1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (BioDeep_00000271550)
代谢物信息卡片
化学式: C10H11NO2 (177.0789746)
中文名称: 外消旋 1,2,3,4-四氢异喹啉-3-羧酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(NCC2=CC=CC=C21)C(=O)O
InChI: InChI=1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Kazuya Otake, Satoru Azukizawa, Shigemitsu Takeda, Masaki Fukui, Arisa Kawahara, Tatsuya Kitao, Hiroaki Shirahase. Novel 2,7-Substituted (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic Acids: Peroxisome Proliferator-Activated Receptor γ Partial Agonists with Protein-Tyrosine Phosphatase 1B Inhibition.
Chemical & pharmaceutical bulletin.
2015; 63(12):998-1014. doi:
10.1248/cpb.c15-00508. [PMID: 26633022] - Rami A Al-Horani, Akul Y Mehta, Umesh R Desai. Potent direct inhibitors of factor Xa based on the tetrahydroisoquinoline scaffold.
European journal of medicinal chemistry.
2012 Aug; 54(?):771-83. doi:
10.1016/j.ejmech.2012.06.032. [PMID: 22770607] - Kazuya Otake, Satoru Azukizawa, Masaki Fukui, Kazuyoshi Kunishiro, Hikaru Kamemoto, Mamoru Kanda, Tomohiro Miike, Masayasu Kasai, Hiroaki Shirahase. Novel (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor γ selective agonists with protein-tyrosine phosphatase 1B inhibition.
Bioorganic & medicinal chemistry.
2012 Jan; 20(2):1060-75. doi:
10.1016/j.bmc.2011.11.035. [PMID: 22197396] - Kazuya Otake, Satoru Azukizawa, Masaki Fukui, Michiko Shibabayashi, Hikaru Kamemoto, Tomohiro Miike, Kazuyoshi Kunishiro, Masayasu Kasai, Hiroaki Shirahase. A novel series of (S)-2,7-substituted-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: peroxisome proliferator-activated receptor α/γ dual agonists with protein-tyrosine phosphatase 1B inhibitory activity.
Chemical & pharmaceutical bulletin.
2011; 59(10):1233-42. doi:
10.1248/cpb.59.1233. [PMID: 21963632] - Satoru Azukizawa, Masayasu Kasai, Kenji Takahashi, Tomohiro Miike, Kazuyoshi Kunishiro, Mamoru Kanda, Chisato Mukai, Hiroaki Shirahase. Synthesis and biological evaluation of (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids: a novel series of PPAR gamma agonists.
Chemical & pharmaceutical bulletin.
2008 Mar; 56(3):335-45. doi:
10.1248/cpb.56.335. [PMID: 18310946]