3,5-Dihydroxyphenylpropionic acid (BioDeep_00000025608)

   

human metabolite Endogenous blood metabolite


代谢物信息卡片


3-(3,5-Dihydroxyphenyl)-1-propanoic acid

化学式: C9H10O4 (182.057906)
中文名称: 3,5-二羟苯基丙酸
谱图信息: 最多检出来源 Homo sapiens(blood) 15.87%

分子结构信息

SMILES: C1=C(C=C(C=C1O)O)CCC(=O)O
InChI: InChI=1S/C9H10O4/c10-7-3-6(1-2-9(12)13)4-8(11)5-7/h3-5,10-11H,1-2H2,(H,12,13)

描述信息

3,5-Dihydroxyphenylpropionic acid (3,5-DHPPA) is an alkylresorcinol metabolite. It is a potential urinary biomarker of whole grain intake (PMID: 15282102). BioTransformer predicts that 3,5-DHPPA is a product of 3,5-dihydroxycinnamic acid metabolism via a reduction-of-alpha-beta-unsaturated-compounds-pattern1 reaction occurring in human gut microbiota and catalyzed by the abkar1 enzyme (PMID: 30612223).

同义名列表

12 个代谢物同义名

3-(3,5-Dihydroxyphenyl)-1-propanoic acid; 3-(3,5-Dihydroxyphenyl)-1-propionic acid; 3-(3,5-Dihydroxyphenyl)propanoic acid;; 3-(3,5-Dihydroxyphenyl)propanoic acid; 3-(3,5-dihydroxyphenyl)propanoic acid; 3,5-Dihydroxybenzenepropionic acid; 3-(3,5-Dihydroxyphenyl)propanoate; 3,5-Dihydroxyphenylpropionic acid; 3,5-Dihydroxyphenylpropanoic acid; 3,5-Dihydroxyphenylpropionate; 26539-01-5; 3,5-DHPPA



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J Montonen, R Landberg, A Kamal-Eldin, P Åman, H Boeing, A Steffen, T Pischon. Reliability of fasting plasma alkylresorcinol metabolites concentrations measured 4 months apart. European journal of clinical nutrition. 2012 Aug; 66(8):968-70. doi: 10.1038/ejcn.2012.66. [PMID: 22713774]
  • Alastair B Ross. Present status and perspectives on the use of alkylresorcinols as biomarkers of wholegrain wheat and rye intake. Journal of nutrition and metabolism. 2012; 2012(?):462967. doi: 10.1155/2012/462967. [PMID: 22363838]
  • Päivi P Söderholm, Johan E Lundin, Anja H Koskela, Matti J Tikkanen, Herman C Adlercreutz. Pharmacokinetics of alkylresorcinol metabolites in human urine. The British journal of nutrition. 2011 Oct; 106(7):1040-4. doi: 10.1017/s0007114511001383. [PMID: 21481288]
  • Matti Marklund, Rikard Landberg, Per Åman, Afaf Kamal-Eldin. Comparison of gas chromatography-mass spectrometry and high-performance liquid chromatography with coulometric electrode array detection for determination of alkylresorcinol metabolites in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Mar; 879(9-10):647-51. doi: 10.1016/j.jchromb.2011.01.034. [PMID: 21334988]
  • Matti Marklund, Rikard Landberg, Per Aman, Afaf Kamal-Eldin. Determination of alkylresorcinol metabolites in human urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Apr; 878(11-12):888-94. doi: 10.1016/j.jchromb.2010.02.007. [PMID: 20223713]
  • Mylène Aubertin-Leheudre, Anja Koskela, Adile Samaletdin, Herman Adlercreutz. Plasma alkylresorcinol metabolites as potential biomarkers of whole-grain wheat and rye cereal fibre intakes in women. The British journal of nutrition. 2010 Feb; 103(3):339-43. doi: 10.1017/s0007114509992315. [PMID: 19874633]
  • Mylène Aubertin-Leheudre, Anja Koskela, Adile Samaletdin, Herman Adlercreutz. Plasma and urinary alkylresorcinol metabolites as potential biomarkers of breast cancer risk in Finnish women: a pilot study. Nutrition and cancer. 2010; 62(6):759-64. doi: 10.1080/01635581003693058. [PMID: 20661824]
  • Anja Koskela, Adile Samaletdin, Mylène Aubertin-Leheudre, Herman Adlercreutz. Quantification of alkylresorcinol metabolites in plasma by high-performance liquid chromatography with coulometric electrode array detection. Journal of agricultural and food chemistry. 2008 Sep; 56(17):7678-81. doi: 10.1021/jf801252s. [PMID: 18690683]
  • Anja Koskela, Anna-Maria Linko-Parvinen, Perttu Hiisivuori, Adile Samaletdin, Afaf Kamal-Eldin, Matti J Tikkanen, Herman Adlercreutz. Quantification of alkylresorcinol metabolites in urine by HPLC with coulometric electrode array detection. Clinical chemistry. 2007 Jul; 53(7):1380-3. doi: 10.1373/clinchem.2006.084764. [PMID: 17495018]
  • Alastair B Ross, Per Aman, Afaf Kamal-Eldin. Identification of cereal alkylresorcinol metabolites in human urine-potential biomarkers of wholegrain wheat and rye intake. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Sep; 809(1):125-30. doi: 10.1016/j.jchromb.2004.06.015. [PMID: 15282102]
  • A Heindl, O Rau, G Spiteller. Identification of aromatic dihydroxy acids in biological fluids. Biomedical mass spectrometry. 1985 Feb; 12(2):59-66. doi: 10.1002/bms.1200120203. [PMID: 3158357]