Chamaechromone (BioDeep_00000231620)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3-[1,1-bis(4-hydroxyphenyl)-3-oxo-3-(2,4,6-trihydroxyphenyl)propan-2-yl]-5,7-dihydroxy-4H-chromen-4-one

化学式: C30H22O10 (542.1213)
中文名称: 狼毒色原酮, 狼毒色酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C(C2=CC=C(C=C2)O)C(C3=COC4=CC(=CC(=C4C3=O)O)O)C(=O)C5=C(C=C(C=C5O)O)O)O
InChI: InChI=1S/C30H22O10/c31-16-5-1-14(2-6-16)25(15-3-7-17(32)8-4-15)26(30(39)27-21(35)9-18(33)10-22(27)36)20-13-40-24-12-19(34)11-23(37)28(24)29(20)38/h1-13,25-26,31-37H

描述信息

Chamaechromone is a natural product found in Stellera chamaejasme and Daphne aurantiaca with data available.
Chamaechromone is a biflavonoid ingredient isolated from the roots of Stellera chamaejasme L. (Thymelaeaceae). Chamaechromone possesses anti-hepatitis B virus (HBV) effects against the surface antigen of HBV (HBsAg) secretion and has insecticidal activities[1].

同义名列表

3 个代谢物同义名

3-[1,1-bis(4-hydroxyphenyl)-3-oxo-3-(2,4,6-trihydroxyphenyl)propan-2-yl]-5,7-dihydroxy-4H-chromen-4-one; 3-[1,1-bis(4-hydroxyphenyl)-3-oxo-3-(2,4,6-trihydroxyphenyl)propan-2-yl]-5,7-dihydroxychromen-4-one; Chamaechromone



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lan-Ying Pan, Kui Zeng, Li Li, Yan Lou, Su Zeng. The inhibition mechanism of the uptake of lamivudine via human organic anion transporter 1 by Stellera chamaejasme L. extracts. Chinese journal of natural medicines. 2019 Sep; 17(9):682-689. doi: 10.1016/s1875-5364(19)30082-2. [PMID: 31526503]
  • Yanyan Ren, Lanying Pan, Wei Zhao, Lei Xu, Jianwei Xu, Haiyin Lu, Yuan Chen. Neochamaejasmin A inhibits KV1.4 channel activity via direct binding to the pore. Brain research. 2018 03; 1683(?):17-26. doi: 10.1016/j.brainres.2018.01.013. [PMID: 29360465]
  • Lanying Pan, Kui Zeng, Xiangjun Wang, Huichang Bi, Haihong Hu, Ming Huang, Yan Lou, Su Zeng. Neochamaejasmin B increases the bioavailability of chamaechromone coexisting in Stellera chamaejasme L. via inhibition of MRP2 and BCRP. International journal of pharmaceutics. 2015 Dec; 496(2):440-7. doi: 10.1016/j.ijpharm.2015.10.038. [PMID: 26475967]
  • Yan Lou, Haihong Hu, Yunqing Qiu, Jinqi Zheng, Linrun Wang, Xingguo Zhang, Su Zeng. Metabolism of chamaechromone in vitro with human liver microsomes and recombinant human drug-metabolizing enzymes. Planta medica. 2014 Apr; 80(6):493-7. doi: 10.1055/s-0034-1368302. [PMID: 24687737]
  • Yan Lou, Jinqi Zheng, Baohong Wang, Xingguo Zhang, Xia Zhang, Su Zeng. Metabolites characterization of chamaechromone in vivo and in vitro by using ultra-performance liquid chromatography/Xevo G2 quadrupole time-of-flight tandem mass spectrometry. Journal of ethnopharmacology. 2014; 151(1):242-52. doi: 10.1016/j.jep.2013.10.027. [PMID: 24189033]
  • Xue-Wei Ji, Mei-Ling Hao, Xia Yang, Yu-Hua Wang. [RP-HPLC fingerprint of milk Stellera chamaejasme]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Nov; 35(11):1754-7. doi: ". [PMID: 23627083]
  • Yan Lou, Haihong Hu, Yao Liu, Qinqin Yu, Li Li, Li Ping, Lushan Yu, Huidi Jiang, Su Zeng. Determination of chamaechromone in rat plasma by liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2011 Jul; 55(5):1163-9. doi: 10.1016/j.jpba.2011.04.009. [PMID: 21549539]