Hederacol (BioDeep_00000230766)

 

Secondary id: BioDeep_00000179689, BioDeep_00000231558

PANOMIX_OTCML-2023


代谢物信息卡片


OLEAN-12-EN-28-OIC ACID, 3- ((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)- .ALPHA.-L-ARABINOPYRANOSYL)OXY)-23-HYDROXY-, O-6-DEOXY-.ALPHA.-L- MANNOPYRANOSYL-(1-4)-O-.BETA.-D-GLUCOPYRANOSYL-(1-6)-.BETA.-D- GLUCOPYRANOSYL ESTER, (3.BETA.,4.ALPHA.)-

化学式: C59H96O26 (1220.6189516)
中文名称: 常春藤皂苷 C, 常春藤单甙 C, 常春藤苷 C, 常春藤甙 C, 常春藤苷C
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OCC3C(C(C(C(O3)OC(=O)C45CCC(CC4C6=CCC7C8(CCC(C(C8CCC7(C6(CC5)C)C)(C)CO)OC9C(C(C(CO9)O)O)OC1C(C(C(C(O1)C)O)O)O)C)(C)C)O)O)O)CO)O)O)O
InChI: InChI=1S/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27-,28-,29+,30+,31+,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1

描述信息

Kalopanaxsaponin B is a triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus. It has a role as an anti-inflammatory agent and a plant metabolite. It is a pentacyclic triterpenoid, a triterpenoid saponin and a carboxylic ester. It is functionally related to a hederagenin.
Hederacoside C is a natural product found in Hedera caucasigena, Akebia trifoliata, and other organisms with data available.
See also: Hedera helix leaf (part of).
A triterpenoid saponin with hederagenin as the aglycone part. It has been isolated from the stem bark of Kalopanax pictus.
Hederacoside C (Kalopanaxsaponin B) is the main bioactive molecular component of ivy leaves. It has expectorant, bronchodilator, antibacterial and other effects and can be used to study respiratory diseases.
Hederacoside C (Kalopanaxsaponin B) is the main bioactive molecular component of ivy leaves. It has expectorant, bronchodilator, antibacterial and other effects and can be used to study respiratory diseases.

同义名列表

30 个代谢物同义名

OLEAN-12-EN-28-OIC ACID, 3- ((2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)- .ALPHA.-L-ARABINOPYRANOSYL)OXY)-23-HYDROXY-, O-6-DEOXY-.ALPHA.-L- MANNOPYRANOSYL-(1-4)-O-.BETA.-D-GLUCOPYRANOSYL-(1-6)-.BETA.-D- GLUCOPYRANOSYL ESTER, (3.BETA.,4.ALPHA.)-; Olean-12-en-28-oic acid, 3- ((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (3beta,4alpha)-; Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-l-mannopyranosyl)-alpha-l-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-l-mannopyranosyl-(1.4)-O-beta-d-glucopyranosyl-(1.6)-beta-d-glucopyranosyl ester, (3beta,4alpha)-; Olean-12-en-28-oic acid, 3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxy-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (3beta,4alpha)-; 6-deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-[(3beta)-3-{[2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl]oxy}-23-hydroxy-28-oxoolean-12-en-28-yl]-beta-D-glucopyranose; 6-deoxy-alpha-L-mannopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-1-O-((3beta)-3-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-alpha-L-arabinopyranosyl)oxy)-23-hydroxy-28-oxoolean-12-en-28-yl)-beta-D-glucopyranose; hederagenin 3-O-alpha-L-rhamnopyranosyl-(1->2)-O-alpha-L-arabinopyranoside 28-O-alpha-L-rhamnopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->6)-O-beta-D-glucopyranosyl ester; Hederasaponin C (Hederacoside C); HEDERACOSIDE C with HPLC; Pericarpsasaponin Pk; kizuta saponin K(12); Pulsatilla saponin F; Pulsatillasaponin II; Pulsatillasaponin F; kalopanax saponin B; Kalopanaxsaponin B; Astrantiasaponin H; kizuta saponin K12; Hederacaucaside D; Pericarsaponin Pk; Akebia saponin PK; Akebiasaponin PK; Tauroside St-H2; Hederacoside C; Glycoside L-H2; Hederoside H1; Akeboside Sth; Tauroside H2; Hederacoside; Hederacol



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid. European journal of medicinal chemistry. 2021 Jan; 209(?):112932. doi: 10.1016/j.ejmech.2020.112932. [PMID: 33131725]
  • Laura Peeters, Charlie Beirnaert, Anastasia Van der Auwera, Sebastiaan Bijttebier, Tess De Bruyne, Kris Laukens, Luc Pieters, Nina Hermans, Kenn Foubert. Revelation of the metabolic pathway of hederacoside C using an innovative data analysis strategy for dynamic multiclass biotransformation experiments. Journal of chromatography. A. 2019 Jun; 1595(?):240-247. doi: 10.1016/j.chroma.2019.02.055. [PMID: 30833026]
  • Le Ba Vinh, Hyun-Jae Jang, Nguyen Viet Phong, Kyoungwon Cho, Sung Sun Park, Jong Seong Kang, Young Ho Kim, Seo Young Yang. Isolation, structural elucidation, and insights into the anti-inflammatory effects of triterpene saponins from the leaves of Stauntonia hexaphylla. Bioorganic & medicinal chemistry letters. 2019 04; 29(8):965-969. doi: 10.1016/j.bmcl.2019.02.022. [PMID: 30808589]
  • Shaheed Ur Rehman, Min Sun Choi, In Sook Kim, Seung Hyun Kim, Hye Hyun Yoo. An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasma. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):90-95. doi: 10.1016/j.jpba.2016.06.039. [PMID: 27411171]
  • Miao Yu, Jiaxin Liu, Lin Li, Haiyan Xu, Yanyan Xing, Yunli Zhao, Zhiguo Yu. Pharmacokinetic parameters of three active ingredients hederacoside C, hederacoside D, and ɑ-hederin in Hedera helix in rats. Journal of separation science. 2016 Sep; 39(17):3292-301. doi: 10.1002/jssc.201600523. [PMID: 27377040]
  • Yue-Wei Ge, Chihiro Tohda, Shu Zhu, Yu-Min He, Kayo Yoshimatsu, Katsuko Komatsu. Effects of Oleanane-Type Triterpene Saponins from the Leaves of Eleutherococcus senticosus in an Axonal Outgrowth Assay. Journal of natural products. 2016 07; 79(7):1834-41. doi: 10.1021/acs.jnatprod.6b00329. [PMID: 27400231]
  • Eun-Ha Joh, Jin-Ju Jeong, Dong-Hyun Kim. Kalopanaxsaponin B inhibits LPS-induced inflammation by inhibiting IRAK1 Kinase. Cellular immunology. 2012 Sep; 279(1):103-8. doi: 10.1016/j.cellimm.2012.10.001. [PMID: 23117333]
  • Stefan Böttger, Katja Hofmann, Matthias F Melzig. Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation?. Bioorganic & medicinal chemistry. 2012 May; 20(9):2822-8. doi: 10.1016/j.bmc.2012.03.032. [PMID: 22503361]
  • Eun-Ha Joh, In-Ah Lee, Dong-Hyun Kim. Kalopanaxsaponins A and B isolated from Kalopanax pictus ameliorate memory deficits in mice. Phytotherapy research : PTR. 2012 Apr; 26(4):546-51. doi: 10.1002/ptr.3596. [PMID: 21928370]
  • Tran H Quang, Nguyen T T Ngan, Chau V Minh, Phan V Kiem, Nguyen X Nhiem, Bui H Tai, Nguyen P Thao, Nguyen H Tung, Seok B Song, Young H Kim. Anti-inflammatory triterpenoid saponins from the stem bark of Kalopanax pictus. Journal of natural products. 2011 Sep; 74(9):1908-15. doi: 10.1021/np200382s. [PMID: 21870831]
  • Yvan Gaillard, Pierre Blaise, Alexandre Darré, Thierry Barbier, Gilbert Pépin. An unusual case of death: suffocation caused by leaves of common ivy (Hedera helix). Detection of hederacoside C, alpha-hederin, and hederagenin by LC-EI/MS-MS. Journal of analytical toxicology. 2003 May; 27(4):257-62. doi: 10.1093/jat/27.4.257. [PMID: 12820750]
  • Jongwon Choi, Keun Huh, Suk-Hwan Kim, Kyung-Tae Lee, Hee-Juhn Park, Yong Nam Han. Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. Journal of ethnopharmacology. 2002 Feb; 79(2):199-204. doi: 10.1016/s0378-8741(01)00383-x. [PMID: 11801382]
  • Jongwon Choi, Keun Huh, Suk Hwan Kim, Kyung Tae Lee, Hyeong Kyu Lee, Hee Juhn Park. Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. Journal of ethnopharmacology. 2002 Jan; 79(1):113-8. doi: 10.1016/s0378-8741(01)00382-8. [PMID: 11744304]
  • S H Cho, D R Hahn. Triterpenoidal saponins from the bark of Kalopanax pictum var. typicum. Archives of pharmacal research. 1991 Mar; 14(1):19-24. doi: 10.1007/bf02857808. [PMID: 10319115]