Napabucasin (BioDeep_00000254593)

   

natural product


代谢物信息卡片


2-Acetylfuro-1,4-naphthoquinone

化学式: C14H8O4 (240.0422568)
中文名称: 癌细胞干抑制剂(Napabucasin)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c12c(C(=O)c3c(C1=O)oc(c3)C(=O)C)cccc2
InChI: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H,1H3

描述信息

C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor

同义名列表

2 个代谢物同义名

Napabucasin; 2-Acetylfuro-1,4-naphthoquinone



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Boping Jing, Feng Guo, Rui An, Yu Gao, Yuman Li, Yuji Xie, Jing Wang, Yihan Chen, He Li, Tang Gao, Qiaofeng Jin, Li Zhang, Mingxing Xie. Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy. Journal of nanobiotechnology. 2023 Feb; 21(1):37. doi: 10.1186/s12951-023-01792-8. [PMID: 36732759]
  • Qian Wang, Bing Lu, Yi Zhang, Jing Yu, Jie Guo, Qianchi Zhou, Hong Lv, Yifeng Sun. STAT3 inhibitor BBI608 enhances the antitumor effect of gefitinib on EGFR-mutated non-small cell lung cancer cells. Human cell. 2021 Nov; 34(6):1855-1865. doi: 10.1007/s13577-021-00582-4. [PMID: 34370268]
  • Xiaoshu Dai, Michael D Karol, Matthew Hitron, Marjie L Hard, Matthew T Goulet, Colleen F McLaughlin, Scott J Brantley. Napabucasin Drug-Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers. Clinical pharmacology in drug development. 2021 08; 10(8):824-839. doi: 10.1002/cpdd.961. [PMID: 34107166]
  • Xiaoshu Dai, Michael D Karol, Matthew Hitron, Marjie L Hard, John Evan Blanchard, Nicola C J E Eraut, Natalie Rich, Brandon T Gufford. Mass balance and pharmacokinetics of an oral dose of 14 C-napabucasin in healthy adult male subjects. Pharmacology research & perspectives. 2021 02; 9(1):e00722. doi: 10.1002/prp2.722. [PMID: 33576192]
  • Kamrul Hasan Chowdhury, Md Riad Chowdhury, Shafi Mahmud, Abu Montakim Tareq, Nujhat Binte Hanif, Naureen Banu, A S M Ali Reza, Talha Bin Emran, Jesus Simal-Gandara. Drug Repurposing Approach against Novel Coronavirus Disease (COVID-19) through Virtual Screening Targeting SARS-CoV-2 Main Protease. Biology. 2020 Dec; 10(1):. doi: 10.3390/biology10010002. [PMID: 33374717]
  • Feng Wang, Kai-Rui Feng, Jia-Ying Zhao, Jian-Wei Zhang, Xin-Wei Shi, Jian Zhou, Dingding Gao, Guo-Qiang Lin, Ping Tian. Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study. Bioorganic & medicinal chemistry. 2020 12; 28(24):115822. doi: 10.1016/j.bmc.2020.115822. [PMID: 33126089]
  • Shuai Hu, Mario Sechi, Pankaj Kumar Singh, Lipeng Dai, Sean McCann, Duxin Sun, Mats Ljungman, Nouri Neamati. A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species. Journal of medicinal chemistry. 2020 09; 63(17):9838-9855. doi: 10.1021/acs.jmedchem.0c01016. [PMID: 32809827]
  • Kai-Rui Feng, Feng Wang, Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li, Guo-Qiang Lin, Dingding Gao, Ping Tian. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. European journal of medicinal chemistry. 2020 Sep; 201(?):112428. doi: 10.1016/j.ejmech.2020.112428. [PMID: 32603980]
  • Kohei Shitara, Yasuhide Yodo, Shuichi Iino. A Phase I Study of Napabucasin Plus Paclitaxel for Japanese Patients With Advanced/Recurrent Gastric Cancer. In vivo (Athens, Greece). 2019 May; 33(3):933-937. doi: 10.21873/invivo.11561. [PMID: 31028219]
  • Hauke Löcken, Cinzia Clamor, Klaus Müller. Napabucasin and Related Heterocycle-Fused Naphthoquinones as STAT3 Inhibitors with Antiproliferative Activity against Cancer Cells. Journal of natural products. 2018 07; 81(7):1636-1644. doi: 10.1021/acs.jnatprod.8b00247. [PMID: 30003778]
  • Alexandra Reichstein, Silke Vortherms, Sven Bannwitz, Jan Tentrop, Helge Prinz, Klaus Müller. Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide. Journal of medicinal chemistry. 2012 Aug; 55(16):7273-84. doi: 10.1021/jm3009597. [PMID: 22845014]
  • Azucena González-Coloma, Matías Reina, Claudia Sáenz, Rodney Lacret, Lastenia Ruiz-Mesia, Vicente J Arán, Jesús Sanz, Rafael A Martínez-Díaz. Antileishmanial, antitrypanosomal, and cytotoxic screening of ethnopharmacologically selected Peruvian plants. Parasitology research. 2012 Apr; 110(4):1381-92. doi: 10.1007/s00436-011-2638-3. [PMID: 21922239]
  • F Tantangmo, B N Lenta, F F Boyom, S Ngouela, M Kaiser, E Tsamo, B Weniger, P J Rosenthal, C Vonthron-Sénécheau. Antiprotozoal activities of some constituents of Markhamia tomentosa (Bignoniaceae). Annals of tropical medicine and parasitology. 2010 Jul; 104(5):391-8. doi: 10.1179/136485910x12743554760180. [PMID: 20819307]
  • Kenneth O Eyong, Ponminor S Kumar, Victor Kuete, Gabriel N Folefoc, Ephriam A Nkengfack, Sundarababu Baskaran. Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol. Bioorganic & medicinal chemistry letters. 2008 Oct; 18(20):5387-90. doi: 10.1016/j.bmcl.2008.09.053. [PMID: 18829316]
  • K Müller, A Sellmer, W Wiegrebe. Potential antipsoriatic agents: lapacho compounds as potent inhibitors of HaCaT cell growth. Journal of natural products. 1999 Aug; 62(8):1134-6. doi: 10.1021/np990139r. [PMID: 10479319]
  • M M Rao, D G Kingston. Plant anticancer agents. XII. Isolation and structure elucidation of new cytotoxic quinones from Tabebuia cassinoides. Journal of natural products. 1982 Sep; 45(5):600-4. doi: 10.1021/np50023a014. [PMID: 7153777]