FILIPIN III (BioDeep_00000234701)

   

natural product


代谢物信息卡片


4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,119E,21E,21E,23E,25E-pentaen-2-one

化学式: C35H58O11 (654.3978918)
中文名称: 菲律平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC(C1C(CC(CC(CC(CC(CC(CC(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O
InChI: InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1

描述信息

A macrolide that is the major component of a mixture of four isomeric polyene macrolides isolated from Streptomyces filipinensis.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents

同义名列表

2 个代谢物同义名

FILIPIN III; 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,119E,21E,21E,23E,25E-pentaen-2-one



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

29 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hailan He, Huiwen Zhang, Hui Chen, Fang He, Fei Yin, Tobias Stauber, Xiaomin Zou, Jing Peng. Functional analysis of two SLC9A6 frameshift variants in lymphoblastoid cells from patients with Christianson syndrome. CNS neuroscience & therapeutics. 2023 12; 29(12):4059-4069. doi: 10.1111/cns.14329. [PMID: 37381736]
  • Yvonne Lange, S M Ali Tabei, Theodore L Steck. A basic model for the association of ligands with membrane cholesterol: application to cytolysin binding. Journal of lipid research. 2023 Feb; ?(?):100344. doi: 10.1016/j.jlr.2023.100344. [PMID: 36791915]
  • Agnese Stanzani, Anna Sansone, Cinzia Brenna, Vito Antonio Baldassarro, Giuseppe Alastra, Luca Lorenzini, Chryssostomos Chatgilialoglu, Ilaria Laface, Carla Ferreri, Luca Maria Neri, Laura Calzà. Erythrocyte Plasma Membrane Lipid Composition Mirrors That of Neurons and Glial Cells in Murine Experimental In Vitro and In Vivo Inflammation. Cells. 2023 02; 12(4):. doi: 10.3390/cells12040561. [PMID: 36831228]
  • Tiezhu Liu, Jiajia Li, Xueqi Wang, Tao Huang, Wei Wu, Aqian Li, Chuan Li, Xiaoxia Huang, Qin Wang, Dexin Li, Shiwen Wang, Mifang Liang. Knockout of CLTC gene reduces but not completely block SFTSV infection. PloS one. 2023; 18(8):e0285673. doi: 10.1371/journal.pone.0285673. [PMID: 37624798]
  • Lilian N D Silva, Israel J P Garcia, Jessica M M Valadares, Marco Tulio C Pessoa, Marina Marques Toledo, Matheus V Machado, Mileane Souza Busch, Isabella Rocha, José Augusto F P Villar, Georgia C Atella, Herica L Santos, Vanessa F Cortes, Leandro A Barbosa. Evaluation of Cardiotonic Steroid Modulation of Cellular Cholesterol and Phospholipid. The Journal of membrane biology. 2021 12; 254(5-6):499-512. doi: 10.1007/s00232-021-00203-z. [PMID: 34716469]
  • Santhosh Chandar Maddila, Chandrashekhar Voshavar, Porkizhi Arjunan, Rashmi Prakash Chowath, Hari Krishna Reddy Rachamalla, Balaji Balakrishnan, Poonkuzhali Balasubramanian, Rajkumar Banerjee, Srujan Marepally. Cholesterol Sequestration from Caveolae/Lipid Rafts Enhances Cationic Liposome-Mediated Nucleic Acid Delivery into Endothelial Cells. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154626. [PMID: 34361779]
  • Cátia Santos-Pereira, María T Andrés, Susana R Chaves, José F Fierro, Hernâni Gerós, Stéphen Manon, Lígia R Rodrigues, Manuela Côrte-Real. Lactoferrin perturbs lipid rafts and requires integrity of Pma1p-lipid rafts association to exert its antifungal activity against Saccharomyces cerevisiae. International journal of biological macromolecules. 2021 Feb; 171(?):343-357. doi: 10.1016/j.ijbiomac.2020.12.224. [PMID: 33421469]
  • Glyn Dawson. Isolation of Lipid Rafts (Detergent-Resistant Microdomains) and Comparison to Extracellular Vesicles (Exosomes). Methods in molecular biology (Clifton, N.J.). 2021; 2187(?):99-112. doi: 10.1007/978-1-0716-0814-2_6. [PMID: 32770503]
  • Valentina Murdica, Elisa Giacomini, Sofia Makieva, Natasa Zarovni, Massimo Candiani, Andrea Salonia, Riccardo Vago, Paola Viganò. In vitro cultured human endometrial cells release extracellular vesicles that can be uptaken by spermatozoa. Scientific reports. 2020 06; 10(1):8856. doi: 10.1038/s41598-020-65517-9. [PMID: 32483153]
  • Jeong Do Kim, Min Young Park, Byeong Jun Jeon, Beom Seok Kim. Disease control efficacy of 32,33-didehydroroflamycoin produced by Streptomyces rectiviolaceus strain DY46 against gray mold of tomato fruit. Scientific reports. 2019 09; 9(1):13533. doi: 10.1038/s41598-019-49779-6. [PMID: 31537850]
  • Riad Ladjohounlou, Catherine Lozza, Alexandre Pichard, Julie Constanzo, Jihad Karam, Pierre Le Fur, Emmanuel Deshayes, Vincent Boudousq, Salomé Paillas, Muriel Busson, Marion Le Blay, Marta Jarlier, Sara Marcatili, Manuel Bardiès, Frank Bruchertseifer, Alfred Morgenstern, Julien Torgue, Isabelle Navarro-Teulon, Jean-Pierre Pouget. Drugs That Modify Cholesterol Metabolism Alter the p38/JNK-Mediated Targeted and Nontargeted Response to Alpha and Auger Radioimmunotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019 08; 25(15):4775-4790. doi: 10.1158/1078-0432.ccr-18-3295. [PMID: 31061069]
  • Lita A Freeman, Robert D Shamburek, Maureen L Sampson, Edward B Neufeld, Masaki Sato, Sotirios K Karathanasis, Alan T Remaley. Plasma lipoprotein-X quantification on filipin-stained gels: monitoring recombinant LCAT treatment ex vivo. Journal of lipid research. 2019 05; 60(5):1050-1057. doi: 10.1194/jlr.d090233. [PMID: 30808683]
  • Martin Rudolf, Christine A Curcio, Ursula Schlötzer-Schrehardt, Armin Mir Mohi Sefat, Aysegül Tura, Zouhair Aherrahrou, Max Brinkmann, Salvatore Grisanti, Yoko Miura, Mahdy Ranjbar. Apolipoprotein A-I Mimetic Peptide L-4F Removes Bruch's Membrane Lipids in Aged Nonhuman Primates. Investigative ophthalmology & visual science. 2019 02; 60(2):461-472. doi: 10.1167/iovs.18-25786. [PMID: 30707219]
  • Kirsty E Waddington, Inés Pineda-Torra, Elizabeth C Jury. Analyzing T-Cell Plasma Membrane Lipids by Flow Cytometry. Methods in molecular biology (Clifton, N.J.). 2019; 1951(?):209-216. doi: 10.1007/978-1-4939-9130-3_16. [PMID: 30825155]
  • Léa P Wilhelm, Laetitia Voilquin, Toshihide Kobayashi, Catherine Tomasetto, Fabien Alpy. Intracellular and Plasma Membrane Cholesterol Labeling and Quantification Using Filipin and GFP-D4. Methods in molecular biology (Clifton, N.J.). 2019; 1949(?):137-152. doi: 10.1007/978-1-4939-9136-5_11. [PMID: 30790254]
  • Hao Wei, Jean-Daniel M Malcor, Matthew T Harper. Lipid rafts are essential for release of phosphatidylserine-exposing extracellular vesicles from platelets. Scientific reports. 2018 07; 8(1):9987. doi: 10.1038/s41598-018-28363-4. [PMID: 29968812]
  • Emily K Pugach, McKenna Feltes, Randal J Kaufman, Daniel S Ory, Anne G Bang. High-content screen for modifiers of Niemann-Pick type C disease in patient cells. Human molecular genetics. 2018 06; 27(12):2101-2112. doi: 10.1093/hmg/ddy117. [PMID: 29659804]
  • Dhirendra P Singh, Gagandeep Kaur, Prathyusha Bagam, Rakeysha Pinkston, Sanjay Batra. Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. Archives of toxicology. 2018 05; 92(5):1767-1783. doi: 10.1007/s00204-018-2185-0. [PMID: 29623357]
  • Bing Han, Ning Yang, Hai Pu, Tai Wang. Quantitative Proteomics and Cytology of Rice Pollen Sterol-Rich Membrane Domains Reveals Pre-established Cell Polarity Cues in Mature Pollen. Journal of proteome research. 2018 04; 17(4):1532-1546. doi: 10.1021/acs.jproteome.7b00852. [PMID: 29508613]
  • Peng Guo, Daxing Liu, Kriti Subramanyam, Biran Wang, Jiang Yang, Jing Huang, Debra T Auguste, Marsha A Moses. Nanoparticle elasticity directs tumor uptake. Nature communications. 2018 01; 9(1):130. doi: 10.1038/s41467-017-02588-9. [PMID: 29317633]
  • Wenmin Yu, Zhi Wang, Yiping Li, Lei Liu, Jing Liu, Fenggan Ding, Xiaoyi Zhang, Zhengyuan Cheng, Pingsheng Chen. Effects of autophagy and endocytosis on the activity of matrix metalloproteinase‑2 in human renal proximal tubular cells under hypoxia. Molecular medicine reports. 2017 May; 15(5):3225-3230. doi: 10.3892/mmr.2017.6358. [PMID: 28339082]
  • Isabel De Castro-Orós, Pilar Irún, Jorge Javier Cebolla, Victor Rodriguez-Sureda, Miguel Mallén, María Jesús Pueyo, Pilar Mozas, Carmen Dominguez, Miguel Pocoví. Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: a prospective observational study. Journal of translational medicine. 2017 02; 15(1):43. doi: 10.1186/s12967-017-1146-3. [PMID: 28222799]
  • Rachid Rezgui, Katy Blumer, Gilbert Yeoh-Tan, Adam J Trexler, Mazin Magzoub. Precise quantification of cellular uptake of cell-penetrating peptides using fluorescence-activated cell sorting and fluorescence correlation spectroscopy. Biochimica et biophysica acta. 2016 Jul; 1858(7 Pt A):1499-506. doi: 10.1016/j.bbamem.2016.03.023. [PMID: 27033412]
  • Kaoutar El-Mounadi, Kazi T Islam, Patricia Hernández-Ortiz, Nick D Read, Dilip M Shah. Antifungal mechanisms of a plant defensin MtDef4 are not conserved between the ascomycete fungi Neurospora crassa and Fusarium graminearum. Molecular microbiology. 2016 05; 100(3):542-59. doi: 10.1111/mmi.13333. [PMID: 26801962]
  • Hao Wang, Weisha Liu, Fei Yu, Liqun Lu. Disruption of clathrin-dependent trafficking results in the failure of grass carp reovirus cellular entry. Virology journal. 2016 Feb; 13(?):25. doi: 10.1186/s12985-016-0485-7. [PMID: 26878859]
  • Alena Koukalová, Šárka Pokorná, Radovan Fišer, Vladimír Kopecký, Jana Humpolíčková, Jan Černý, Martin Hof. Membrane activity of the pentaene macrolide didehydroroflamycoin in model lipid bilayers. Biochimica et biophysica acta. 2015 Feb; 1848(2):444-52. doi: 10.1016/j.bbamem.2014.10.038. [PMID: 25450349]
  • Shikha Kumari, Ashutosh Kumar, Puspendu Sardar, Manoj Yadav, Rakesh Kumar Majhi, Abhishek Kumar, Chandan Goswami. Influence of membrane cholesterol in the molecular evolution and functional regulation of TRPV4. Biochemical and biophysical research communications. 2015 Jan; 456(1):312-9. doi: 10.1016/j.bbrc.2014.11.077. [PMID: 25434996]
  • Marie T Vanier, Philippe Latour. Laboratory diagnosis of Niemann-Pick disease type C: the filipin staining test. Methods in cell biology. 2015; 126(?):357-75. doi: 10.1016/bs.mcb.2014.10.028. [PMID: 25665455]
  • Carolina Piña-Vázquez, Magda Reyes-López, Guillermo Mendoza-Hernández, Rosa María Bermúdez-Cruz, Mireya de la Garza. Identification of phosphatidylcholine transfer protein-like in the parasite Entamoeba histolytica. Biochimie. 2014 Dec; 107 Pt B(?):223-34. doi: 10.1016/j.biochi.2014.09.007. [PMID: 25223890]
  • Sayaka Nagasawa, Kohei Ogura, Hiroyasu Tsutsuki, Hisako Saitoh, Joel Moss, Hirotaro Iwase, Masatoshi Noda, Kinnosuke Yahiro. Uptake of Shiga-toxigenic Escherichia coli SubAB by HeLa cells requires an actin- and lipid raft-dependent pathway. Cellular microbiology. 2014 Oct; 16(10):1582-601. doi: 10.1111/cmi.12315. [PMID: 24844382]
  • Qiaoya Lin, Juan Chen, Kenneth K Ng, Weiguo Cao, Zhihong Zhang, Gang Zheng. Imaging the cytosolic drug delivery mechanism of HDL-like nanoparticles. Pharmaceutical research. 2014 Jun; 31(6):1438-49. doi: 10.1007/s11095-013-1046-z. [PMID: 23625096]
  • Allen S W Oak, Jeffrey D Messinger, Christine A Curcio. Subretinal drusenoid deposits: further characterization by lipid histochemistry. Retina (Philadelphia, Pa.). 2014 Apr; 34(4):825-6. doi: 10.1097/iae.0000000000000121. [PMID: 24589874]
  • Leah K Cuddy, Warren Winick-Ng, Rebecca Jane Rylett. Regulation of the high-affinity choline transporter activity and trafficking by its association with cholesterol-rich lipid rafts. Journal of neurochemistry. 2014 Mar; 128(5):725-40. doi: 10.1111/jnc.12490. [PMID: 24127780]
  • Miya Sharfman, Maya Bar, Silvia Schuster, Meirav Leibman, Adi Avni. Sterol-dependent induction of plant defense responses by a microbe-associated molecular pattern from Trichoderma viride. Plant physiology. 2014 Feb; 164(2):819-27. doi: 10.1104/pp.113.230136. [PMID: 24351686]
  • Karla Dias Cruz, Thayana Araújo Cruz, Gabriela Veras de Moraes, Tatiana Christina Paredes-Santos, Marcia Attias, Wanderley de Souza. Disruption of lipid rafts interferes with the interaction of Toxoplasma gondii with macrophages and epithelial cells. BioMed research international. 2014; 2014(?):687835. doi: 10.1155/2014/687835. [PMID: 24734239]
  • Ludmila A Kasatkina, Tatiana A Borisova. Glutamate release from platelets: exocytosis versus glutamate transporter reversal. The international journal of biochemistry & cell biology. 2013 Nov; 45(11):2585-95. doi: 10.1016/j.biocel.2013.08.004. [PMID: 23994539]
  • Ayumi Takamura, Norio Sakai, Michiko Shinpoo, Atsuko Noguchi, Tsutomu Takahashi, Shin Matsuda, Masanari Yamamoto, Aya Narita, Kosaku Ohno, Toya Ohashi, Hiroyuki Ida, Yoshikatsu Eto. The useful preliminary diagnosis of Niemann-Pick disease type C by filipin test in blood smear. Molecular genetics and metabolism. 2013 Nov; 110(3):401-4. doi: 10.1016/j.ymgme.2013.08.006. [PMID: 24001525]
  • Irina V Majoul, Liang Gao, Eric Betzig, Daria Onichtchouk, Eugenia Butkevich, Yuri Kozlov, Feliksas Bukauskas, Michael V L Bennett, Jennifer Lippincott-Schwartz, Rainer Duden. Fast structural responses of gap junction membrane domains to AB5 toxins. Proceedings of the National Academy of Sciences of the United States of America. 2013 Oct; 110(44):E4125-33. doi: 10.1073/pnas.1315850110. [PMID: 24133139]
  • M I Arleevskaya, A I Zabotin, A G Gabdulkhakova, O M Semenova, A P Tsibulkin. Lipid imbalance in individuals predisposed to rheumatoid arthritis: possible relationship with common infections. Bulletin of experimental biology and medicine. 2013 Oct; 155(6):778-84. doi: 10.1007/s10517-013-2251-9. [PMID: 24288765]
  • Elena C Calabrese, Sabrina Castellano, Marisabella Santoriello, Cristina Sgherri, Mike F Quartacci, Lucia Calucci, Andrew G S Warrilow, David C Lamb, Steven L Kelly, Ciro Milite, Ilaria Granata, Gianluca Sbardella, Giorgio Stefancich, Bruno Maresca, Amalia Porta. Antifungal activity of azole compounds CPA18 and CPA109 against azole-susceptible and -resistant strains of Candida albicans. The Journal of antimicrobial chemotherapy. 2013 May; 68(5):1111-9. doi: 10.1093/jac/dks506. [PMID: 23292344]
  • Elina Siljamäki, Nina Rintanen, Maija Kirsi, Paula Upla, Wei Wang, Mikko Karjalainen, Elina Ikonen, Varpu Marjomäki. Cholesterol dependence of collagen and echovirus 1 trafficking along the novel α2β1 integrin internalization pathway. PloS one. 2013; 8(2):e55465. doi: 10.1371/journal.pone.0055465. [PMID: 23393580]
  • Patrycja Kozik, Nicola A Hodson, Daniela A Sahlender, Nikol Simecek, Christina Soromani, Jiahua Wu, Lucy M Collinson, Margaret S Robinson. A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Nature cell biology. 2013 Jan; 15(1):50-60. doi: 10.1038/ncb2652. [PMID: 23263279]
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  • Oren Moskovich, Lee-Or Herzog, Marcelo Ehrlich, Zvi Fishelson. Caveolin-1 and dynamin-2 are essential for removal of the complement C5b-9 complex via endocytosis. The Journal of biological chemistry. 2012 Jun; 287(24):19904-15. doi: 10.1074/jbc.m111.333039. [PMID: 22528500]
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