Naphazoline (BioDeep_00000025275)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Bausch and lomb brand 1 OF naphazoline hydrochloride

  化学式: C14H14N2 (210.1157)
中文名称: 萘甲唑啉, 2-（萘-2-基甲基）-4,5-二氢-1H-咪唑
  谱图信息: 最多检出来源 Homo sapiens(urine) 6.24%

分子结构信息

SMILES: C(C1=NCCN1)C1=CC=CC2=CC=CC=C12
InChI: InChI=1S/C14H14N2/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14/h1-7H,8-10H2,(H,15,16)


描述信息

Naphazoline is only found in individuals that have used or taken this drug. It is a rapid acting sympathomimetic vasoconstrictor of occular artierioles. It acts to decrease congestion of the conjunctiva and is found in many over-the-counter eye drops.Naphazoline is a direct acting sympathomimetic drug, which acts on alpha-adrenergic receptors in the arterioles of the nasal mucosa. This activates the adrenal system to yield systemic vasoconstrction. In producing vasoconstriction, the result is a decrease in blood flow in the nasal passages and consequently decreased nasal congestion. The vasoconstriction means that there is less pressure in the capillaries and less water can filter out, thus less discharge is made.
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AB - Sympathomimetics, combinations excl. corticosteroids
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AA - Sympathomimetics, plain
S - Sensory organs > S01 - Ophthalmologicals > S01G - Decongestants and antiallergics > S01GA - Sympathomimetics used as decongestants
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C87053 - Adrenergic Agonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D019141 - Respiratory System Agents > D014663 - Nasal Decongestants
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents

同义名列表

129 个代谢物同义名

Bausch and lomb brand 1 OF naphazoline hydrochloride; Bausch and lomb brand 2 OF naphazoline hydrochloride; 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole; Ciba vision brand 1 OF naphazoline hydrochloride; Ciba vision brand 2 OF naphazoline hydrochloride; Novartis brand 2 OF naphazoline hydrochloride; Novartis brand 1 OF naphazoline hydrochloride; Whitehall brand OF naphazoline hydrochloride; Warner lambert brand OF naphazoline nitrate; Allergan brand OF naphazoline hydrochloride; Iquinosa brand OF naphazoline hydrochloride; Warner-lambert brand OF naphazoline nitrate; Alcon brand 1 OF naphazoline hydrochloride; Alcon brand 2 OF naphazoline hydrochloride; Chauvin brand OF naphazoline hydrochloride; Optima brand OF naphazoline hydrochloride; Febena brand OF naphazoline hydrochloride; Winzer brand OF naphazoline hydrochloride; Stulln brand OF naphazoline hydrochloride; Abbot brand OF naphazoline hydrochloride; Akorn brand OF naphazoline hydrochloride; Ross brand OF naphazoline hydrochloride; Grin brand OF naphazoline hydrochloride; Monohydrochloride, naphazoline; Naphazoline monohydrochloride; Hydrochloride, naphazoline; Naphazoline hydrochloride; Pensa, vasoconstrictor; Vasoconstrictor pensa; Nitrate, naphazoline; Naphazoline nitrate; Regular, vasocon; Vasocon regular; Forte, naphcon; Alfa, colirio; Naphcon forte; Grin, afazol; Colirio alfa; naphazoline; tele-Stulln; Afazol grin; tele Stulln; Eyes, clear; Clear, all; Clear eyes; TeleStulln; Nafazolin; all Clear; Vasoclear; Miraclar; Proculin; Optazine; Nafazair; Albalon; Vasocon; Naphcon; Privine; VasoNit; Siozwo; Privin; AK CON; AK-CON; Idril; AKCon; 2-(naphthalen-2-ylmethyl)-4,5-dihydro-1H-imidazole; .alpha.-Naphthylmethyl imidazoline; 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-; 2-(.alpha.-Naphthylmethyl)-imidazoline; 2-(1-Naphthalenylmethyl)-2-imidazoline; 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole; 2-(1-Naphthylmethyl)-2-imidazoline; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole; 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole #; 2-(alpha-Naphthylmethyl)-imidazoline; 2-(Naphthyl-(1')-methyl)imidazolin; 2-(Naphthyl-(1')-methyl)imidazolin [German]; 2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole; 2-Imidazoline, 2-(1-naphthylmethyl)-; 2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; hydrochloride; 4,5-Dihydro-2-(1-naphthylmethyl)imidazole; 5-23-08-00293 (Beilstein Handbook Reference); alpha-Naphthylmethyl imidazoline; Antan; BPBio1_000189; Clearine; DivK1c_000456; IDI1_000456; Imidin; KBio1_000456; KBio2_001455; KBio2_004023; KBio2_006591; KBio3_001565; Nadaplatin; Nafazolin (TN); Nafazolina; Nafazolina [DCIT]; Nafazoline; Nafazoline [Spanish]; Naphazoline (INN); NAPHAZOLINE (MART.); Naphazoline [INN:BAN]; NAPHAZOLINE [INN]; NAPHAZOLINE [MART.]; NAPHAZOLINE [MI]; NAPHAZOLINE [VANDF]; NAPHAZOLINE [WHO-DD]; Naphazolinum; Naphazolinum (INN-Latin); Naphazolinum (Latin); Naphazolinum [INN-Latin]; Naphazolinum [Latin]; Naphthizine; Prestwick0_000046; Prestwick1_000046; Prestwick2_000046; Prestwick3_000046; Privine (Salt/Mix); R01AA08; R01AB02; Rhinazine; S01GA01; Sanorin (Salt/Mix); Spectrum2_001054; Spectrum3_000513; Spectrum4_000068; Spectrum5_001424; Tox21_113058; Tox21_113645



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Benedikt Fritzsching. Title Not Available. MMW Fortschritte der Medizin. 2022 03; 164(5):28-29. doi: 10.1007/s15006-022-0919-7. [PMID: 35274248]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • I Andreica, B Guminski, J Sokolar, A Patru, X Baraliakos, J Braun. [Threat of a SARS-CoV-2 endemic in a large hospital specialized in rheumatic diseases-relative all clear through consistent testing]. Zeitschrift fur Rheumatologie. 2021 Feb; 80(1):45-47. doi: 10.1007/s00393-021-00959-8. [PMID: 33495854]
  • Amin Imani-Nabiyyi, Mohammad H Sorouraddin. Determination of naphazoline hydrochloride in biological and pharmaceutical samples by a quantum dot-assisted chemiluminescence system using response-surface methodology. Luminescence : the journal of biological and chemical luminescence. 2014 Dec; 29(8):994-1002. doi: 10.1002/bio.2649. [PMID: 24733642]
  • D B Fedorov, S V Volchenko, N A Novokshonova, V N Kuklin. [The study of naphthyzin present in material evidence and biological fluids]. Sudebno-meditsinskaia ekspertiza. 2013 Sep; 56(5):29-33. doi: NULL. [PMID: 24432425]
  • Shizhong Zhu, Yang Liu. Spectroscopic analyses on interaction of Naphazoline hydrochloride with bovine serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2012 Dec; 98(?):142-7. doi: 10.1016/j.saa.2012.08.040. [PMID: 22995546]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Shun-Fan Wu, Yao Yao, Jia Huang, Gong-Yin Ye. Characterization of a β-adrenergic-like octopamine receptor from the rice stem borer (Chilo suppressalis). The Journal of experimental biology. 2012 Aug; 215(Pt 15):2646-52. doi: 10.1242/jeb.068932. [PMID: 22786641]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Judy Peat, Uttam Garg. Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.). 2010; 603(?):501-8. doi: 10.1007/978-1-60761-459-3_49. [PMID: 20077102]
  • Marie Granier, Christophe Dadure, Sophie Bringuier, Marie-Caroline Bonnet-Boyer, Yves Ryckwaert, Estelle Loriaux, Xavier Capdevila. Intranasal lidocaine plus naphazoline nitrate improves surgical conditions and perioperative analgesia in septorhinoplasty surgery. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2009 Feb; 56(2):102-8. doi: 10.1007/s12630-008-9020-7. [PMID: 19247757]
  • Takeshi Saito, Seiji Morita, Izumi Kishiyama, Shota Miyazaki, Akihiro Nakamoto, Manami Nishida, Akira Namera, Masataka Nagao, Sadaki Inokuchi. Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Sep; 872(1-2):186-90. doi: 10.1016/j.jchromb.2008.07.007. [PMID: 18657485]
  • Yoshiki Tanaka, Nobuaki Mizutani, Masanori Fujii, Takeshi Nabe, Shigekatsu Kohno. Different mechanisms between thromboxane A2- and leukotriene D4-induced nasal blockage in guinea pigs. Prostaglandins & other lipid mediators. 2006 Sep; 80(3-4):144-54. doi: 10.1016/j.prostaglandins.2006.06.003. [PMID: 16939879]
  • Sabina Strano-Rossi, Francesco Molaioni, Francesco Botrè. Application of solid-phase microextraction to antidoping analysis: determination of stimulants, narcotics, and other classes of substances excreted free in urine. Journal of analytical toxicology. 2005 May; 29(4):217-22. doi: 10.1093/jat/29.4.217. [PMID: 15975249]
  • V T Pal'chun, T S Poliakova, N A Kunel'skaia, S A Bogdanets. [Pharmacological correction of cochleovestibular impairments]. Vestnik otorinolaringologii. 2004; ?(4):36-9. doi: ". [PMID: 15496841]
  • F Musshoff, A Gerschlauer, B Madea. Naphazoline intoxication in a child-a clinical and forensic toxicological case. Forensic science international. 2003 Jul; 134(2-3):234-7. doi: 10.1016/s0379-0738(03)00158-0. [PMID: 12850424]
  • Wei Li, Ling-xian Cao, Gai-ru Li, Wei-jun Jin. [Applications of phosphorimetry in pharmaceutical analysis]. Guang pu xue yu guang pu fen xi = Guang pu. 2002 Jun; 22(3):518-22. doi: ". [PMID: 12938353]
  • C Lee, K O Martin, N B Javitt. Bile acid synthesis: 7 alpha-hydroxylation of intermediates in the sterol 27-hydroxylase metabolic pathway. Journal of lipid research. 1996 Jun; 37(6):1356-62. doi: . [PMID: 8808770]
  • A C MacKinnon, M Stewart, H J Olverman, M Spedding, C M Brown. [3H]p-aminoclonidine and [3H]idazoxan label different populations of imidazoline sites on rat kidney. European journal of pharmacology. 1993 Feb; 232(1):79-87. doi: 10.1016/0014-2999(93)90731-v. [PMID: 8096190]
  • C Chabenat, P Boucly. Determination of naphazoline in rat plasma using column liquid chromatography with ultraviolet detection. Biomedical chromatography : BMC. 1992 Sep; 6(5):241-3. doi: 10.1002/bmc.1130060508. [PMID: 1334441]
  • R R Ruffolo. Fundamentals of receptor theory: basics for shock research. Circulatory shock. 1992 Jun; 37(2):176-84. doi: NULL. [PMID: 1511510]
  • W R Rush, O F Alexander, D J Hall, R J Dow, L Tokes, L Kurz, D J Graham. The metabolism of nafimidone hydrochloride in the dog, primates and man. Xenobiotica; the fate of foreign compounds in biological systems. 1990 Jan; 20(1):123-32. doi: 10.3109/00498259009046819. [PMID: 2109431]
  • D J Graham, K M Hama, S A Smith, L Kurz, M D Chaplin, D J Hall. Disposition of nafimidone in rats. Drug metabolism and disposition: the biological fate of chemicals. 1987 Jul; 15(4):565-70. doi: NULL. [PMID: 2888632]
  • W R Rush, S A Smith, J H Mulvey, D J Graham, M D Chaplin. Inhibition and induction of hepatic drug metabolism in rats and mice by nafimidone and its major metabolite nafimidone alcohol. Drug metabolism and disposition: the biological fate of chemicals. 1987 Jul; 15(4):571-8. doi: NULL. [PMID: 2888633]
  • D M Treiman, S Gunawan. Pharmacokinetics of nafimidone in patients with chronic intractable epilepsy. Clinical pharmacokinetics. 1987 Jun; 12(6):433-9. doi: 10.2165/00003088-198712060-00003. [PMID: 3608344]
  • S Gunawan, D M Treiman. High-performance liquid chromatographic determination of nafimidone and its major metabolite nafimidone alcohol in human plasma and urine. Journal of chromatography. 1987 Mar; 414(2):389-98. doi: 10.1016/0378-4347(87)80063-4. [PMID: 3571406]
  • D M Treiman, A J Wilensky, E Ben-Menachem, L Ojemann, M Yerby, K O Barber, K B McCormick, J J Cereghino, B G White, K Swisher. Efficacy of nafimidone in the treatment of intractable partial seizures: report of a two-center pilot study. Epilepsia. 1985 Nov; 26(6):607-11. doi: 10.1111/j.1528-1157.1985.tb05700.x. [PMID: 3935425]
  • D J Graham, J Eadie, B M Leadbetter, R Metcalf. Simultaneous determination of nafimidone [1-(2-naphthoylmethyl)imidazole], a new anticonvulsant agent, and a major metabolite in plasma by high-performance liquid chromatography. Journal of chromatography. 1983 Jun; 275(1):211-6. doi: 10.1016/s0378-4347(00)84364-9. [PMID: 6409915]
  • C Chevillard, R Pasquier, N Duchene, J M Alexandre. Mechanism of inhibition of renin release by clonidine in rats. European journal of pharmacology. 1978 Apr; 48(4):451-4. doi: 10.1016/0014-2999(78)90174-7. [PMID: 648588]
  • F de Bros, E M Wolshin. Determination of phentolamine in blood and urine by high performance liquid chromatography. Analytical chemistry. 1978 Mar; 50(3):521-5. doi: 10.1021/ac50025a038. [PMID: 637302]
  • A Brock. Binding of digitoxin to human serum albumin: influence of ionic strength and ionic medium on the digitoxin-albumin complex formation. Acta pharmacologica et toxicologica. 1975 Nov; 37(5):361-8. doi: 10.1111/j.1600-0773.1975.tb00854.x. [PMID: 887]
  • H Armbruster, W Vetter, G Reck, R Beckerhoff, W Siegenthaler. Severe arterial hypertension caused by chronical abuse of a topical mineralocorticoid. International journal of clinical pharmacology and biopharmacy. 1975 Jul; 12(1-2):170-3. doi: NULL. [PMID: 51837]
  • H Salem, B J Dunn, J J Loux. Conjunctival temperature: a measure of ocular decongestant and anti-inflammatory activity. Annals of ophthalmology. 1975 Jun; 7(6):819-24. doi: ". [PMID: 1147509]
  • A Chattoraj, W C Boyd. A specific anti-B lectin for routine diagnostic purposes. Journal of immunology (Baltimore, Md. : 1950). 1966 May; 96(5):898-900. doi: ". [PMID: 5913759]