Wogonoside (BioDeep_00000231519)

Main id: BioDeep_00000230971

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-Phenyl-5-hydroxy-7- (beta-D-glucopyranuronosyloxy) -8-methoxy-4H-1-benzopyran-4-one

化学式: C22H20O11 (460.100557)
中文名称: 汉黄芩甙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c(C(=O)3)(c(O)1)c(OC(c(c4)cccc4)=C3)c(OC)c(OC(O2)C(O)C(C(O)C2C(O)=O)O)c1
InChI: InChI=1S/C22H20O11/c1-30-18-13(32-22-17(27)15(25)16(26)20(33-22)21(28)29)8-11(24)14-10(23)7-12(31-19(14)18)9-5-3-2-4-6-9/h2-8,15-17,20,22,24-27H,1H3,(H,28,29)/t15-,16-,17+,20-,22+/m0/s1

描述信息

Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2].
Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway[1][2].

同义名列表

3 个代谢物同义名

2-Phenyl-5-hydroxy-7- (beta-D-glucopyranuronosyloxy) -8-methoxy-4H-1-benzopyran-4-one; Wogonin 7-glucuronide; Wogonoside



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xin Xu, Jun Xia, Shiyi Zhao, Qun Wang, Guangbo Ge, Feng Xu, Xia Liu, Weidong Zhang, Yili Yang. Qing-Fei-Pai-Du decoction and wogonoside exert anti-inflammatory action through down-regulating USP14 to promote the degradation of activating transcription factor 2. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 09; 35(9):e21870. doi: 10.1096/fj.202100370rr. [PMID: 34436790]
  • Guangyu Jiang, Dayin Chen, Wenpeng Li, Chengcheng Liu, Jiguang Liu, Yingxue Guo. Effects of wogonoside on the inflammatory response and oxidative stress in mice with nonalcoholic fatty liver disease. Pharmaceutical biology. 2020 Dec; 58(1):1177-1183. doi: 10.1080/13880209.2020.1845747. [PMID: 33253604]
  • Sophia Yui Kau Fong, Chenrui Li, Yiu Cheong Ho, Rui Li, Qian Wang, Yin Cheong Wong, Hong Xue, Zhong Zuo. Brain Uptake of Bioactive Flavones in Scutellariae Radix and Its Relationship to Anxiolytic Effect in Mice. Molecular pharmaceutics. 2017 09; 14(9):2908-2916. doi: 10.1021/acs.molpharmaceut.7b00029. [PMID: 28426226]
  • Shihua Xing, Mengyue Wang, Ying Peng, Xiaobo Li. Effects of Intestinal Microecology on Metabolism and Pharmacokinetics of Oral Wogonoside and Baicalin. Natural product communications. 2017 Apr; 12(4):509-514. doi: NULL. [PMID: 30520584]
  • Xiao-Ming Meng, Gui-Ling Ren, Li Gao, Hai-Di Li, Wei-Feng Wu, Xiao-Feng Li, Tao Xu, Xue-Fu Wang, Tao-Tao Ma, Zeng Li, Cheng Huang, Yan Huang, Lei Zhang, Xiong-Wen Lv, Jun Li. Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms. European journal of pharmacology. 2016 Oct; 789(?):134-143. doi: 10.1016/j.ejphar.2016.07.014. [PMID: 27397431]
  • Yu Cai, Sai Li, Ting Li, Ruina Zhou, Alfred Tai-Seng Wai, Ru Yan. Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jul; 1026(?):124-133. doi: 10.1016/j.jchromb.2015.11.049. [PMID: 26809374]
  • Yuan-Zheng Gao, Lian-Feng Zhao, Jun Ma, Wei-Hong Xue, Hui Zhao. Protective mechanisms of wogonoside against Lipopolysaccharide/D-galactosamine-induced acute liver injury in mice. European journal of pharmacology. 2016 Jun; 780(?):8-15. doi: 10.1016/j.ejphar.2016.02.040. [PMID: 26921756]
  • Qichao Wang, Rui Wen, Qinghua Lin, Na Wang, Ping Lu, Xianmin Zhu. Wogonoside Shows Antifibrotic Effects in an Experimental Regression Model of Hepatic Fibrosis. Digestive diseases and sciences. 2015 Nov; 60(11):3329-39. doi: 10.1007/s10620-015-3751-4. [PMID: 26130019]
  • Yang Sun, Yue Zhao, Jing Yao, Li Zhao, Zhaoqiu Wu, Yu Wang, Di Pan, Hanchi Miao, Qinglong Guo, Na Lu. Wogonoside protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB and NLRP3 inflammasome activation. Biochemical pharmacology. 2015 Mar; 94(2):142-54. doi: 10.1016/j.bcp.2015.02.002. [PMID: 25677765]
  • Izabela Grzegorczyk-Karolak, Halina Wysokińska, Beata Olas. Studies on the antioxidant properties of extracts from the roots and shoots of two Scutellaria species in human blood plasma. Acta biochimica Polonica. 2015; 62(2):253-8. doi: 10.18388/abp.2014_944. [PMID: 26015995]
  • Tao Li, Yi-Wei Wang, Yan-Li Wang, Dong Zhang, Hui-Hui Zhang, Li Chen, Shuai-Xing Zhuang, Zhong-Ming Zhou, Wei-Peng Yang. [Pharmacokinetics and pharmacodynamics of huangqin tang in febrile rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 Oct; 49(10):1418-25. doi: . [PMID: 25577872]
  • Sophia Yui Kau Fong, Yin Cheong Wong, Zhong Zuo. Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 97(?):9-23. doi: 10.1016/j.jpba.2014.03.033. [PMID: 24803030]
  • Zhao-Tang Ma, Xiu-Wei Yang, Ying Zhang, Jian-Xun Liu. Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction. Journal of Asian natural products research. 2014; 16(5):483-96. doi: 10.1080/10286020.2014.913577. [PMID: 24797560]
  • Tao Li, Yi-Wei Wang, Yan-Li Wang, Ri-Xin Liang, Dong Zhang, Hui-Hui Zhang, Li Chen, Zhong-Ming Zhou, Wei-Peng Yang. [LC-MS quantification and pharmacokinetics of the multi-constituents of Huangqin Tang in rat plasma after different single oral doses]. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 Jun; 48(6):917-24. doi: . [PMID: 23984529]
  • Ling Tong, Meixu Wan, Lihua Zhang, Yonghong Zhu, He Sun, Kaishun Bi. Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2012 Nov; 70(?):6-12. doi: 10.1016/j.jpba.2012.03.051. [PMID: 22703838]
  • Guan Ye, Yi-Hong Tang, Gui-Yun Wang, Zhi-Xiong Li, Hai-Yan Zhu, Chun-Hui Ma, Zhao-Ling Sun, Cheng-Gang Huang. Characterization of the multiple absorbed constituents in rats after oral administration of Chai-Huang decoction by liquid chromatography coupled with electrospray-ionization mass spectrometry. Chemistry & biodiversity. 2010 Dec; 7(12):2917-30. doi: 10.1002/cbdv.200900387. [PMID: 21162005]
  • Zhenyu Zhu, Liang Zhao, Xiaofan Liu, Jun Chen, Hai Zhang, Guoqing Zhang, Yifeng Chai. Comparative pharmacokinetics of baicalin and wogonoside by liquid chromatography-mass spectrometry after oral administration of Xiaochaihu Tang and Radix scutellariae extract to rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Aug; 878(24):2184-90. doi: 10.1016/j.jchromb.2010.06.021. [PMID: 20643590]
  • Rong Shi, Hui Zhou, Zhaoming Liu, Yueming Ma, Tianming Wang, Yingying Liu, Changhong Wang. Influence of coptis Chinensis on pharmacokinetics of flavonoids after oral administration of radix Scutellariae in rats. Biopharmaceutics & drug disposition. 2009 Oct; 30(7):398-410. doi: 10.1002/bdd.674. [PMID: 19688740]
  • Ying Wang, Yamin Yao, Rui An, Lisha You, Xinhong Wang. Simultaneous determination of puerarin, daidzein, baicalin, wogonoside and liquiritin of GegenQinlian decoction in rat plasma by ultra-performance liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jul; 877(20-21):1820-6. doi: 10.1016/j.jchromb.2009.05.035. [PMID: 19493706]
  • Jing-chao Yan, Zhao-ming Liu, Tian-ming Wang, Rong Shi, Yue-ming Ma. [Pharmacokinetics of flavonoids from xiexin decoction in rats]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Jul; 42(7):722-9. doi: NULL. [PMID: 17882955]
  • Tong Lu, Jue Song, Fang Huang, Yuanxiong Deng, Lin Xie, Guangji Wang, Xiaodong Liu. Comparative pharmacokinetics of baicalin after oral administration of pure baicalin, Radix scutellariae extract and Huang-Lian-Jie-Du-Tang to rats. Journal of ethnopharmacology. 2007 Apr; 110(3):412-8. doi: 10.1016/j.jep.2006.09.036. [PMID: 17110066]
  • Jian-rong Li, Feng Zuo, Lei Zhang, Norio Nakamura, Masao Hattori. [Study on the metabolism of the precipitation of Xiexin decoction in rats I]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Nov; 30(21):1673-6. doi: ". [PMID: 16400946]