Myriocin (BioDeep_00000002673)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid;ISP-I;Thermozymocidin

化学式: C21H39NO6 (401.2777234)
中文名称: 多球壳菌素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.35%

分子结构信息

SMILES: C([C@](C(O)=O)(N)[C@H](O)[C@H](O)C/C=C/CCCCCCC(=O)CCCCCC)O
InChI: InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1

描述信息

An amino acid-based antibiotic derived from certain thermophilic fungi; acts as a potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis. Myriocin also possesses immunosuppressant activity.
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
[Raw Data] CBA29_Myriocin_pos_20eV_1-3_01_1557.txt
[Raw Data] CBA29_Myriocin_neg_40eV_1-3_01_1590.txt
[Raw Data] CBA29_Myriocin_pos_10eV_1-3_01_1546.txt
[Raw Data] CBA29_Myriocin_neg_30eV_1-3_01_1589.txt
[Raw Data] CBA29_Myriocin_pos_40eV_1-3_01_1559.txt
[Raw Data] CBA29_Myriocin_pos_30eV_1-3_01_1558.txt
[Raw Data] CBA29_Myriocin_pos_50eV_1-3_01_1560.txt
[Raw Data] CBA29_Myriocin_neg_10eV_1-3_01_1578.txt
[Raw Data] CBA29_Myriocin_neg_20eV_1-3_01_1588.txt
Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection[1][2][3].

同义名列表

7 个代谢物同义名

Myriocin; (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid;ISP-I;Thermozymocidin; (2S,3R,4R,6E)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid; 2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid; FT-0672574; Thermozymocidin; ISP-I



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hanna Stieber, Lara Junghanns, Hannah Wilhelm, Maria Batliner, Alexander Maximilian Aldejohann, Oliver Kurzai, Ronny Martin. The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B. Mycoses. 2024 Apr; 67(4):e13723. doi: 10.1111/myc.13723. [PMID: 38551121]
  • Michal K Handzlik, Jivani M Gengatharan, Katie E Frizzi, Grace H McGregor, Cameron Martino, Gibraan Rahman, Antonio Gonzalez, Ana M Moreno, Courtney R Green, Lucie S Guernsey, Terry Lin, Patrick Tseng, Yoichiro Ideguchi, Regis J Fallon, Amandine Chaix, Satchidananda Panda, Prashant Mali, Martina Wallace, Rob Knight, Marin L Gantner, Nigel A Calcutt, Christian M Metallo. Insulin-regulated serine and lipid metabolism drive peripheral neuropathy. Nature. 2023 Feb; 614(7946):118-124. doi: 10.1038/s41586-022-05637-6. [PMID: 36697822]
  • Ting Wang, Jingmin Zhang, Meng Yang, Jinxiu Guo, Duolu Li, Ying Li. Lipidomics Analysis Reveals a Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats. Journal of molecular neuroscience : MN. 2022 Sep; 72(9):1846-1858. doi: 10.1007/s12031-022-02014-w. [PMID: 35776315]
  • Bingen G Monasterio, Noemi Jiménez-Rojo, Aritz B García-Arribas, Howard Riezman, Félix M Goñi, Alicia Alonso. Plasma membrane effects of sphingolipid-synthesis inhibition by myriocin in CHO cells: a biophysical and lipidomic study. Scientific reports. 2022 01; 12(1):955. doi: 10.1038/s41598-021-04648-z. [PMID: 35046440]
  • Qian Chen, Fan Xu, Li Wang, Xiaodong Suo, Qiaoling Wang, Qian Meng, Li Huang, Caixia Ma, Guiming Li, Ming Luo. Sphingolipid Profile during Cotton Fiber Growth Revealed That a Phytoceramide Containing Hydroxylated and Saturated VLCFA Is Important for Fiber Cell Elongation. Biomolecules. 2021 09; 11(9):. doi: 10.3390/biom11091352. [PMID: 34572565]
  • Amanda N Davis, William A Myers, Jorge Eduardo Rico, Lin Feng Wang, Crystal Chang, Andrew T Richards, Mohammed Moniruzzaman, Norman J Haughey, Joseph W McFadden. Effects of serine palmitoyltransferase inhibition by myriocin in ad libitum-fed and nutrient-restricted ewes. Journal of animal science. 2021 Aug; 99(8):. doi: 10.1093/jas/skab221. [PMID: 34324668]
  • Alessandra Mingione, Francesca Pivari, Nicoletta Plotegher, Michele Dei Cas, Aida Zulueta, Tommaso Bocci, Marco Trinchera, Elisabetta Albi, Vittorio Maglione, Anna Caretti, Luigi Bubacco, Rita Paroni, Daniele Bottai, Riccardo Ghidoni, Paola Signorelli. Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson's Disease. International journal of molecular sciences. 2021 Jun; 22(12):. doi: 10.3390/ijms22126469. [PMID: 34208778]
  • Paola Signorelli, Francesca Pivari, Matteo Barcella, Ivan Merelli, Aida Zulueta, Michele Dei Cas, Lorenzo Rosso, Riccardo Ghidoni, Anna Caretti, Rita Paroni, Alessandra Mingione. Myriocin modulates the altered lipid metabolism and storage in cystic fibrosis. Cellular signalling. 2021 05; 81(?):109928. doi: 10.1016/j.cellsig.2021.109928. [PMID: 33482299]
  • Hengxu Wang, Zhigang Wang, Zeping Liu, Kexin Wang, Weihui Xu. Membrane disruption of Fusarium oxysporum f. sp. niveum induced by myriocin from Bacillus amyloliquefaciens LZN01. Microbial biotechnology. 2021 03; 14(2):517-534. doi: 10.1111/1751-7915.13659. [PMID: 32954686]
  • Chun Ru Li, Yu Qin Wang, Wen Ming Cheng, Zhu An Chen, Nigel Hywel-Jones, Zeng Zhi Li. Review on Research Progress and Prospects of Cicada Flower, Isaria cicadae (Ascomycetes). International journal of medicinal mushrooms. 2021; 23(4):81-91. doi: 10.1615/intjmedmushrooms.2021038085. [PMID: 33822510]
  • H Ma, C-M Liu, S-Q Shao, Y-Y Song, J Zhou, L-N Cao, H-Q Yin, S-L Yin. Myriocin alleviates Oleic/Palmitate induced chondrocyte degeneration via the suppression of ceramide. European review for medical and pharmacological sciences. 2020 12; 24(24):12938-12947. doi: 10.26355/eurrev_202012_24197. [PMID: 33378044]
  • Alessandra Mingione, Emerenziana Ottaviano, Matteo Barcella, Ivan Merelli, Lorenzo Rosso, Tatiana Armeni, Natalia Cirilli, Riccardo Ghidoni, Elisa Borghi, Paola Signorelli. Cystic Fibrosis Defective Response to Infection Involves Autophagy and Lipid Metabolism. Cells. 2020 08; 9(8):. doi: 10.3390/cells9081845. [PMID: 32781626]
  • Chang Yun Woo, Ji Yeon Baek, Ah Ram Kim, Chung Hwan Hong, Ji Eun Yoon, Hyoun Sik Kim, Hyun Ju Yoo, Tae Sik Park, Ranjan Kc, Ki Up Lee, Eun Hee Koh. Inhibition of Ceramide Accumulation in Podocytes by Myriocin Prevents Diabetic Nephropathy. Diabetes & metabolism journal. 2020 08; 44(4):581-591. doi: 10.4093/dmj.2019.0063. [PMID: 31701696]
  • Francisca Randez-Gil, Jose A Prieto, Alejandro Rodríguez-Puchades, Josefina Casas, Vicente Sentandreu, Francisco Estruch. Myriocin-induced adaptive laboratory evolution of an industrial strain of Saccharomyces cerevisiae reveals its potential to remodel lipid composition and heat tolerance. Microbial biotechnology. 2020 07; 13(4):1066-1081. doi: 10.1111/1751-7915.13555. [PMID: 32212314]
  • David García-Seisdedos, Bohdan Babiy, Milagros Lerma, María E Casado, Javier Martínez-Botas, Miguel A Lasunción, Óscar Pastor, Rebeca Busto. Curcumin stimulates exosome/microvesicle release in an in vitro model of intracellular lipid accumulation by increasing ceramide synthesis. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 05; 1865(5):158638. doi: 10.1016/j.bbalip.2020.158638. [PMID: 31988047]
  • Zemou Yu, Qing Peng, Songyue Li, Hongjun Hao, Jianwen Deng, Lingbing Meng, Zhiyuan Shen, Weiwei Yu, Ding Nan, Yu Bai, Yining Huang. Myriocin and d-PDMP ameliorate atherosclerosis in ApoE-/- mice via reducing lipid uptake and vascular inflammation. Clinical science (London, England : 1979). 2020 03; 134(5):439-458. doi: 10.1042/cs20191028. [PMID: 32091078]
  • Alessandra Mingione, Michele Dei Cas, Fabiola Bonezzi, Anna Caretti, Marco Piccoli, Luigi Anastasia, Riccardo Ghidoni, Rita Paroni, Paola Signorelli. Inhibition of Sphingolipid Synthesis as a Phenotype-Modifying Therapy in Cystic Fibrosis. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2020 01; 54(1):110-125. doi: 10.33594/000000208. [PMID: 31999897]
  • Chiara Bianca Maria Platania, Michele Dei Cas, Simona Cianciolo, Annamaria Fidilio, Francesca Lazzara, Rita Paroni, Rosario Pignatello, Enrica Strettoi, Riccardo Ghidoni, Filippo Drago, Claudio Bucolo. Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa. Drug delivery. 2019 Dec; 26(1):237-243. doi: 10.1080/10717544.2019.1574936. [PMID: 30883241]
  • Rui-Xu Yang, Qin Pan, Xiao-Lin Liu, Da Zhou, Feng-Zhi Xin, Ze-Hua Zhao, Rui-Nan Zhang, Jing Zeng, Liang Qiao, Chun-Xiu Hu, Guo-Wang Xu, Jian-Gao Fan. Therapeutic effect and autophagy regulation of myriocin in nonalcoholic steatohepatitis. Lipids in health and disease. 2019 Oct; 18(1):179. doi: 10.1186/s12944-019-1118-0. [PMID: 31639005]
  • Lauren E Rylaarsdam, Grace N Johnecheck, Brendan D Looyenga, Larry L Louters. GLUT1 is associated with sphingolipid-organized, cholesterol-independent domains in L929 mouse fibroblast cells. Biochimie. 2019 Jul; 162(?):88-96. doi: 10.1016/j.biochi.2019.04.010. [PMID: 30980844]
  • Tzu-Chieh Chen, Rebecca A Lee, Sam L Tsai, Deepthi Kanamaluru, Nora E Gray, Nicholas Yiv, Rachel T Cheang, Jenna H Tan, Justin Y Lee, Mark D Fitch, Marc K Hellerstein, Jen-Chywan Wang. An ANGPTL4-ceramide-protein kinase Cζ axis mediates chronic glucocorticoid exposure-induced hepatic steatosis and hypertriglyceridemia in mice. The Journal of biological chemistry. 2019 06; 294(23):9213-9224. doi: 10.1074/jbc.ra118.006259. [PMID: 31053639]
  • Piotr Zabielski, Jarosław Daniluk, Hady Razak Hady, Adam R Markowski, Monika Imierska, Jan Górski, Agnieszka U Blachnio-Zabielska. The effect of high-fat diet and inhibition of ceramide production on insulin action in liver. Journal of cellular physiology. 2019 02; 234(2):1851-1861. doi: 10.1002/jcp.27058. [PMID: 30067865]
  • Agnieszka U Blachnio-Zabielska, Hady Razak Hady, Adam R Markowski, Adam Kurianiuk, Alicja Karwowska, Jan Górski, Piotr Zabielski. Inhibition of Ceramide De Novo Synthesis Affects Adipocytokine Secretion and Improves Systemic and Adipose Tissue Insulin Sensitivity. International journal of molecular sciences. 2018 Dec; 19(12):. doi: 10.3390/ijms19123995. [PMID: 30545025]
  • Kristin L Leskoske, Françoise M Roelants, Anita Emmerstorfer-Augustin, Christoph M Augustin, Edward P Si, Jennifer M Hill, Jeremy Thorner. Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2. Genes & development. 2018 12; 32(23-24):1576-1590. doi: 10.1101/gad.318709.118. [PMID: 30478248]
  • Jihui Ren, Justin Snider, Michael V Airola, Aaron Zhong, Nadia A Rana, Lina M Obeid, Yusuf A Hannun. Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae. Journal of lipid research. 2018 01; 59(1):162-170. doi: 10.1194/jlr.d078535. [PMID: 29092960]
  • Marie Kodedová, Hana Sychrová. Synthetic antimicrobial peptides of the halictines family disturb the membrane integrity of Candida cells. Biochimica et biophysica acta. Biomembranes. 2017 Oct; 1859(10):1851-1858. doi: 10.1016/j.bbamem.2017.06.005. [PMID: 28600071]
  • Aida Zulueta, Anna Caretti, Giuseppe Matteo Campisi, Andrea Brizzolari, Jose Luis Abad, Rita Paroni, Paola Signorelli, Riccardo Ghidoni. Inhibitors of ceramide de novo biosynthesis rescue damages induced by cigarette smoke in airways epithelia. Naunyn-Schmiedeberg's archives of pharmacology. 2017 Jul; 390(7):753-759. doi: 10.1007/s00210-017-1375-2. [PMID: 28409208]
  • Corey Giles, Ryusuke Takechi, Natalie A Mellett, Peter J Meikle, Satvinder Dhaliwal, John C Mamo. Differential regulation of sphingolipid metabolism in plasma, hippocampus, and cerebral cortex of mice administered sphingolipid modulating agents. Journal of neurochemistry. 2017 05; 141(3):413-422. doi: 10.1111/jnc.13964. [PMID: 28129448]
  • Krzysztof Kurek, Marta Garbowska, Dominika M Ziembicka, Bartłomiej Łukaszuk, Jakub Rogowski, Adrian Chabowski, Jan Górski, Małgorzata Żendzian-Piotrowska. Myriocin treatment affects lipid metabolism in skeletal muscles of rats with streptozotocin-induced type 1 diabetes. Advances in medical sciences. 2017 Mar; 62(1):65-73. doi: 10.1016/j.advms.2016.04.003. [PMID: 28189121]
  • Nicolas Lebesgue, Márton Megyeri, Alba Cristobal, Arjen Scholten, Silvia G Chuartzman, Yoav Voichek, Richard A Scheltema, Shabaz Mohammed, Anthony H Futerman, Maya Schuldiner, Albert J R Heck, Simone Lemeer. Combining Deep Sequencing, Proteomics, Phosphoproteomics, and Functional Screens To Discover Novel Regulators of Sphingolipid Homeostasis. Journal of proteome research. 2017 02; 16(2):571-582. doi: 10.1021/acs.jproteome.6b00691. [PMID: 28152593]
  • Hanin Aburasayn, Rami Al Batran, John R Ussher. Targeting ceramide metabolism in obesity. American journal of physiology. Endocrinology and metabolism. 2016 08; 311(2):E423-35. doi: 10.1152/ajpendo.00133.2016. [PMID: 27382035]
  • Michael J Genin, Isabel C Gonzalez Valcarcel, William G Holloway, Jason Lamar, Marian Mosior, Eric Hawkins, Thomas Estridge, Jeffrey Weidner, Thomas Seng, David Yurek, Lisa A Adams, Jennifer Weller, Vincent L Reynolds, Joseph T Brozinick. Imidazopyridine and Pyrazolopiperidine Derivatives as Novel Inhibitors of Serine Palmitoyl Transferase. Journal of medicinal chemistry. 2016 06; 59(12):5904-10. doi: 10.1021/acs.jmedchem.5b01851. [PMID: 27213958]
  • Sara García-Marqués, Francisca Randez-Gil, Sebastien Dupont, Elena Garre, Jose A Prieto. Sng1 associates with Nce102 to regulate the yeast Pkh-Ypk signalling module in response to sphingolipid status. Biochimica et biophysica acta. 2016 Jun; 1863(6 Pt A):1319-33. doi: 10.1016/j.bbamcr.2016.03.025. [PMID: 27033517]
  • Shutao Yin, Xiao Guo, Jinghua Li, Linghong Fan, Hongbo Hu. Fumonisin B1 induces autophagic cell death via activation of ERN1-MAPK8/9/10 pathway in monkey kidney MARC-145 cells. Archives of toxicology. 2016 Apr; 90(4):985-96. doi: 10.1007/s00204-015-1514-9. [PMID: 25925693]
  • Lina Lindahl, Samuel Genheden, Leif A Eriksson, Lisbeth Olsson, Maurizio Bettiga. Sphingolipids contribute to acetic acid resistance in Zygosaccharomyces bailii. Biotechnology and bioengineering. 2016 Apr; 113(4):744-53. doi: 10.1002/bit.25845. [PMID: 26416641]
  • Agnieszka Błachnio-Zabielska, Marcin Baranowski, Beata Wójcik, Jan Górski. Reduction of ceramide de novo synthesis in solid tissues changes sphingolipid levels in rat plasma, erythrocytes and platelets. Advances in medical sciences. 2016 Mar; 61(1):72-7. doi: 10.1016/j.advms.2015.09.006. [PMID: 26521206]
  • M R Reforgiato, G Milano, G Fabriàs, J Casas, P Gasco, R Paroni, M Samaja, R Ghidoni, A Caretti, Paola Signorelli. Inhibition of ceramide de novo synthesis as a postischemic strategy to reduce myocardial reperfusion injury. Basic research in cardiology. 2016 Mar; 111(2):12. doi: 10.1007/s00395-016-0533-x. [PMID: 26786259]
  • Erwann Salaun, Luz Lefeuvre-Orfila, Thibault Cavey, Brice Martin, Bruno Turlin, Martine Ropert, Olivier Loreal, Frédéric Derbré. Myriocin prevents muscle ceramide accumulation but not muscle fiber atrophy during short-term mechanical unloading. Journal of applied physiology (Bethesda, Md. : 1985). 2016 Jan; 120(2):178-87. doi: 10.1152/japplphysiol.00720.2015. [PMID: 26542521]
  • Agnieszka U Blachnio-Zabielska, Marta Chacinska, Mikkel H Vendelbo, Piotr Zabielski. The Crucial Role of C18-Cer in Fat-Induced Skeletal Muscle Insulin Resistance. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2016; 40(5):1207-1220. doi: 10.1159/000453174. [PMID: 27960149]
  • Leena P Bharath, Ting Ruan, Youyou Li, Anindita Ravindran, Xin Wan, Jennifer Kim Nhan, Matthew Lewis Walker, Lance Deeter, Rebekah Goodrich, Elizabeth Johnson, Derek Munday, Robert Mueller, David Kunz, Deborah Jones, Van Reese, Scott A Summers, Pon Velayutham Anandh Babu, William L Holland, Quan-Jiang Zhang, E Dale Abel, J David Symons. Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo. Diabetes. 2015 Nov; 64(11):3914-26. doi: 10.2337/db15-0244. [PMID: 26253611]
  • Alexandros Athanasopoulos, Christos Gournas, Sotiris Amillis, Vicky Sophianopoulou. Characterization of AnNce102 and its role in eisosome stability and sphingolipid biosynthesis. Scientific reports. 2015 Oct; 5(?):15200. doi: 10.1038/srep15200. [PMID: 26468899]
  • Turgut E Aktepe, Helen Pham, Jason M Mackenzie. Differential utilisation of ceramide during replication of the flaviviruses West Nile and dengue virus. Virology. 2015 Oct; 484(?):241-250. doi: 10.1016/j.virol.2015.06.015. [PMID: 26122470]
  • Victor Samokhvalov, Igor Zlobine, Kristi L Jamieson, Paul Jurasz, Christopher Chen, Kin Sing Stephen Lee, Bruce D Hammock, John M Seubert. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Toxicology letters. 2015 Jan; 232(1):10-20. doi: 10.1016/j.toxlet.2014.09.029. [PMID: 25300478]
  • Takhar Kasumov, Ling Li, Min Li, Kailash Gulshan, John P Kirwan, Xiuli Liu, Stephen Previs, Belinda Willard, Jonathan D Smith, Arthur McCullough. Ceramide as a mediator of non-alcoholic Fatty liver disease and associated atherosclerosis. PloS one. 2015; 10(5):e0126910. doi: 10.1371/journal.pone.0126910. [PMID: 25993337]
  • Beth A Surlow, Benjamin M Cooley, Patrick G Needham, Jeffrey L Brodsky, Jana Patton-Vogt. Loss of Ypk1, the yeast homolog to the human serum- and glucocorticoid-induced protein kinase, accelerates phospholipase B1-mediated phosphatidylcholine deacylation. The Journal of biological chemistry. 2014 Nov; 289(45):31591-604. doi: 10.1074/jbc.m114.581157. [PMID: 25258318]
  • Suryaprakash Raichur, Siew Tein Wang, Puck Wee Chan, Ying Li, Jianhong Ching, Bhagirath Chaurasia, Bghagirath Chaurasia, Shaillay Dogra, Miina K Öhman, Kosuke Takeda, Shigeki Sugii, Yael Pewzner-Jung, Anthony H Futerman, Scott A Summers. CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell metabolism. 2014 Oct; 20(4):687-95. doi: 10.1016/j.cmet.2014.09.015. [PMID: 25295789]
  • Krzysztof Kurek, Dominika M Piotrowska, Patrycja Wiesiołek-Kurek, Bartłomiej Łukaszuk, Adrian Chabowski, Jan Górski, Małgorzata Zendzian-Piotrowska. Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver. 2014 Aug; 34(7):1074-83. doi: 10.1111/liv.12331. [PMID: 24106929]
  • Jason M Correnti, Egle Juskeviciute, Aditi Swarup, Jan B Hoek. Pharmacological ceramide reduction alleviates alcohol-induced steatosis and hepatomegaly in adiponectin knockout mice. American journal of physiology. Gastrointestinal and liver physiology. 2014 Jun; 306(11):G959-73. doi: 10.1152/ajpgi.00395.2013. [PMID: 24742988]
  • M-Ángeles Curto, Mohammad Reza Sharifmoghadam, Eduardo Calpena, Nagore De León, Marta Hoya, Cristina Doncel, Janet Leatherwood, M-Henar Valdivieso. Membrane organization and cell fusion during mating in fission yeast requires multipass membrane protein Prm1. Genetics. 2014 Apr; 196(4):1059-76. doi: 10.1534/genetics.113.159558. [PMID: 24514900]
  • Ming Tong, Lisa Longato, Teresa Ramirez, Valerie Zabala, Jack R Wands, Suzanne M de la Monte. Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin. International journal of experimental pathology. 2014 Feb; 95(1):49-63. doi: 10.1111/iep.12052. [PMID: 24456332]
  • Krzysztof Kurek, Patrycja Wiesiołek-Kurek, Dominika M Piotrowska, Bartłomiej Łukaszuk, Adrian Chabowski, Małgorzata Żendzianendzian-Piotrowska. Inhibition of ceramide de novo synthesis with myriocin affects lipid metabolism in the liver of rats with streptozotocin-induced type 1 diabetes. BioMed research international. 2014; 2014(?):980815. doi: 10.1155/2014/980815. [PMID: 24701589]
  • Anna Caretti, Alessandra Bragonzi, Marcella Facchini, Ida De Fino, Camilla Riva, Paolo Gasco, Claudia Musicanti, Josefina Casas, Gemma Fabriàs, Riccardo Ghidoni, Paola Signorelli. Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis. Biochimica et biophysica acta. 2014 Jan; 1840(1):586-94. doi: 10.1016/j.bbagen.2013.10.018. [PMID: 24141140]
  • Wenjing Li, Xiaoyan Yang, Shasha Xing, Fang Bian, Wanjing Yao, Xiangli Bai, Tao Zheng, Guangjie Wu, Si Jin. Endogenous ceramide contributes to the transcytosis of oxLDL across endothelial cells and promotes its subendothelial retention in vascular wall. Oxidative medicine and cellular longevity. 2014; 2014(?):823071. doi: 10.1155/2014/823071. [PMID: 24817993]
  • Erwin Swinnen, Tobias Wilms, Jolanta Idkowiak-Baldys, Bart Smets, Pepijn De Snijder, Sabina Accardo, Ruben Ghillebert, Karin Thevissen, Bruno Cammue, Dirk De Vos, Jacek Bielawski, Yusuf A Hannun, Joris Winderickx. The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae. Molecular biology of the cell. 2014 Jan; 25(1):196-211. doi: 10.1091/mbc.e13-06-0340. [PMID: 24196832]
  • Diana Lizarazo, Valerie Zabala, Ming Tong, Lisa Longato, Suzanne M de la Monte. Ceramide inhibitor myriocin restores insulin/insulin growth factor signaling for liver remodeling in experimental alcohol-related steatohepatitis. Journal of gastroenterology and hepatology. 2013 Oct; 28(10):1660-8. doi: 10.1111/jgh.12291. [PMID: 23802886]
  • Takhar Kasumov, Belinda Willard, Ling Li, Min Li, Heather Conger, Jennifer A Buffa, Stephen Previs, Arthur McCullough, Stanley L Hazen, Jonathan D Smith. 2H2O-based high-density lipoprotein turnover method for the assessment of dynamic high-density lipoprotein function in mice. Arteriosclerosis, thrombosis, and vascular biology. 2013 Aug; 33(8):1994-2003. doi: 10.1161/atvbaha.113.301700. [PMID: 23766259]
  • Mark J Dekker, Chris Baker, Mark Naples, Josh Samsoondar, Rianna Zhang, Wei Qiu, Jennifer Sacco, Khosrow Adeli. Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction. Atherosclerosis. 2013 May; 228(1):98-109. doi: 10.1016/j.atherosclerosis.2013.01.041. [PMID: 23466071]
  • Fikadu G Tafesse, Sumana Sanyal, Joseph Ashour, Carla P Guimaraes, Martin Hermansson, Pentti Somerharju, Hidde L Ploegh. Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proceedings of the National Academy of Sciences of the United States of America. 2013 Apr; 110(16):6406-11. doi: 10.1073/pnas.1219909110. [PMID: 23576732]
  • Peter Meszaros, Karin Klappe, Annie van Dam, Pavlina T Ivanova, Stephen B Milne, David S Myers, H Alex Brown, Hjalmar Permentier, Dick Hoekstra, Jan W Kok. Long term myriocin treatment increases MRP1 transport activity. The international journal of biochemistry & cell biology. 2013 Feb; 45(2):326-34. doi: 10.1016/j.biocel.2012.11.009. [PMID: 23178537]
  • Irina Gorshkova, Tong Zhou, Biji Mathew, Jeffrey R Jacobson, Daisuke Takekoshi, Palash Bhattacharya, Brett Smith, Bulent Aydogan, Ralph R Weichselbaum, Viswanathan Natarajan, Joe G N Garcia, Evgeny V Berdyshev. Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression. Journal of lipid research. 2012 Aug; 53(8):1553-68. doi: 10.1194/jlr.m026039. [PMID: 22615416]
  • Quan-Jiang Zhang, William L Holland, Lloyd Wilson, Jason M Tanner, Devin Kearns, Judd M Cahoon, Dix Pettey, Jason Losee, Bradlee Duncan, Derrick Gale, Christopher A Kowalski, Nicholas Deeter, Alexandrea Nichols, Michole Deesing, Colton Arrant, Ting Ruan, Christoph Boehme, Dane R McCamey, Janvida Rou, Kapil Ambal, Krishna K Narra, Scott A Summers, E Dale Abel, J David Symons. Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS-Akt complex. Diabetes. 2012 Jul; 61(7):1848-59. doi: 10.2337/db11-1399. [PMID: 22586587]
  • Halina Car, Małgorzata Zendzian-Piotrowska, Sławomir Prokopiuk, Anna Fiedorowicz, Anna Sadowska, Krzysztof Kurek, Diana Sawicka. Ceramide profiles in the brain of rats with diabetes induced by streptozotocin. The FEBS journal. 2012 Jun; 279(11):1943-52. doi: 10.1111/j.1742-4658.2012.08575.x. [PMID: 22429392]
  • Kenji Chiba, Kunitomo Adachi. Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis. Future medicinal chemistry. 2012 Apr; 4(6):771-81. doi: 10.4155/fmc.12.25. [PMID: 22530640]
  • Kyong-Oh Shin, Myong-Yong Park, Cho-Hee Seo, Yong-Ill Lee, Hyun Sik Kim, Hwan-Soo Yoo, Jin Tae Hong, Jae-Kyung Jung, Yong-Moon Lee. Terpene alcohols inhibit de novo sphingolipid biosynthesis. Planta medica. 2012 Mar; 78(5):434-9. doi: 10.1055/s-0031-1298155. [PMID: 22274813]
  • Youn-Sun Lee, Kyeong-Mi Choi, Seunghyun Lee, Dong-Mi Sin, Yong Lim, Yong-Moon Lee, Jin-Tae Hong, Yeo-Pyo Yun, Hwan-Soo Yoo. Myriocin, a serine palmitoyltransferase inhibitor, suppresses tumor growth in a murine melanoma model by inhibiting de novo sphingolipid synthesis. Cancer biology & therapy. 2012 Jan; 13(2):92-100. doi: 10.4161/cbt.13.2.18870. [PMID: 22336910]
  • John R Ussher, Clifford D L Folmes, Wendy Keung, Natasha Fillmore, Jagdip S Jaswal, Virgilio J Cadete, Donna L Beker, Victoria H Lam, Liyan Zhang, Gary D Lopaschuk. Inhibition of serine palmitoyl transferase I reduces cardiac ceramide levels and increases glycolysis rates following diet-induced insulin resistance. PloS one. 2012; 7(5):e37703. doi: 10.1371/journal.pone.0037703. [PMID: 22629445]
  • Ali Abdul Lattif, Pranab K Mukherjee, Jyotsna Chandra, Mary R Roth, Ruth Welti, Mahmoud Rouabhia, Mahmoud A Ghannoum. Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. Microbiology (Reading, England). 2011 Nov; 157(Pt 11):3232-3242. doi: 10.1099/mic.0.051086-0. [PMID: 21903752]
  • Jorge Matias Caviglia, Constance Gayet, Tsuguhito Ota, Antonio Hernandez-Ono, Donna M Conlon, Hongfeng Jiang, Edward A Fisher, Henry N Ginsberg. Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy. Journal of lipid research. 2011 Sep; 52(9):1636-51. doi: 10.1194/jlr.m016931. [PMID: 21719579]
  • Carsten Schwan, Thilo Nölke, Anna S Kruppke, Daniel M Schubert, Alexander E Lang, Klaus Aktories. Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT). The Journal of biological chemistry. 2011 Aug; 286(33):29356-29365. doi: 10.1074/jbc.m111.261925. [PMID: 21705797]
  • Maki Yamagata, Keisuke Obara, Akio Kihara. Sphingolipid synthesis is involved in autophagy in Saccharomyces cerevisiae. Biochemical and biophysical research communications. 2011 Jul; 410(4):786-91. doi: 10.1016/j.bbrc.2011.06.061. [PMID: 21703229]
  • Xian-Cheng Jiang, Ira J Goldberg, Tae-Sik Park. Sphingolipids and cardiovascular diseases: lipoprotein metabolism, atherosclerosis and cardiomyopathy. Advances in experimental medicine and biology. 2011; 721(?):19-39. doi: 10.1007/978-1-4614-0650-1_2. [PMID: 21910080]
  • Myriam Chentouf, Maxime Rigo, Soufiane Ghannam, Isabelle Navarro-Teulon, Sébastien Mongrand, André Pèlegrin, Thierry Chardès. The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts. Immunology letters. 2010 Oct; 133(2):62-9. doi: 10.1016/j.imlet.2010.07.003. [PMID: 20659502]
  • Enrica Strettoi, Claudia Gargini, Elena Novelli, Giusy Sala, Ilaria Piano, Paolo Gasco, Riccardo Ghidoni. Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa. Proceedings of the National Academy of Sciences of the United States of America. 2010 Oct; 107(43):18706-11. doi: 10.1073/pnas.1007644107. [PMID: 20937879]
  • John R Ussher, Timothy R Koves, Virgilio J J Cadete, Liyan Zhang, Jagdip S Jaswal, Suzanne J Swyrd, David G Lopaschuk, Spencer D Proctor, Wendy Keung, Deborah M Muoio, Gary D Lopaschuk. Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes. 2010 Oct; 59(10):2453-64. doi: 10.2337/db09-1293. [PMID: 20522596]
  • Karin Klappe, Anne-Jan Dijkhuis, Ina Hummel, Annie van Dam, Pavlina T Ivanova, Stephen B Milne, David S Myers, H Alex Brown, Hjalmar Permentier, Jan W Kok. Extensive sphingolipid depletion does not affect lipid raft integrity or lipid raft localization and efflux function of the ABC transporter MRP1. The Biochemical journal. 2010 Sep; 430(3):519-29. doi: 10.1042/bj20091882. [PMID: 20604746]
  • G Frangioudakis, J Garrard, K Raddatz, J L Nadler, T W Mitchell, C Schmitz-Peiffer. Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. Endocrinology. 2010 Sep; 151(9):4187-96. doi: 10.1210/en.2010-0250. [PMID: 20660065]
  • Max Scherer, Kerstin Leuthäuser-Jaschinski, Josef Ecker, Gerd Schmitz, Gerhard Liebisch. A rapid and quantitative LC-MS/MS method to profile sphingolipids. Journal of lipid research. 2010 Jul; 51(7):2001-11. doi: 10.1194/jlr.d005322. [PMID: 20228220]
  • Beom Jae Lee, Jae Seon Kim, Byung Kyu Kim, Sung Joo Jung, Moon Kyung Joo, Seung Goun Hong, Jang Soo Kim, Ji Hoon Kim, Jong Eun Yeon, Jong-Jae Park, Kwan Soo Byun, Young-Tae Bak, Hwan-Soo Yoo, Seikwan Oh. Effects of sphingolipid synthesis inhibition on cholesterol gallstone formation in C57BL/6J mice. Journal of gastroenterology and hepatology. 2010 Jun; 25(6):1105-10. doi: 10.1111/j.1440-1746.2010.06246.x. [PMID: 20594226]
  • Elias N Glaros, Woojin S Kim, Brett Garner. Myriocin-mediated up-regulation of hepatocyte apoA-I synthesis is associated with ERK inhibition. Clinical science (London, England : 1979). 2010 Mar; 118(12):727-36. doi: 10.1042/cs20090452. [PMID: 20102334]
  • Fikadu G Tafesse, Joost C M Holthuis. Cell biology: A brake on lipid synthesis. Nature. 2010 Feb; 463(7284):1028-9. doi: 10.1038/4631028a. [PMID: 20182499]
  • Xie Xiao-Yun, Chen Zhuo-Xiong, Lei Min-Xiang, He Xingxuan, Edward H Schuchman, Liu Feng, Xu Han-Song, Lin An-Hua. Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells. Medical science monitor : international medical journal of experimental and clinical research. 2009 Sep; 15(9):BR254-61. doi: ". [PMID: 19721393]
  • Jorge Cerbon, Teresa Olguin, Pindaro R Alvarez-Grave, Rosa C López-Sánchez. Entamoeba invadens: sphingolipids metabolic regulation is the main component of a PKC signaling pathway in controlling cell growth and proliferation. Experimental parasitology. 2009 Jun; 122(2):106-11. doi: 10.1016/j.exppara.2009.02.011. [PMID: 19249300]
  • David Wheeler, Edward Knapp, Veera V R Bandaru, Yue Wang, David Knorr, Christophe Poirier, Mark P Mattson, Jonathan D Geiger, Norman J Haughey. Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors. Journal of neurochemistry. 2009 Jun; 109(5):1237-49. doi: 10.1111/j.1471-4159.2009.06038.x. [PMID: 19476542]
  • Zhiqiang Li, Tae-Sik Park, Yan Li, Xiaoyue Pan, Jahangir Iqbal, David Lu, Weiqing Tang, Liqing Yu, Ira J Goldberg, M Mahmood Hussain, Xian-Cheng Jiang. Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol. Biochimica et biophysica acta. 2009 Apr; 1791(4):297-306. doi: 10.1016/j.bbalip.2009.01.010. [PMID: 19416652]
  • Shaojie Li, Ana M Calvo, Gary Y Yuen, Liangcheng Du, Steven D Harris. Induction of cell wall thickening by the antifungal compound dihydromaltophilin disrupts fungal growth and is mediated by sphingolipid biosynthesis. The Journal of eukaryotic microbiology. 2009 Mar; 56(2):182-7. doi: 10.1111/j.1550-7408.2008.00384.x. [PMID: 21462551]
  • Benjamín Nieto, Oriol Forés, Montserrat Arró, Albert Ferrer. Arabidopsis 3-hydroxy-3-methylglutaryl-CoA reductase is regulated at the post-translational level in response to alterations of the sphingolipid and the sterol biosynthetic pathways. Phytochemistry. 2009 Jan; 70(1):53-9. doi: 10.1016/j.phytochem.2008.10.010. [PMID: 19041104]
  • W Wang, Y J Fu, Y G Zu, N Wu, J Reichling, T Efferth. Lipid rafts play an important role in the vesicular stomatitis virus life cycle. Archives of virology. 2009; 154(4):595-600. doi: 10.1007/s00705-009-0348-2. [PMID: 19288237]
  • Yoshihiro Takahashi, Thomas Berberich, Hiroyuki Kanzaki, Hideo Matsumura, Hiromasa Saitoh, Tomonobu Kusano, Ryohei Terauchi. Serine palmitoyltransferase, the first step enzyme in sphingolipid biosynthesis, is involved in nonhost resistance. Molecular plant-microbe interactions : MPMI. 2009 Jan; 22(1):31-8. doi: 10.1094/mpmi-22-1-0031. [PMID: 19061400]
  • Tae-Sik Park, Yunying Hu, Hye-Lim Noh, Konstantinos Drosatos, Kazue Okajima, Jonathan Buchanan, Joseph Tuinei, Shunichi Homma, Xian-Cheng Jiang, E Dale Abel, Ira J Goldberg. Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. Journal of lipid research. 2008 Oct; 49(10):2101-12. doi: 10.1194/jlr.m800147-jlr200. [PMID: 18515784]
  • Rémi Lasserre, Xiao-Jun Guo, Fabien Conchonaud, Yannick Hamon, Omar Hawchar, Anne-Marie Bernard, Saïdi M'Homa Soudja, Pierre-François Lenne, Hervé Rigneault, Daniel Olive, Georges Bismuth, Jacques A Nunès, Bernard Payrastre, Didier Marguet, Hai-Tao He. Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. Nature chemical biology. 2008 Sep; 4(9):538-47. doi: 10.1038/nchembio.103. [PMID: 18641634]
  • Tae-Sik Park, Wendy Rosebury, Erick K Kindt, Mark C Kowala, Robert L Panek. Serine palmitoyltransferase inhibitor myriocin induces the regression of atherosclerotic plaques in hyperlipidemic ApoE-deficient mice. Pharmacological research. 2008 Jul; 58(1):45-51. doi: 10.1016/j.phrs.2008.06.005. [PMID: 18611440]
  • Norimasa Tamehiro, Suiping Zhou, Keiichiro Okuhira, Yair Benita, Cari E Brown, Debbie Z Zhuang, Eicke Latz, Thorsten Hornemann, Arnold von Eckardstein, Ramnik J Xavier, Mason W Freeman, Michael L Fitzgerald. SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry. 2008 Jun; 47(23):6138-47. doi: 10.1021/bi800182t. [PMID: 18484747]
  • Xi-Qin Ding, J Browning Fitzgerald, Alexander V Matveev, Mark E McClellan, Michael H Elliott. Functional activity of photoreceptor cyclic nucleotide-gated channels is dependent on the integrity of cholesterol- and sphingolipid-enriched membrane domains. Biochemistry. 2008 Mar; 47(12):3677-87. doi: 10.1021/bi7019645. [PMID: 18303857]
  • Alina Fridberg, Cheryl L Olson, Ernesto S Nakayasu, Kevin M Tyler, Igor C Almeida, David M Engman. Sphingolipid synthesis is necessary for kinetoplast segregation and cytokinesis in Trypanosoma brucei. Journal of cell science. 2008 Feb; 121(Pt 4):522-35. doi: 10.1242/jcs.016741. [PMID: 18230649]
  • Elias N Glaros, Woojin S Kim, Carmel M Quinn, Wendy Jessup, Kerry-Anne Rye, Brett Garner. Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. Journal of lipid research. 2008 Feb; 49(2):324-31. doi: 10.1194/jlr.m700261-jlr200. [PMID: 17978313]
  • Jean Bismuth, Peter Lin, Qizhi Yao, Changyi Chen. Ceramide: a common pathway for atherosclerosis?. Atherosclerosis. 2008 Feb; 196(2):497-504. doi: 10.1016/j.atherosclerosis.2007.09.018. [PMID: 17963772]
  • Vera Meyer, Robbert A Damveld, Mark Arentshorst, Ulf Stahl, Cees A M J J van den Hondel, Arthur F J Ram. Survival in the presence of antifungals: genome-wide expression profiling of Aspergillus niger in response to sublethal concentrations of caspofungin and fenpropimorph. The Journal of biological chemistry. 2007 Nov; 282(45):32935-48. doi: 10.1074/jbc.m705856200. [PMID: 17804411]
  • Elias N Glaros, Woojin S Kim, Benjamin J Wu, Cacang Suarna, Carmel M Quinn, Kerry-Anne Rye, Roland Stocker, Wendy Jessup, Brett Garner. Inhibition of atherosclerosis by the serine palmitoyl transferase inhibitor myriocin is associated with reduced plasma glycosphingolipid concentration. Biochemical pharmacology. 2007 May; 73(9):1340-6. doi: 10.1016/j.bcp.2006.12.023. [PMID: 17239824]
  • C J Baier, F J Barrantes. Sphingolipids are necessary for nicotinic acetylcholine receptor export in the early secretory pathway. Journal of neurochemistry. 2007 May; 101(4):1072-84. doi: 10.1111/j.1471-4159.2007.04561.x. [PMID: 17437537]