4-Hydroxyquinazoline (BioDeep_00000269145)

Main id: BioDeep_00000017723

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


4-Hydroxyquinazoline

化学式: C8H6N2O (146.0480106)
中文名称: 4-羟基喹唑啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C(=O)N=CN2
InChI: InChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

描述信息

COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities[1][2].
4(3H)-Quinazolinone is a building block in chemical synthesis. Biologically active nitrogen heterocyclic compounds. Possesses a wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancerous and analgesic activities[1][2].

同义名列表

2 个代谢物同义名

4-Hydroxyquinazoline; 4(3H)-Quinazolinone



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lijie Zhu, Binzhuo Liu, Feng Jin, Weilong Cao, Guangzhao Xu, Xinwei Zhang, Peng Peng, Dingding Gao, Bin Wang, Kairui Feng. Discovery of Novel 4-Hydroxyquinazoline Derivatives: In Silico, In Vivo and In Vitro Studies Using Primary PARPi-Resistant Cell Lines. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061407. [PMID: 38543043]
  • Desy W Triningsih, Tao Zhou, Keisuke Fukaya, Enjuro Harunari, Naoya Oku, Daisuke Urabe, Yasuhiro Igarashi. Cyclic enaminones and a 4-quinazolinone from an unidentified actinomycete of the family Micromonosporaceae. The Journal of antibiotics. 2022 11; 75(11):610-618. doi: 10.1038/s41429-022-00558-y. [PMID: 36076014]
  • Nahed N E El-Sayed, Taghreed M Al-Otaibi, Mona Alonazi, Vijay H Masand, Assem Barakat, Zainab M Almarhoon, Abir Ben Bacha. Synthesis and Characterization of Some New Quinoxalin-2(1H)one and 2-Methyl-3H-quinazolin-4-one Derivatives Targeting the Onset and Progression of CRC with SAR, Molecular Docking, and ADMET Analyses. Molecules (Basel, Switzerland). 2021 05; 26(11):. doi: 10.3390/molecules26113121. [PMID: 34071141]
  • Shankar Sengottuvelan, Ritika Uppal, Suneetha Vuppu. Validation of a sensitive simultaneous LC-MS/MS method for the quantification of novel anti-cancer thiazolidinedione and quinazolin-4-one derivatives in rat plasma and its application in a rat pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Jul; 1121(?):18-27. doi: 10.1016/j.jchromb.2019.05.003. [PMID: 31082683]
  • N G Grushka. [THE EFFECT OF OF POLY(ADP-RIBOSE) POLYMERASE INHIBITOR 4-HYDROXY-QUINAZOLINE ON DEATH OF IMMUNE CELLS UNDER IMMUNE COMPLEX-MEDIATED INJURY IN MICE]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). 2017; 63(1):43-50. doi: 10.15407/fz63.01.043. [PMID: 29975827]
  • Xiang Wang, Pei Li, Zhining Li, Juan Yin, Ming He, Wei Xue, Zhiwei Chen, Baoan Song. Synthesis and bioactivity evaluation of novel arylimines containing a 3-aminoethyl-2-[(p-trifluoromethoxy)anilino]-4(3H)-quinazolinone moiety. Journal of agricultural and food chemistry. 2013 Oct; 61(40):9575-82. doi: 10.1021/jf403193q. [PMID: 24028303]
  • Dearg S Brown, John G Cumming, Paul Bethel, Jonathan Finlayson, Stefan Gerhardt, Ian Nash, Richard A Pauptit, Kurt G Pike, Alan Reid, Wendy Snelson, Steve Swallow, Caroline Thompson. The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases. Bioorganic & medicinal chemistry letters. 2012 Jun; 22(12):3879-83. doi: 10.1016/j.bmcl.2012.04.116. [PMID: 22608965]
  • Merav Leiba, Jana Jakubikova, Steffen Klippel, Constantine S Mitsiades, Teru Hideshima, Yu-Tzu Tai, Adi Leiba, Mark Pines, Paul G Richardson, Arnon Nagler, Kenneth C Anderson. Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents. British journal of haematology. 2012 Jun; 157(6):718-31. doi: 10.1111/j.1365-2141.2012.09120.x. [PMID: 22533681]
  • Marek Banasik, Todd Stedeford, Robert P Strosznajder, Masanori Takehashi, Seigo Tanaka, Kunihiro Ueda. Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride. Journal of enzyme inhibition and medicinal chemistry. 2011 Dec; 26(6):883-9. doi: 10.3109/14756366.2011.557315. [PMID: 21395487]
  • Sophie C Turfus, Robin A Braithwaite, David A Cowan, Mark C Parkin, Norman W Smith, Andrew T Kicman. Metabolites of lorazepam: Relevance of past findings to present day use of LC-MS/MS in analytical toxicology. Drug testing and analysis. 2011 Oct; 3(10):695-704. doi: 10.1002/dta.305. [PMID: 21837620]
  • Xiang-Shan Wang, Jie Sheng, Lian Lu, Ke Yang, Yu-Ling Li. Combinatorial synthesis of 3-arylideneaminoquinazolin-4(1H)-one derivatives catalyzed by iodine in ionic liquids. ACS combinatorial science. 2011 Mar; 13(2):196-9. doi: 10.1021/co1000713. [PMID: 21210708]
  • Lee-Chung Lin, Jen-Hung Hsu, Long-Chi Wang. Identification of novel inhibitors of 1-aminocyclopropane-1-carboxylic acid synthase by chemical screening in Arabidopsis thaliana. The Journal of biological chemistry. 2010 Oct; 285(43):33445-33456. doi: 10.1074/jbc.m110.132498. [PMID: 20682786]
  • Xiang-Shan Wang, Ke Yang, Jie Zhou, Shu-Jiang Tu. Facile method for the combinatorial synthesis of 2,2-disubstituted quinazolin-4(1H)-one derivatives catalyzed by iodine in ionic liquids. Journal of combinatorial chemistry. 2010 Jul; 12(4):417-21. doi: 10.1021/cc900174p. [PMID: 20334422]
  • Zarif U Samarov, Rasul Ya Okmanov, Kambarali K Turgunov, Bakhodir Tashkhodjaev, Khusnutdin M Shakhidoyatov. 11-(2-Oxopyrrolidin-1-ylmeth-yl)-1,2,3,4,5,6,11,11a-octa-hydro-pyrido[2,1-b]quinazolin-6-one dihydrate. Acta crystallographica. Section E, Structure reports online. 2010 Mar; 66(Pt 4):o890. doi: 10.1107/s1600536810009955. [PMID: 21580707]
  • Jean-Luc Genet, Grazyna Jaworska. Baseline sensitivity to proquinazid in Blumeria graminis f. sp. tritici and Erysiphe necator and cross-resistance with other fungicides. Pest management science. 2009 Aug; 65(8):878-84. doi: 10.1002/ps.1768. [PMID: 19418441]
  • William J Watkins, Lee Chong, Aesop Cho, Ramona Hilgenkamp, Maria Ludwikow, Negar Garizi, Nadeem Iqbal, John Barnard, Rajeshwar Singh, Deidre Madsen, Karen Lolans, Olga Lomovskaya, Uma Oza, Padmapriya Kumaraswamy, Andrea Blecken, Shuang Bai, David J Loury, David C Griffith, Michael N Dudley. Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization. Bioorganic & medicinal chemistry letters. 2007 May; 17(10):2802-6. doi: 10.1016/j.bmcl.2007.02.047. [PMID: 17350259]
  • A G Eshimbetov, E L Kristallovich, N D Abdullaev, T S Tulyaganov, Kh M Shakhidoyatov. AM1/CI, CNDO/S and ZINDO/S computations of absorption bands and their intensities in the UV spectra of some 4(3H)-quinazolinones. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2006 Oct; 65(2):299-307. doi: 10.1016/j.saa.2005.10.046. [PMID: 16495133]
  • M J A de Jonge, H Dumez, J Verweij, S Yarkoni, D Snyder, D Lacombe, S Marréaud, T Yamaguchi, C J A Punt, A van Oosterom. Phase I and pharmacokinetic study of halofuginone, an oral quinazolinone derivative in patients with advanced solid tumours. European journal of cancer (Oxford, England : 1990). 2006 Aug; 42(12):1768-74. doi: 10.1016/j.ejca.2005.12.027. [PMID: 16815702]
  • Krisztina Kovacs, Ambrus Toth, Peter Deres, Tamas Kalai, Kalman Hideg, Ferenc Gallyas, Balazs Sumegi. Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion. Biochemical pharmacology. 2006 Feb; 71(4):441-52. doi: 10.1016/j.bcp.2005.05.036. [PMID: 16337154]
  • Fawzia M Refaie, Amr Y Esmat, Soad M Abdel Gawad, Aida M Ibrahim, Mona A Mohamed. The antihyperlipidemic activities of 4(3H) quinazolinone and two halogenated derivatives in rats. Lipids in health and disease. 2005 Oct; 4(?):22. doi: 10.1186/1476-511x-4-22. [PMID: 16202158]
  • Saroj Kumari, Neetu Kalra, Pushpa Mishra, Krishna Chutani, Anil Mishra, Madhu Chopra. Novel 99mTc radiolabeled quinazolinone derivative [Qn-In]: synthesis, evaluation and biodistribution studies in mice and rabbit. Nuclear medicine and biology. 2004 Nov; 31(8):1087-95. doi: 10.1016/j.nucmedbio.2004.03.014. [PMID: 15607491]
  • Balazs Veres, Balazs Radnai, Ferenc Gallyas, Gabor Varbiro, Zoltan Berente, Erzsebet Osz, Balazs Sumegi. Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice. The Journal of pharmacology and experimental therapeutics. 2004 Jul; 310(1):247-55. doi: 10.1124/jpet.104.065151. [PMID: 14999056]
  • P Kastner, J Klimes, M Láznícek, Th Jira. HPLC assay in plasma and preliminary pharmacokinetic study of a quinazolinone derivative with spasmolytic effect. Die Pharmazie. 2003 Apr; 58(4):242-4. doi: NULL. [PMID: 12749404]
  • Saibal Kumar Das, V L Narasimha Rao Krovvidi, H Jagadheshan, Javed Iqbal. Synthetic studies of cis-4-Amino-L-proline derivatives as novel lipid lowering agents. Bioorganic & medicinal chemistry letters. 2002 Dec; 12(24):3579-81. doi: 10.1016/s0960-894x(02)00799-0. [PMID: 12443780]
  • Francisco Javier Martín-Romero, Elena García-Martín, Carlos Gutiérrez-Merino. Inhibition of oxidative stress produced by plasma membrane NADH oxidase delays low-potassium-induced apoptosis of cerebellar granule cells. Journal of neurochemistry. 2002 Aug; 82(3):705-15. doi: 10.1046/j.1471-4159.2002.01023.x. [PMID: 12153494]
  • R Halmosi, Z Berente, E Osz, K Toth, P Literati-Nagy, B Sumegi. Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system. Molecular pharmacology. 2001 Jun; 59(6):1497-505. doi: 10.1124/mol.59.6.1497. [PMID: 11353811]
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  • M AKAGI, Y OKETANI, S YAMANE. 2-METHYL-3-O-HYDROXYMETHYLPHENYL-4(3H)-QUINAZOLINONE, A METABOLITE OF 2-METHYL-3-O-TOLYL-4(3H)-QUINAZOLINONE IN RABBIT. Chemical & pharmaceutical bulletin. 1963 Sep; 11(?):1216-7. doi: 10.1248/cpb.11.1216. [PMID: 14068751]