AMINOREX (BioDeep_00000270848)

   


代谢物信息卡片


AMINOREX

化学式: C9H10N2O (162.079309)
中文名称: 氨苯恶唑啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(OC(=N1)N)C2=CC=CC=C2
InChI: InChI=1S/C9H10N2O/c10-9-11-6-8(12-9)7-4-2-1-3-5-7/h1-5,8H,6H2,(H2,10,11)

描述信息

C78272 - Agent Affecting Nervous System > C29728 - Anorexiant

同义名列表

1 个代谢物同义名

AMINOREX



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sucheta Kudrimoti, Jacob Machin, Adedamola S Arojojoye, Samuel G Awuah, Rodney Eisenberg, Clara Fenger, George Maylin, Andreas F Lehner, Thomas Tobin. Synthesis and characterization of d5 -barbarin for use in barbarin-related research. Drug testing and analysis. 2023 Jan; 15(1):42-46. doi: 10.1002/dta.3357. [PMID: 35975356]
  • Jacob Machin, Taylor Childers, Sucheta Kudrimoti, Rod Eisenberg, Clara Fenger, Petra Hartmann, George Maylin, Theodore Shults, Thomas Tobin. Synthesis and characterization of barbarin, a possible source of unexplained aminorex identifications in forensic science. Drug testing and analysis. 2020 Oct; 12(10):1477-1482. doi: 10.1002/dta.2883. [PMID: 32567235]
  • S A Handley, S L Belsey, L Couchman, R J Flanagan. Plasma and Urine Levamisole in Clinical Samples Containing Benzoylecgonine: Absence of Aminorex. Journal of analytical toxicology. 2019 May; 43(4):299-306. doi: 10.1093/jat/bky102. [PMID: 30590551]
  • Anna Rickli, Karolina Kolaczynska, Marius C Hoener, Matthias E Liechti. Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR. Neurotoxicology. 2019 05; 72(?):95-100. doi: 10.1016/j.neuro.2019.02.011. [PMID: 30776375]
  • Céline Eiden, Hélène Peyrière, Caroline Diot, Olivier Mathieu. Prevalence of levamisole and aminorex in patients tested positive for cocaine in a French University Hospital. Clinical toxicology (Philadelphia, Pa.). 2015; 53(7):604-8. doi: 10.3109/15563650.2015.1054499. [PMID: 26065363]
  • Cornelius Hess, Natalie Ritke, Konrad Sydow, Lena-Maria Mehling, Hauke Ruehs, Burkhard Madea, Frank Musshoff. Determination of levamisole, aminorex, and pemoline in plasma by means of liquid chromatography-mass spectrometry and application to a pharmacokinetic study of levamisole. Drug testing and analysis. 2014 Oct; 6(10):1049-54. doi: 10.1002/dta.1619. [PMID: 24574157]
  • Tina Hofmaier, Anton Luf, Amir Seddik, Thomas Stockner, Marion Holy, Michael Freissmuth, Gerhard F Ecker, Rainer Schmid, Harald H Sitte, Oliver Kudlacek. Aminorex, a metabolite of the cocaine adulterant levamisole, exerts amphetamine like actions at monoamine transporters. Neurochemistry international. 2014 Jul; 73(?):32-41. doi: 10.1016/j.neuint.2013.11.010. [PMID: 24296074]
  • Steven B Karch, Beatrice Defraia, Luca Messerini, Francesco Mari, Fabio Vaiano, Elisabetta Bertol. Aminorex associated with possible idiopathic pulmonary hypertension in a cocaine user. Forensic science international. 2014 Jul; 240(?):e7-10. doi: 10.1016/j.forsciint.2014.03.028. [PMID: 24794740]
  • Cornelius Hess, Natalie Ritke, Sebastian Broecker, Burkhard Madea, Frank Musshoff. Metabolism of levamisole and kinetics of levamisole and aminorex in urine by means of LC-QTOF-HRMS and LC-QqQ-MS. Analytical and bioanalytical chemistry. 2013 May; 405(12):4077-88. doi: 10.1007/s00216-013-6829-x. [PMID: 23436169]
  • Elisabetta Bertol, Francesco Mari, Maria Grazia Di Milia, Lucia Politi, Sandra Furlanetto, Steven B Karch. Determination of aminorex in human urine samples by GC-MS after use of levamisole. Journal of pharmaceutical and biomedical analysis. 2011 Jul; 55(5):1186-9. doi: 10.1016/j.jpba.2011.03.039. [PMID: 21531521]
  • Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Baumann. Altered gene expression in pulmonary tissue of tryptophan hydroxylase-1 knockout mice: implications for pulmonary arterial hypertension. PloS one. 2011 Mar; 6(3):e17735. doi: 10.1371/journal.pone.0017735. [PMID: 21464983]
  • Margaret R Maclean, Yvonne Dempsie. The serotonin hypothesis of pulmonary hypertension revisited. Advances in experimental medicine and biology. 2010; 661(?):309-22. doi: 10.1007/978-1-60761-500-2_20. [PMID: 20204739]
  • E N M Ho, D K K Leung, G N W Leung, T S M Wan, A S Y Wong, C H F Wong, L R Soma, J A Rudy, C Uboh, R Sams. Aminorex and rexamino as metabolites of levamisole in the horse. Analytica chimica acta. 2009 Apr; 638(1):58-68. doi: 10.1016/j.aca.2009.02.033. [PMID: 19298880]
  • S A Barker. The formation of aminorex in racehorses following levamisole administration. A quantitative and chiral analysis following synthetic aminorex or levamisole administration vs. aminorex-positive samples from the field: a preliminary report. Journal of veterinary pharmacology and therapeutics. 2009 Apr; 32(2):160-6. doi: 10.1111/j.1365-2885.2008.01015.x. [PMID: 19290946]
  • Y Dempsie, M R MacLean. Pulmonary hypertension: therapeutic targets within the serotonin system. British journal of pharmacology. 2008 Oct; 155(4):455-62. doi: 10.1038/bjp.2008.241. [PMID: 18536742]
  • Yvonne Dempsie, Ian Morecroft, David J Welsh, Neil A MacRitchie, Nigel Herold, Lynn Loughlin, Margaret Nilsen, Andrew J Peacock, Anthony Harmar, Michael Bader, Margaret R MacLean. Converging evidence in support of the serotonin hypothesis of dexfenfluramine-induced pulmonary hypertension with novel transgenic mice. Circulation. 2008 Jun; 117(22):2928-37. doi: 10.1161/circulationaha.108.767558. [PMID: 18506000]
  • Lawrence R Soma, Jeffrey A Rudy, Cornelius E Uboh, Fran Xu, Heidi M Snapp. Pharmacokinetics and effects of aminorex in horses. American journal of veterinary research. 2008 May; 69(5):675-81. doi: 10.2460/ajvr.69.5.675. [PMID: 18447801]
  • Saadia Eddahibi, Serge Adnot. Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis. Respiratory research. 2002; 3(?):9. doi: 10.1186/rr181. [PMID: 11806844]
  • L Perchenet, L Hilfiger, J Mizrahi, O Clément-Chomienne. Effects of anorexinogen agents on cloned voltage-gated K(+) channel hKv1.5. The Journal of pharmacology and experimental therapeutics. 2001 Sep; 298(3):1108-19. doi: . [PMID: 11504808]
  • M Humbert, H Nunes, O Sitbon, F Parent, P Hervé, G Simonneau. Risk factors for pulmonary arterial hypertension. Clinics in chest medicine. 2001 Sep; 22(3):459-75. doi: 10.1016/s0272-5231(05)70284-7. [PMID: 11590841]
  • R B Rothman, M H Baumann, C M Dersch, D V Romero, K C Rice, F I Carroll, J S Partilla. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse (New York, N.Y.). 2001 Jan; 39(1):32-41. doi: 10.1002/1098-2396(20010101)39:1<32::aid-syn5>3.0.co;2-3. [PMID: 11071707]
  • J Bíbová, V Hampl. [Anorectics and pulmonary hypertension]. Casopis lekaru ceskych. 2000 Feb; 139(3):67-70. doi: NULL. [PMID: 10838744]
  • R B Rothman, M A Ayestas, C M Dersch, M H Baumann. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug; 100(8):869-75. doi: 10.1161/01.cir.100.8.869. [PMID: 10458725]
  • K T Weber. Herbs, seeds, oil and eggs: a vasotoxic salad. Cardiovascular research. 1997 May; 34(2):266-7. doi: 10.1016/s0008-6363(97)00052-7. [PMID: 9205538]
  • J Stepanek, F Zak. [Two-year peroral administration of aminorex in the dog. 2]. Zeitschrift fur Kardiologie. 1975 Aug; 64(8):768-81. doi: NULL. [PMID: 808916]