor-positive, recipient-negative cytomegalovirus serostatus) kidney transplant recipients. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2017 Dec; 65(?):50-56. doi: 10.1016/j.ijid.2017.09.023. [PMID: 28986314]
  • Takuhito Nagai, Osamu Uemura, Hisashi Kaneda, Katsumi Ushijima, Kazuhide Ohta, Yoshimitsu Gotoh, Kenichi Satomura, Masaki Shimizu, Mikiya Fujieda, Masashi Morooka, Takuji Yamada, Masayoshi Yamada, Naohiro Wada, Yukiya Hashimoto. The true distribution volume and bioavailability of mizoribine in children with chronic kidney disease. Clinical and experimental nephrology. 2017 Oct; 21(5):884-888. doi: 10.1007/s10157-016-1353-x. [PMID: 27873037]
  • Akira Mima. Efficacy of mizoribine and prednisolone combination therapy in adult patients with IgA vasculitis. Rheumatology international. 2017 Aug; 37(8):1387-1393. doi: 10.1007/s00296-017-3685-6. [PMID: 28255645]
  • S Harada, T Nakamura, H Ushigome, N Akutsu, K Akioka, T Nakatani, N Yoshimura. Beneficial Effects of High-Dose Mizoribine on ABO-Incompatible Living-Related Kidney Transplantation: Two-Year Results by a Japanese Multicenter Study. Transplantation proceedings. 2017 Jun; 49(5):967-970. doi: 10.1016/j.transproceed.2017.03.033. [PMID: 28583569]
  • Keigo Ikeda, Kozo Watanabe, Takuya Hirai, Kana Tanji, Tomoko Miyashita, Shihoko Nakajima, Kaori Uomori, Shinji Morimoto, Kenji Takamori, Hideoki Ogawa, Yoshinari Takasaki, Iwao Sekigawa. Mizoribine Synchronized Methotrexate Therapy should be Considered when Treating Rheumatoid Arthritis Patients with an Inadequate Response to Various Combination Therapies. Internal medicine (Tokyo, Japan). 2017; 56(10):1147-1152. doi: 10.2169/internalmedicine.56.7886. [PMID: 28502927]
  • Y Shi, H Liu, X-G Chen, Z-Y Shen. Comparison of Mizoribine and Mycophenolate Mofetil With a Tacrolimus-Based Immunosuppressive Regimen in Living-Donor Kidney Transplantation Recipients: A Retrospective Study in China. Transplantation proceedings. 2017 Jan; 49(1):26-31. doi: 10.1016/j.transproceed.2016.10.018. [PMID: 28104150]
  • K Akioka, T Ishikawa, M Osaka, Y Kadotani, K Okugawa, K Nakano, Y Osaka, K Tsuchiya, H Sako. Hyperuricemia and Acute Renal Failure in Renal Transplant Recipients Treated With High-Dose Mizoribine. Transplantation proceedings. 2017 Jan; 49(1):73-77. doi: 10.1016/j.transproceed.2016.11.015. [PMID: 28104163]
  • N Nakamura, T Miyazaki, H Matsuzaki, R Furuya, S Miyajima, S Irie, H Matsuoka, M Tanaka. Experience of Quatro-Therapy With Everolimus to Minimize Calcineurin Inhibitor for Kidney Transplant Recipients. Transplantation proceedings. 2017 Jan; 49(1):32-36. doi: 10.1016/j.transproceed.2016.11.005. [PMID: 28104152]
  • Takuya Hirai, Keigo Ikeda, Maki Fujishiro, Hiroshi Tsushima, Kunihiro Hayakawa, Satoshi Suzuki, Ayako Yamaguchi, Kazuhisa Nozawa, Shinji Morimoto, Yoshinari Takasaki, Hideoki Ogawa, Kenji Takamori, Naoto Tamura, Iwao Sekigawa. The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study. Clinical rheumatology. 2017 Jan; 36(1):51-58. doi: 10.1007/s10067-016-3458-8. [PMID: 27783236]
  • Kosuke Masutani, Akihiro Tsuchimoto, Tomomi Yamada, Makoto Hirakawa, Koji Mitsuiki, Ritsuko Katafuchi, Hideki Hirakata, Takanari Kitazono, Kazuhiko Tsuruya. Comparison of steroid-pulse therapy and combined with mizoribine in IgA nephropathy: a randomized controlled trial. Clinical and experimental nephrology. 2016 Dec; 20(6):896-903. doi: 10.1007/s10157-016-1226-3. [PMID: 26758039]
  • Hisashi Kaneda, Masaki Shimizu, Kazuhide Ohta, Katsumi Ushijima, Yoshimitsu Gotoh, Kenichi Satomura, Takuhito Nagai, Mikiya Fujieda, Masashi Morooka, Takuji Yamada, Masayoshi Yamada, Naohiro Wada, Mari Takaai, Yukiya Hashimoto, Osamu Uemura. Population pharmacokinetics of mizoribine in pediatric patients with kidney disease. Clinical and experimental nephrology. 2016 Oct; 20(5):757-763. doi: 10.1007/s10157-015-1209-9. [PMID: 26649561]
  • Hideki Ishida, Shiro Takahara, Noritoshi Amada, Shinji Tomikawa, Tatsuya Chikaraishi, Kota Takahashi, Kazuhiro Uchida, Takahiro Akiyama, Kazunari Tanabe, Hiroshi Toma. A Prospective Randomized, Comparative Trial of High-Dose Mizoribine Versus Mycophenolate Mofetil in Combination With Tacrolimus and Basiliximab for Living Donor Renal Transplant: A Multicenter Trial. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 2016 Oct; 14(5):518-525. doi: NULL. [PMID: 27733107]
  • Kimberly Trotter, Marcus R Clark, Vladimir M Liarski. Overview of pathophysiology and treatment of human lupus nephritis. Current opinion in rheumatology. 2016 09; 28(5):460-7. doi: 10.1097/bor.0000000000000319. [PMID: 27341623]
  • Jishi Liu, Ke Zhang, Ying Ji, Wei Zhang, Wei Li, Qing Yong, Jianwen Wang, Jian Sun, Hao Zhang. Safety and efficacy of mizoribine treatment in nephrotic syndrome complicated with hepatitis B virus infection: a clinical study. Renal failure. 2016 Jun; 38(5):723-7. doi: 10.3109/0886022x.2016.1158035. [PMID: 26983690]
  • Xichao Wang, Xinyuan Song, Ying Liu, Wenyu Zhang, Wenwen An, Yangke Tu. Treatment of membranous nephropathy with mizoribine: A control trial. Life sciences. 2016 Jun; 154(?):75-8. doi: 10.1016/j.lfs.2016.04.012. [PMID: 27079740]
  • H Ushigome, K Uchida, K Nishimura, K Akioka, Y Fukuda, K Yuzawa, M Fujisawa, A Sugitani, S-I Ito, T Nakatani, T Horimi, N Yoshimura. Efficacy and Safety of High-Dose Mizoribine Combined With Cyclosporine, Basiliximab, and Corticosteroids in Renal Transplantation: A Japanese Multicenter Study. Transplantation proceedings. 2016 Apr; 48(3):794-8. doi: 10.1016/j.transproceed.2015.12.117. [PMID: 27234738]
  • N Yoshimura, T Nakao, T Nakamura, S Harada, K Koshino, T Suzuki, T Ito, S Nobori, H Ushigome. Effectiveness of the Combination of Everolimus and Tacrolimus With High Dosage of Mizoribine for Living Donor-Related Kidney Transplantation. Transplantation proceedings. 2016 Apr; 48(3):786-9. doi: 10.1016/j.transproceed.2015.12.102. [PMID: 27234736]
  • Ji Hong Kim, Yeon Hee Lee, Beom Jin Lim, Hyeon Joo Jeong, Pyung Kil Kim, Jae Il Shin. Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats. Scientific reports. 2016 Mar; 6(?):22374. doi: 10.1038/srep22374. [PMID: 26947764]
  • Hang Liu, Yong Wang, Baohan Fan, Liang Ren, Wei Wang, Pengxiao Hu, Xiaodong Zhang. Improvement in Severe Mycophenolic Acid-associated Gastrointestinal Symptoms after Changing Enteric-coated Mycophenolate Sodium to Mizoribine in Renal Transplant Recipients: Two Case Reports. Internal medicine (Tokyo, Japan). 2016; 55(15):2005-10. doi: 10.2169/internalmedicine.55.5968. [PMID: 27477406]
  • Norihiko Sakai, Takashi Wada. [Immunosuppressants-induced kidney injury]. Nihon Jinzo Gakkai shi. 2016; 58(7):1073-1078. doi: NULL. [PMID: 30620815]
  • Yuan Feng, Changyuan Wang, Qi Liu, Qiang Meng, Xiaokui Huo, Zhihao Liu, Pengyuan Sun, Xiaobo Yang, Huijun Sun, Jianhua Qin, Kexin Liu. Bezafibrate-mizoribine interaction: Involvement of organic anion transporters OAT1 and OAT3 in rats. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Jan; 81(?):119-28. doi: 10.1016/j.ejps.2015.10.008. [PMID: 26474691]
  • Hitoshi Yokoyama, Hitoshi Sugiyama, Ichiei Narita, Takao Saito, Kunihiro Yamagata, Saori Nishio, Shouichi Fujimoto, Noriko Mori, Yukio Yuzawa, Seiya Okuda, Shoichi Maruyama, Hiroshi Sato, Yoshihiko Ueda, Hirofumi Makino, Seiichi Matsuo. Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR). Clinical and experimental nephrology. 2015 Jun; 19(3):496-505. doi: 10.1007/s10157-014-1022-x. [PMID: 25230687]
  • Hiroshi Tanaka, Kazushi Tsuruga, Taddatsu Imaizumi. Mizoribine in the treatment of pediatric-onset glomerular disease. World journal of pediatrics : WJP. 2015 May; 11(2):108-12. doi: 10.1007/s12519-015-0013-7. [PMID: 25754750]
  • N Ichimaru, K Yamanaka, T Kato, Y Kakuta, T Abe, R Imamura, N Nonomura, J-Y Kaimori, S Takahara. Risk factors and incidence for lipid abnormalities in kidney transplant patients. Transplantation proceedings. 2015 Apr; 47(3):672-4. doi: 10.1016/j.transproceed.2014.12.029. [PMID: 25891708]
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