Triprolidine (BioDeep_00000026944)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine

化学式: C19H22N2 (278.1782892)
中文名称: 曲普立啶
谱图信息: 最多检出来源 Homo sapiens(blood) 41.44%

分子结构信息

SMILES: CC1=CC=C(C=C1)C(=C/CN1CCCC1)\C1=CC=CC=N1
InChI: InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+

描述信息

Triprolidine is only found in individuals that have used or taken this drug. It is the first generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. [PubChem]Triprolidine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents

同义名列表

23 个代谢物同义名

2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine; trans-1-(4-Methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene; trans-2-(3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)pyridine; (e)-2-[3-(1-Pyrrolidinyl)-1-p-toluenepropenyl]pyridine; trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene; Triprolidine monohydrochloride, monohydrate; Triprolidine monohydrochloride, (Z)-isomer; Hydrochloride anhydrous, triprolidine; Anhydrous, triprolidine hydrochloride; Triprolidine hydrochloride anhydrous; Triprolidine oxalate, (trans)-isomer; Triprolidine monohydrochloride; Wellcome brand OF triprolidine; Hydrochloride, triprolidine; Triprolidine hydrochloride; Triprolidine, (Z)-isomer; Triprolidine oxalate; Triprolidinum; Tripyrolidine; triprolidine; Pro actidil; Tripolidina; Actidil



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Salvatore Febbraro, Tim Shea, Ana Santos Cravo. Bioavailability of Triprolidine as a Single Agent or in Combination With Pseudoephedrine: A Randomized, Open-Label Crossover Study in Healthy Volunteers. Clinical pharmacology in drug development. 2020 05; 9(4):486-495. doi: 10.1002/cpdd.777. [PMID: 32133778]
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  • B Sandhya, Ashwini H Hegde, Shankara S Kalanur, Umesha Katrahalli, J Seetharamappa. Interaction of triprolidine hydrochloride with serum albumins: thermodynamic and binding characteristics, and influence of site probes. Journal of pharmaceutical and biomedical analysis. 2011 Apr; 54(5):1180-6. doi: 10.1016/j.jpba.2010.12.012. [PMID: 21215548]
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  • Ashok K Shakya, Tawfiq A Arafat, Ahmad N Abuawwad, Munther Melhim, Jafar Al-Ghani, Mahmoud J Yacoub. Simultaneous determination of triprolidine and pseudoephedrine in human plasma by liquid chromatography-ion trap mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(32):4071-8. doi: 10.1016/j.jchromb.2009.10.021. [PMID: 19926351]
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  • Sang-Chul Shin, Jun-Shik Choi. Enhanced bioavailability of triprolidine from the transdermal TPX matrix system in rabbits. International journal of pharmaceutics. 2002 Mar; 234(1-2):67-73. doi: 10.1016/s0378-5173(01)00960-7. [PMID: 11839438]
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