Safflomin A (BioDeep_00000230494)
Main id: BioDeep_00000231019
PANOMIX_OTCML-2023
代谢物信息卡片
2-Hydroxy-4-(€-3-(4-hydroxyphenyl)acryloyl)-2-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethy, AldrichCPR
化学式: C27H32O16 (612.1690272)
中文名称: 羟基红花黄A, 羟基红花黄色素A, 羟基红花黄色素 A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC=C1C=CC(=C2C(=C(C(=O)C(C2=O)(C3C(C(C(C(O3)CO)O)O)O)O)C4C(C(C(C(O4)CO)O)O)O)O)O)O
InChI: InChI=1S/C27H32O16/c28-7-12-16(32)19(35)21(37)23(42-12)15-18(34)14(11(31)6-3-9-1-4-10(30)5-2-9)24(39)27(41,25(15)40)26-22(38)20(36)17(33)13(8-29)43-26/h1-6,12-13,16-17,19-23,26,28-38,41H,7-8H2/b6-3+,14-11+/t12-,13-,16-,17-,19+,20+,21-,22-,23+,26-,27?/m1/s1
描述信息
Hydroxysafflor yellow A is a C-glycosyl compound that is 3,4,5-trihydroxycyclohexa-2,5-dien-1-one which is substituted by beta-D-glucosyl groups at positions 2 and 4, and by a p-hydroxycinnamoyl group at position 6. It is the main bioactive compound of a traditional Chinese medicine obtained from safflower (Carthamus tinctorius). It has a role as an anti-inflammatory agent, an antioxidant, a platelet aggregation inhibitor, an antineoplastic agent, a radical scavenger, an EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor, a neuroprotective agent and a plant metabolite. It is a C-glycosyl compound, a member of phenols, an enone and an enol.
Hydroxysafflor Yellow A is a natural product found in Carthamus tinctorius with data available.
Hydroxysafflor yellow A is a flavonoid natural product isolated from the traditional Chinese medicine safflower and has anti-cancer activity.
Hydroxysafflor yellow A is a flavonoid natural product isolated from the traditional Chinese medicine safflower and has anti-cancer activity.
同义名列表
17 个代谢物同义名
3,4,5-trihydroxy-2-[(2Z)-3-(4-hydroxyphenyl)prop-2-enoyl]-4,6-bis[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-2,5-dien-1-one; Hydroxysafflor Yellow A; Safflomin A; 3,4,5-trihydroxy-2-[hydroxy(3,4,5-trihydroxyoxan-2-yl)methyl]-6-[(2Z)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-2,5-dien-1-one; SY-1; 2-Hydroxy-4-(€-3-(4-hydroxyphenyl)acryloyl)-2-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-6-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethy, AldrichCPR; (6E)-2,5-dihydroxy-6-[(E)-1-hydroxy-3-(4-hydroxyphenyl)prop-2-enylidene]-2,4-bis[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohex-4-ene-1,3-dione; 2,5-CYCLOHEXADIEN-1-ONE, 2,4-DI-.BETA.-D-GLUCOPYRANOSYL-3,4,5-TRIHYDROXY-6-((2E)-3-(4-HYDROXYPHENYL)-1-OXO-2-PROPEN-1-YL)-; 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-prop-2-en-1-yl)]cyclohexa-2,5-dien-1-one; 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)]-2,5-cyclohexadien-1-one; 2,5-Cyclohexadien-1-one, 2,4-di-beta-D-glucopyranosyl-3,4,5-trihydroxy-6-((2E)-3-(4-hydroxyphenyl)-1-oxo-2-propenyl)-; 2,4-Di-b-D-glucopyranosyl-3,4,5-trihydroxy-6-[(2E)-3-(4-hydroxyphenyl-1-oxo-2-propen-1-yl)-2,5-cyclohexadien-1-one; hydroxy safflower yellow pigment A; Hydroxy safflor yellow A; UNII-HI7O919OYZ; HI7O919OYZ; HSYA
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:139030
- PubChem: 6443665
- Metlin: METLIN95152
- Metlin: METLIN87060
- MeSH: hydroxysafflor yellow A
- ChemIDplus: 0078281024
- CAS: 146087-19-6
- CAS: 78281-02-4
- CAS: 855782-18-2
- medchemexpress: HY-N0567
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- En Hu, Teng Li, Zhilin Li, Hong Su, Qiuju Yan, Lei Wang, Haigang Li, Wei Zhang, Tao Tang, Yang Wang. Metabolomics reveals the effects of hydroxysafflor yellow A on neurogenesis and axon regeneration after experimental traumatic brain injury.
Pharmaceutical biology.
2023 Dec; 61(1):1054-1064. doi:
10.1080/13880209.2023.2229379. [PMID: 37416997] - Jianjie Rong, Chuanyong Li, Qiang Zhang, Guangfeng Zheng, Weijian Fan, Zhichang Pan, Shuming Shi. Hydroxysafflor yellow A inhibits endothelial cell ferroptosis in diabetic atherosclerosis mice by regulating miR-429/SLC7A11.
Pharmaceutical biology.
2023 Dec; 61(1):404-415. doi:
10.1080/13880209.2023.2225543. [PMID: 37410531] - Xi Han, Huifen Zhou, Junjun Yin, Jiaqi Zhu, Jiehong Yang, Haitong Wan. Network Analysis and Experimental Verification of the Mechanisms of Hydroxysafflor Yellow A in Ischemic Stroke Following Atherosclerosis.
Molecules (Basel, Switzerland).
2023 Nov; 28(23):. doi:
10.3390/molecules28237829. [PMID: 38067558] - Chaowen Ge, Yuqin Peng, Jiacheng Li, Lei Wang, Xiaoyu Zhu, Ning Wang, Dongmei Yang, Xian Zhou, Dennis Chang. Hydroxysafflor Yellow A Alleviates Acute Myocardial Ischemia/Reperfusion Injury in Mice by Inhibiting Ferroptosis via the Activation of the HIF-1α/SLC7A11/GPX4 Signaling Pathway.
Nutrients.
2023 Jul; 15(15):. doi:
10.3390/nu15153411. [PMID: 37571350] - Yingqi Hong, Yanxi Lv, Jianyi Zhang, Naveed Ahmad, Xiaokun Li, Na Yao, Xiuming Liu, Haiyan Li. The safflower MBW complex regulates HYSA accumulation through degradation by the E3 ligase CtBB1.
Journal of integrative plant biology.
2023 May; 65(5):1277-1296. doi:
10.1111/jipb.13444. [PMID: 36598461] - Xiaoteng Feng, Min Du, Sijin Li, Yifan Zhang, Jie Ding, Jiarou Wang, Yiru Wang, Ping Liu. Hydroxysafflor yellow A regulates lymphangiogenesis and inflammation via the inhibition of PI3K on regulating AKT/mTOR and NF-κB pathway in macrophages to reduce atherosclerosis in ApoE-/- mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Apr; 112(?):154684. doi:
10.1016/j.phymed.2023.154684. [PMID: 36738477] - Zelin Lai, Cong Li, Huihan Ma, Shiting Hua, Zhizheng Liu, Sixian Huang, Kunlin Liu, Jinghuan Li, Zhiming Feng, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang. Hydroxysafflor yellow a confers neuroprotection against acute traumatic brain injury by modulating neuronal autophagy to inhibit NLRP3 inflammasomes.
Journal of ethnopharmacology.
2023 Feb; 308(?):116268. doi:
10.1016/j.jep.2023.116268. [PMID: 36842723] - Xueqin Chen, Jingyue Yu, Huan Lei, Lei Li, Xupin Liu, Bo Liu, Yanfei Xie, Haihong Fang. Exploring the Mechanism of Buyang Huanwu Decoction Alleviating Restenosis by Regulating VSMC Phenotype Switching and Proliferation by Network Pharmacology and Molecular Docking.
Current computer-aided drug design.
2023 Feb; ?(?):. doi:
10.2174/1573409919666230203144207. [PMID: 36740793] - Jiling Feng, Jiaying Guo, Jirong Yan, Xiaoqing Zhang, Huiyan Qu, Tao Yang, Qian Liu, Hongxi Xu, Hua Zhou. Luhong Formula and Hydroxysafflor yellow A protect cardiomyocytes by inhibiting autophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Feb; 110(?):154636. doi:
10.1016/j.phymed.2022.154636. [PMID: 36608503] - Zhen Yan, Rebiguli Alimu, Jiawei Wan, Xuewei Liao, Shimin Lin, Shijie Dai, Fei Chen, Shuang Zhang, Yiqi Tong, Hong Liu, Rui Qin, Jiao Liu. Composition of major quinochalcone hydroxysafflor yellow A and anhydrosafflor yellow B is associated with colour of safflower (Carthamus tinctorius) during colour-transition but not with overall antioxidant capacity: A study on 144 cultivars.
Food research international (Ottawa, Ont.).
2022 12; 162(Pt B):112098. doi:
10.1016/j.foodres.2022.112098. [PMID: 36461404] - Ruheng Wei, Lijuan Song, Zhuyue Miao, Kexin Liu, Guangyuan Han, Haifei Zhang, Dong Ma, Jianjun Huang, Hao Tian, Baoguo Xiao, Cungen Ma. Hydroxysafflor Yellow A Exerts Neuroprotective Effects via HIF-1α/BNIP3 Pathway to Activate Neuronal Autophagy after OGD/R.
Cells.
2022 Nov; 11(23):. doi:
10.3390/cells11233726. [PMID: 36496986] - Yu Du, Chang Li, Shouchao Xu, Jiehong Yang, Haitong Wan, Yu He. LC-MS/MS combined with blood-brain dual channel microdialysis for simultaneous determination of active components of astragali radix-safflower combination and neurotransmitters in rats with cerebral ischemia reperfusion injury: Application in pharmacokinetic and pharmacodynamic study.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154432. doi:
10.1016/j.phymed.2022.154432. [PMID: 36113188] - Qianqian Chen, Jiayang Wan, Yangyang Zhang, Yu He, Yida Bao, Li Yu, Jiehong Yang. Pharmacokinetic-pharmacodynamic modeling analysis for hydroxysafflor yellow A-calycosin in compatibility in normal and cerebral ischemic rats: A comparative study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):112950. doi:
10.1016/j.biopha.2022.112950. [PMID: 35427818] - Zhibing Feng, Ping Zhou, Xiao Wu, Junbiao Zhang, Min Zhang. Hydroxysafflor yellow A protects against ulcerative colitis via suppressing TLR4/NF-κB signaling pathway.
Chemical biology & drug design.
2022 06; 99(6):897-907. doi:
10.1111/cbdd.14045. [PMID: 35319164] - Shengju Wang, Huajuan Jiang, Qianqian Liu, Yongfeng Zhou, Yanfen Cheng, Tao Zhou, Jinming Zhang, Yao He, Chaoxiang Ren, Jin Pei. A comparative study on the traditional versus modern yellow rice wine processing methods using Taohong Siwu Decoction for pharmaceutical production.
Journal of ethnopharmacology.
2022 May; 290(?):115114. doi:
10.1016/j.jep.2022.115114. [PMID: 35181489] - Xiaorui Lyu, Kemin Yan, Hanyuan Xu, Huijuan Zhu, Hui Pan, Linjie Wang, Hongbo Yang, Fengying Gong. Intragastric safflower yellow and its main component HSYA improve leptin sensitivity before body weight change in diet-induced obese mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2022 05; 395(5):579-591. doi:
10.1007/s00210-022-02220-8. [PMID: 35201390] - Guangwei Chen, Chang Li, Ling Zhang, Jiehong Yang, Huanhuan Meng, Haitong Wan, Yu He. Hydroxysafflor yellow A and anhydrosafflor yellow B alleviate ferroptosis and parthanatos in PC12 cells injured by OGD/R.
Free radical biology & medicine.
2022 02; 179(?):1-10. doi:
10.1016/j.freeradbiomed.2021.12.262. [PMID: 34923102] - Yuliang Zhang, Yi Liu, Qian Cui, Zitong Fu, Haoyu Yu, Ao Liu, Jingjing Liu, Xiude Qin, Shaoqin Ge, Guowei Zhang. Hydroxysafflor Yellow A Alleviates Ischemic Stroke in Rats via HIF-1[Formula: see text], BNIP3, and Notch1-Mediated Inhibition of Autophagy.
The American journal of Chinese medicine.
2022; 50(3):799-815. doi:
10.1142/s0192415x22500331. [PMID: 35300568] - Jiyuan Wang, Yu Chen. Protective effect of hydroxysafflor yellow A on cyclosporin A-induced renal oxidative stress in vitro and in vivo.
Acta cirurgica brasileira.
2022; 37(3):e370305. doi:
10.1590/acb370305. [PMID: 35730865] - Zhiqiang Liu, Yongzhou Zou, Min He, Ping Yang, Xinhui Qu, Lijun Xu. Hydroxysafflor yellow A can improve depressive behavior by inhibiting hippocampal inflammation and oxidative stress through regulating HPA axis.
Journal of biosciences.
2022; 47(?):. doi:
". [PMID: 35092409] - Qian Cui, Yu-Hui Ma, Hao-Yu Yu, Yu-Liang Zhang, Xiu-de Qin, Shao-Qin Ge, Guo-Wei Zhang. Systematic analysis of the mechanism of hydroxysafflor yellow A for treating ischemic stroke based on network pharmacology technology.
European journal of pharmacology.
2021 Oct; 908(?):174360. doi:
10.1016/j.ejphar.2021.174360. [PMID: 34302817] - Xinyan Xue, Ying Deng, Jing Wang, Mengting Zhou, Li Liao, Cheng Wang, Cheng Peng, Yunxia Li. Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153694. doi:
10.1016/j.phymed.2021.153694. [PMID: 34403879] - Rui Yao, Yu Cao, Ruibin Jiang, Xuan Zhang, Feng Li, Siwang Wang. Pharmacokinetic characteristics of hydroxysafflor yellow A in normal and diabetic cardiomyopathy mice.
Biomedical chromatography : BMC.
2021 Oct; 35(10):e5173. doi:
10.1002/bmc.5173. [PMID: 33982286] - Dong-Wei Li, Xiao-Tong Wang, Bai-Chen Mu, De-Qiang Dou, Ting-Guo Kang. Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis.
Biochemical and biophysical research communications.
2021 09; 570(?):26-34. doi:
10.1016/j.bbrc.2021.07.026. [PMID: 34271433] - Peng Wang, Min Wang, Tingling Zhuo, Ying Li, Weiping Lin, Lingli Ding, Meng Zhang, Chi Zhou, Jinfang Zhang, Gang Li, Haibin Wang, Liangliang Xu. Hydroxysafflor yellow A promotes osteogenesis and bone development via epigenetically regulating β-catenin and prevents ovariectomy-induced bone loss.
The international journal of biochemistry & cell biology.
2021 08; 137(?):106033. doi:
10.1016/j.biocel.2021.106033. [PMID: 34216755] - Jingxue Ye, Ruiying Wang, Min Wang, Jianhua Fu, Qiong Zhang, Guibo Sun, Xiaobo Sun. Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis.
Oxidative medicine and cellular longevity.
2021; 2021(?):6643615. doi:
10.1155/2021/6643615. [PMID: 34093960] - Xiaomei Yang, Yun Li, Lin Chen, Mingguo Xu, Jianbo Wu, Peng Zhang, Deon Nel, Baozhu Sun. Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Pharmaceutical biology.
2020 Dec; 58(1):686-694. doi:
10.1080/13880209.2020.1784237. [PMID: 32658590] - Lu Yu, Zhili Liu, Wendi He, Huifen Chen, Zelin Lai, Yanhong Duan, Xiaohua Cao, Jie Tao, Chuan Xu, Qiujuan Zhang, Zheng Zhao, Jun Zhang. Hydroxysafflor Yellow A Confers Neuroprotection from Focal Cerebral Ischemia by Modulating the Crosstalk Between JAK2/STAT3 and SOCS3 Signaling Pathways.
Cellular and molecular neurobiology.
2020 Nov; 40(8):1271-1281. doi:
10.1007/s10571-020-00812-7. [PMID: 32060857] - Xiaomei Yang, Lin Chen, Yun Li, Feng Gao, Zhibo Yan, Peng Zhang, Jianbo Wu, Huanliang Wang, Baozhu Sun. Protective effect of Hydroxysafflor Yellow A on cerebral ischemia reperfusion-injury by regulating GSK3β-mediated pathways.
Neuroscience letters.
2020 09; 736(?):135258. doi:
10.1016/j.neulet.2020.135258. [PMID: 32693014] - Fei Min, Hequn Sun, Bo Wang, Naveed Ahmad, Hao Guo, Hongtao Gao, Yanyan Gao, Xin Liu, Haiyan Li. Hepatoprotective effects of hydroxysafflor yellow A in D-galactose-treated aging mice.
European journal of pharmacology.
2020 Aug; 881(?):173214. doi:
10.1016/j.ejphar.2020.173214. [PMID: 32454116] - Ling Lin, Manfei Xu, Lijuan Ma, Jingqi Zeng, Fangyu Zhang, Yanjiang Qiao, Zhisheng Wu. A rapid analysis method of safflower (Carthamus tinctorius L.) using combination of computer vision and near-infrared.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Aug; 236(?):118360. doi:
10.1016/j.saa.2020.118360. [PMID: 32330825] - Jianfeng Yang, Rui Wang, Xiaohan Cheng, HuiChong Qu, Jing Qi, Dan Li, Yan Xing, Yuhua Bai, Xiaodong Zheng. The vascular dilatation induced by Hydroxysafflor yellow A (HSYA) on rat mesenteric artery through TRPV4-dependent calcium influx in endothelial cells.
Journal of ethnopharmacology.
2020 Jun; 256(?):112790. doi:
10.1016/j.jep.2020.112790. [PMID: 32234595] - Ming-Zhe Hu, Zi-Yi Zhou, Zhong-Yu Zhou, Hui Lu, Min Gao, Long-Min Liu, Hai-Qing Song, An-Ji Lin, Qing-Ming Wu, Hong-Fei Zhou, Lei Li, Xia Wang, Ye-Feng Cai. Effect and Safety of Hydroxysafflor Yellow A for Injection in Patients with Acute Ischemic Stroke of Blood Stasis Syndrome: A Phase II, Multicenter, Randomized, Double-Blind, Multiple-Dose, Active-Controlled Clinical Trial.
Chinese journal of integrative medicine.
2020 Jun; 26(6):420-427. doi:
10.1007/s11655-020-3094-7. [PMID: 32361934] - Chenxia Sheng, Weijun Peng, Zian Xia, Yang Wang. Plasma and cerebrospinal fluid pharmacokinetics of hydroxysafflor yellow A in patients with traumatic brain injury after intravenous administration of Xuebijing using LC-MS/MS method.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 May; 50(5):545-551. doi:
10.1080/00498254.2019.1668983. [PMID: 31524030] - Yangyang Zhang, Li Yu, Weifeng Jin, Chang Li, Yu Wang, Haitong Wan, Jiehong Yang. Simultaneous Optimization of the Ultrasonic Extraction Method and Determination of the Antioxidant Activities of Hydroxysafflor Yellow A and Anhydrosafflor Yellow B from Safflower Using a Response Surface Methodology.
Molecules (Basel, Switzerland).
2020 Mar; 25(5):. doi:
10.3390/molecules25051226. [PMID: 32182800] - Man Luo, Ji-Cheng Huang, Zhan-Qing Yang, Yu-Si Wang, Bin Guo, Zhan-Peng Yue. Hydroxysafflor yellow A exerts beneficial effects by restoring hormone secretion and alleviating oxidative stress in polycystic ovary syndrome mice.
Experimental physiology.
2020 02; 105(2):282-292. doi:
10.1113/ep088147. [PMID: 31803965] - Yun-Peng Wang, Yu Guo, Ping-Shan Wen, Zhen-Zhen Zhao, Jian Xie, Kai Yang, Qing Yang, Jia-Feng Wang, Xiao-Ming Deng. Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide.
Mediators of inflammation.
2020; 2020(?):2720369. doi:
10.1155/2020/2720369. [PMID: 32189992] - Maosheng Lee, Hengxia Zhao, Xuemei Liu, Deliang Liu, Jianping Chen, Zengying Li, Shufang Chu, Xinhui Kou, Si Liao, Yuxiu Deng, Huilin Li, Weidong Xie. Protective Effect of Hydroxysafflor Yellow A on Nephropathy by Attenuating Oxidative Stress and Inhibiting Apoptosis in Induced Type 2 Diabetes in Rat.
Oxidative medicine and cellular longevity.
2020; 2020(?):7805393. doi:
10.1155/2020/7805393. [PMID: 32256962] - Hang Xu, Tianlong Liu, Wenjun Wang, Ning Su, Liudi Yang, Zhifu Yang, Fang Dou, Jia Cui, Fei Fei, Jing Ma, Aidong Wen, Yi Ding. Proteomic Analysis of Hydroxysafflor Yellow A Against Cerebral Ischemia/Reperfusion Injury in Rats.
Rejuvenation research.
2019 Dec; 22(6):503-512. doi:
10.1089/rej.2018.2145. [PMID: 30712471] - Lan Luo, Jiazhen Kang, Weijun Zhao, Yue Qi, Shengwang Liang. Validated LC-MS/MS method for simultaneous quantification of seven components of Naodesheng in rat serum after oral administration and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2019 Sep; 174(?):1-7. doi:
10.1016/j.jpba.2019.05.036. [PMID: 31153133] - Xinjing Guo, Meng Zheng, Ruiyan Pan, Baoxia Zang, Jianwei Gao, Hanying Ma, Ming Jin. Hydroxysafflor yellow A (HSYA) targets the platelet-activating factor (PAF) receptor and inhibits human bronchial smooth muscle activation induced by PAF.
Food & function.
2019 Aug; 10(8):4661-4673. doi:
10.1039/c9fo00896a. [PMID: 31292579] - Hongbo Li, Yanan Liu, Minyong Wen, Fu Zhao, Zhihui Zhao, Yunsong Liu, Xinfeng Lin, Lin Wang. Hydroxysafflor yellow A (HSYA) alleviates apoptosis and autophagy of neural stem cells induced by heat stress via p38 MAPK/MK2/Hsp27-78 signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jun; 114(?):108815. doi:
10.1016/j.biopha.2019.108815. [PMID: 30954890] - Ming Jiang, Li-Yang Zhou, Nan Xu, Qing An. Hydroxysafflor yellow A inhibited lipopolysaccharide-induced non-small cell lung cancer cell proliferation, migration, and invasion by suppressing the PI3K/AKT/mTOR and ERK/MAPK signaling pathways.
Thoracic cancer.
2019 06; 10(6):1319-1333. doi:
10.1111/1759-7714.13019. [PMID: 31055884] - Suning Chen, Mao Sun, Xianghui Zhao, Zhifu Yang, Wenxing Liu, Jinyi Cao, Yi Qiao, Xiaoxing Luo, Aidong Wen. Neuroprotection of hydroxysafflor yellow A in experimental cerebral ischemia/reperfusion injury via metabolic inhibition of phenylalanine and mitochondrial biogenesis.
Molecular medicine reports.
2019 Apr; 19(4):3009-3020. doi:
10.3892/mmr.2019.9959. [PMID: 30816517] - Ya-Li Wang, Qian Zhang, Shi-Jun Yin, Liang Cai, Yu-Xiu Yang, Wen-Jing Liu, Yuan-Jia Hu, Hua Chen, Feng-Qing Yang. Screening of blood-activating active components from Danshen-Honghua herbal pair by spectrum-effect relationship analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Feb; 54(?):149-158. doi:
10.1016/j.phymed.2018.09.176. [PMID: 30668364] - Lihua Zuo, Zhi Sun, Zhenhui Wang, Daling Ding, Tanye Xu, Liwei Liu, Li Gao, Shuzhang Du, Jian Kang, Xiaojian Zhang. Tissue distribution profiles of multiple major bioactive components in rats after intravenous administration of Xuebijing injection by UHPLC-Q-Orbitrap HRMS.
Biomedical chromatography : BMC.
2019 Feb; 33(2):e4400. doi:
10.1002/bmc.4400. [PMID: 30255561] - Chuanjun Qu, Weiwei Zhu, Kaijie Dong, Zhaohai Pan, Ying Chen, Xiaoyu Chen, Xiaona Liu, Wenjuan Xu, Haiyan Lin, Qiusheng Zheng, Defang Li. Inhibitory Effect of Hydroxysafflor Yellow B on the Proliferation of Human Breast Cancer MCF-7 Cells.
Recent patents on anti-cancer drug discovery.
2019; 14(2):187-197. doi:
10.2174/1574891x14666190516102218. [PMID: 31096897] - Ying Zhao, Hanchen Sun, Xiaosai Li, Yumei Zha, Weikai Hou. Hydroxysafflor yellow A attenuates high glucose-induced pancreatic β-cells oxidative damage via inhibiting JNK/c-jun signaling pathway.
Biochemical and biophysical research communications.
2018 10; 505(2):353-359. doi:
10.1016/j.bbrc.2018.09.036. [PMID: 30249395] - Rui Liu, Tingting Zhao, Delu Che, Jiao Cao, Jue Wang, Yanni Lv, Pengyu Ma, Yuanyuan Ding, Nana Wang, Xiaoyang Wang, Nan Wang, Jianli Wang, Zijun Gao, Tao Zhang. The anti-anaphylactoid effects of hydroxysafflor yellow A on the suppression of mast cell Ca2+ influx and degranulation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Sep; 48(?):43-50. doi:
10.1016/j.phymed.2018.05.009. [PMID: 30195879] - Zhi-Chao Hu, Zhong-Jie Xie, Qian Tang, Xiao-Bin Li, Xin Fu, Zhen-Hua Feng, Jiang-Wei Xuan, Wen-Fei Ni, Ai-Min Wu. Hydroxysafflor yellow A (HSYA) targets the NF-κB and MAPK pathways and ameliorates the development of osteoarthritis.
Food & function.
2018 Aug; 9(8):4443-4456. doi:
10.1039/c8fo00732b. [PMID: 30070297] - Juan Liu, Shijun Yue, Zhirui Yang, Wuwen Feng, Xintong Meng, Aiting Wang, Cheng Peng, Changyun Wang, Dan Yan. Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism.
Pharmacological research.
2018 08; 134(?):40-50. doi:
10.1016/j.phrs.2018.05.012. [PMID: 29787870] - Juan Bai, Jinyi Zhao, Dongxiao Cui, Fan Wang, Ying Song, Lianghua Cheng, Kai Gao, Jin Wang, Long Li, Shujun Li, Yanyan Jia, Aidong Wen. Protective effect of hydroxysafflor yellow A against acute kidney injury via the TLR4/NF-κB signaling pathway.
Scientific reports.
2018 06; 8(1):9173. doi:
10.1038/s41598-018-27217-3. [PMID: 29907783] - Tian Wang, Yu-Xin Ding, Jie He, Cheng-Jun Ma, Yue Zhao, Zhen-Hua Wang, Bing Han. Hydroxysafflor Yellow A Attenuates Lipopolysaccharide-Induced Neurotoxicity and Neuroinflammation in Primary Mesencephalic Cultures.
Molecules (Basel, Switzerland).
2018 May; 23(5):. doi:
10.3390/molecules23051210. [PMID: 29783643] - Yingying Xu, Jinhyuk Lee, Yong-Doo Park, Jun-Mo Yang, Jimin Zheng, Qian Zhang. Molecular dynamics simulation integrating the inhibition kinetics of hydroxysafflor yellow A on α-glucosidase.
Journal of biomolecular structure & dynamics.
2018 03; 36(4):830-840. doi:
10.1080/07391102.2017.1300544. [PMID: 28264629] - Li Liu, Na Si, YiCong Ma, DongYu Ge, Xue Yu, AngRan Fan, Xu Wang, JingHong Hu, Peng Wei, Long Ma, ZiWei Chen, Qian Zhang, CuiLing Feng. Hydroxysafflor-Yellow A Induces Human Gastric Carcinoma BGC-823 Cell Apoptosis by Activating Peroxisome Proliferator-Activated Receptor Gamma (PPARγ).
Medical science monitor : international medical journal of experimental and clinical research.
2018 Feb; 24(?):803-811. doi:
10.12659/msm.905587. [PMID: 29417935] - Liang Wu, Yuping Tang, Chenxiao Shan, Chuan Chai, Zhu Zhou, Xuqin Shi, Ning Ding, Jiaying Wang, Liping Lin, Renxiang Tan. A comprehensive in vitro and in vivo metabolism study of hydroxysafflor yellow A.
Journal of mass spectrometry : JMS.
2018 Feb; 53(2):99-108. doi:
10.1002/jms.4041. [PMID: 29076598] - Bingxiang Zhao, Sufang Gu, Yong Du, Minjie Shen, Xiangrui Liu, Youqing Shen. Solid lipid nanoparticles as carriers for oral delivery of hydroxysafflor yellow A.
International journal of pharmaceutics.
2018 Jan; 535(1-2):164-171. doi:
10.1016/j.ijpharm.2017.10.040. [PMID: 29107614] - Jing Zhou, Min Li, Weifeng Jin, Xiaohong Li, Hongjin Fan, Yuyan Zhang. Pharmacokinetic Study on Protocatechuic Aldehyde and Hydroxysafflor Yellow A of Danhong Injection in Rats with Hyperlipidemia.
Pharmacology.
2018; 102(3-4):154-160. doi:
10.1159/000491020. [PMID: 30045035] - Ming Jin, Lin Wang, Yan Wu, Bao-Xia Zang, Li Tan. Protective effect of hydroxysafflor yellow A on bleomycin- induced pulmonary inflammation and fibrosis in rats.
Chinese journal of integrative medicine.
2018 Jan; 24(1):32-39. doi:
10.1007/s11655-017-2094-z. [PMID: 29294256] - Weiling Pu, Huijie Zhang, Meng Wang, Yanan Liu, Lili Sun, Xiaoliang Ren. Superior Stability of Hydroxysafflor Yellow A in Xuebijing Injection and the Associated Mechanism.
Molecules (Basel, Switzerland).
2017 Dec; 22(12):. doi:
10.3390/molecules22122129. [PMID: 29207486] - Hong-Jing Fan, Li Yu, Wei-Feng Jin, Min Li, Jing Zhou, Xiao-Hong Li, Yu-Yan Zhang. [Pharmacokinetics-pharmacodynamics correlation of protocatechuic aldehyde and hydroxysafflor yellow A alone or their combination use in rats with hyperlipidemia].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Jul; 42(13):2564-2570. doi:
10.19540/j.cnki.cjcmm.20170523.008. [PMID: 28840700] - Jun-Peng Pei, Li-Hong Fan, Kai Nan, Jia Li, Xiao-Qian Dang, Kun-Zheng Wang. HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury.
Journal of neuroinflammation.
2017 05; 14(1):97. doi:
10.1186/s12974-017-0870-1. [PMID: 28468657] - Fang Dong, Changjiang Xue, Yu Wang, Yuanyuan Peng, Yadan Zhang, Ming Jin, Baoxia Zang. Hydroxysafflor yellow A attenuates the expression of inflammatory cytokines in acute soft tissue injury.
Scientific reports.
2017 01; 7(?):40584. doi:
10.1038/srep40584. [PMID: 28074914] - Yanuo Li, Yan Shi, Yan Sun, Luying Liu, Xianyong Bai, Dong Wang, Hongxing Li. Restorative effects of hydroxysafflor yellow A on hepatic function in an experimental regression model of hepatic fibrosis induced by carbon tetrachloride.
Molecular medicine reports.
2017 Jan; 15(1):47-56. doi:
10.3892/mmr.2016.5965. [PMID: 27909717] - Yadan Zhang, Lijuan Song, Ruiyan Pan, Jianwei Gao, Bao-Xia Zang, Ming Jin. Hydroxysafflor Yellow A Alleviates Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Mice.
Biological & pharmaceutical bulletin.
2017; 40(2):135-144. doi:
10.1248/bpb.b16-00329. [PMID: 28154251] - Bin-Feng Cheng, Yao-Xin Gao, Jun-Jiang Lian, Dan-Dan Guo, Lei Wang, Mian Wang, Hai-Jie Yang, Zhi-Wei Feng. Hydroxysafflor yellow A inhibits IL-1β-induced release of IL-6, IL-8, and MMP-1 via suppression of ERK, NF-κB and AP-1 signaling in SW982 human synovial cells.
Food & function.
2016 Nov; 7(11):4516-4522. doi:
10.1039/c6fo01045h. [PMID: 27713966] - Cheng Qu, Lin-Yan Wang, Wen-Tao Jin, Yu-Ping Tang, Yi Jin, Xu-Qin Shi, Li-Li Shang, Er-Xin Shang, Jin-Ao Duan. Comparative Analysis of the Effects of Hydroxysafflor Yellow A and Anhydrosafflor Yellow B in Safflower Series of Herb Pairs Using Prep-HPLC and a Selective Knock-Out Approach.
Molecules (Basel, Switzerland).
2016 Nov; 21(11):. doi:
10.3390/molecules21111480. [PMID: 27827969] - Yang Wang, Chunhu Zhang, Weijun Peng, Zian Xia, Pingping Gan, Wei Huang, Yafei Shi, Rong Fan. Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury.
Molecular medicine reports.
2016 Oct; 14(4):3690-6. doi:
10.3892/mmr.2016.5720. [PMID: 27599591] - Tianxin Hu, Guo Wei, Miaomiao Xi, Jiajia Yan, Xiaoxiao Wu, Yanhua Wang, Yanrong Zhu, Chao Wang, Aidong Wen. Synergistic cardioprotective effects of Danshensu and hydroxysafflor yellow A against myocardial ischemia-reperfusion injury are mediated through the Akt/Nrf2/HO-1 pathway.
International journal of molecular medicine.
2016 Jul; 38(1):83-94. doi:
10.3892/ijmm.2016.2584. [PMID: 27176815] - Lei Li, Pengda Dong, Congjia Hou, Fangyuan Cao, Shouli Sun, Fa He, Yanping Song, Sen Li, Yuhua Bai, Daling Zhu. Hydroxysafflor yellow A (HSYA) attenuates hypoxic pulmonary arterial remodelling and reverses right ventricular hypertrophy in rats.
Journal of ethnopharmacology.
2016 Jun; 186(?):224-233. doi:
10.1016/j.jep.2016.04.004. [PMID: 27063983] - Yi Jin, Liang Wu, Yuping Tang, Yujie Cao, Shujiao Li, Juan Shen, Shijun Yue, Cheng Qu, Chenxiao Shan, Xiaobing Cui, Li Zhang, Jin-ao Duan. UFLC-Q-TOF/MS based screening and identification of the metabolites in plasma, bile, urine and feces of normal and blood stasis rats after oral administration of hydroxysafflor yellow A.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Feb; 1012-1013(?):124-9. doi:
10.1016/j.jchromb.2016.01.023. [PMID: 26827279] - Tangting Chen, Ni Chen, Ningbo Pang, Lamei Xiao, Yongjie Li, Rong Li, Mao Luo, Xin Deng, Meiping Ren, Jianbo Wu, Liqun Wang. Hydroxysafflor Yellow A Promotes Angiogenesis via the Angiopoietin 1/ Tie-2 Signaling Pathway.
Journal of vascular research.
2016; 53(5-6):245-254. doi:
10.1159/000452408. [PMID: 27894114] - Naping Hu, Jialin Duan, Huihui Li, Yanhua Wang, Fang Wang, Jianjie Chu, Jin Sun, Meiyou Liu, Chao Wang, Chengtao Lu, Aidong Wen. Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition.
PloS one.
2016; 11(4):e0153409. doi:
10.1371/journal.pone.0153409. [PMID: 27088510] - Le-Le Zhang, Ke Tian, Zheng-Hai Tang, Xiao-Jia Chen, Zhao-Xiang Bian, Yi-Tao Wang, Jin-Jian Lu. Phytochemistry and Pharmacology of Carthamus tinctorius L.
The American journal of Chinese medicine.
2016; 44(2):197-226. doi:
10.1142/s0192415x16500130. [PMID: 27080938] - Xiaolong Xu, Yuhong Guo, Jingxia Zhao, Ning Wang, Junying Ding, Qingquan Liu. Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages.
Mediators of inflammation.
2016; 2016(?):8172706. doi:
10.1155/2016/8172706. [PMID: 27433030] - Guan-nan Ma, Fang-lin Yu, Shan Wang, Zhi-ping Li, Xiang-yang Xie, Xing-guo Mei. A novel oral preparation of hydroxysafflor yellow A base on a chitosan complex: a strategy to enhance the oral bioavailability.
AAPS PharmSciTech.
2015 Jun; 16(3):675-82. doi:
10.1208/s12249-014-0255-z. [PMID: 25511808] - Fangfang Yang, Jingmin Li, Jinhui Zhu, Dong Wang, Shaoshui Chen, Xianyong Bai. Hydroxysafflor yellow A inhibits angiogenesis of hepatocellular carcinoma via blocking ERK/MAPK and NF-κB signaling pathway in H22 tumor-bearing mice.
European journal of pharmacology.
2015 May; 754(?):105-14. doi:
10.1016/j.ejphar.2015.02.015. [PMID: 25720342] - Chang-Yin Li, Jun-Gang Yin, Jun Zhang, Xiao-Xiao Wang, Mei-Juan Xu, Fang Liu, Jian-Dong Zou, Wen-Zheng Ju. Pharmacokinetic profiles of hydroxysafflor yellow A following intravenous administration of its pure preparations in healthy Chinese volunteers.
Journal of ethnopharmacology.
2015 Mar; 162(?):225-30. doi:
10.1016/j.jep.2014.12.068. [PMID: 25576896] - Yanhao He, Qiang Liu, Yanxiang Li, Xiaofeng Yang, Weirong Wang, Tingting Li, Wei Zhang, Yuexin Cui, Chaoyun Wang, Rong Lin. Protective effects of hydroxysafflor yellow A (HSYA) on alcohol-induced liver injury in rats.
Journal of physiology and biochemistry.
2015 Mar; 71(1):69-78. doi:
10.1007/s13105-015-0382-3. [PMID: 25626885] - Jia Hao, Yingyue Zhang, Xingrui Wang, Huo Yan, Erwei Liu, Xiumei Gao. Interaction between the Natural Components in Danhong Injection (DHI) with Serum Albumin (SA) and the Influence of the Coexisting Multi-Components on the SaB-BSA Binding System: Fluorescence and Molecular Docking Studies.
PloS one.
2015; 10(6):e0128919. doi:
10.1371/journal.pone.0128919. [PMID: 26035712] - Chang-Yin Li, Ji-Hong Chu, Jun Zhang, Bing-Ting Sun, Guo-Liang Dai, Shi-Jia Liu, Wen-Zheng Ju. Measurement of hydroxysafflor yellow A in human urine by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Jan; 974(?):131-7. doi:
10.1016/j.jchromb.2014.10.036. [PMID: 25463208] - Ya-Li Liu, Ya-Juan Liu, Yang Liu, Xue-Song Li, Shuan-Hu Liu, Yong-Gui Pan, Jian Zhang, Qiang Liu, Ying-Yan Hao. Hydroxysafflor yellow A ameliorates lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathways.
International immunopharmacology.
2014 Dec; 23(2):649-57. doi:
10.1016/j.intimp.2014.10.018. [PMID: 25466274] - Shi-Jun Yue, Yu-Ping Tang, Lin-Yan Wang, Hao Tang, Shu-Jiao Li, Pei Liu, Shu-Lan Su, Jin-Ao Duan. [Separation and evaluation of antioxidant constituents from Carthamus tinctorius].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Sep; 39(17):3295-300. doi:
. [PMID: 25522615] - Q Liu, C Y Wang, Z Liu, X S Ma, Y H He, S S Chen, X Y Bai. Hydroxysafflor yellow A suppresses liver fibrosis induced by carbon tetrachloride with high-fat diet by regulating PPAR-γ/p38 MAPK signaling.
Pharmaceutical biology.
2014 Sep; 52(9):1085-93. doi:
10.3109/13880209.2013.877491. [PMID: 24618007] - Yanmin Song, Lili Long, Ning Zhang, Yunhai Liu. Inhibitory effects of hydroxysafflor yellow A on PDGF‑BB‑induced proliferation and migration of vascular smooth muscle cells via mediating Akt signaling.
Molecular medicine reports.
2014 Sep; 10(3):1555-60. doi:
10.3892/mmr.2014.2336. [PMID: 24939805] - Yong Guo, Yang Wang, Xi Huang, Huiying Lv, Rong Fan, Wei Huang, Pingping Gan, Wei Liu, Kuipo Yan, Zian Xia, Jinfang Liu. Determination of hydroxysafflor yellow A in biological fluids of patients with traumatic brain injury by UPLC-ESI-MS/MS after injection of Xuebijing.
Biomedical chromatography : BMC.
2014 Aug; 28(8):1090-5. doi:
10.1002/bmc.3124. [PMID: 24535782] - Zuo-Hui Zhang, Lin-Jie Yu, Xin-Chen Hui, Zheng-Zheng Wu, Kai-Lin Yin, Hui Yang, Yun Xu. Hydroxy-safflor yellow A attenuates Aβ₁₋₄₂-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway.
Brain research.
2014 May; 1563(?):72-80. doi:
10.1016/j.brainres.2014.03.036. [PMID: 24690200] - Hui-juan Zhu, Lin-jie Wang, Xiang-qing Wang, Hui Pan, Nai-shi Li, Hong-bo Yang, Ming Jin, Bao-xia Zang, Feng-ying Gong. Hormone-sensitive lipase is involved in the action of hydroxysafflor yellow A (HYSA) inhibiting adipogenesis of 3T3-L1cells.
Fitoterapia.
2014 Mar; 93(?):182-8. doi:
10.1016/j.fitote.2014.01.001. [PMID: 24440907] - Chaoyun Wang, Chunhua Wang, Chunlei Ma, Qingxian Huang, Hongliu Sun, Xiaomin Zhang, Xianyong Bai. Hydroxysafflor yellow A of Carthamus tinctorius attenuates lung injury of aged rats exposed to gasoline engine exhaust by down-regulating platelet activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Feb; 21(3):199-206. doi:
10.1016/j.phymed.2013.09.018. [PMID: 24192212] - Ren-Ai Xu, Zhi-Sheng Xu, Ren-Shan Ge. Effects of hydroxysafflor yellow A on the activity and mRNA expression of four CYP isozymes in rats.
Journal of ethnopharmacology.
2014 Feb; 151(3):1141-1146. doi:
10.1016/j.jep.2013.12.025. [PMID: 24373810] - Jianping Wang, Qing Zhang, Xiuhua Mei, Xiuzhen Zhang. Hydroxysafflor yellow A attenuates left ventricular remodeling after pressure overload-induced cardiac hypertrophy in rats.
Pharmaceutical biology.
2014 Jan; 52(1):31-5. doi:
10.3109/13880209.2013.805791. [PMID: 24033225] - Shujun Jiang, Zhen Shi, Changyong Li, Chunlei Ma, Xianyong Bai, Chaoyun Wang. Hydroxysafflor yellow A attenuates ischemia/reperfusion-induced liver injury by suppressing macrophage activation.
International journal of clinical and experimental pathology.
2014; 7(5):2595-608. doi:
". [PMID: 24966974] - Li Sun, Li Yang, Ying Fu, Jing Han, Yanwei Xu, Hao Liang, Yan Cheng. Capacity of HSYA to inhibit nitrotyrosine formation induced by focal ischemic brain injury.
Nitric oxide : biology and chemistry.
2013 Nov; 35(?):144-51. doi:
10.1016/j.niox.2013.10.002. [PMID: 24126016] - Lin Chen, Yanxiao Xiang, Lingjun Kong, Xiumei Zhang, Baozhu Sun, Xinbing Wei, Huiqing Liu. Hydroxysafflor yellow A protects against cerebral ischemia-reperfusion injury by anti-apoptotic effect through PI3K/Akt/GSK3β pathway in rat.
Neurochemical research.
2013 Nov; 38(11):2268-75. doi:
10.1007/s11064-013-1135-8. [PMID: 23990223] - Zi-Ming Feng, Jun He, Jian-Shuang Jiang, Zhong Chen, Ya-Nan Yang, Pei-Cheng Zhang. NMR solution structure study of the representative component hydroxysafflor yellow A and other quinochalcone C-glycosides from Carthamus tinctorius.
Journal of natural products.
2013 Feb; 76(2):270-4. doi:
10.1021/np300814k. [PMID: 23387865] - Zhu Jin, Wenhui Zhang, Weiran Chai, Yanqian Zheng, Jianming Zhi. Antibodies against AT1 receptors are associated with vascular endothelial and smooth muscle function impairment: protective effects of hydroxysafflor yellow A.
PloS one.
2013; 8(6):e67020. doi:
10.1371/journal.pone.0067020. [PMID: 23826187] - Li Xia, Xiang-Mei Chen, Li-Rong Peng, Shi-Xiang Wang, Xiao-Wen Wang, Yan Zuo, Peng Zhang, Qin-She Liu, Xiao-Hui Zheng. [Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Jan; 38(2):269-72. doi:
NULL. [PMID: 23672054] - Chang-Lian Chen, Si-Le Hu. [HPLC determination of hydroxysafflor yellow A in Mongolian medicine Dedu Honghuaqiwei pill].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Dec; 37(23):3673-5. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2012 Jun; 32(2):243-8. doi:
10.1016/s0254-6272(13)60019-9. [PMID: 22876451]