ponicidin (BioDeep_00000230959)

 

Secondary id: BioDeep_00000171586

PANOMIX_OTCML-2023


代谢物信息卡片


(1R,2S,5R,8R,9S,11S,13S,14S,15R,19S)-13,14,19-trihydroxy-16,16-dimethyl-6-methylidene-10,12-dioxahexacyclo[9.8.0.01,15.02,8.05,9.08,13]nonadecan-7-one

化学式: C20H26O6 (362.1729)
中文名称: 冬凌草乙素
谱图信息: 最多检出来源 Homo sapiens(blood) 49.46%

分子结构信息

SMILES: C=C1C(=O)C23C4OC5OC2(O)C(O)C2C(C)(C)CCC(O)C52C3CCC14
InChI: InChI=1S/C20H26O6/c1-8-9-4-5-10-18-11(21)6-7-17(2,3)12(18)14(23)20(24)19(10,13(8)22)15(9)25-16(18)26-20/h9-12,14-16,21,23-24H,1,4-7H2,2-3H3

描述信息

A natural product found in Isodon adenolomus.
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1].
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1].

同义名列表

7 个代谢物同义名

ponicidin; (1R,2S,5R,8R,9S,11S,13S,14S,15R,19S)-13,14,19-trihydroxy-16,16-dimethyl-6-methylidene-10,12-dioxahexacyclo[9.8.0.01,15.02,8.05,9.08,13]nonadecan-7-one; (2S,5S,8R,9S,11S,13S,14S,15R,19S)-13,14,19-trihydroxy-16,16-dimethyl-6-methylidene-10,12-dioxahexacyclo[9.8.0.01,15.02,8.05,9.08,13]nonadecan-7-one; (1-alpha,6-beta,7-alpha,14S,20S)-7,20:14,20-Diepoxy-1,6,7-trihydroxykaur-16-en-15-one; Rubescensin B; Ponicidin/Rubescensin; Rubescensine B



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Xuerong Zhang, Yuanhang Xu, Minqi Fan, Xueqing Lv, Jiachan Long, Rong Yang, Rong Zhang, Zhongqiu Liu, Jiangyong Gu, Peng Wu, Caiyan Wang. Ponicidin-induced conformational changes of HSP90 regulates the MAPK pathway to relieve ulcerative colitis. Journal of ethnopharmacology. 2024 Mar; 321(?):117483. doi: 10.1016/j.jep.2023.117483. [PMID: 38008273]
  • Cheng Zhao, Jian Zhang, Zi-Yi Yang, Liu-Qing Shi, Shi-Lei Liu, Li-Jia Pan, Ping Dong, Yi Zhang, Shan-Shan Xiang, Yi-Jun Shu, Jia-Wei Mei. Ponicidin inhibited gallbladder cancer proliferation and metastasis by decreasing MAGEB2 expression through FOXO4. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Mar; 114(?):154785. doi: 10.1016/j.phymed.2023.154785. [PMID: 37002972]
  • Shuqiang An, Yang Li, Xiaojing Jia, Yaqin Yang, Xiaojuan Jia, Xiaozhao Jia, Wujun Xue. Ponicidin attenuates streptozotocin-induced diabetic nephropathy in rats via modulating hyperlipidemia, oxidative stress, and inflammatory markers. Journal of biochemical and molecular toxicology. 2022 Apr; 36(4):e22988. doi: 10.1002/jbt.22988. [PMID: 35187780]
  • Seiji Tanaka, Michiho Ito. Quantitative Analysis of Ent-Kaurane Diterpenoids in Isodon Herb (Enmei-So) by HPLC-UV. Chemical & pharmaceutical bulletin. 2021; 69(3):246-252. doi: 10.1248/cpb.c20-00769. [PMID: 33642472]
  • Muhammad Torequl Islam, Sajal Biswas, Rajat Bagchi, Md Roich Khan, Abul Bashar Ripon Khalipha, Razina Rouf, Shaikh Jamal Uddin, Jamil A Shilpi, Sanaa K Bardaweel, Dima A Sabbah, Mohammad S Mubarak. Ponicidin as a promising anticancer agent: Its biological and biopharmaceutical profile along with a molecular docking study. Biotechnology and applied biochemistry. 2019 May; 66(3):434-444. doi: 10.1002/bab.1740. [PMID: 30801842]
  • Xiaotian Li, Yanle Chu, Bin Du, Linxi Wang, Tong Yu. LC-MS-MS for the determination of ponicidin in dog plasma. Journal of chromatographic science. 2014 Mar; 52(3):211-7. doi: 10.1093/chromsci/bmt013. [PMID: 23505290]
  • Bo Ma, Yubin Wang, Qi Zhang, Yinhui Liu, Jing Li, Qiuyu Xu, Hanjie Ying. Simultaneous determination of oridonin, ponicidin and rosmarinic acid from Herba Isodi Rubescentis extract by LC-MS-MS in rat plasma. Journal of chromatographic science. 2013 Nov; 51(10):910-8. doi: 10.1093/chromsci/bms189. [PMID: 23357046]
  • Xiaotian Li, Wenjing Hou, Jingjing Song, Hongmin Liu, Shumei Song, Lingchun Zhang, Yingying Shi. A simple and sensitive HPLC-UV method for the determination of ponicidin in rat plasma and its application in a pharmacokinetic study. Biomedical chromatography : BMC. 2011 Mar; 25(3):362-6. doi: 10.1002/bmc.1456. [PMID: 21110387]
  • Yingfeng Du, Pengwei Liu, Xiaowei Shi, Yiran Jin, Qiao Wang, Xiaowei Zhang, Xiaona Sheng, Lantong Zhang. A novel analysis method for diterpenoids in rat plasma by liquid chromatography-electrospray ionization mass spectrometry. Analytical biochemistry. 2010 Dec; 407(1):111-9. doi: 10.1016/j.ab.2010.07.009. [PMID: 20643094]
  • Xia Xu, Yu Ke, Qi Zhang, Xiaoyu Qi, Hongmin Liu. DNA binding and cleavage properties of ponicidin. Tumori. 2009 May; 95(3):348-51. doi: 10.1177/030089160909500313. [PMID: 19688975]
  • Yanbin Lu, Cuirong Sun, Rui Liu, Yuanjiang Pan. Effective two-dimensional counter-current chromatographic method for simultaneous isolation and purification of oridonin and ponicidin from the crude extract of Rabdosia rubescens. Journal of chromatography. A. 2007 Mar; 1146(1):125-30. doi: 10.1016/j.chroma.2007.01.141. [PMID: 17328904]
  • Jia-Jun Liu, Ren-Wei Huang, Dong-Jun Lin, Xiang-Yuan Wu, Qu Lin, Jun Peng, Xianglin Pan, Yu-Qin Song, Mao-Hong Zhang, Ming Hou, Feng Chen. Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro. Oncology reports. 2005 Apr; 13(4):653-7. doi: 10.3892/or.13.4.653. [PMID: 15756438]
  • K Hayashi, T Hayashi, H D Sun, Y Takeda. Potentiation of ganciclovir toxicity in the herpes simplex virus thymidine kinase/ganciclovir administration system by ponicidin. Cancer gene therapy. 2000 Jan; 7(1):45-52. doi: 10.1038/sj.cgt.7700084. [PMID: 10678355]