Aspalathin (BioDeep_00000269964)
Secondary id: BioDeep_00000018706
PANOMIX_OTCML-2023
代谢物信息卡片
3- (3,4-Dihydroxyphenyl) -1- (3-beta-D-glucopyranosyl-2,4,6-trihydroxyphenyl) -1-propanone
化学式: C21H24O11 (452.13185539999995)
中文名称: 阿司巴汀
谱图信息:
最多检出来源 Viridiplantae(plant) 2.92%
分子结构信息
SMILES: c(c(O)1)(O)ccc(CCC(=O)c(c2O)c(O)cc(c2C(C(O)3)OC(CO)C(O)C3O)O)c1
InChI: InChI=1S/C21H24O11/c22-7-14-17(28)19(30)20(31)21(32-14)16-13(27)6-12(26)15(18(16)29)10(24)4-2-8-1-3-9(23)11(25)5-8/h1,3,5-6,14,17,19-23,25-31H,2,4,7H2
描述信息
A member of the class of dihydrochalcones that is the 2-C-beta-D-glucopyranide of phloroglucinol and which is substituted at position 4 by a 3-(3,4-dihydroxyphenyl)propanoyl group. A metabolite of red bush, Aspalathus linearis (and present in the herbal tea made from the leaves), aspalathin exhibits significant hypoglycemic activity.
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:79078
- PubChem: 11282394
- PubChem: 16752601
- Metlin: METLIN52331
- LipidMAPS: LMPK12120529
- KNApSAcK: C00006096
- CAS: 6027-43-6
- MoNA: MetaboBASE0547
- MoNA: MetaboBASE0546
- MoNA: MetaboBASE0545
- MoNA: MetaboBASE0544
- MoNA: MetaboBASE0543
- MoNA: MetaboBASE0542
- MoNA: MetaboBASE0541
- Flavonoid: FL1DACCS0001
- MetaboLights: MTBLC79078
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 155124 - Aspalathus linearis:
- 155124 - Aspalathus linearis: 10.1016/S0040-4039(01)89333-3
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dalene de Beer, Chantelle Human, Marieta van der Rijst, Elizabeth Joubert. Reaction kinetics of aspalathin degradation and flavanone isomer formation in aqueous model solutions: Effect of temperature, pH and metal chelators.
Food research international (Ottawa, Ont.).
2023 10; 172(?):113188. doi:
10.1016/j.foodres.2023.113188. [PMID: 37689940] - Katarzyna Bednarska, Izabela Fecka. Aspalathin and Other Rooibos Flavonoids Trapped α-Dicarbonyls and Inhibited Formation of Advanced Glycation End Products In Vitro.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314738. [PMID: 36499065] - Christo J F Muller, Elizabeth Joubert, Nireshni Chellan, Yutaka Miura, Kazumi Yagasaki. New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes-A Review.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010356. [PMID: 35008779] - Oelfah Patel, Christo J F Muller, Elizabeth Joubert, Bernd Rosenkranz, Johan Louw, Charles Awortwe. Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice.
PloS one.
2021; 16(5):e0251069. doi:
10.1371/journal.pone.0251069. [PMID: 33983968] - Danielle A Millar, Sandra Bowles, Shantal Lynn Windvogel, Johan Louw, Christo J F Muller. Effect of Rooibos (Aspalathus linearis) extract on atorvastatin-induced toxicity in C3A liver cells.
Journal of cellular physiology.
2020 12; 235(12):9487-9496. doi:
10.1002/jcp.29756. [PMID: 32458430] - Nils Mertens, Thomas Heymann, Marcus A Glomb. Oxidative Fragmentation of Aspalathin Leads to the Formation of Dihydrocaffeic Acid and the Related Lysine Amide Adduct.
Journal of agricultural and food chemistry.
2020 Nov; 68(46):13111-13120. doi:
10.1021/acs.jafc.9b07689. [PMID: 32023062] - Shih-Han Huang, Yung-Hsi Kao, Christo J F Muller, Elizabeth Joubert, Chih-Pin Chuu. Aspalathin-rich green Aspalathus linearis extract suppresses migration and invasion of human castration-resistant prostate cancer cells via inhibition of YAP signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Apr; 69(?):153210. doi:
10.1016/j.phymed.2020.153210. [PMID: 32217447] - Amsha Viraragavan, Nokulunga Hlengwa, Dalene de Beer, Sylvia Riedel, Neil Miller, Sandra Bowles, Beata Walczak, Christo Muller, Elizabeth Joubert. Model development for predicting in vitro bio-capacity of green rooibos extract based on composition for application as screening tool in quality control.
Food & function.
2020 Apr; 11(4):3084-3094. doi:
10.1039/c9fo02480h. [PMID: 32195502] - Shih-Han Huang, Jen-Chih Tseng, Ching-Yu Lin, Ying-Yu Kuo, Bi-Juan Wang, Yung-Hsi Kao, Christo J F Muller, Elizabeth Joubert, Chih-Pin Chuu. Rooibos suppresses proliferation of castration-resistant prostate cancer cells via inhibition of Akt signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Nov; 64(?):153068. doi:
10.1016/j.phymed.2019.153068. [PMID: 31419729] - Patrick Orlando, Nireshni Chellan, Johan Louw, Luca Tiano, Ilenia Cirilli, Phiwayinkosi Dludla, Elizabeth Joubert, Christo J F Muller. Aspalathin-Rich Green Rooibos Extract Lowers LDL-Cholesterol and Oxidative Status in High-Fat Diet-Induced Diabetic Vervet Monkeys.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091713. [PMID: 31052590] - Chantelle Human, Dalene De Beer, Marieta Van Der Rijst, Marique Aucamp, Elizabeth Joubert. Electrospraying as a suitable method for nanoencapsulation of the hydrophilic bioactive dihydrochalcone, aspalathin.
Food chemistry.
2019 Mar; 276(?):467-474. doi:
10.1016/j.foodchem.2018.10.016. [PMID: 30409621] - Emily Amor Stander, Wesley Williams, Fanie Rautenbach, Marilize Le Roes-Hill, Yamkela Mgwatyu, Jeanine Marnewick, Uljana Hesse. Visualization of Aspalathin in Rooibos (Aspalathus linearis) Plant and Herbal Tea Extracts Using Thin-Layer Chromatography.
Molecules (Basel, Switzerland).
2019 Mar; 24(5):. doi:
10.3390/molecules24050938. [PMID: 30866512] - Sithandiwe E Mazibuko-Mbeje, Phiwayinkosi V Dludla, Candice Roux, Rabia Johnson, Samira Ghoor, Elizabeth Joubert, Johan Louw, Andy R Opoku, Christo J F Muller. Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways.
International journal of molecular sciences.
2019 Feb; 20(3):. doi:
10.3390/ijms20030633. [PMID: 30717198] - Sithandiwe E Mazibuko-Mbeje, Phiwayinkosi V Dludla, Rabia Johnson, Elizabeth Joubert, Johan Louw, Khanyisani Ziqubu, Luca Tiano, Sonia Silvestri, Patrick Orlando, Andy R Opoku, Christo J F Muller. Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration.
PloS one.
2019; 14(5):e0216172. doi:
10.1371/journal.pone.0216172. [PMID: 31048842] - Sameega Abrahams, Sedicka Samodien, Mariska Lilly, Elizabeth Joubert, Wentzel Gelderblom. Differential Modulation of Gene Expression Encoding Hepatic and Renal Xenobiotic Metabolizing Enzymes by an Aspalathin-Enriched Rooibos Extract and Aspalathin.
Planta medica.
2019 Jan; 85(1):6-13. doi:
10.1055/a-0656-7500. [PMID: 30016826] - Sumin Yang, Changhun Lee, Bong-Seon Lee, Eui Kyun Park, Kyung-Min Kim, Jong-Sup Bae. Renal protective effects of aspalathin and nothofagin from rooibos (Aspalathus linearis) in a mouse model of sepsis.
Pharmacological reports : PR.
2018 Dec; 70(6):1195-1201. doi:
10.1016/j.pharep.2018.07.004. [PMID: 30340097] - P V Dludla, K B Gabuza, C J F Muller, E Joubert, J Louw, R Johnson. Aspalathin, a C-glucosyl dihydrochalcone from rooibos improves the hypoglycemic potential of metformin in type 2 diabetic (db/db) mice.
Physiological research.
2018 11; 67(5):813-818. doi:
10.33549/physiolres.933891. [PMID: 30044119] - Rabia Johnson, Dalene de Beer, Phiwayinkosi V Dludla, Daneel Ferreira, Christo J F Muller, Elizabeth Joubert. Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome.
Planta medica.
2018 Jul; 84(9-10):568-583. doi:
10.1055/s-0044-100622. [PMID: 29388183] - Sybrand Engelbrecht Smit, Rabia Johnson, Mignon Alberta Van Vuuren, Barbara Huisamen. Myocardial Glucose Clearance by Aspalathin Treatment in Young, Mature, and Obese Insulin-Resistant Rats.
Planta medica.
2018 Jan; 84(2):75-82. doi:
10.1055/s-0043-117415. [PMID: 28772334] - Neil Miller, Dalene De Beer, Elizabeth Joubert. Minimising variation in aspalathin content of aqueous green rooibos extract: optimising extraction and identifying critical material attributes.
Journal of the science of food and agriculture.
2017 Nov; 97(14):4937-4942. doi:
10.1002/jsfa.8370. [PMID: 28397329] - Sandra Bowles, Elizabeth Joubert, Dalene de Beer, Johan Louw, Christel Brunschwig, Mathew Njoroge, Nina Lawrence, Lubbe Wiesner, Kelly Chibale, Christo Muller. Intestinal Transport Characteristics and Metabolism of C-Glucosyl Dihydrochalcone, Aspalathin.
Molecules (Basel, Switzerland).
2017 Mar; 22(4):. doi:
10.3390/molecules22040554. [PMID: 28358310] - Rabia Johnson, Phiwayinkosi V Dludla, Christo J F Muller, Barbara Huisamen, M Faadiel Essop, Johan Louw. The Transcription Profile Unveils the Cardioprotective Effect of Aspalathin against Lipid Toxicity in an In Vitro H9c2 Model.
Molecules (Basel, Switzerland).
2017 Jan; 22(2):. doi:
10.3390/molecules22020219. [PMID: 28146135] - Oelfah Patel, Christo Muller, Elizabeth Joubert, Johan Louw, Bernd Rosenkranz, Charles Awortwe. Inhibitory Interactions of Aspalathus linearis (Rooibos) Extracts and Compounds, Aspalathin and Z-2-(β-d-Glucopyranosyloxy)-3-phenylpropenoic Acid, on Cytochromes Metabolizing Hypoglycemic and Hypolipidemic Drugs.
Molecules (Basel, Switzerland).
2016 Nov; 21(11):. doi:
10.3390/molecules21111515. [PMID: 27845750] - Johanna Debora van der Merwe, Dalene de Beer, Elizabeth Joubert, Wentzel C A Gelderblom. Short-Term and Sub-Chronic Dietary Exposure to Aspalathin-Enriched Green Rooibos (Aspalathus linearis) Extract Affects Rat Liver Function and Antioxidant Status.
Molecules (Basel, Switzerland).
2015 Dec; 20(12):22674-90. doi:
10.3390/molecules201219868. [PMID: 26694346] - Sithandiwe E Mazibuko, Elizabeth Joubert, Rabia Johnson, Johan Louw, Andrew R Opoku, Christo J F Muller. Aspalathin improves glucose and lipid metabolism in 3T3-L1 adipocytes exposed to palmitate.
Molecular nutrition & food research.
2015 Nov; 59(11):2199-208. doi:
10.1002/mnfr.201500258. [PMID: 26310822] - Dalene de Beer, Christiaan J Malherbe, Theresa Beelders, Elize L Willenburg, D Jacobus Brand, Elizabeth Joubert. Isolation of aspalathin and nothofagin from rooibos (Aspalathus linearis) using high-performance countercurrent chromatography: sample loading and compound stability considerations.
Journal of chromatography. A.
2015 Feb; 1381(?):29-36. doi:
10.1016/j.chroma.2014.12.078. [PMID: 25614190] - Sae-Kwang Ku, Soyoung Kwak, Yaesol Kim, Jong-Sup Bae. Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) inhibits high glucose-induced inflammation in vitro and in vivo.
Inflammation.
2015 Feb; 38(1):445-55. doi:
10.1007/s10753-014-0049-1. [PMID: 25338943] - Wonhwa Lee, Kyung-Min Kim, Jong-Sup Bae. Ameliorative Effect of Aspalathin and Nothofagin from Rooibos (Aspalathus linearis) on HMGB1-Induced Septic Responses In Vitro and In Vivo.
The American journal of Chinese medicine.
2015; 43(5):991-1012. doi:
10.1142/s0192415x15500573. [PMID: 26224030] - Ze Han, Matthew C Achilonu, Pravin S Kendrekar, Elizabeth Joubert, Daneel Ferreira, Susan L Bonnet, Jan H van der Westhuizen. Concise and scalable synthesis of aspalathin, a powerful plasma sugar-lowering natural product.
Journal of natural products.
2014 Mar; 77(3):583-8. doi:
10.1021/np4008443. [PMID: 24354397] - Makoto Kondo, Yoshiaki Hirano, Masahiro Nishio, Yutaka Furuya, Hiromichi Nakamura, Tsuyoshi Watanabe. Xanthine oxidase inhibitory activity and hypouricemic effect of aspalathin from unfermented rooibos.
Journal of food science.
2013 Dec; 78(12):H1935-9. doi:
10.1111/1750-3841.12304. [PMID: 24261664] - I Stanimirova, M Kazura, D de Beer, E Joubert, A E Schulze, T Beelders, A de Villiers, B Walczak. High-dimensional nested analysis of variance to assess the effect of production season, quality grade and steam pasteurization on the phenolic composition of fermented rooibos herbal tea.
Talanta.
2013 Oct; 115(?):590-9. doi:
10.1016/j.talanta.2013.06.023. [PMID: 24054637] - Madeline J Simpson, Daisy Hjelmqvist, Camilo López-Alarcón, Nadja Karamehmedovic, Thomas G Minehan, Akop Yepremyan, Baback Salehani, Eduardo Lissi, Elizabeth Joubert, Klas I Udekwu, Emilio I Alarcon. Anti-peroxyl radical quality and antibacterial properties of rooibos infusions and their pure glycosylated polyphenolic constituents.
Molecules (Basel, Switzerland).
2013 Sep; 18(9):11264-80. doi:
10.3390/molecules180911264. [PMID: 24036515] - Myoung Jin Son, Miki Minakawa, Yutaka Miura, Kazumi Yagasaki. Aspalathin improves hyperglycemia and glucose intolerance in obese diabetic ob/ob mice.
European journal of nutrition.
2013 Sep; 52(6):1607-19. doi:
10.1007/s00394-012-0466-6. [PMID: 23238530] - Wei Chen, Ikhwan Resmala Sudji, Erjia Wang, Elizabeth Joubert, Ben-Erik van Wyk, Michael Wink. Ameliorative effect of aspalathin from rooibos (Aspalathus linearis) on acute oxidative stress in Caenorhabditis elegans.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Feb; 20(3-4):380-6. doi:
10.1016/j.phymed.2012.10.006. [PMID: 23218401] - C J F Muller, E Joubert, D de Beer, M Sanderson, C J Malherbe, S J Fey, J Louw. Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Dec; 20(1):32-9. doi:
10.1016/j.phymed.2012.09.010. [PMID: 23083813] - Theres Heinrich, Ina Willenberg, Marcus A Glomb. Chemistry of color formation during rooibos fermentation.
Journal of agricultural and food chemistry.
2012 May; 60(20):5221-8. doi:
10.1021/jf300170j. [PMID: 22571468] - Lindie Schloms, Karl-Heinz Storbeck, Pieter Swart, Wentzel C A Gelderblom, Amanda C Swart. The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: quantification of steroid intermediates and end products in H295R cells.
The Journal of steroid biochemistry and molecular biology.
2012 Feb; 128(3-5):128-38. doi:
10.1016/j.jsbmb.2011.11.003. [PMID: 22101210] - Dalene de Beer, Elizabeth Joubert, Melvi Viljoen, Marena Manley. Enhancing aspalathin stability in rooibos (Aspalathus linearis) ready-to-drink iced teas during storage: the role of nano-emulsification and beverage ingredients, citric and ascorbic acids.
Journal of the science of food and agriculture.
2012 Jan; 92(2):274-82. doi:
10.1002/jsfa.4571. [PMID: 21780136] - Theresa Beelders, Gunnar O Sigge, Elizabeth Joubert, Dalene de Beer, André de Villiers. Kinetic optimisation of the reversed phase liquid chromatographic separation of rooibos tea (Aspalathus linearis) phenolics on conventional high performance liquid chromatographic instrumentation.
Journal of chromatography. A.
2012 Jan; 1219(?):128-39. doi:
10.1016/j.chroma.2011.11.012. [PMID: 22153205] - Christiaan J Malherbe, Dalene De Beer, Elizabeth Joubert. Development of on-line high performance liquid chromatography (HPLC)-biochemical detection methods as tools in the identification of bioactives.
International journal of molecular sciences.
2012; 13(3):3101-3133. doi:
10.3390/ijms13033101. [PMID: 22489144] - Miki Minakawa, Atutoshi Kawano, Yutaka Miura, Kazumi Yagasaki. Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells.
Journal of clinical biochemistry and nutrition.
2011 May; 48(3):237-44. doi:
10.3164/jcbn.10-119. [PMID: 21562645] - Linda Sissing, Jeanine Marnewick, Maryna de Kock, Sonja Swanevelder, Elizabeth Joubert, Wentzel Gelderblom. Modulating effects of rooibos and honeybush herbal teas on the development of esophageal papillomas in rats.
Nutrition and cancer.
2011; 63(4):600-10. doi:
10.1080/01635581.2011.539313. [PMID: 21541901] - Elizabeth Joubert, Melvi Viljoen, Dalene De Beer, Christiaan J Malherbe, D Jacobus Brand, Marena Manley. Use of green rooibos (Aspalathus linearis) extract and water-soluble nanomicelles of green rooibos extract encapsulated with ascorbic acid for enhanced aspalathin content in ready-to-drink iced teas.
Journal of agricultural and food chemistry.
2010 Oct; 58(20):10965-71. doi:
10.1021/jf103552f. [PMID: 20923193] - Polimetla Srilaxmi, Gangadhara Reddy Sareddy, Polavarapu Bilhan Kavi Kishor, Oruganti Hussainaiah Setty, Phanithi Prakash Babu. Protective efficacy of natansnin, a dibenzoyl glycoside from Salvinia natans against CCl4 induced oxidative stress and cellular degeneration in rat liver.
BMC pharmacology.
2010 Oct; 10(?):13. doi:
10.1186/1471-2210-10-13. [PMID: 20939865] - Viera Nosál'ová, Ružena Sotníková, Katarína Drábiková, Silvia Fialová, Daniela Košťálová, Silvia Banášová, Jana Navarová. Chemiluminescence response induced by mesenteric ischaemia/reperfusion: effect of antioxidative compounds ex vivo.
Interdisciplinary toxicology.
2010 Sep; 3(3):105-8. doi:
10.2478/v10102-010-0021-3. [PMID: 21217883] - Kati Hanhineva, Riitta Törrönen, Isabel Bondia-Pons, Jenna Pekkinen, Marjukka Kolehmainen, Hannu Mykkänen, Kaisa Poutanen. Impact of dietary polyphenols on carbohydrate metabolism.
International journal of molecular sciences.
2010 Mar; 11(4):1365-402. doi:
10.3390/ijms11041365. [PMID: 20480025] - Haruna Baba, Yoshikazu Ohtsuka, Hidenori Haruna, Tsubasa Lee, Satoru Nagata, Masato Maeda, Yuichiro Yamashiro, Toshiaki Shimizu. Studies of anti-inflammatory effects of Rooibos tea in rats.
Pediatrics international : official journal of the Japan Pediatric Society.
2009 Oct; 51(5):700-4. doi:
10.1111/j.1442-200x.2009.02835.x. [PMID: 19419525] - Fraser L Courts, Gary Williamson. The C-glycosyl flavonoid, aspalathin, is absorbed, methylated and glucuronidated intact in humans.
Molecular nutrition & food research.
2009 Sep; 53(9):1104-11. doi:
10.1002/mnfr.200800569. [PMID: 19653227] - Petra W Snijman, Elizabeth Joubert, Daneel Ferreira, Xing-Cong Li, Yuanqing Ding, Ivan R Green, Wentzel C A Gelderblom. Antioxidant activity of the dihydrochalcones Aspalathin and Nothofagin and their corresponding flavones in relation to other Rooibos ( Aspalathus linearis ) Flavonoids, Epigallocatechin Gallate, and Trolox.
Journal of agricultural and food chemistry.
2009 Aug; 57(15):6678-84. doi:
10.1021/jf901417k. [PMID: 19722573] - Nicole Krafczyk, Theres Heinrich, Andrea Porzel, Marcus A Glomb. Oxidation of the dihydrochalcone aspalathin leads to dimerization.
Journal of agricultural and food chemistry.
2009 Aug; 57(15):6838-43. doi:
10.1021/jf901614y. [PMID: 19601579] - Angélique Stalmach, William Mullen, Monia Pecorari, Mauro Serafini, Alan Crozier. Bioavailability of C-linked dihydrochalcone and flavanone glucosides in humans following ingestion of unfermented and fermented rooibos teas.
Journal of agricultural and food chemistry.
2009 Aug; 57(15):7104-11. doi:
10.1021/jf9011642. [PMID: 19534535] - Elizabeth Joubert, Melvi Viljoen, Dalene De Beer, Marena Manley. Effect of heat on aspalathin, iso-orientin, and orientin contents and color of fermented rooibos (Aspalathus linearis) iced tea.
Journal of agricultural and food chemistry.
2009 May; 57(10):4204-11. doi:
10.1021/jf9005033. [PMID: 21314198] - Elizabeth Joubert, Wentzel C A Gelderblom, Dalene De Beer. Phenolic contribution of South African herbal teas to a healthy diet.
Natural product communications.
2009 May; 4(5):701-18. doi:
. [PMID: 19445319] - Atsutoshi Kawano, Hiromichi Nakamura, Shu-ichi Hata, Miki Minakawa, Yutaka Miura, Kazumi Yagasaki. Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2009 May; 16(5):437-43. doi:
10.1016/j.phymed.2008.11.009. [PMID: 19188054] - Susanne Kreuz, Elizabeth Joubert, Karl-Heinz Waldmann, Waldemar Ternes. Aspalathin, a flavonoid in Aspalathus linearis (rooibos), is absorbed by pig intestine as a C-glycoside.
Nutrition research (New York, N.Y.).
2008 Oct; 28(10):690-701. doi:
10.1016/j.nutres.2008.08.002. [PMID: 19083477] - Mia Pengilly, Elizabeth Joubert, Willem H van Zyl, Alfred Botha, Marinda Bloom. Enhancement of Rooibos (Aspalathus linearis) aqueous extract and antioxidant yield with fungal enzymes.
Journal of agricultural and food chemistry.
2008 Jun; 56(11):4047-53. doi:
10.1021/jf073095y. [PMID: 18476700] - Miao Huang, Jeanetta du Plessis, Jan du Preez, Josias Hamman, Alvaro Viljoen. Transport of aspalathin, a Rooibos tea flavonoid, across the skin and intestinal epithelium.
Phytotherapy research : PTR.
2008 May; 22(5):699-704. doi:
10.1002/ptr.2422. [PMID: 18350515] - Elizabeth Joubert, Marena Manley, Mariza Botha. Evaluation of spectrophotometric methods for screening of green rooibos (Aspalathus linearis) and green honeybush (Cyclopia genistoides) extracts for high levels of Bio-active compounds.
Phytochemical analysis : PCA.
2008 Mar; 19(2):169-78. doi:
10.1002/pca.1033. [PMID: 17893845] - D P Singh, R Govindarajan, A K S Rawat. High-performance liquid chromatography as a tool for the chemical standardisation of Triphala--an Ayurvedic formulation.
Phytochemical analysis : PCA.
2008 Mar; 19(2):164-8. doi:
10.1002/pca.1032. [PMID: 17879225] - Diane L McKay, Jeffrey B Blumberg. A review of the bioactivity of South African herbal teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia).
Phytotherapy research : PTR.
2007 Jan; 21(1):1-16. doi:
10.1002/ptr.1992. [PMID: 16927447] - J D van der Merwe, E Joubert, E S Richards, M Manley, P W Snijman, J L Marnewick, W C A Gelderblom. A comparative study on the antimutagenic properties of aqueous extracts of Aspalathus linearis (rooibos), different Cyclopia spp. (honeybush) and Camellia sinensis teas.
Mutation research.
2006 Dec; 611(1-2):42-53. doi:
10.1016/j.mrgentox.2006.06.030. [PMID: 16949333] - Malgorzata Baranska, Hartwig Schulz, Elizabeth Joubert, Marena Manley. In situ flavonoid analysis by FT-Raman spectroscopy: identification, distribution, and quantification of aspalathin in green rooibos (Aspalathus linearis).
Analytical chemistry.
2006 Nov; 78(22):7716-21. doi:
10.1021/ac061123q. [PMID: 17105163] - Elizabeth Joubert, Paula Winterton, Trevor J Britz, Wentzel C A Gelderblom. Antioxidant and pro-oxidant activities of aqueous extracts and crude polyphenolic fractions of rooibos (Aspalathus linearis).
Journal of agricultural and food chemistry.
2005 Dec; 53(26):10260-7. doi:
10.1021/jf051355a. [PMID: 16366725] - Lorenzo Bramati, Francesca Aquilano, Piergiorgio Pietta. Unfermented rooibos tea: quantitative characterization of flavonoids by HPLC-UV and determination of the total antioxidant activity.
Journal of agricultural and food chemistry.
2003 Dec; 51(25):7472-4. doi:
10.1021/jf0347721. [PMID: 14640601]