Bullatine (BioDeep_00000230897)
Secondary id: BioDeep_00000396712
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C22H33NO2 (343.25111580000004)
中文名称: 雪上一枝蒿甲素, 一枝蒿甲素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN1CC2(CCCC34C2CC(C31)C56C4C(C(CC5)C(=C)C6O)O)C
InChI: InChI=1S/C22H33NO2/c1-4-23-11-20(3)7-5-8-22-15(20)10-14(18(22)23)21-9-6-13(12(2)19(21)25)16(24)17(21)22/h13-19,24-25H,2,4-11H2,1,3H3/t13?,14?,15-,16+,17+,18?,19-,20+,21?,22?/m1/s1
描述信息
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1]. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].
Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects. Bullatine A is a potent P2X7 antagonist, inhibits ATP-induced cell death/apoptosis and P2X receptor-mediated inflammatory responses[1]. Bullatine A attenuates pain hypersensitivity, regardless of the pain models employed[2].
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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2 个相关的物种来源信息
- 33090 - Plants: -
- 33090 - 小白撑: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Shuhan Liu, Na Che, Wen Ou, Meichen Yan, Yajin Liao, Yong Cheng. Bullatine A exerts anti-inflammatory effects by inhibiting the ROS/JNK/NF-κB pathway and attenuating systemic inflammatory responses in mice.
Pharmaceutical biology.
2022 Dec; 60(1):1840-1849. doi:
10.1080/13880209.2022.2121410. [PMID: 36200648] - Hong-Yan Tang, Xiao-Lan Chen, Yu-Mei Wu, Wen-Zhen Wei, Ya-Jie Dai. [In vitro recovery rate of bullatine A microdialysis probe].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Jul; 41(13):2538-2542. doi:
10.4268/cjcmm20161328. [PMID: 28905582] - Yu-Mei Wu, Xiao-Lan Chen, Wen Liu, Fang-Fang Yang, Hong-Yan Tang, Ya-Jie Dai. [Pharmacokinetics of bullatine A in Aconitum brachypodum total alkaloids gel in transdermal delivery].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2016 Apr; 41(8):1530-1534. doi:
10.4268/cjcmm20160827. [PMID: 28884551] - Shi-Yong Teng, Si-Xi Zhang, Kai Niu, Li-Jie Zhai, Shi-Ji Wang. Development and validation of an LC-MS/MS method for the determination of bullatine A in rat plasma: application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2015 Dec; 29(12):1798-804. doi:
10.1002/bmc.3498. [PMID: 26033334]