Ginsenoside (BioDeep_00000230873)

Main id: BioDeep_00000230610

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C42H70O12 (766.4867)
中文名称: 人参皂苷Rk1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCCC(=C)C1CCC2(C1C(CC3C2(CCC4C3(CCC(C4(C)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(C(O6)CO)O)O)O)C)C)O)C)C
InChI: InChI=1S/C42H70O12/c1-21(2)10-9-11-22(3)23-12-16-42(8)30(23)24(45)18-28-40(6)15-14-29(39(4,5)27(40)13-17-41(28,42)7)53-38-36(34(49)32(47)26(20-44)52-38)54-37-35(50)33(48)31(46)25(19-43)51-37/h10,23-38,43-50H,3,9,11-20H2,1-2,4-8H3/t23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33+,34+,35-,36-,37+,38+,40+,41-,42-/m1/s1

描述信息

ginsenoside Rk1 is a natural product found in Panax ginseng, Panax notoginseng, and Centella asiatica with data available.
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures[1]. Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB[2]. Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis[1]. Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway[3].

同义名列表

7 个代谢物同义名

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-(6-methylhepta-1,5-dien-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; b-D-Glucopyranoside, (3b,12b)-12-hydroxydammara-20,24-dien-3-yl2-O-b-D-glucopyranosyl-; 3beta,6alpha,12beta-trihydroxydammar-20(21),24-diene-6-O-beta-D-glucopyranoside; Ginsenoside Rk1 (Rk1:Rz1=5:2); ginsenoside Rk1; Gisenoside Rk1; Ginsenoside



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Lingchao Miao, Yan Zhou, Dechao Tan, Chunxiu Zhou, Cheng-Chao Ruan, Shengpeng Wang, Yitao Wang, Chi Teng Vong, Wai San Cheang. Ginsenoside Rk1 improves endothelial function in diabetes through activating peroxisome proliferator-activated receptors. Food & function. 2024 May; 15(10):5485-5495. doi: 10.1039/d3fo05222b. [PMID: 38690748]
  • Jian Xiong, Jianing Yang, Kai Yan, Jing Guo. Ginsenoside Rk1 protects human melanocytes from H2O2‑induced oxidative injury via regulation of the PI3K/AKT/Nrf2/HO‑1 pathway. Molecular medicine reports. 2021 Nov; 24(5):. doi: 10.3892/mmr.2021.12462. [PMID: 34558653]
  • Chao Ma, Qiyan Lin, Yafu Xue, Zhengcai Ju, Gang Deng, Wei Liu, Yuting Sun, Huida Guan, Xuemei Cheng, Changhong Wang. Pharmacokinetic studies of ginsenosides Rk1 and Rg5 in rats by UFLC-MS/MS. Biomedical chromatography : BMC. 2021 Aug; 35(8):e5108. doi: 10.1002/bmc.5108. [PMID: 33650162]
  • Chao Ma, Huida Guan, Qiyan Lin, Chang Liu, Zhengcai Ju, Yafu Xue, Xuemei Cheng, Changhong Wang. Dynamic changes in chemical compositions and anti-acetylcholinesterase activity associated with steaming process of stem-leaf saponins of Panax notoginseng. Biomedical chromatography : BMC. 2021 Jun; 35(6):e5077. doi: 10.1002/bmc.5077. [PMID: 33475178]
  • Zhiman Li, Lijuan Zhao, Jianbo Chen, Chang Liu, Shanshan Li, Mei Hua, Di Qu, Zijun Shao, Yinshi Sun. Ginsenoside Rk1 alleviates LPS-induced depression-like behavior in mice by promoting BDNF and suppressing the neuroinflammatory response. Biochemical and biophysical research communications. 2020 10; 530(4):658-664. doi: 10.1016/j.bbrc.2020.07.098. [PMID: 32768191]
  • Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. 2020 Sep; 882(?):173272. doi: 10.1016/j.ejphar.2020.173272. [PMID: 32535096]
  • Jun-Nan Hu, Xing-Yue Xu, Shuang Jiang, Ying Liu, Zhi Liu, Ying-Ping Wang, Xiao-Jie Gong, Ke-Ke Li, Shen Ren, Wei Li. Protective effect of ginsenoside Rk1, a major rare saponin from black ginseng, on cisplatin-induced nephrotoxicity in HEK-293 cells. The Kaohsiung journal of medical sciences. 2020 Sep; 36(9):732-740. doi: 10.1002/kjm2.12220. [PMID: 32374939]
  • Jingjing Shao, Xiaoyan Zheng, Linlin Qu, Hui Zhang, Huifang Yuan, Junfeng Hui, Yu Mi, Pei Ma, Daidi Fan. Ginsenoside Rg5/Rk1 ameliorated sleep via regulating the GABAergic/serotoninergic signaling pathway in a rodent model. Food & function. 2020 Feb; 11(2):1245-1257. doi: 10.1039/c9fo02248a. [PMID: 32052003]
  • Jian Li, Yongjie Zhang, Ali Fan, Geng Li, Qingwang Liu. Pharmacokinetics and bioavailability study of ginsenoside Rk1 in rat by liquid chromatography/electrospray ionization tandem mass spectrometry. Biomedical chromatography : BMC. 2019 Sep; 33(9):e4580. doi: 10.1002/bmc.4580. [PMID: 31077415]
  • Kyu Sup An, Yeo Ok Choi, So Min Lee, Hyeon Yeol Ryu, Su Jin Kang, Yong Yeon, Yu Ri Kim, Jae Geun Lee, Chul Joong Kim, Ye Ji Lee, Byeong Ju Kang, Jee Eun Choi, Kyung Seuk Song. Ginsenosides Rg5 and Rk1 Enriched Cultured Wild Ginseng Root Extract Bioconversion of Pediococcus pentosaceus HLJG0702: Effect on Scopolamine-Induced Memory Dysfunction in Mice. Nutrients. 2019 May; 11(5):. doi: 10.3390/nu11051120. [PMID: 31137483]
  • Ang Ying, Qing-Tao Yu, Li Guo, Wen-Song Zhang, Jin-Feng Liu, Yun Li, Hong Song, Ping Li, Lian-Wen Qi, Ya-Zhong Ge, E-Hu Liu, Qun Liu. Structural-Activity Relationship of Ginsenosides from Steamed Ginseng in the Treatment of Erectile Dysfunction. The American journal of Chinese medicine. 2018; 46(1):137-155. doi: 10.1142/s0192415x18500088. [PMID: 29298510]
  • Qian Yu, Ke-Wu Zeng, Xiao-Li Ma, Yong Jiang, Peng-Fei Tu, Xue-Mei Wang. Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway. Chinese journal of natural medicines. 2017 Oct; 15(10):751-757. doi: 10.1016/s1875-5364(17)30106-1. [PMID: 29103460]
  • Li-Yuan Ma, Qi-Le Zhou, Xiu-Wei Yang. New SIRT1 activator from alkaline hydrolysate of total saponins in the stems-leaves of Panax ginseng. Bioorganic & medicinal chemistry letters. 2015 Nov; 25(22):5321-5. doi: 10.1016/j.bmcl.2015.09.039. [PMID: 26420067]
  • Jun Yeon Park, Pilju Choi, Taejung Kim, Hyeonseok Ko, Ho-kyong Kim, Ki Sung Kang, Jungyeob Ham. Protective Effects of Processed Ginseng and Its Active Ginsenosides on Cisplatin-Induced Nephrotoxicity: In Vitro and in Vivo Studies. Journal of agricultural and food chemistry. 2015 Jul; 63(25):5964-9. doi: 10.1021/acs.jafc.5b00782. [PMID: 26050847]
  • Hai Ying Bao, Jing Zhang, Soo Jeong Yeo, Chang-Seon Myung, Hyang Mi Kim, Jong Moon Kim, Jeong Hill Park, Jungsook Cho, Jong Seong Kang. Memory enhancing and neuroprotective effects of selected ginsenosides. Archives of pharmacal research. 2005 Mar; 28(3):335-42. doi: 10.1007/bf02977802. [PMID: 15832823]
  • Il Ho Park, Na Young Kim, Sang Beom Han, Jong Moon Kim, Sung Won Kwon, Hyun Jung Kim, Man Ki Park, Jeong Hill Park. Three new dammarane glycosides from heat processed ginseng. Archives of pharmacal research. 2002 Aug; 25(4):428-32. doi: 10.1007/bf02976595. [PMID: 12214849]