Oroxylin (BioDeep_00000230914)

 

Secondary id: BioDeep_00000230276, BioDeep_00000267591

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-6-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid

化学式: C22H20O11 (460.100557)
中文名称: 千层纸素A-7-0-β-D-葡萄糖醛酸苷, 千层纸素A-7-0-Β-D-葡萄糖醛酸苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 94.44%

分子结构信息

SMILES: COC1=C(C=C2C(=C1O)C(=O)C=C(O2)C3=CC=CC=C3)OC4C(C(C(C(O4)C(=O)O)O)O)O
InChI: InChI=1S/C22H20O11/c1-30-19-13(32-22-18(27)16(25)17(26)20(33-22)21(28)29)8-12-14(15(19)24)10(23)7-11(31-12)9-5-3-2-4-6-9/h2-8,16-18,20,22,24-27H,1H3,(H,28,29)/t16-,17-,18+,20-,22+/m0/s1

描述信息

Oroxylin A 7-O-beta-D-glucuronide is the glycosyloxyflavone which is the 7-O-glucuronide of oroxylin A. It has a role as a plant metabolite. It is a glycosyloxyflavone, a monomethoxyflavone, a monohydroxyflavone, a monosaccharide derivative and a beta-D-glucosiduronic acid. It is functionally related to an oroxylin A. It is a conjugate acid of an oroxylin A 7-O-beta-D-glucuronate.
Oroxylin A glucoronide is a natural product found in Scutellaria racemosa, Scutellaria squarrosa, and other organisms with data available.
Oroxylin A-7-O-glucuronide (Oroxyloside; Oroxylin A-7-O-β-D-glucuronide) is a flavonoid glucuronide isolated from the dried root of Scutellaria baicalensis, with prolyl oligopeptidase (POP) inhibitory activity[1].
Oroxylin A-7-O-glucuronide (Oroxyloside; Oroxylin A-7-O-β-D-glucuronide) is a flavonoid glucuronide isolated from the dried root of Scutellaria baicalensis, with prolyl oligopeptidase (POP) inhibitory activity[1].

同义名列表

26 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(5-hydroxy-6-methoxy-4-oxo-2-phenylchromen-7-yl)oxyoxane-2-carboxylic acid; .BETA.-D-GLUCOPYRANOSIDURONIC ACID, 5-HYDROXY-6-METHOXY-4-OXO-2-PHENYL-4H-1-BENZOPYRAN-7-YL; beta-D-Glucopyranosiduronic acid, 5-hydroxy-6-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl; 5-hydroxy-6-methoxy-4-oxo-2-phenyl-4H-chromen-7-yl beta-D-glucopyranosiduronic acid; 5-hydroxy-6-methoxy-flavone-7-yl beta-D-glucopyranosiduronic acid; 5,7-dihydroxy-6-methoxyflavone 7-O-beta-D-glucuronide; Oroxyloside;Oroxylin A-7-O--D-glucuronide; Oroxyloside; Oroxylin A 7-glucuronide; OROXYLIN A-7-O-.BETA.-D-GLUCURONIDE; Oroxylin A 7-O-beta-D-glucuronide; oroxylinA-7-O-beta-d-Glucuronide; 6-Methoxybaicalein 7-glucuronide; oroxylin 7-O-beta-D-glucuronide; Oroxylin A 7-o-glucuronide; oroxylin A-7-O-glucuronide; Oroxylin A 7-glucuronide; Oroxylin a-7-glucoronide; Oroxylin 7-glucuronide; Oroxylin A glucoronide; UNII-O84RM2NAEQ; MEGxp0_000536; ACon1_001096; oroxyloside; O84RM2NAEQ; Oroxylin; Oroxylin A-7-O-β-D-glucuronide



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sharmila Kameyanda Poonacha, Madhyastha Harishkumar, Madhyastha Radha, Remya Varadarajan, Suchetha Kumari Nalilu, Shilpa Sharathraj Shetty, Praveen Kumar Shetty, Revanasiddappa Bistuvalli Chandrashekharappa, Mahendra Gowdru Sreenivas, Satheesh Kumar Bhandary Bavabeedu. Insight into OroxylinA-7-O-β-d-Glucuronide-Enriched Oroxylum indicum Bark Extract in Oral Cancer HSC-3 Cell Apoptotic Mechanism: Role of Mitochondrial Microenvironment. Molecules (Basel, Switzerland). 2021 Dec; 26(24):. doi: 10.3390/molecules26247430. [PMID: 34946511]
  • Yuxin Zhou, Yongjian Guo, Yejin Zhu, Yuening Sun, Wei Li, Zhiyu Li, Libin Wei. Dual PPARγ/ɑ agonist oroxyloside suppresses cell cycle progression by glycolipid metabolism switch-mediated increase of reactive oxygen species levels. Free radical biology & medicine. 2021 05; 167(?):205-217. doi: 10.1016/j.freeradbiomed.2021.02.032. [PMID: 33713839]
  • Guanghui Ren, Huili Chen, Mei Zhang, Nan Yang, Hui Yang, Chuanru Xu, Jiaming Li, Chen Ning, Zhongjin Song, Shiyu Zhou, Siliang Zhang, Xiaoqian Wang, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao. Determination of oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate in beagle dogs by using UHPLC MS/MS Application in a pharmacokinetic study. Journal of separation science. 2020 Jun; 43(12):2290-2300. doi: 10.1002/jssc.201901259. [PMID: 32187438]
  • Guanghui Ren, Huili Chen, Mei Zhang, Nan Yang, Hui Yang, Chuanru Xu, Jiaming Li, Chen Ning, Zhongjin Song, Shiyu Zhou, Yueying Bian, Yang Lu, Ning Li, Yongjie Zhang, Xijing Chen, Di Zhao. Pharmacokinetics, tissue distribution and excretion study of Oroxylin A, Oroxylin A 7-O-glucuronide and Oroxylin A sodium sulfonate in rats after administration of Oroxylin A. Fitoterapia. 2020 Apr; 142(?):104480. doi: 10.1016/j.fitote.2020.104480. [PMID: 31927013]
  • Tao Wang, Hongmei Jiang, Shijie Cao, Qian Chen, Mingyuan Cui, Zhijie Wang, Dandan Li, Jing Zhou, Tao Wang, Feng Qiu, Ning Kang. Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells. European journal of medicinal chemistry. 2017 Dec; 141(?):92-100. doi: 10.1016/j.ejmech.2017.09.049. [PMID: 29028535]
  • Yu Cai, Sai Li, Ting Li, Ruina Zhou, Alfred Tai-Seng Wai, Ru Yan. Oral pharmacokinetics of baicalin, wogonoside, oroxylin A 7-O-β-d-glucuronide and their aglycones from an aqueous extract of Scutellariae Radix in the rat. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jul; 1026(?):124-133. doi: 10.1016/j.jchromb.2015.11.049. [PMID: 26809374]
  • Sophia Yui Kau Fong, Yin Cheong Wong, Zhong Zuo. Development of a SPE-LC/MS/MS method for simultaneous quantification of baicalein, wogonin, oroxylin A and their glucuronides baicalin, wogonoside and oroxyloside in rats and its application to brain uptake and plasma pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 97(?):9-23. doi: 10.1016/j.jpba.2014.03.033. [PMID: 24803030]