Ginkgolide (BioDeep_00000230987)

 

Secondary id: BioDeep_00000179416, BioDeep_00000396673

PANOMIX_OTCML-2023


代谢物信息卡片


9H-1,7a-(Epoxymethano)-1H,6ah-cyclopenta(C)furo(2,3-b)furo(3,2:3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)-2,3,10a,11-tetrahydro-4,11-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aS,10aR,11R,11aR)-

化学式: C20H22O9 (406.1263762)
中文名称: 银杏内酯k, 银杏内酯K
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 3.85%

分子结构信息

SMILES: CC1=C2C(C(C34C25C(=O)OC3CC(C46C(C(=O)OC6O5)O)C(C)(C)C)O)OC1=O
InChI: InChI=1S/C20H22O9/c1-6-9-10(27-13(6)23)11(21)19-8-5-7(17(2,3)4)18(19)12(22)14(24)28-16(18)29-20(9,19)15(25)26-8/h7-8,10-12,16,21-22H,5H2,1-4H3/t7-,8+,10+,11-,12-,16-,18-,19+,20+/m0/s1

描述信息

Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity[1].
Ginkgolide K, isolated from Ginkgo biloba, induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K possesses neuroprotective activity[1].

同义名列表

7 个代谢物同义名

9H-1,7a-(Epoxymethano)-1H,6ah-cyclopenta(C)furo(2,3-b)furo(3,2:3,4)cyclopenta(1,2-d)furan-5,9,12(4H)-trione, 3-(1,1-dimethylethyl)-2,3,10a,11-tetrahydro-4,11-dihydroxy-8-methyl-, (1R,3S,3aS,4R,6aR,7aS,10aR,11R,11aR)-; GINKGOLIDE A, 3,14-DIDEHYDRO-3-DEOXY-1-HYDROXY-, (1.BETA.)-; Ginkgolide A, 3,14-didehydro-3-deoxy-1-hydroxy-, (1beta)-; 1,10-dihydroxy-3,14-didehydroginkgolide; Ginkgolide K [WHO-DD]; ginkgolide K; Ginkgolide



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Qiang Miao, Zhi Chai, Li-Juan Song, Qing Wang, Guo-Bin Song, Jing Wang, Jie-Zhong Yu, Bao-Guo Xiao, Cun-Gen Ma. The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson' disease mice. Journal of neuroimmunology. 2022 03; 364(?):577806. doi: 10.1016/j.jneuroim.2022.577806. [PMID: 35121334]
  • Qin-Ying Li, Qiang Miao, Ruo-Xuan Sui, Liang Cao, Cun-Gen Ma, Bao-Guo Xiao, Wei Xiao, Wen-Bo Yu. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis. International immunopharmacology. 2019 Oct; 75(?):105819. doi: 10.1016/j.intimp.2019.105819. [PMID: 31421546]
  • Wen-Bo Yu, Qing Wang, Sheng Chen, Liang Cao, Jie Tang, Cun-Gen Ma, Wei Xiao, Bao-Guo Xiao. The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation. International immunopharmacology. 2019 May; 70(?):284-294. doi: 10.1016/j.intimp.2019.02.035. [PMID: 30851709]
  • Wen-Bo Yu, Liang Cao, Yan-Yin Zhao, Wei Xiao, Bao-Guo Xiao. Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen‑glucose deprivation. Molecular medicine reports. 2018 Nov; 18(5):4417-4427. doi: 10.3892/mmr.2018.9450. [PMID: 30221704]
  • Xiao-Qian Tao, Ze-Yu Cao, Liang Cao, Wei Xiao. [Effects of ginkgolide K on platelet aggregation activity and neuroprotection]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Dec; 42(24):4727-4732. doi: 10.19540/j.cnki.cjcmm.2017.0208. [PMID: 29493138]
  • Shu-Yao Wang, Ji-Ye A, Fei Fei, Jian-Liang Geng, Ying Peng, Bing-Chen Ouyang, Pei Wang, Xiao-Liang Jin, Yu-Qing Zhao, Jian-Kun Wang, Ting Geng, Yan-Jing Li, Wen-Zhe Huang, Zhen-Zhong Wang, Wei Xiao, Guang-Ji Wang. Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs. Chinese journal of natural medicines. 2017 Oct; 15(10):775-784. doi: 10.1016/s1875-5364(17)30109-7. [PMID: 29103463]
  • Shuyao Wang, Bingchen Ouyang, Jiye Aa, Jianliang Geng, Fei Fei, Pei Wang, Jiankun Wang, Ying Peng, Ting Geng, Yanjing Li, Wenzhe Huang, Zhenzhong Wang, Wei Xiao, Guangji Wang. Pharmacokinetics and tissue distribution of ginkgolide A, ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model. Journal of pharmaceutical and biomedical analysis. 2016 Jul; 126(?):109-16. doi: 10.1016/j.jpba.2016.04.035. [PMID: 27182682]
  • Zhi-Ying Fan, Xin-Guang Liu, Ru-Zhou Guo, Xin Dong, Wen Gao, Ping Li, Hua Yang. Pharmacokinetic studies of ginkgolide K in rat plasma and tissues after intravenous administration using ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Apr; 988(?):1-7. doi: 10.1016/j.jchromb.2015.02.015. [PMID: 25734938]
  • Xiao-wen Zhou, Zheng Ma, Ting Geng, Zhen-zhong Wang, Gang Ding, Bi Yu-an, Wei Xiao. Evaluation of in vitro inhibition and induction of cytochrome P450 activities by hydrolyzed ginkgolides. Journal of ethnopharmacology. 2014 Dec; 158 Pt A(?):132-9. doi: 10.1016/j.jep.2014.10.023. [PMID: 25456428]
  • Shuwei Ma, Xingyan Liu, Qingrui Xun, Xiantao Zhang. Neuroprotective effect of Ginkgolide K against H2O2-induced PC12 cell cytotoxicity by ameliorating mitochondrial dysfunction and oxidative stress. Biological & pharmaceutical bulletin. 2014; 37(2):217-25. doi: 10.1248/bpb.b13-00378. [PMID: 24225258]
  • Shuwei Ma, Huafeng Yin, Lvyi Chen, Hongxia Liu, Ming Zhao, Xiantao Zhang. Neuroprotective effect of ginkgolide K against acute ischemic stroke on middle cerebral ischemia occlusion in rats. Journal of natural medicines. 2012 Jan; 66(1):25-31. doi: 10.1007/s11418-011-0545-7. [PMID: 21611909]
  • Y Wang, L S Sheng, F C Lou. [Analysis and structure identification of trace constituent in the total ginkgolide by using LC/DAD/ESI/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2001 Aug; 36(8):606-8. doi: . [PMID: 12579939]