pongamol (BioDeep_00000270641)

 

Secondary id: BioDeep_00000180382

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(2Z)-3-hydroxy-1-(4-methoxy-1-benzofuran-5-yl)-3-phenylprop-2-en-1-one

  化学式: C18H14O4 (294.0892)
中文名称: 水黄皮籽素
  谱图信息: 最多检出来源 Viridiplantae(plant) 14.41%

分子结构信息

SMILES: c(c23)(occ3)ccc(c2OC)C(=O)CC(=O)c(c1)cccc1
InChI: InChI=1S/C18H14O4/c1-21-18-13(7-8-17-14(18)9-10-22-17)16(20)11-15(19)12-5-3-2-4-6-12/h2-11,19H,1H3/b15-11-


描述信息

Pongamol (Lanceolatin C) is potent α-glucosidase inhibitor (IC50=103.5 μM) and has free-radical (DPPH) scavenging,antihyperglycemic, and antihyperglycemic activities[1].

同义名列表

16 个代谢物同义名

(2Z)-3-hydroxy-1-(4-methoxy-1-benzofuran-5-yl)-3-phenylprop-2-en-1-one; pongamol; 1- (4-Methoxybenzofuran-5-yl) -3-phenyl-1,3-propanedione; Lanceolatin C; (Z)-3-hydroxy-1-(4-methoxy-1-benzofuran-5-yl)-3-phenylprop-2-en-1-one; 1-(4-methoxy-1-benzofuran-5-yl)-3-phenylpropane-1,3-dione; 1-(4-methoxy-5-benzofuranyl)-3-phenyl-1,3-propanedione; 1-(4-methoxy-5-benzofuranyl)-3-phenyl-1,3-propanedione; Lanceolatin C; 1-(4-Methoxy-benzofuran-5-yl)-3-phenyl-propane-1,3-dione; 1-(4-methoxybenzofuran-5-yl)-3-phenylpropane-1,3-dione; 1,3-Propanedione, 1-(4-methoxy-5-benzofuranyl)-3-phenyl-; 8Y19QCY6I4; A1-00787; PONGAMOL [INCI]; UNII-8Y19QCY6I4; XTLSKKJNOIMMBK-UHFFFAOYSA-N



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Kitherian Sahayaraj, Poolpandi Kombiah, Jesu Antony Martin Rathi. A chalcone (Pongamol) and phytoconstituents of Tephrosia purpurea. Natural product research. 2022 Apr; 36(7):1870-1873. doi: 10.1080/14786419.2020.1808640. [PMID: 32840388]
  • Shamima Jahan, Md Hasan Mahmud, Zidan Khan, Ashraful Alam, Anees Ahmed Khalil, Abdur Rauf, Abu Montakim Tareq, Firzan Nainu, Syed Mohammed Tareq, Talha Bin Emran, Muneeb Khan, Ishaq N Khan, Polrat Wilairatana, Mohammad S Mubarak. Health promoting benefits of pongamol: An overview. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112109. doi: 10.1016/j.biopha.2021.112109. [PMID: 34470730]
  • Rajni Sharma, Ibidapo S Williams, Linda Gatchie, Vinay R Sonawane, Bhabatosh Chaudhuri, Sandip B Bharate. Furanoflavones pongapin and lanceolatin B blocks the cell cycle and induce senescence in CYP1A1-overexpressing breast cancer cells. Bioorganic & medicinal chemistry. 2018 12; 26(23-24):6076-6086. doi: 10.1016/j.bmc.2018.11.013. [PMID: 30448188]
  • Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
  • Haribalan Perumalsamy, Myung Jin Jang, Jun-Ran Kim, Murugan Kadarkarai, Young-Joon Ahn. Larvicidal activity and possible mode of action of four flavonoids and two fatty acids identified in Millettia pinnata seed toward three mosquito species. Parasites & vectors. 2015 Apr; 8(?):237. doi: 10.1186/s13071-015-0848-8. [PMID: 25928224]
  • Wenli Wang, Jian Wang, Ning Li, Xiangrong Zhang, Weihong Zhao, Jiayuan Li, Yingying Si. Chemopreventive flavonoids from Millettia pulchra Kurz var-laxior (Dunn) Z.Wei (Yulangsan) function as Michael reaction acceptors. Bioorganic & medicinal chemistry letters. 2015 Mar; 25(5):1078-81. doi: 10.1016/j.bmcl.2015.01.009. [PMID: 25630222]
  • Chung-Hung Chan, Gek-Cheng Ngoh, Rozita Yusoff. A brief review on anti diabetic plants: Global distribution, active ingredients, extraction techniques and acting mechanisms. Pharmacognosy reviews. 2012 Jan; 6(11):22-8. doi: 10.4103/0973-7847.95854. [PMID: 22654401]
  • Akhilesh K Tamrakar, Natasha Jaiswal, Prem P Yadav, Rakesh Maurya, Arvind K Srivastava. Pongamol from Pongamia pinnata stimulates glucose uptake by increasing surface GLUT4 level in skeletal muscle cells. Molecular and cellular endocrinology. 2011 Jun; 339(1-2):98-104. doi: 10.1016/j.mce.2011.03.023. [PMID: 21497640]
  • R Ranga Rao, Ashok K Tiwari, P Prabhakar Reddy, K Suresh Babu, Amtul Z Ali, K Madhusudana, J Madhusudana Rao. New furanoflavanoids, intestinal alpha-glucosidase inhibitory and free-radical (DPPH) scavenging, activity from antihyperglycemic root extract of Derris indica (Lam.). Bioorganic & medicinal chemistry. 2009 Jul; 17(14):5170-5. doi: 10.1016/j.bmc.2009.05.051. [PMID: 19515570]
  • Akhilesh K Tamrakar, Prem P Yadav, Priti Tiwari, Rakesh Maurya, Arvind K Srivastava. Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. Journal of ethnopharmacology. 2008 Aug; 118(3):435-9. doi: 10.1016/j.jep.2008.05.008. [PMID: 18572336]
  • Aderbal F Magalhães, Ana Maria G A Tozzi, Eva G Magalhães, Miriam Sannomiya, Maria del Pilar C Soriano, Mary A F Perez. Flavonoids of Lonchocarpus montanus A.M.G. Azevedo and biological activity. Anais da Academia Brasileira de Ciencias. 2007 Sep; 79(3):351-67. doi: 10.1590/s0001-37652007000300001. [PMID: 17768528]
  • R S Zand, D J Jenkins, E P Diamandis. Steroid hormone activity of flavonoids and related compounds. Breast cancer research and treatment. 2000 Jul; 62(1):35-49. doi: 10.1023/a:1006422302173. [PMID: 10989984]
  • L C Chang, C Gerhäuser, L Song, N R Farnsworth, J M Pezzuto, A D Kinghorn. Activity-guided isolation of constituents of Tephrosia purpurea with the potential to induce the phase II enzyme, quinone reductase. Journal of natural products. 1997 Sep; 60(9):869-73. doi: 10.1021/np970236p. [PMID: 9322358]