Daruisoline (BioDeep_00000230491)

 

Secondary id: BioDeep_00000870716

PANOMIX_OTCML-2023


代谢物信息卡片


7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-, (R-(R*,R*))-

化学式: C37H42N2O6 (610.3042712000001)
中文名称: 蝙蝠葛苏林碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)O)O)OC)OC
InChI: InChI=1S/C37H42N2O6/c1-38-15-13-26-20-36(43-4)37(44-5)22-29(26)30(38)16-23-6-9-27(10-7-23)45-35-18-24(8-11-32(35)40)17-31-28-21-33(41)34(42-3)19-25(28)12-14-39(31)2/h6-11,18-22,30-31,40-41H,12-17H2,1-5H3/t30-,31-/m1/s1

描述信息

Daurisoline is a member of isoquinolines.
Daurisoline is a natural product found in Menispermum dauricum with data available.
Daurisoline is a hERG inhibitor and also an autophagy blocker.
Daurisoline is a hERG inhibitor and also an autophagy blocker.

同义名列表

7 个代谢物同义名

7-Isoquinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-, (R-(R*,R*))-; (R-(R*,R*))-1,2,3,4-Tetrahydro-1-((4-hydroxy-3-(4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)phenoxy)phenyl)methyl)-6-methoxy-2-methyl-7-isoquinolinol; (1R)-1-[[3-[4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]phenoxy]-4-hydroxyphenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol; O(sup 7)-Demethyldauricine; (R,R)-Daurisoline; Daruisoline; Daurisoline



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shuying Yuan, Yongfu Pan, Tong Xu, Li Zhang, Xihui Chen, Fengying Wang, Qian Liu, Lijun Jia. Daurisoline Inhibits ESCC by Inducing G1 Cell Cycle Arrest and Activating ER Stress to Trigger Noxa-Dependent Intrinsic and CHOP-DR5-Dependent Extrinsic Apoptosis via p-eIF2α-ATF4 Axis. Oxidative medicine and cellular longevity. 2022; 2022(?):5382263. doi: 10.1155/2022/5382263. [PMID: 35965681]
  • Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of natural products. 2021 03; 84(3):750-761. doi: 10.1021/acs.jnatprod.0c00946. [PMID: 33226219]
  • Qiangni Liu, Xiaofang Mao, Fandian Zeng, Si Jin, Xiaoyan Yang. Effect of daurisoline on HERG channel electrophysiological function and protein expression. Journal of natural products. 2012 Sep; 75(9):1539-45. doi: 10.1021/np300232b. [PMID: 22974355]
  • Qiang-Ni Liu, Li Zhang, Pei-Li Gong, Xiao-Yan Yang, Fan-Dian Zeng. Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium current. The American journal of Chinese medicine. 2010; 38(1):37-49. doi: 10.1142/s0192415x1000766x. [PMID: 20128043]
  • Xiang-Ying Kong, Pei-Li Gong. [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]. Yao xue xue bao = Acta pharmaceutica Sinica. 2005 Oct; 40(10):916-9. doi: NULL. [PMID: 16408809]
  • Shi-fen Gu, Shao-jun Shi, Hui Chen. [Determination of daurisoline in rabbit plasma and study on its pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Dec; 38(12):908-10. doi: . [PMID: 15040082]
  • Shao-Jun Shi, Hui Chen, Shi-Fen Gu, Fan-Dian Zeng. Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs. Acta pharmacologica Sinica. 2003 Oct; 24(10):1011-5. doi: . [PMID: 14531944]
  • Ling He, Guo-Qing Liu. Interaction of multidrug resistance reversal agents with P-glycoprotein ATPase activity on blood-brain barrier. Acta pharmacologica Sinica. 2002 May; 23(5):423-9. doi: . [PMID: 11978192]
  • S Chen, Y Yang, L Zhang, X Pang, Z Dai, F Zeng. A sensitive HPLC technique for the quantitation of dauricine. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao. 2000; 20(1):39-42. doi: 10.1007/bf02887672. [PMID: 12845753]
  • X Pan, C Hu, F Zeng, S Zhang, J Xu. [Isolation and identification of alkaloids form Menispermum dauricum growing in Xianning]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 1998 Sep; 21(9):456-8. doi: . [PMID: 12569837]
  • T Wang, H Mu, G Liu. [The anti-ischemic effect of O, O-acetyldaurisoline]. Yao xue xue bao = Acta pharmaceutica Sinica. 1998; 33(4):241-4. doi: ". [PMID: 11939060]