Quercetin 3'-sulfate (BioDeep_00000025967)

   

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


[2-hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl]oxidanesulfonic acid

化学式: C15H10O10S (381.99946800000004)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 5.41%

分子结构信息

SMILES: c1(cc(c2c(c1)oc(c(c2=O)O)c1cc(c(cc1)O)OS(=O)(=O)O)O)O
InChI: InChI=1S/C15H10O10S/c16-7-4-9(18)12-11(5-7)24-15(14(20)13(12)19)6-1-2-8(17)10(3-6)25-26(21,22)23/h1-5,16-18,20H,(H,21,22,23)

描述信息

Quercetin 3-sulfate is a polyphenol metabolite detected in biological fluids (PMID: 20428313).

同义名列表

8 个代谢物同义名

[2-hydroxy-5-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenyl]oxidanesulfonic acid; Quercetin 3-sulphuric acid; Quercetin 3-sulfuric acid; Quercetin 3-O-sulphate; Quercetin 3-O-sulfate; Quercetin 3-sulphate; Quercetin-3-sulfate; quercetin 3-sulfate



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Itziar Eseberri, Jonatan Miranda, Arrate Lasa, Andrea Mosqueda-Solís, Susana González-Manzano, Celestino Santos-Buelga, Maria P Portillo. Effects of Quercetin Metabolites on Triglyceride Metabolism of 3T3-L1 Preadipocytes and Mature Adipocytes. International journal of molecular sciences. 2019 Jan; 20(2):. doi: 10.3390/ijms20020264. [PMID: 30641871]
  • Kateřina Valentová, Kristýna Káňová, Florent Di Meo, Helena Pelantová, Christopher Steven Chambers, Lenka Rydlová, Lucie Petrásková, Alena Křenková, Josef Cvačka, Patrick Trouillas, Vladimír Křen. Chemoenzymatic Preparation and Biophysical Properties of Sulfated Quercetin Metabolites. International journal of molecular sciences. 2017 Oct; 18(11):. doi: 10.3390/ijms18112231. [PMID: 29068411]
  • Cheng-Hung Chuang, Chiao-Lin Yeh, Shu-Lan Yeh, En-Shyh Lin, Li-Yu Wang, Ying-Hsuna Wang. Quercetin metabolites inhibit MMP-2 expression in A549 lung cancer cells by PPAR-γ associated mechanisms. The Journal of nutritional biochemistry. 2016 07; 33(?):45-53. doi: 10.1016/j.jnutbio.2016.03.011. [PMID: 27260467]
  • Shu-Lan Yeh, Yi-Chin Lin, Yi-Ling Lin, Chien-Chun Li, Cheng-Hung Chuang. Comparing the metabolism of quercetin in rats, mice and gerbils. European journal of nutrition. 2016 Feb; 55(1):413-22. doi: 10.1007/s00394-015-0862-9. [PMID: 25691233]
  • Patricia Baier Krepsky, Raquel Geralda Isidório, José Dias de Souza Filho, Steyner França Côrtes, Fernão Castro Braga. Chemical composition and vasodilatation induced by Cuphea carthagenensis preparations. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Aug; 19(11):953-7. doi: 10.1016/j.phymed.2012.05.011. [PMID: 22739415]
  • Chi Chun Wong, Yasutoshi Akiyama, Takaaki Abe, Jonathan D Lippiat, Caroline Orfila, Gary Williamson. Carrier-mediated transport of quercetin conjugates: involvement of organic anion transporters and organic anion transporting polypeptides. Biochemical pharmacology. 2012 Aug; 84(4):564-70. doi: 10.1016/j.bcp.2012.05.011. [PMID: 22634047]
  • Pilar Galindo, Isabel Rodriguez-Gómez, Susana González-Manzano, Montserrat Dueñas, Rosario Jiménez, Carmen Menéndez, Félix Vargas, Juan Tamargo, Celestino Santos-Buelga, Francisco Pérez-Vizcaíno, Juan Duarte. Glucuronidated quercetin lowers blood pressure in spontaneously hypertensive rats via deconjugation. PloS one. 2012; 7(3):e32673. doi: 10.1371/journal.pone.0032673. [PMID: 22427863]
  • Shu-Lan Yeh, Chiao-Lin Yeh, Shu-Ting Chan, Cheng-Hung Chuang. Plasma rich in quercetin metabolites induces G2/M arrest by upregulating PPAR-γ expression in human A549 lung cancer cells. Planta medica. 2011 Jul; 77(10):992-8. doi: 10.1055/s-0030-1250735. [PMID: 21267808]
  • Chi Chun Wong, Nigel P Botting, Caroline Orfila, Nawaf Al-Maharik, Gary Williamson. Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochemical pharmacology. 2011 Apr; 81(7):942-9. doi: 10.1016/j.bcp.2011.01.004. [PMID: 21244849]
  • Bernice Wright, Leonardo A Moraes, Charles F Kemp, William Mullen, Alan Crozier, Julie A Lovegrove, Jonathan M Gibbins. A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids. British journal of pharmacology. 2010 Mar; 159(6):1312-25. doi: 10.1111/j.1476-5381.2009.00632.x. [PMID: 20148891]
  • Akiyuki Yokoyama, Hiroyuki Sakakibara, Alan Crozier, Yoshichika Kawai, Asako Matsui, Junji Terao, Shigenori Kumazawa, Kayoko Shimoi. Quercetin metabolites and protection against peroxynitrite-induced oxidative hepatic injury in rats. Free radical research. 2009 Oct; 43(10):913-21. doi: 10.1080/10715760903137010. [PMID: 19669999]
  • Federica Lodi, Rosario Jimenez, Laura Moreno, Paul A Kroon, Paul W Needs, David A Hughes, Celestino Santos-Buelga, Ana Gonzalez-Paramas, Angel Cogolludo, Rocío Lopez-Sepulveda, Juan Duarte, Francisco Perez-Vizcaino. Glucuronidated and sulfated metabolites of the flavonoid quercetin prevent endothelial dysfunction but lack direct vasorelaxant effects in rat aorta. Atherosclerosis. 2009 May; 204(1):34-9. doi: 10.1016/j.atherosclerosis.2008.08.007. [PMID: 18801486]
  • Mark S Winterbone, Sandra Tribolo, Paul W Needs, Paul A Kroon, David A Hughes. Physiologically relevant metabolites of quercetin have no effect on adhesion molecule or chemokine expression in human vascular smooth muscle cells. Atherosclerosis. 2009 Feb; 202(2):431-8. doi: 10.1016/j.atherosclerosis.2008.04.040. [PMID: 18489909]
  • William Mullen, Christine A Edwards, Alan Crozier. Absorption, excretion and metabolite profiling of methyl-, glucuronyl-, glucosyl- and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. The British journal of nutrition. 2006 Jul; 96(1):107-16. doi: 10.1079/bjn20061809. [PMID: 16869998]
  • Sandra Donnini, Federica Finetti, Lorenzo Lusini, Lucia Morbidelli, Veronique Cheynier, Denis Barron, Gary Williamson, Johannes Waltenberger, Marina Ziche. Divergent effects of quercetin conjugates on angiogenesis. The British journal of nutrition. 2006 May; 95(5):1016-23. doi: 10.1079/bjn20061753. [PMID: 16611395]
  • William Mullen, Aurelie Boitier, Amanda J Stewart, Alan Crozier. Flavonoid metabolites in human plasma and urine after the consumption of red onions: analysis by liquid chromatography with photodiode array and full scan tandem mass spectrometric detection. Journal of chromatography. A. 2004 Nov; 1058(1-2):163-8. doi: 10.1016/s0021-9673(04)01476-1. [PMID: 15595664]
  • Kerstin M Janisch, Gary Williamson, Paul Needs, Geoffrey W Plumb. Properties of quercetin conjugates: modulation of LDL oxidation and binding to human serum albumin. Free radical research. 2004 Aug; 38(8):877-84. doi: 10.1080/10715760410001728415. [PMID: 15493462]
  • Sonia de Pascual-Teresa, Kelly L Johnston, M Susan DuPont, Karen A O'Leary, Paul W Needs, Linda M Morgan, Mike N Clifford, Yongping Bao, Gary Williamson. Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo. The Journal of nutrition. 2004 Mar; 134(3):552-7. doi: 10.1093/jn/134.3.552. [PMID: 14988445]
  • A J Day, F Mellon, D Barron, G Sarrazin, M R Morgan, G Williamson. Human metabolism of dietary flavonoids: identification of plasma metabolites of quercetin. Free radical research. 2001 Dec; 35(6):941-52. doi: 10.1080/10715760100301441. [PMID: 11811545]