diuvaretin (BioDeep_00000269654)

PANOMIX_OTCML-2023 Cytotoxicity natural product

代谢物信息卡片

1- [ 2,4-Dihydroxy-3,5-bis [ (2-hydroxyphenyl) methyl ] -6-methoxyphenyl ] -3-phenyl-1-propanone

化学式: C30H28O6 (484.1886)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 69.23%

分子结构信息

SMILES: c(c(Cc(c(O)2)c(O)c(C(CCc(c4)cccc4)=O)c(OC)c2Cc(c3)c(O)ccc3)1)cccc(O)1
InChI: InChI=1S/C30H28O6/c1-36-30-23(18-21-12-6-8-14-25(21)32)28(34)22(17-20-11-5-7-13-24(20)31)29(35)27(30)26(33)16-15-19-9-3-2-4-10-19/h2-14,31-32,34-35H,15-18H2,1H3

描述信息

A member of the class of dihydrochalcones that is dihydrochalcone substituted by 2-hydroxybenzyl groups at positions 3 and 5, hydroxy groups at positions 2 and 4 and a methoxy group at position 6. Isolated from the roots of Uvaria acuminata and Uvaria chamae, it exhibits cytotoxicity towards human promyelocytic leukemia HL-60 cells.

同义名列表

2 个代谢物同义名

diuvaretin; 1- [ 2,4-Dihydroxy-3,5-bis [ (2-hydroxyphenyl) methyl ] -6-methoxyphenyl ] -3-phenyl-1-propanone

数据库引用编号

11 个数据库交叉引用编号

ChEBI: CHEBI:65802
PubChem: 3085222
Metlin: METLIN52275
ChEMBL: CHEMBL464771
LipidMAPS: LMPK12120472
KNApSAcK: C00007965
CAS: 61463-04-5
PMhub: MS000057386
Flavonoid: FL1DA9NC0006
MetaboLights: MTBLC65802
LOTUS: LTS0155029

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

31 个相关的物种来源信息

22140 - Annonaceae: LTS0155029
2759 - Eukaryota: LTS0155029
3398 - Magnoliopsida: LTS0155029
35493 - Streptophyta: LTS0155029
58023 - Tracheophyta: LTS0155029
174969 - Uvaria: LTS0155029
672960 - Uvaria acuminata: 10.1080/10575630290020604
672960 - Uvaria acuminata: 10.1248/CPB.52.138
672960 - Uvaria acuminata: LTS0155029
672961 - Uvaria angolensis: 10.1021/NP50040A009
672961 - Uvaria angolensis: 10.1080/10575630290020604
672961 - Uvaria angolensis: 10.1248/CPB.52.138
672961 - Uvaria angolensis: LTS0155029
174970 - Uvaria chamae: 10.1021/JO00428A006
174970 - Uvaria chamae: 10.1021/NP50040A009
174970 - Uvaria chamae: 10.1080/10575630290020604
174970 - Uvaria chamae: 10.1248/CPB.52.138
174970 - Uvaria chamae: LTS0155029
2588161 - Uvaria kirkii: 10.1021/NP50040A009
2588161 - Uvaria kirkii: 10.1021/NP50042A028
2588161 - Uvaria kirkii: 10.1080/10575630290020604
2588161 - Uvaria kirkii: 10.1248/CPB.52.138
2588161 - Uvaria kirkii: LTS0155029
673191 - Uvaria leptocladon: 10.1016/S0031-9422(00)95109-4
673191 - Uvaria leptocladon: 10.1021/NP50040A009
673191 - Uvaria leptocladon: 10.1080/10575630290020604
673191 - Uvaria leptocladon: 10.1248/CPB.52.138
673191 - Uvaria leptocladon: LTS0155029
2695412 - Uvaria tanzaniae: 10.1021/JO00020A030
2695412 - Uvaria tanzaniae: LTS0155029
33090 - Viridiplantae: LTS0155029

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表

文献列表

Gasper Maeda, Jelle van der Wal, Arvind Kumar Gupta, Joan J E Munissi, Andreas Orthaber, Per Sunnerhagen, Stephen S Nyandoro, Máté Erdélyi. Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa. Journal of natural products. 2020 02; 83(2):210-215. doi: 10.1021/acs.jnatprod.9b00363. [PMID: 31986029]
Tulika Mishra, Madhu Khullar, Aruna Bhatia. Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):. doi: 10.1155/2011/765029. [PMID: 20953391]
Momoyo Ichimaru, Noriyoshi Nakatani, Tomoko Takahashi, Yumi Nishiyama, Masataka Moriyasu, Atsushi Kato, Simon G Mathenge, Francis D Juma, Joseph N Nganga. Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata. Chemical & pharmaceutical bulletin. 2004 Jan; 52(1):138-41. doi: 10.1248/cpb.52.138. [PMID: 14709883]
John J Makangara, Stephan A Jonker, Mayunga H H Nkunya. A novel phenanthrenolide and C-benzyl dihydrochalcones from Uvaria puguensis. Natural product letters. 2002 Aug; 16(4):267-72. doi: 10.1080/10575630290020604. [PMID: 12168763]