8-Epidiosbulbin E acetate (BioDeep_00000026519)

 

Secondary id: BioDeep_00000396890

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


8-(Furan-3-yl)-10-methyl-6,15-dioxo-7,14-dioxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadecan-3-yl acetic acid

化学式: C21H24O7 (388.1521954)
中文名称: 8-表黄药子素E乙酸酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 25%

分子结构信息

SMILES: CC(=O)OC1CC2C(=O)OC(c3ccoc3)CC2(C)C2CC3CC(C(=O)O3)C12
InChI: InChI=1S/C21H24O7/c1-10(22)26-16-7-15-20(24)28-17(11-3-4-25-9-11)8-21(15,2)14-6-12-5-13(18(14)16)19(23)27-12/h3-4,9,12-18H,5-8H2,1-2H3

描述信息

8-Epidiosbulbin E acetate is found in root vegetables. 8-Epidiosbulbin E acetate is isolated from Dioscorea bulbifera (air potato
Isolated from Dioscorea bulbifera (air potato). 8-Epidiosbulbin E acetate is found in root vegetables.
8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice[1][2].
8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice[1][2].

同义名列表

4 个代谢物同义名

8-(Furan-3-yl)-10-methyl-6,15-dioxo-7,14-dioxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadecan-3-yl acetic acid; 8-(furan-3-yl)-10-methyl-6,15-dioxo-7,14-dioxatetracyclo[11.2.1.0²,¹¹.0⁵,¹⁰]hexadecan-3-yl acetate; 8-Epidiosbulbin e acetic acid; 8-epidiosbulbin E acetate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Na Zhang, Yi Yang, Wei Li, Shenzhi Zhou, Weiwei Li, Ying Peng, Jiang Zheng. Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate In Vitro and In Vivo. Chemical research in toxicology. 2022 10; 35(10):1821-1830. doi: 10.1021/acs.chemrestox.2c00130. [PMID: 35839447]
  • Na Zhang, Shenzhi Zhou, Zhengyu Zhang, Wei Li, Ying Peng, Jiang Zheng. Evidence for adduction of biologic amines with reactive metabolite of 8-epidiosbulbin E acetate in vitro and in vivo. Toxicology letters. 2022 Jul; 365(?):1-10. doi: 10.1016/j.toxlet.2022.05.008. [PMID: 35680040]
  • Shiyu Zhang, Ying Liu, Ting Liu, Jie Pan, Rong Tan, Zixia Hu, Bowen Gong, Yufen Liao, Peng Luo, Qibing Zeng, Weiwei Li, Jiang Zheng. DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo. Toxicology and applied pharmacology. 2022 05; 443(?):116007. doi: 10.1016/j.taap.2022.116007. [PMID: 35367474]
  • Shenzhi Zhou, Na Zhang, Zixia Hu, Dongju Lin, Weiwei Li, Ying Peng, Jiang Zheng. Immunochemical Detection of Protein Modification Derived from Metabolic Activation of 8-Epidiosbulbin E Acetate. Chemical research in toxicology. 2020 07; 33(7):1752-1760. doi: 10.1021/acs.chemrestox.0c00016. [PMID: 32347100]
  • Dongju Lin, Weiwei Li, Xutong Tian, Ying Peng, Jiang Zheng. In Vitro DNA Adduction Resulting from Metabolic Activation of Diosbulbin B and 8-Epidiosbulbin E Acetate. Chemical research in toxicology. 2019 01; 32(1):38-48. doi: 10.1021/acs.chemrestox.8b00071. [PMID: 30520628]
  • Wei Shi, Cai Zhang, Dongsheng Zhao, Lingli Wang, Ping Li, Huijun Li. Discovery of Hepatotoxic Equivalent Combinatorial Markers from Dioscorea bulbifera tuber by Fingerprint-Toxicity Relationship Modeling. Scientific reports. 2018 01; 8(1):462. doi: 10.1038/s41598-017-18929-z. [PMID: 29323207]
  • Zhengyu Zhang, Dongju Lin, Weiwei Li, Huiyuan Gao, Ying Peng, Jiang Zheng. Sensitive bromine-based screening of potential toxic furanoids in Dioscorea bulbifera L. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jul; 1057(?):1-14. doi: 10.1016/j.jchromb.2017.04.033. [PMID: 28477535]
  • Dongju Lin, Kai Wang, Xiucai Guo, Huiyuan Gao, Ying Peng, Jiang Zheng. Lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate. Toxicology letters. 2016 Dec; 264(?):20-28. doi: 10.1016/j.toxlet.2016.10.007. [PMID: 27816466]
  • Dongju Lin, Weiwei Li, Ying Peng, Chunfeng Jiang, Youjun Xu, Huiyuan Gao, Jiang Zheng. Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid. Chemical research in toxicology. 2016 Mar; 29(3):359-66. doi: 10.1021/acs.chemrestox.5b00501. [PMID: 26886724]
  • Dongju Lin, Xiucai Guo, Huiyuan Gao, Li Cheng, Maosheng Cheng, Shaojiang Song, Ying Peng, Jiang Zheng. In vitro and in vivo studies of the metabolic activation of 8-epidiosbulbin E acetate. Chemical research in toxicology. 2015 Sep; 28(9):1737-46. doi: 10.1021/acs.chemrestox.5b00174. [PMID: 26286065]
  • Varsha Shriram, Sheetal Jahagirdar, C Latha, Vinay Kumar, Vedavati Puranik, Supada Rojatkar, Prashant K Dhakephalkar, M G Shitole. A potential plasmid-curing agent, 8-epidiosbulbin E acetate, from Dioscorea bulbifera L. against multidrug-resistant bacteria. International journal of antimicrobial agents. 2008 Nov; 32(5):405-10. doi: 10.1016/j.ijantimicag.2008.05.013. [PMID: 18718743]