Licocoumarone (BioDeep_00000270452)

 

Secondary id: BioDeep_00000019075

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4-[6-Hydroxy-4-methoxy-5-(3-methyl-but-2-enyl)-benzofuran-2-yl]-benzene-1,3-diol

化学式: C20H20O5 (340.13106700000003)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 76.92%

分子结构信息

SMILES: C(c(c3OC)c(O)cc(c31)oc(c(c2)c(O)cc(O)c2)c1)C=C(C)C
InChI: InChI=1S/C20H20O5/c1-11(2)4-6-14-17(23)10-19-15(20(14)24-3)9-18(25-19)13-7-5-12(21)8-16(13)22/h4-5,7-10,21-23H,6H2,1-3H3

描述信息

A member of the class of 1-benzofurans which consists of 1-benzofuran substituted by a hydroxy group at position 6, a methoxy group at position 4, a prenyl group at position 5 and a 2,4-dihydroxyphenyl group at position 2. It has been isolated from Glycyrrhiza uralensis.

同义名列表

9 个代谢物同义名

Licocoumarone; 4-[6-Hydroxy-4-methoxy-5-(3-methyl-but-2-enyl)-benzofuran-2-yl]-benzene-1,3-diol; 4-[6-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol; 4-[6-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)-2-benzofuranyl]benzene-1,3-diol; 4-[6-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)benzofuran-2-yl]benzene-1,3-diol; 4-[6-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)benzofuran-2-yl]resorcinol; AIDS-166092; AIDS166092; 2- (2,4-Dihydroxyphenyl) -4-methoxy-5- (3-methyl-2-butenyl) -6-hydroxybenzofuran



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jing-Ran Fan, Yi Kuang, Ze-Yuan Dong, Yang Yi, Yan-Xia Zhou, Bin Li, Xue Qiao, Min Ye. Prenylated Phenolic Compounds from the Aerial Parts of Glycyrrhiza uralensis as PTP1B and α-Glucosidase Inhibitors. Journal of natural products. 2020 04; 83(4):814-824. doi: 10.1021/acs.jnatprod.9b00262. [PMID: 32196343]
  • Chao Zhao, Dun Wang, Zexuan Gao, Hongfeng Kan, Feng Qiu, Lixia Chen, Hua Li. Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A. Chemico-biological interactions. 2020 Jan; 316(?):108913. doi: 10.1016/j.cbi.2019.108913. [PMID: 31838052]
  • Takashi Matsui, Subehan Lallo, Khoirun Nisa, Hiroyuki Morita. Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action. Bioorganic & medicinal chemistry letters. 2017 03; 27(6):1420-1424. doi: 10.1016/j.bmcl.2017.01.095. [PMID: 28196701]
  • Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu, Min Ye. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. Journal of natural products. 2016 Feb; 79(2):281-92. doi: 10.1021/acs.jnatprod.5b00877. [PMID: 26841168]
  • Hyung-Jun Kwon, Ha-Hyun Kim, Young Bae Ryu, Jang Hoon Kim, Hyung Jae Jeong, Seung-Woong Lee, Jong Sun Chang, Kyoung-Oh Cho, Mun-Chual Rho, Su-Jin Park, Woo Song Lee. In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorganic & medicinal chemistry. 2010 Nov; 18(21):7668-74. doi: 10.1016/j.bmc.2010.07.073. [PMID: 20850329]
  • Songpei Li, Wei Li, Yinghua Wang, Yoshihisa Asada, Kazuo Koike. Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorganic & medicinal chemistry letters. 2010 Sep; 20(18):5398-401. doi: 10.1016/j.bmcl.2010.07.110. [PMID: 20724155]
  • Young Bae Ryu, Jang Hoon Kim, Su-Jin Park, Jong Sun Chang, Mun-Chual Rho, Ki-Hwan Bae, Ki Hun Park, Woo Song Lee. Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorganic & medicinal chemistry letters. 2010 Feb; 20(3):971-4. doi: 10.1016/j.bmcl.2009.12.106. [PMID: 20064716]
  • Makoto Watanabe, Sumio Hayakawa, Mamoru Isemura, Shigenori Kumazawa, Tsutomu Nakayama, Chihiro Mori, Toshioki Kawakami. Identification of licocoumarone as an apoptosis-inducing component in licorice. Biological & pharmaceutical bulletin. 2002 Oct; 25(10):1388-90. doi: 10.1248/bpb.25.1388. [PMID: 12392103]