denbinobin (BioDeep_00000253780)

   


代谢物信息卡片


denbinobin

化学式: C16H12O5 (284.0684702)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC(=O)c2ccc3cc(OC)cc(O)c3c2C1=O
InChI:

描述信息

同义名列表

1 个代谢物同义名

denbinobin



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Barbara Tóth, Judit Hohmann, Andrea Vasas. Phenanthrenes: A Promising Group of Plant Secondary Metabolites. Journal of natural products. 2018 03; 81(3):661-678. doi: 10.1021/acs.jnatprod.7b00619. [PMID: 29280630]
  • Te-Ling Lu, Chien-Kuo Han, Yuan-Shiun Chang, Te-Jung Lu, Hui-Chi Huang, Bo-Ying Bao, Hsing-Yu Wu, Chieh-Hung Huang, Chia-Yen Li, Tian-Shung Wu. Denbinobin, a phenanthrene from Dendrobium nobile, impairs prostate cancer migration by inhibiting Rac1 activity. The American journal of Chinese medicine. 2014; 42(6):1539-54. doi: 10.1142/s0192415x14500967. [PMID: 25427623]
  • Xiu-Juan Chen, Wen-Li Mei, Wen-Jian Zuo, Yan-Bo Zeng, Zhi-Kai Guo, Xi-Qiang Song, Hao-Fu Dai. A new antibacterial phenanthrenequinone from Dendrobium sinense. Journal of Asian natural products research. 2013; 15(1):67-70. doi: 10.1080/10286020.2012.740473. [PMID: 23228193]
  • Hyekyung Yang, Phil-Jun Lee, Eun Ju Jeong, Hong Pyo Kim, Young Choong Kim. Selective apoptosis in hepatic stellate cells mediates the antifibrotic effect of phenanthrenes from Dendrobium nobile. Phytotherapy research : PTR. 2012 Jul; 26(7):974-80. doi: 10.1002/ptr.3632. [PMID: 22144089]
  • Jae In Song, Yu Jin Kang, Hae-Young Yong, Young Choong Kim, Aree Moon. Denbinobin, a phenanthrene from dendrobium nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer cells. Oncology reports. 2012 Mar; 27(3):813-8. doi: 10.3892/or.2011.1551. [PMID: 22089965]
  • Gonzalo Sánchez-Duffhues, Marco A Calzado, Amaya García de Vinuesa, Giovanni Appendino, Bernd L Fiebich, Ulich Loock, Annette Lefarth-Risse, Karsten Krohn, Eduardo Muñoz. Denbinobin inhibits nuclear factor-kappaB and induces apoptosis via reactive oxygen species generation in human leukemic cells. Biochemical pharmacology. 2009 Apr; 77(8):1401-9. doi: 10.1016/j.bcp.2009.01.004. [PMID: 19426679]
  • Gonzalo Sánchez-Duffhues, Marco A Calzado, Amaya García de Vinuesa, Francisco J Caballero, Abdellah Ech-Chahad, Giovanni Appendino, Karsten Krohn, Bernd L Fiebich, Eduardo Muñoz. Denbinobin, a naturally occurring 1,4-phenanthrenequinone, inhibits HIV-1 replication through an NF-kappaB-dependent pathway. Biochemical pharmacology. 2008 Nov; 76(10):1240-50. doi: 10.1016/j.bcp.2008.09.006. [PMID: 18840408]
  • Hyekyung Yang, Sang Hyun Sung, Young Choong Kim. Antifibrotic phenanthrenes of Dendrobium nobile stems. Journal of natural products. 2007 Dec; 70(12):1925-9. doi: 10.1021/np070423f. [PMID: 18052323]
  • Yu-Chun Huang, Jih-Hwa Guh, Che-Ming Teng. Denbinobin-mediated anticancer effect in human K562 leukemia cells: role in tubulin polymerization and Bcr-Abl activity. Journal of biomedical science. 2005; 12(1):113-21. doi: 10.1007/s11373-004-8171-y. [PMID: 15864744]
  • Eun Young Bae, Hyuncheol Oh, Won Keun Oh, Min Soo Kim, Beom Seok Kim, Bo Yeon Kim, Cheon Bae Sohn, Hiroyuki Osada, Jong Seog Ahn. A new VHR dual-specificity protein tyrosine phosphatase inhibitor from Dendrobium moniliforme. Planta medica. 2004 Sep; 70(9):869-70. doi: 10.1055/s-2004-827238. [PMID: 15386195]
  • T H Lin, S J Chang, C C Chen, J P Wang, L T Tsao. Two phenanthraquinones from Dendrobium moniliforme. Journal of natural products. 2001 Aug; 64(8):1084-6. doi: 10.1021/np010016i. [PMID: 11520233]
  • H Y Chen, M S Shiao, Y L Huang, C C Shen, Y L Lin, Y H Kuo, C C Chen. Antioxidant principles from Ephemerantha lonchophylla. Journal of natural products. 1999 Sep; 62(9):1225-7. doi: 10.1021/np990025f. [PMID: 10514302]