Glycyrol (BioDeep_00000270267)

Main id: BioDeep_00000000939

 

PANOMIX_OTCML-2023


代谢物信息卡片


3,9-Dihydroxy-1-methoxy-2- (3-methyl-2-buten-1-yl) -6H-benzofuro [3,2-c] [1] benzopyran-6-one

化学式: C21H18O6 (366.1103328)
中文名称: 甘草酚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(=O)c1c2oc2c1ccc(c2)O)O)CC=C(C)C)OC
InChI: InChI=1S/C21H18O6/c1-10(2)4-6-12-14(23)9-16-18(19(12)25-3)20-17(21(24)27-16)13-7-5-11(22)8-15(13)26-20/h4-5,7-9,22-23H,6H2,1-3H3

描述信息

Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch[1]. Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP)[2].
Neoglycyrol is isolated from the root of Glycyrrhiza uralensis Fisch[1]. Neoglycyrol is a potential myocardial protection active compound screened from traditional patent medicine Tongmai Yangxin pill (TMYXP)[2].

同义名列表

12 个代谢物同义名

6H-Benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-1-methoxy-2-(3-methyl-2-butenyl)-; 3,9-Dihydroxy-1-methoxy-2-(3-methyl-but-2-enyl)-benzofuro[3,2-c][1]benzopyran-6-one; 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)-[1]benzoxolo[3,2-c]chromen-6-one; 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)benzofurano[3,2-c]chromen-6-one; 3,9-dihydroxy-1-methoxy-2-(3-methylbut-2-enyl)-6-benzofurano[3,2-c]chromenone; Neoglycyrol; AIDS-095929; AIDS095929; 23013-84-5; Glycyrol; 1,9-Dihydroxy-3-methoxy-2-prenylcoumestan; 3,9-Dihydroxy-1-methoxy-2- (3-methyl-2-buten-1-yl) -6H-benzofuro [3,2-c] [1] benzopyran-6-one



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuai Ji, Ziwei Li, Wei Song, Yongrui Wang, Wenfei Liang, Kai Li, Shunan Tang, Qi Wang, Xue Qiao, Demin Zhou, Siwang Yu, Min Ye. Bioactive Constituents of Glycyrrhiza uralensis (Licorice): Discovery of the Effective Components of a Traditional Herbal Medicine. Journal of natural products. 2016 Feb; 79(2):281-92. doi: 10.1021/acs.jnatprod.5b00877. [PMID: 26841168]
  • Qiang-Song Wang, Yaozu Xiang, Yuan-Lu Cui, Ke-Ming Lin, Xin-Fang Zhang. Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-κB inactivation. PloS one. 2012; 7(3):e34122. doi: 10.1371/journal.pone.0034122. [PMID: 22479539]
  • Eun Myoung Shin, Sanghee Kim, Irmgard Merfort, Yeong Shik Kim. Glycyrol induces apoptosis in human Jurkat T cell lymphocytes via the Fas-FasL/caspase-8 pathway. Planta medica. 2011 Feb; 77(3):242-7. doi: 10.1055/s-0030-1250260. [PMID: 20717871]
  • Jiayu Li, Ying Tu, Li Tong, Wen Zhang, Jianquan Zheng, Qun Wei. Immunosuppressive activity on the murine immune responses of glycyrol from Glycyrrhiza uralensis via inhibition of calcineurin activity. Pharmaceutical biology. 2010 Oct; 48(10):1177-84. doi: 10.3109/13880200903573169. [PMID: 20860439]
  • Young Bae Ryu, Jang Hoon Kim, Su-Jin Park, Jong Sun Chang, Mun-Chual Rho, Ki-Hwan Bae, Ki Hun Park, Woo Song Lee. Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorganic & medicinal chemistry letters. 2010 Feb; 20(3):971-4. doi: 10.1016/j.bmcl.2009.12.106. [PMID: 20064716]
  • Ling Zhou, Yu-Ping Tang, Lu Gao, Xin-Sheng Fan, Chun-Mei Liu, De-Kang Wu. Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'. Molecules (Basel, Switzerland). 2009 Oct; 14(10):3942-51. doi: 10.3390/molecules14103942. [PMID: 19924040]
  • SungGa Lee, Hyun-Mee Oh, Won-Bong Lim, Eun-Ju Choi, Young-Na Park, Jeong-Ah Kim, Ji-Young Choi, Suk-Jin Hong, Hee-Kyun Oh, Jong-Keun Son, Seung-Ho Lee, Ok-Joon Kim, Hong-ran Choi, Chang-Duk Jun. Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis. Anti-cancer drugs. 2008 Jun; 19(5):503-15. doi: 10.1097/cad.0b013e3282fba582. [PMID: 18418217]
  • Minpei Kuroda, Yoshihiro Mimaki, Yutaka Sashida, Tatsumasa Mae, Hideyuki Kishida, Tozo Nishiyama, Misuzu Tsukagawa, Eisaku Konishi, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara. Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice. Bioorganic & medicinal chemistry letters. 2003 Dec; 13(24):4267-72. doi: 10.1016/j.bmcl.2003.09.052. [PMID: 14643306]
  • Y Tanaka, H Kikuzaki, S Fukuda, N Nakatani. Antibacterial compounds of licorice against upper airway respiratory tract pathogens. Journal of nutritional science and vitaminology. 2001 Jun; 47(3):270-3. doi: 10.3177/jnsv.47.270. [PMID: 11575586]