Platelet-activating factor (BioDeep_00000027028)
human metabolite LipidSearch
代谢物信息卡片
(R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium hydroxide inner salt 4-oxide
化学式: C26H54NO7P (523.3637704)
中文名称: 1-O-十六烷基-2-乙酰基-sn-甘油-3-磷酸胆碱
谱图信息:
最多检出来源 Homo sapiens(lipidsearch) 0.37%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C
InChI: InChI=1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
描述信息
Platelet-activating factor, also known as PAF and PC(O-16:0/2:0), is a ubiquitous, potent phospholipid activator and mediator of inflammation that has an important role in the pathogenesis of inflammatory disorders and cardiovascular disease. PAF is able to cause platelet aggregation and anaphylaxis. PAF is synthesized continuously in low quantities in many different types of cells, but especially those involved in host defence, such as macrophages, monocytes, granulocytes, neutrophils, platelets, and endothelial cells. Platelet-activating factor receptor (PAFR) is a G-protein coupled receptor (GPCR) located on the cell membranes of a variety of cells. Once bound to its receptor, PAF mobilizes calcium and activates a wide range of signalling pathways (e.g. phospholipase C-mediated signalling (PMID: 26616844).
C16-PAF (PAF (C16)), a phospholipid mediator, is a platelet-activating factor and ligand for PAF G-protein-coupled receptor (PAFR). C16-PAF exhibits anti-apoptotic effect and inhibits caspase-dependent death by activating the PAFR. C16-PAF is a potent MAPK and MEK/ERK activator. C16-PAF induces increased vascular permeability[1][2][3][4][5].
同义名列表
65 个代谢物同义名
(R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium hydroxide inner salt 4-oxide; (2-{[(S)-((2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl phosphono)]oxy}ethyl)trimethylazanium; 1-O-Hexadecyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine; 1-O-Hexadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine; 1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosophocholine; 1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine; 1-Hexadecyl-2-acetyl-sn-glycero-phosphatidylcholine; 1-O-HEXADECYL-2-ACETYL-SN-GLYCERO-3-PHOSPHOCHOLINE; 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine; 1-O-Hexadecyl-2-acetyl-sn-glycerophosphocholine; 1-Hexadecyl-2-acetyl-glycero-3-phosphocholine; 1-Hexadecyl-2-acetyl-glycerophosphocholine; Antihypertensive polar renomedullary lipid; Platelet-activating factor (1-O-hexadecyl); 1-Alkyl-2-acetyl-sn-glycerophosphocholine; 1 Alkyl 2 acetyl sn glycerophosphocholine; Blood platelet-activating factor acether; 1-O-Hexadecyl-platelet-activating factor; Phosphorylcholine, acetyl glyceryl ether; Acetyl-glyceryl-ether-phosphorylcholine; Acetyl glyceryl ether phosphorylcholine; Platelet aggregation enhancing factor; Platelet-activating factor acether; Blood platelet-activating factor; Thrombocyte aggregating activity; Phosphatidylcholine(O-16:0/2:0); Platelet-activating factor C16; Phosphatidylcholine(16:0/2:0); Platelet activating substance; Platelet-activating substance; Aggregating factor, platelet; Platelet aggregating factor; Factor, platelet activating; Platelet-activating factor; Platelet activating factor; Phosphatidylcholine(18:0); 1-Hexadecyl-2-acetyl-GPC; Hexadecyl-paf-acether; 1-O-Hexadecyl paf; GPCho(O-16:0/2:0); Enantio-PAF C-16; C16-PAF acether; GPCho(16:0/2:0); GPC(O-16:0/2:0); PC(O-16:0/2:0); GPC(16:0/2:0); PC(16:0/2:0); PAF-acether; PAF acether; Gpcho(18:0); PAF-16 CPD; C16:0 PAF; GPC(18:0); PAF C 16; PC(18:0); C16 PAF; C16-PAF; HAG-PC; HD-PAF; PAF 16; AGEPC; HAGPC; APRL; PAF; PAF (C16)
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:44811
- PubChem: 108156
- HMDB: HMDB0062195
- DrugBank: DB02261
- ChEMBL: CHEMBL1235246
- Wikipedia: Platelet-activating_factor
- MeSH: Platelet Activating Factor
- chemspider: 97241
- CAS: 74389-68-7
- PMhub: MS000241471
- medchemexpress: HY-108635
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Ether Lipid Metabolism:
2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine + Cytidine monophosphate ⟶ Acetic acid + Hydrogen Ion + Lyso-PAF C-16 - Ether Lipid Metabolism:
2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine + Water ⟶ 1-Organyl-2-lyso-sn-glycero-3-phosphocholine + Acetic acid
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hanan H Wahid, Fatin N Anahar, Nurul H Isahak, Juwairiyah Mohd Zoharodzi, Siti N L Mohammad Khoiri, Nurul H Mohamad Zainal, Norhidayah Kamarudin, Hamizah Ismail, Mohammed I A Mustafa Mahmud. Role of Platelet Activating Factor as a Mediator of Inflammatory Diseases and Preterm Delivery.
The American journal of pathology.
2024 Jun; 194(6):862-878. doi:
10.1016/j.ajpath.2024.01.018. [PMID: 38403163] - Hiroaki Murano, Sumito Inoue, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Yoichiro Otaki, Yukihiro Minegishi, Takumi Kitaoka, Mitsuru Futakuchi, Akira Igarashi, Michiko Nishiwaki, Takako Nemoto, Masamichi Sato, Maki Kobayashi, Kento Sato, Toshinari Hanawa, Osamu Miyazaki, Masafumi Watanabe. Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor.
American journal of respiratory cell and molecular biology.
2024 Jun; 70(6):482-492. doi:
10.1165/rcmb.2023-0253oc. [PMID: 38377392] - Tetsuya Tachibana, Chisato One, Sakirul Khan, Mark A Cline. Effect of platelet-activating factor on food intake, cloacal temperature, voluntary activity and crop emptying rate in chicks.
Prostaglandins & other lipid mediators.
2024 Jun; 172(?):106818. doi:
10.1016/j.prostaglandins.2024.106818. [PMID: 38340978] - Pilar Irún, Patricia Carrera-Lasfuentes, Marta Sánchez-Luengo, Úrsula Belio, María José Domper-Arnal, Gustavo A Higuera, Malena Hawkins, Xavier de la Rosa, Angel Lanas. Pharmacokinetics and Changes in Lipid Mediator Profiling after Consumption of Specialized Pro-Resolving Lipid-Mediator-Enriched Marine Oil in Healthy Subjects.
International journal of molecular sciences.
2023 Nov; 24(22):. doi:
10.3390/ijms242216143. [PMID: 38003333] - Antigoni Margariti, Vasiliki D Papakonstantinou, George M Stamatakis, Constantinos A Demopoulos, Christina Machalia, Evangelia Emmanouilidou, Gregor Schnakenburg, Maria-Christina Nika, Nikolaos S Thomaidis, Athanassios I Philippopoulos. First-Row Transition Metal Complexes Incorporating the 2-(2'-pyridyl)quinoxaline Ligand (pqx), as Potent Inflammatory Mediators: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin.
Molecules (Basel, Switzerland).
2023 Oct; 28(19):. doi:
10.3390/molecules28196899. [PMID: 37836742] - Yang Jiao, Ti Zhang, Mei Liu, Luyang Zhou, Mengzhi Qi, Xin Xie, Xueyin Shi, Xiaoping Gu, Zhengliang Ma. Exosomal PGE2 from M2 macrophages inhibits neutrophil recruitment and NET formation through lipid mediator class switching in sepsis.
Journal of biomedical science.
2023 Aug; 30(1):62. doi:
10.1186/s12929-023-00957-9. [PMID: 37533081] - Audrey Siew Foong Kow, Leng Wei Khoo, Ji Wei Tan, Faridah Abas, Ming-Tatt Lee, Daud Ahmad Israf, Khozirah Shaari, Chau Ling Tham. Clinacanthus nutans aqueous leaves extract exerts anti-allergic activity in preclinical anaphylactic models via alternative IgG pathway.
Journal of ethnopharmacology.
2023 Mar; 303(?):116003. doi:
10.1016/j.jep.2022.116003. [PMID: 36464074] - Jonatan C S de Carvalho, Pedro V da Silva-Neto, Diana M Toro, Carlos A Fuzo, Viviani Nardini, Vinícius E Pimentel, Malena M Pérez, Thais F C Fraga-Silva, Camilla N S Oliveira, Augusto M Degiovani, Fátima M Ostini, Marley R Feitosa, Rogerio S Parra, José J R da Rocha, Omar Feres, Fernando C Vilar, Gilberto G Gaspar, Isabel K F M Santos, Ana P M Fernandes, Sandra R Maruyama, Elisa M S Russo, Vânia L D Bonato, Cristina R B Cardoso, Marcelo Dias-Baruffi, Lúcia H Faccioli, Carlos A Sorgi, On Behalf Of The ImmunoCovid Study Group. The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19.
Viruses.
2023 02; 15(2):. doi:
10.3390/v15020573. [PMID: 36851787] - Alexandros Kalampalidis, Artemis Damati, Demetrios Matthopoulos, Alexandros B Tsoupras, Constantinos A Demopoulos, Gregor Schnakenburg, Athanassios I Philippopoulos. Tin(II) and Tin(IV) Complexes Incorporating the Oxygen Tripodal Ligands [(η5-C5R5)Co{P(OEt)2O}3]-, (R = H, Me; Et = -C2H5) as Potent Inflammatory Mediator Inhibitors: Cytotoxic Properties and Biological Activities against the Platelet-Activating Factor (PAF) and Thrombin.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041859. [PMID: 36838847] - Izumi Tsukayama, Yuki Kawakami, Asako Tamenobu, Keisuke Toda, Saya Maruoka, Yuki Nagasaki, Yoshiko Mori, Risa Sawazumi, Kensuke Okamoto, Keita Kanzaki, Hideyuki Ito, Yoshitaka Takahashi, Yoshimi Miki, Kei Yamamoto, Makoto Murakami, Toshiko Suzuki-Yamamoto. Malabaricone C derived from nutmeg inhibits arachidonate 5-lipoxygenase activity and ameliorates psoriasis-like skin inflammation in mice.
Free radical biology & medicine.
2022 11; 193(Pt 1):1-8. doi:
10.1016/j.freeradbiomed.2022.09.028. [PMID: 36183930] - Carson J Rohan, Rushabh P Lohade, Chad Brewer, Jeffrey B Travers. Platelet-activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury.
BioFactors (Oxford, England).
2022 Nov; 48(6):1250-1256. doi:
10.1002/biof.1917. [PMID: 36342751] - Marie-Ève Tremblay, Zakaria A Almsherqi, Yuru Deng. Plasmalogens and platelet-activating factor roles in chronic inflammatory diseases.
BioFactors (Oxford, England).
2022 Nov; 48(6):1203-1216. doi:
10.1002/biof.1916. [PMID: 36370412] - Rajendran Harishkumar, Sakshi Hans, Janelle E Stanton, Andreas M Grabrucker, Ronan Lordan, Ioannis Zabetakis. Targeting the Platelet-Activating Factor Receptor (PAF-R): Antithrombotic and Anti-Atherosclerotic Nutrients.
Nutrients.
2022 Oct; 14(20):. doi:
10.3390/nu14204414. [PMID: 36297097] - Xue Gao, Yijie Liu, Yuancheng Li, Hao Fan, Rong Wu, Rukang Zhang, Brandon Faubert, Yu-Ying He, Marc B Bissonnette, Siyuan Xia, Dong Chen, Hui Mao, Titus J Boggon, Jing Chen. Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation.
Molecular cell.
2022 06; 82(11):1992-2005.e9. doi:
10.1016/j.molcel.2022.03.026. [PMID: 35417664] - Hanaa Mohamed Khalaf, Sara Mohamed Naguib Abdel Hafez, Ahlam Mohamed Abdalla, Nermeen N Welson, Walaa Yehia Abdelzaher, Fatma Alzhraa Fouad Abdelbaky. Role of Platelet-activating factor and HO-1 in mediating the protective effect of rupatadine against 5-fluorouracil-induced hepatotoxicity in rats.
Environmental science and pollution research international.
2022 Jun; 29(26):40190-40203. doi:
10.1007/s11356-022-18899-4. [PMID: 35119631] - Akira Sato, Takahiro Fukase, Keiichi Ebina. Biotinylated peptides substituted with D-amino acids with high stability as anti-anaphylactic agents targeting platelet-activating factor.
Journal of peptide science : an official publication of the European Peptide Society.
2022 Apr; ?(?):e3412. doi:
10.1002/psc.3412. [PMID: 35437860] - Linna Cao, Yiwei Zhang, Jinxia Mi, Zhanhao Shi, Zhaoqin Fang, Dongwei Jia, Zhiqiang Pan, Peike Peng. α-Hederin inhibits the platelet activating factor-induced metastasis of HCC cells through disruption of PAF/PTAFR axis cascaded STAT3/MMP-2 expression.
Pharmacological research.
2022 04; 178(?):106180. doi:
10.1016/j.phrs.2022.106180. [PMID: 35288308] - Jesmond Dalli, Esteban Alberto Gomez, Charlotte Camille Jouvene. Utility of the Specialized Pro-Resolving Mediators as Diagnostic and Prognostic Biomarkers in Disease.
Biomolecules.
2022 02; 12(3):. doi:
10.3390/biom12030353. [PMID: 35327544] - Alexandros Tsoupras, Vassili N Kouvelis, Katherine M Pappas, Constantinos A Demopoulos, Milton A Typas. Anti-inflammatory and anti-thrombotic properties of lipid bioactives from the entomopathogenic fungus Beauveria bassiana.
Prostaglandins & other lipid mediators.
2022 02; 158(?):106606. doi:
10.1016/j.prostaglandins.2021.106606. [PMID: 34923152] - Timothy C Frommeyer, Michael M Gilbert, Garrett V Brittain, Tongfan Wu, Trang Q Nguyen, Craig A Rohan, Jeffrey B Travers. UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.
Frontiers in immunology.
2022; 13(?):880850. doi:
10.3389/fimmu.2022.880850. [PMID: 35603177] - Yoshitaka Taketomi, Makoto Murakami. Regulatory Roles of Phospholipase A2 Enzymes and Bioactive Lipids in Mast Cell Biology.
Frontiers in immunology.
2022; 13(?):923265. doi:
10.3389/fimmu.2022.923265. [PMID: 35833146] - Shler Ghafour Raheem. Investigating platelet-activating factor as a potent proinflammatory mediator in coronary atherosclerotic patients.
Cellular and molecular biology (Noisy-le-Grand, France).
2021 Nov; 67(3):1-4. doi:
10.14715/cmb/2021.67.3.1. [PMID: 34933739] - Felipe S Coelho, Mauricio M Oliveira, Danielle P Vieira, Pedro H M Torres, Isabel C F Moreira, Erica S Martins-Duarte, Inês C Gonçalves, Adriana Cabanelas, Pedro G Pascutti, Stenio P Fragoso, Angela H Lopes. A novel receptor for platelet-activating factor and lysophosphatidylcholine in Trypanosoma cruzi.
Molecular microbiology.
2021 09; 116(3):890-908. doi:
10.1111/mmi.14778. [PMID: 34184334] - Preeti Gupta, Rachna Agarwal, Sruthi Bhaskaran, Seema Garg, Mohit Mehndiratta, Gita Radhakrishnan, Alpana Singh, Richa Agarwal, Divya Narang. Evaluation of maternal plasma platelet activating factor acetylhydrolase activity and mRNA expression in pre-eclampsia: a case control study.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.
2021 Jul; 41(5):726-732. doi:
10.1080/01443615.2020.1789956. [PMID: 33073639] - Mengying Ke, Liqing Kang, Ling Wang, Shu Yang, Yajun Wang, Haiyan Liu, Chunyan Gu, Hongming Huang, Ye Yang. CAR-T therapy alters synthesis of platelet-activating factor in multiple myeloma patients.
Journal of hematology & oncology.
2021 06; 14(1):90. doi:
10.1186/s13045-021-01101-6. [PMID: 34108020] - Maria Detopoulou, Agathi Ntzouvani, Filio Petsini, Labrini Gavriil, Elizabeth Fragopoulou, Smaragdi Antonopoulou. Consumption of Enriched Yogurt with PAF Inhibitors from Olive Pomace Affects the Major Enzymes of PAF Metabolism: A Randomized, Double Blind, Three Arm Trial.
Biomolecules.
2021 05; 11(6):. doi:
10.3390/biom11060801. [PMID: 34071485] - Langni Liu, Azeezat A Awoyemi, Katherine E Fahy, Pariksha Thapa, Christina Borchers, Benita Y Wu, Cameron L McGlone, Benjamin Schmeusser, Zafer Sattouf, Craig A Rohan, Amy R Williams, Elizabeth E Cates, Christina Knisely, Lisa E Kelly, Ji C Bihl, David R Cool, Ravi P Sahu, Jinju Wang, Yanfang Chen, Christine M Rapp, Michael G Kemp, R Michael Johnson, Jeffrey B Travers. Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation-induced systemic immunosuppression.
The Journal of clinical investigation.
2021 05; 131(10):. doi:
10.1172/jci144963. [PMID: 33830943] - Akira Sato, Hinako Watanabe, Miyuki Yamazaki, Eiko Sakurai, Keiichi Ebina. Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
The protein journal.
2021 04; 40(2):192-204. doi:
10.1007/s10930-021-09971-y. [PMID: 33665770] - Barbara Dalmaso, Ildefonso Alves da Silva-Junior, Lucianne Fragel-Madeira, Sonia Jancar, Carolina Beltrame Del Debbio. Platelet activating factor in the eye: Physiological roles, diseases and future perspectives.
Prostaglandins & other lipid mediators.
2021 04; 153(?):106522. doi:
10.1016/j.prostaglandins.2020.106522. [PMID: 33358892] - Soodeh Mahdian, Reihaneh Pirjani, Raha Favaedi, Monireh Movahedi, Ashraf Moini, Maryam Shahhoseini. Platelet-activating factor and antiphospholipid antibodies in recurrent implantation failure.
Journal of reproductive immunology.
2021 02; 143(?):103251. doi:
10.1016/j.jri.2020.103251. [PMID: 33271420] - Yonggyun Kim, David Stanley. Eicosanoid Signaling in Insect Immunology: New Genes and Unresolved Issues.
Genes.
2021 02; 12(2):. doi:
10.3390/genes12020211. [PMID: 33535438] - Paraskevi Detopoulou, Constantinos A Demopoulos, Smaragdi Antonopoulou. Micronutrients, Phytochemicals and Mediterranean Diet: A Potential Protective Role against COVID-19 through Modulation of PAF Actions and Metabolism.
Nutrients.
2021 Jan; 13(2):. doi:
10.3390/nu13020462. [PMID: 33573169] - Katie Shiels, Alexandros Tsoupras, Ronan Lordan, Constantina Nasopoulou, Ioannis Zabetakis, Patrick Murray, Sushanta Kumar Saha. Bioactive Lipids of Marine Microalga Chlorococcum sp. SABC 012504 with Anti-Inflammatory and Anti-Thrombotic Activities.
Marine drugs.
2021 Jan; 19(1):. doi:
10.3390/md19010028. [PMID: 33435162] - Mark Klein, Vinh Dao, Fatima Khan. A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
2021 Jan; 27(?):10760296211051764. doi:
10.1177/10760296211051764. [PMID: 34755565] - E Fragopoulou, P Detopoulou, E Alepoudea, T Nomikos, N Kalogeropoulos, S Antonopoulou. Associations between red blood cells fatty acids, desaturases indices and metabolism of platelet activating factor in healthy volunteers.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 01; 164(?):102234. doi:
10.1016/j.plefa.2020.102234. [PMID: 33373961] - Paraskevi Detopoulou, Tzortzis Nomikos, Elizabeth Fragopoulou, Smaragdi Antonopoulou. Association of PAF and its Metabolic Enzymes with GGT and the Fatty Liver Index in Healthy Volunteers.
Current vascular pharmacology.
2021; 19(6):663-672. doi:
10.2174/1570161119666210628125239. [PMID: 34182909] - Jeffrey B Travers, Joyce G Rohan, Ravi P Sahu. New Insights Into the Pathologic Roles of the Platelet-Activating Factor System.
Frontiers in endocrinology.
2021; 12(?):624132. doi:
10.3389/fendo.2021.624132. [PMID: 33796070] - Krzysztof Łukasz Piwowarek, Agnieszka Rzeszotarska, Jolanta Łukasz Korsak, Aleksandra Juszkiewicz, Andrzej Chciałowski, Jerzy Kruszewski. Clinical significance of plasma PAF acetylhydrolase activity measurements as a biomarker of anaphylaxis: Cross-sectional study.
PloS one.
2021; 16(8):e0256168. doi:
10.1371/journal.pone.0256168. [PMID: 34388201] - L-N Pei, X-H Liu, H Zhang, J Zhu, Z Gao, M-Z Bi. Clinical efficacy of mouse nerve growth factor plus nimodipine in neonatal intracranial hemorrhage and its effect on plasma PAF, CNP, MMP-2, and neurological function.
European review for medical and pharmacological sciences.
2021 01; 25(1):215-221. doi:
10.26355/eurrev_202101_24387. [PMID: 33506910] - Meredith A Jackson, Shrusti S Patel, Fang Yu, Matthew A Cottam, Evan B Glass, Ella N Hoogenboezem, R Brock Fletcher, Bryan R Dollinger, Prarthana Patil, Danielle D Liu, Isom B Kelly, Sean K Bedingfield, Allyson R King, Rachel E Miles, Alyssa M Hasty, Todd D Giorgio, Craig L Duvall. Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers.
Biomaterials.
2021 01; 268(?):120528. doi:
10.1016/j.biomaterials.2020.120528. [PMID: 33285438] - Lasti Erfinanda, Krishnan Ravindran, Franziska Kohse, Kathleen Gallo, Robert Preissner, Thomas Walther, Wolfgang M Kuebler. Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation.
The European respiratory journal.
2021 01; 57(1):. doi:
10.1183/13993003.00921-2020. [PMID: 32764118] - Chandan Sarkar, Cristina Quispe, Sarmin Jamaddar, Rajib Hossain, Pranta Ray, Milon Mondal, Zeinab Abdulwanis Mohamed, Mohammed Sani Jaafaru, Bahare Salehi, Muhammad Torequl Islam, Ahmad Faizal Abdull Razis, Miquel Martorell, Edgar Pastene-Navarrete, Javad Sharifi-Rad. Therapeutic promises of ginkgolide A: A literature-based review.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Dec; 132(?):110908. doi:
10.1016/j.biopha.2020.110908. [PMID: 33254431] - Gopal Kedihithlu Marathe, Vyala Hanumanthareddy Chaithra, Liang-Yin Ke, Chu-Huang Chen. Effect of acyl and alkyl analogs of platelet-activating factor on inflammatory signaling.
Prostaglandins & other lipid mediators.
2020 12; 151(?):106478. doi:
10.1016/j.prostaglandins.2020.106478. [PMID: 32711129] - Fabian Dorninger, Sonja Forss-Petter, Isabella Wimmer, Johannes Berger. Plasmalogens, platelet-activating factor and beyond - Ether lipids in signaling and neurodegeneration.
Neurobiology of disease.
2020 11; 145(?):105061. doi:
10.1016/j.nbd.2020.105061. [PMID: 32861763] - Constantinos Demopoulos, Smaragdi Antonopoulou, Theoharis C Theoharides. COVID-19, microthromboses, inflammation, and platelet activating factor.
BioFactors (Oxford, England).
2020 Nov; 46(6):927-933. doi:
10.1002/biof.1696. [PMID: 33296106] - Theoharis C Theoharides, Smaragdi Antonopoulou, Constantinos A Demopoulos. Coronavirus 2019, Microthromboses, and Platelet Activating Factor.
Clinical therapeutics.
2020 10; 42(10):1850-1852. doi:
10.1016/j.clinthera.2020.08.006. [PMID: 32883529] - Heba M Hafez, Elshymaa A Abdel-Hakeem, Hanaa Hassanein. Rupatadine, a dual antagonist of histamine and platelet-activating factor (PAF), attenuates experimentally induced diabetic nephropathy in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2020 08; 393(8):1487-1500. doi:
10.1007/s00210-020-01856-8. [PMID: 32200462] - Benita C Y Tse, Scott N Byrne. Lipids in ultraviolet radiation-induced immune modulation.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2020 Jul; 19(7):870-878. doi:
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Journal of immunology (Baltimore, Md. : 1950).
2020 07; 205(1):193-201. doi:
10.4049/jimmunol.1901393. [PMID: 32434939] - Lunyu Yi, Jing Zhang, Jiarong Zhong, Yuqiang Zheng. Elevated Levels of Platelet Activating Factor and Its Acetylhydrolase Indicate High Risk of Kawasaki Disease.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
2020 03; 40(3):159-167. doi:
10.1089/jir.2019.0141. [PMID: 31841639] - Mengyi Wu, Aijing Liu, Quankun Zhuang, Ranran Jia, Yinping Zhou, Yali Liu, Hongyun Wang. Development and validation of a UPLC-MS/MS method for simultaneous determination of LBPT and its metabolites in human plasma.
Bioanalysis.
2020 Feb; 12(4):211-220. doi:
10.4155/bio-2019-0289. [PMID: 32083490] - Nerea Mendez-Barbero, Alma Yuste-Montalvo, Emilio Nuñez-Borque, Bettina M Jensen, Carmen Gutiérrez-Muñoz, Jaime Tome-Amat, María Garrido-Arandia, Araceli Díaz-Perales, Contanza Ballesteros-Martinez, Jose Julio Laguna, J M Beitia, Lars K Poulsen, Javier Cuesta-Herranz, Luis Miguel Blanco-Colio, Vanesa Esteban. The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock.
The Journal of allergy and clinical immunology.
2020 02; 145(2):583-596.e6. doi:
10.1016/j.jaci.2019.09.019. [PMID: 31679818] - Dmitry V Chistyakov, Viktoriia E Baksheeva, Veronika V Tiulina, Sergei V Goriainov, Nadezhda V Azbukina, Olga S Gancharova, Eugene A Arifulin, Sergey V Komarov, Viktor V Chistyakov, Natalia K Tikhomirova, Andrey A Zamyatnin, Pavel P Philippov, Ivan I Senin, Marina G Sergeeva, Evgeni Yu Zernii. Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor.
International journal of molecular sciences.
2020 Jan; 21(3):. doi:
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Military medicine.
2020 01; 185(Suppl 1):197-204. doi:
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Circulation research.
2020 01; 126(1):75-90. doi:
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Handbook of experimental pharmacology.
2020; 259(?):185-203. doi:
10.1007/164_2019_218. [PMID: 31087194] - L Liang, Y Li, X Tian, J Zhou, L Zhong. Comprehensive lipidomic, metabolomic and proteomic profiling reveals the role of immune system in vitiligo.
Clinical and experimental dermatology.
2019 Oct; 44(7):e216-e223. doi:
10.1111/ced.13961. [PMID: 30859585] - Xinjing Guo, Meng Zheng, Ruiyan Pan, Baoxia Zang, Jianwei Gao, Hanying Ma, Ming Jin. Hydroxysafflor yellow A (HSYA) targets the platelet-activating factor (PAF) receptor and inhibits human bronchial smooth muscle activation induced by PAF.
Food & function.
2019 Aug; 10(8):4661-4673. doi:
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Science translational medicine.
2019 07; 11(500):. doi:
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Annals of hematology.
2019 Jul; 98(7):1593-1602. doi:
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Biochimica et biophysica acta. Molecular and cell biology of lipids.
2019 06; 1864(6):922-931. doi:
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Natural product research.
2019 May; 33(10):1399-1405. doi:
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International immunopharmacology.
2019 May; 70(?):284-294. doi:
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The British journal of nutrition.
2019 05; 121(9):982-991. doi:
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Cell communication and signaling : CCS.
2019 03; 17(1):21. doi:
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Clinics in perinatology.
2019 03; 46(1):1-17. doi:
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American journal of reproductive immunology (New York, N.Y. : 1989).
2019 03; 81(3):e13091. doi:
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Frontiers in immunology.
2019; 10(?):494. doi:
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Acta pharmacologica Sinica.
2018 Dec; 39(12):1935-1946. doi:
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The Journal of investigative dermatology.
2018 11; 138(11):2461-2469. doi:
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Journal of lipid research.
2018 11; 59(11):2063-2074. doi:
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Molecular medicine reports.
2018 Nov; 18(5):4417-4427. doi:
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Brain, behavior, and immunity.
2018 11; 74(?):7-27. doi:
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Journal of natural products.
2018 09; 81(9):1968-1975. doi:
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Fitoterapia.
2018 Sep; 129(?):42-46. doi:
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Clinical biochemistry.
2018 Sep; 60(?):1-10. doi:
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Cutaneous and ocular toxicology.
2018 Sep; 37(3):207-209. doi:
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Proceedings. Biological sciences.
2018 08; 285(1884):. doi:
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Scientific reports.
2018 08; 8(1):11826. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Aug; 43(16):3341-3345. doi:
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European review for medical and pharmacological sciences.
2018 07; 22(14):4657-4662. doi:
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Marine drugs.
2018 May; 16(6):. doi:
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Nutrients.
2018 May; 10(5):. doi:
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Biomedical chromatography : BMC.
2018 May; 32(5):e4181. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Apr; 43(7):1392-1403. doi:
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Cancer science.
2018 Apr; 109(4):1032-1043. doi:
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Zhongguo gu shang = China journal of orthopaedics and traumatology.
2018 Feb; 31(2):170-174. doi:
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Zhongguo gu shang = China journal of orthopaedics and traumatology.
2018 Jan; 31(1):67-73. doi:
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Journal of Alzheimer's disease : JAD.
2018; 62(2):841-854. doi:
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Acta cirurgica brasileira.
2018 Jan; 33(1):22-30. doi:
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Neuropharmacology.
2018 Jan; 128(?):54-62. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Dec; 42(24):4750-4755. doi:
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FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2017 10; 31(10):4370-4381. doi:
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Pathogens and disease.
2017 09; 75(7):. doi:
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PLoS neglected tropical diseases.
2017 Sep; 11(9):e0005943. doi:
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Molecular neurobiology.
2017 09; 54(7):5563-5572. doi:
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The Journal of clinical investigation.
2017 Aug; 127(8):2895-2896. doi:
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Biochimica et biophysica acta. Biomembranes.
2017 Aug; 1859(8):1381-1387. doi:
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Immunology.
2017 07; 151(3):261-269. doi:
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