13,14-Dihydro-15-keto-PGD2 (BioDeep_00000026774)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


(5Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid

化学式: C20H32O5 (352.2249622)
中文名称: 13,14-二氢-15-酮前列腺素d2
谱图信息: 最多检出来源 Danio rerio(blood) 6.25%

分子结构信息

SMILES: CCCCCC(=O)CCC1C(=O)CC(O)C1CC=CCCCC(=O)O
InChI: InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-18,22H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+/m1/s1

描述信息

13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2), (CAS 59894-07-4), is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. 13,14-dihydro-15-keto PGD2 was recently identified as a selective agonist for the CRTH2/DP2 receptor. It also inhibits ion flux in a canine colonic mucosa preparation. In humans, 13,14-dihydro-15-keto PGD2 is further metabolized to give 11β-hydroxy compounds which have also undergone β-oxidation of one or both side chains. Virtually no 13,14-dihydro-15-keto PGD2 survives intact in the urine. (http://www.caymanchem.com)

同义名列表

6 个代谢物同义名

(5Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid; 13,14-dihydro-15-keto Prostaglandin D2; 13,14-dihydro-15-keto-Prostaglandin D2; 13,14-Dihydro-15-ketoprostaglandin D2; 13,14-dihydro-15-keto-PGD2; 59894-07-4



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

1 个相关的代谢反应过程信息。

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Satonori Higuchi, Masanori Kobayashi, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. Journal of applied toxicology : JAT. 2012 Oct; 32(10):815-22. doi: 10.1002/jat.1706. [PMID: 21735453]
  • Satonori Higuchi, Masanori Kobayashi, Yukitaka Yoshikawa, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. IL-4 mediates dicloxacillin-induced liver injury in mice. Toxicology letters. 2011 Feb; 200(3):139-45. doi: 10.1016/j.toxlet.2010.11.006. [PMID: 21094227]
  • Kang Cheng, Tsuei-Ju Wu, Kenneth K Wu, Claudio Sturino, Kathleen Metters, Keith Gottesdiener, Samuel D Wright, Zhaoyin Wang, Gary O'Neill, Eseng Lai, M Gerard Waters. Antagonism of the prostaglandin D2 receptor 1 suppresses nicotinic acid-induced vasodilation in mice and humans. Proceedings of the National Academy of Sciences of the United States of America. 2006 Apr; 103(17):6682-7. doi: 10.1073/pnas.0601574103. [PMID: 16617107]
  • D H Wright, K M Metters, M Abramovitz, A W Ford-Hutchinson. Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. British journal of pharmacology. 1998 Apr; 123(7):1317-24. doi: 10.1038/sj.bjp.0701708. [PMID: 9579725]
  • D J Meuten, G V Segre, C C Capen, G J Kociba, E F Voelkel, L Levine, A H Tashjian, D J Chew, L A Nagode. Hypercalcemia in dogs with adenocarcinoma derived from apocrine glands of the anal sac. Biochemical and histomorphometric investigations. Laboratory investigation; a journal of technical methods and pathology. 1983 Apr; 48(4):428-35. doi: . [PMID: 6300551]