Methylophiopogonanone (BioDeep_00000231009)
Main id: BioDeep_00000229999
PANOMIX_OTCML-2023
Metabolite Card
Formula: C19H18O6 (342.1103)
Chinese Names: 甲基麦冬二氢高异黄酮A, 甲基麦冬黄烷酮A, 麦冬高异黄酮 A
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Molecular Structure
SMILES: CC1=C(C(=C2C(=C1O)C(=O)C(CO2)CC3=CC4=C(C=C3)OCO4)C)O
InChI: InChI=1S/C19H18O6/c1-9-16(20)10(2)19-15(17(9)21)18(22)12(7-23-19)5-11-3-4-13-14(6-11)25-8-24-13/h3-4,6,12,20-21H,5,7-8H2,1-2H3/t12-/m1/s1
Description
Methylophiopogonanone A is a homoflavonoid.
Methylophiopogonanone A is a natural product found in Ophiopogon japonicus with data available.
Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1].
Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1].
Synonyms
7 synonym names
(3R)-3-[(2H-1,3-Benzodioxol-5-yl)methyl]-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one,3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl-, (3R)-; (3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one; Methylophiopogonanone A, analytical standard; 8-Methylophiopogonanone A; Methylophiopogonanone A; Methylophiopogonanone
Cross Reference
6 cross reference id
- ChEBI: CHEBI:189526
- PubChem: 53466984
- MeSH: methylophiopogonanone A
- chemspider: 24534133
- CAS: 74805-92-8
- medchemexpress: HY-N2437
Classification Terms
Related Pathways
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Biological Process
0 related biological process reactions.
Reactome(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 organism taxonomy source information
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
Literature Reference
- Ting Zhang, Qi Mo, Nan Jiang, Yuesong Wu, Xin Yang, Wang Chen, Qinyao Li, Shuo Yang, Jing Yang, Jing Zeng, Feihong Huang, Qianqian Huang, Jiesi Luo, Jianming Wu, Long Wang. The combination of machine learning and transcriptomics reveals a novel megakaryopoiesis inducer, MO-A, that promotes thrombopoiesis by activating FGF1/FGFR1/PI3K/Akt/NF-κB signaling.
European journal of pharmacology.
2023 Feb; 944(?):175604. doi:
10.1016/j.ejphar.2023.175604. [PMID: 36804544] - Qi-Hang Zhou, Guang-Hao Zhu, Yun-Qing Song, Yuan-Fang Que, Qing-Qing He, Dong-Zhu Tu, Hai-Rong Zeng, Wei-Wei Qin, Chun-Zhi Ai, Guang-Bo Ge. Methylophiopogonanone A is a naturally occurring broad-spectrum inhibitor against human UDP-glucuronosyltransferases: Inhibition behaviours and implication in herb-drug interactions.
Basic & clinical pharmacology & toxicology.
2021 Dec; 129(6):437-449. doi:
10.1111/bcpt.13651. [PMID: 34478607] - Qi-Hang Zhou, Wei-Wei Qin, Moshe Finel, Qing-Qing He, Dong-Zhu Tu, Chao-Ran Wang, Guang-Bo Ge. A broad-spectrum substrate for the human UDP-glucuronosyltransferases and its use for investigating glucuronidation inhibitors.
International journal of biological macromolecules.
2021 Jun; 180(?):252-261. doi:
10.1016/j.ijbiomac.2021.03.073. [PMID: 33741369] - Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng, Guang-Bo Ge. Reversible and Irreversible Inhibition of Cytochrome P450 Enzymes by Methylophiopogonanone A.
Drug metabolism and disposition: the biological fate of chemicals.
2020 06; 49(6):459-469. doi:
10.1124/dmd.120.000325. [PMID: 33811108] - Zhao Li, Ying-Ying Wu, Bei-Xin Yu. Methylophiopogonanone A, an Ophiopogon homoisoflavonoid, alleviates high-fat diet-induced hyperlipidemia: assessment of its potential mechanism.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2020; 53(3):e9201. doi:
10.1590/1414-431x20199201. [PMID: 32130294] - Fei He, Bang-Long Xu, Cai Chen, Hong-Jing Jia, Ji-Xiong Wu, Xiao-Chen Wang, Jian-Long Sheng, Li Huang, Jing Cheng. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway.
Acta pharmacologica Sinica.
2016 Jun; 37(6):763-71. doi:
10.1038/aps.2016.14. [PMID: 27063216] - Mingbao Lin, Wei Sun, Wan Gong, Zhiyu Zhou, Yasi Ding, Qi Hou. Methylophiopogonanone A Protects against Cerebral Ischemia/Reperfusion Injury and Attenuates Blood-Brain Barrier Disruption In Vitro.
PloS one.
2015; 10(4):e0124558. doi:
10.1371/journal.pone.0124558. [PMID: 25897666] - Jin Wang, Han-Qing Liu, Lin Liu, Hai-Tao Tang, Ping Zhang, Yun Tang. [Development of full-quantified HPLC fingerprint for quality evaluation of ophiopogonis radix of sichuan].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2013 May; 36(5):721-5. doi:
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