Glutamylalanine (BioDeep_00000025025)

   

human metabolite Endogenous Chemicals and Drugs


代谢物信息卡片


(4S)-4-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acid

化学式: C8H14N2O5 (218.09026740000002)
中文名称: 谷丙二肽
谱图信息: 最多检出来源 Mentha canadensis(plant) 50%

分子结构信息

SMILES: CC(C(=O)O)NC(=O)C(CCC(=O)O)N
InChI: InChI=1S/C8H14N2O5/c1-4(8(14)15)10-7(13)5(9)2-3-6(11)12/h4-5H,2-3,9H2,1H3,(H,10,13)(H,11,12)(H,14,15)/t4-,5-/m0/s1

描述信息

Glutamylalanine is a naturally occurring dipeptide, composed of glutamate and alanine. Glutamylalanine is essential in the supply of glutamate to human erythrocytes. Human erythrocytes are essentially impermeable to glutamate and yet there is a continual requirement for the amino acid for glutathione synthesis. In addition, the intracellular glutamate concentration is approximately five times that of plasma. Glutamylalanine enters the human erythrocyte through saturable membrane-transport systems describable by Michaelis-Menten kinetics. The cytosolic red cell peptidases have a vast capacity to hydrolyse the dipeptide in a process also describable by simple Michaelis-Menten kinetics. The transport process is the rate-determining step in the pathway leading to the production of intracellular glutamate from extracellular glutamylalanine. Glutamylalanine is transported by the human oligopeptide transporter, hPepT1, situated in the small intestine, which is involved in the absorption of nutrient oligopeptides and transports numerous di- and tripeptides. This active transport is being tested for use as a strategy to increase the permeability across the intestine for larger biologically active molecules with low intestinal permeability, in a therapeutic attempt to transport dipeptide-coupled active drug substances via hPepT1 (PMID: 2860897, 11557350).

同义名列表

44 个代谢物同义名

(4S)-4-amino-4-{[(1S)-1-carboxyethyl]carbamoyl}butanoic acid; 4-Amino-N-(1-carboxyethyl)-glutaramic acid; Glutamic acid-alanine dipeptide; Glutamic acid alanine dipeptide; L-alpha-Glutamyl-L-amino acid; N-alpha-L-Glutamyl-L-alanine; N-L-alpha-Glutamyl-L-alanine; Glutamate alanine dipeptide; Glutamate-alanine dipeptide; L-alpha-Glutamyl-L-alanine; alpha-L-Glutamyl-L-alanine; N-L-alpha-Glutamylalanine; N-L-Α-glutamyl-L-alanine; N-Α-L-glutamyl-L-alanine; N-L-a-Glutamyl-L-alanine; N-alpha-Glutamylalanine; L-Α-glutamyl-L-alanine; Α-L-glutamyl-L-alanine; a-L-Glutamyl-L-alanine; N-L-Glutamyl-L-alanine; alpha-Glutamylalanine; N-L-Α-glutamylalanine; L-Glutamyl-L-alanine; N-Α-glutamylalanine; Α-glutamylalanine; N-Glutamylalanine; a-Glutamylalanine; L-alpha-Glu-L-ala; alpha-L-Glu-L-ala; Glutamyl-alanine; Glutamylalanine; Α-L-glu-L-ala; e-a Dipeptide; L-a-Glu-L-ala; L-Α-glu-L-ala; alpha-Glu-ala; EA dipeptide; H-Glu-Ala-OH; L-Glu-L-ala; NSC 334200; Α-glu-ala; a-Glu-ala; Glu-ala; EA



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • L V Obukhova, V K Shumny. [The Inheritance of Endosperm Storage Proteins by the Line of the Saratovskaya 29 Cultivar of Common Wheat from its Parental Forms]. Genetika. 2016 Jan; 52(1):59-65. doi: . [PMID: 27183793]
  • I A Kostanyan, E V Navolotskaya, R I Nurieva, V P Zav'ialov, V M Lipkin. [Interaction of L-glutamic acid with human T-lymphocytes]. Bioorganicheskaia khimiia. 1997 Oct; 23(10):805-8. doi: . [PMID: 9490616]
  • G F King, P W Kuchel. Assimilation of alpha-glutamyl-peptides by human erythrocytes. A possible means of glutamate supply for glutathione synthesis. The Biochemical journal. 1985 May; 227(3):833-42. doi: 10.1042/bj2270833. [PMID: 2860897]