AcKBA (BioDeep_00000230372)
Secondary id: BioDeep_00000018189, BioDeep_00000606747
PANOMIX_OTCML-2023
代谢物信息卡片
(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid
化学式: C32H48O5 (512.3502)
中文名称: 11-羰基-β-乙酰乳香酸, 乳香, 3-乙酰基-11-酮基-β-乳香酸, 乙酰基-11-酮基-β-乳香酸, 11-羰基-Β-乙酰乳香酸, 乙酰基-11-酮基-beta-乳香酸
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 85.12%
分子结构信息
SMILES: C1[C@@]2(C)[C@@]([H])(CC[C@]3(C)[C@]2([H])C(=O)C=C2[C@@]3(C)CC[C@]3(C)[C@@]2([H])[C@@H](C)[C@H](C)CC3)[C@@](C)(C(=O)O)[C@H](OC(=O)C)C1
InChI: InChI=1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
描述信息
3-Acetyl-11-keto-beta-boswellic acid is a triterpenoid.
3-Acetyl-11-keto-beta-boswellic acid is a natural product found in Boswellia papyrifera, Boswellia sacra, and Boswellia serrata with data available.
See also: Indian frankincense (part of).
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
AKBA (Acetyl-11-keto-β-boswellic acid) is an active triterpenoid compound from the extract of Boswellia serrate and a novel Nrf2 activator.
同义名列表
45 个代谢物同义名
(3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid; (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetyloxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4a,5,6,7,8,9,10,11,12,12a,14a-tetradecahydropicene-4-carboxylic acid; 3-Acetyl-11-keto-beta-boswellic acid, United States Pharmacopeia (USP) Reference Standard; 3-ACETYL-11-KETO-.BETA.-BOSWELLIC ACID (CONSTITUENT OF BOSWELLIA SERRATA) [DSC]; 3-ACETYL-11-KETO-beta-BOSWELLIC ACID (CONSTITUENT OF BOSWELLIA SERRATA); 3-O-Acetyl-11-keto-|A-boswellic acid; Acetyl-11-keto-|A-boswellic acid; URS-12-EN-23-OIC ACID, 3-(ACETYLOXY)-11-OXO-, (3.ALPHA.,4.BETA.)-; (3.ALPHA.,4.BETA.)-3-(ACETYLOXY)-11-OXOURS-12-EN-23-OIC ACID; 3-O-Acetyl-11-keto-beta-boswellic acid, analytical standard; (3alpha,4beta)-3-(ACETYLOXY)-11-OXOURS-12-EN-23-OIC ACID; Acetyl-11-keto- beta -Boswellic Acid, Boswellia serrata; Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata; (4R)-3alpha-acetoxy-11-oxo-urs-12-en-23-oic acid; 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID (USP-RS); 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID [USP-RS]; 3.ALPHA.-ACETYL-11-KETO-.BETA.-BOSWELLIC ACID; 3.ALPHA.-ACETOXY-11-OXO-12-URSEN-24-OIC ACID; 3alpha-acetoxy-11-keto-beta-boswellic acid; 3alpha-Acetoxy-11-oxo-12-ursen-24-oic acid; 3alpha-Acetyl-11-keto-beta-boswellic acid; 3-O-ACETYL-11-KETO-.BETA.-BOSWELLIC ACID; 3-Acetyl-11-keto-.beta.-boswellic acid; 3-O-Acetyl-11-keto-beta-Boswellic Acid; 11-KETO-.BETA.-BOSWELLIC ACID ACETATE; ACETYL-11-KETO-.BETA.-BOSWELLIC ACID; 3-ACETYL-11-KETO-beta-BOSWELLIC ACID; 3-O-Acetyl-11-keto-b-boswellic acid; ACETYL-11-OXO-.BETA.-BOSWELLIC ACID; acetyl-11-keto-beta-boswellic acid; 3-Acetyl-11-keto-ss-boswellic acid; 3-O-acetyl-11-keto-boswellic acid; ACETYL-11-OXO-beta-BOSWELLIC ACID; 3-Acetyl-11-keto-β-boswellic Acid; Acetyl-11-keto-b-boswellic acid; Acetyl-11-keto--boswellic acid; acetyl-11-keto-boswellic acid; acetyl-11-ketoboswellic acid; HMMGKOVEOFBCAU-BCDBGHSCSA-N; Acetyl-11-keto-β-boswellic; UNII-BS16QT99Q1; BS16QT99Q1; AKBA cpd; AcKBA; AKBA; Acetyl-11-keto-β-boswellic acid
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:166842
- PubChem: 71463896
- PubChem: 11168203
- ChEMBL: CHEMBL237111
- LipidMAPS: LMPR0106180024
- MeSH: acetyl-11-ketoboswellic acid
- ChemIDplus: 0067416619
- chemspider: 24022866
- CAS: 67416-61-9
- medchemexpress: HY-N0892
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 1461607 - Boswellia papyrifera: 10.1021/NP040142X
- 173701 - Boswellia sacra: 10.1080/10286020.2010.548808
- 613112 - Boswellia serrata:
- 33090 - Plants: -
- 80276 - 乳香: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jakob Lauß, Christoph Kappacher, Olivia Isser, Christian W Huck, Matthias Rainer. Species-Specific quantification of bioactive boswellic acids in Boswellia resin using NIR spectroscopy, HPLC and Multivariate data analysis.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Aug; 316(?):124384. doi:
10.1016/j.saa.2024.124384. [PMID: 38701576] - Chong Zhou, Yao Wang, Qiyuan Zhang, Guanghu Zhou, Xianglin Ma, Xiaowen Jiang, Wenhui Yu. Acetyl-11-Keto-Beta-Boswellic Acid Activates the Nrf2/HO-1 Signaling Pathway in Schwann Cells to Reduce Oxidative Stress and Promote Sciatic Nerve Injury Repair.
Planta medica.
2023 Dec; 89(15):1468-1482. doi:
10.1055/a-2148-7427. [PMID: 37541437] - Reza Ataei Kachouei, Alireza Doagoo, Maral Jalilzadeh, Seyyed Hossein Khatami, Shima Rajaei, Ali Jahanbazi Jahan-Abad, Farzaneh Salmani, Roya Pakrad, Somayeh Mahmoodi Baram, Mitra Nourbakhsh, Mohammad-Amin Abdollahifar, Hojjat Allah Abbaszadeh, Shokoofeh Noori, Mitra Rezaei, Meisam Mahdavi, Mohammad Reza Shahmohammadi, Saeed Karima. Acetyl-11-Keto-Beta-Boswellic Acid Has Therapeutic Benefits for NAFLD Rat Models That Were Given a High Fructose Diet by Ameliorating Hepatic Inflammation and Lipid Metabolism.
Inflammation.
2023 Jun; ?(?):. doi:
10.1007/s10753-023-01853-y. [PMID: 37310644] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - Friedemann Börner, Simona Pace, Paul M Jordan, Jana Gerstmeier, Mario Gomez, Antonietta Rossi, Nathaniel C Gilbert, Marcia E Newcomer, Oliver Werz. Allosteric Activation of 15-Lipoxygenase-1 by Boswellic Acid Induces the Lipid Mediator Class Switch to Promote Resolution of Inflammation.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2023 02; 10(6):e2205604. doi:
10.1002/advs.202205604. [PMID: 36567268] - Jiao Song, Wei Liao, Xuan Deng, Dingkun Zhang, Junzhi Lin, Runchun Xu, Li Han. Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics.
Journal of ethnopharmacology.
2023 Jan; 300(?):115723. doi:
10.1016/j.jep.2022.115723. [PMID: 36115600] - Akhalesh Kumar, Saurabh Sharma, Sudhanshu Mishra, Smriti Ojha, Pawan Upadhyay. ADME Prediction, Structure-activity Relationship of Boswellic Acid Scaffold for the Aspect of Anticancer & Anti-inflammatory Potency.
Anti-cancer agents in medicinal chemistry.
2023; 23(13):1499-1505. doi:
10.2174/1871520623666230417080437. [PMID: 37070442] - Yuqing Gong, Xinyi Jiang, Suibi Yang, Yue Huang, Jinhui Hong, Yanxiu Ma, Xin Fang, Yong Fang, Jing Wu. The Biological Activity of 3-O-Acetyl-11-keto-β-Boswellic Acid in Nervous System Diseases.
Neuromolecular medicine.
2022 12; 24(4):374-384. doi:
10.1007/s12017-022-08707-0. [PMID: 35303275] - Priti Bhardwaj, Manoj Kumar, Sunil Kumar Dhatwalia, Mohan Lal Garg, Devinder Kumar Dhawan. Protective role of AKBA against benzo(a)pyrene-induced lung carcinogenesis by modulating biotransformation enzymes and oxidative stress.
Journal of biochemical and molecular toxicology.
2022 Jul; 36(7):e23072. doi:
10.1002/jbt.23072. [PMID: 35437857] - Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Wedad Sarawi, Sabry M Attia, Wael A Alanazi, Khalid E Ibrahim, Sary Alsanea, Saleh A Alqarni, Ali S Alfardan, Saleh A Bakheet. Acetyl-11-keto-β-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-κB pathways in SJL/J mouse model of experimental autoimmune encephalomyelitis.
International immunopharmacology.
2022 Jun; 107(?):108703. doi:
10.1016/j.intimp.2022.108703. [PMID: 35306283] - Akinbobola Peace Otitoju, Ishaya Yohanna Longdet, Taiwo Emmanuel Alemika, Vikram Prakash Gota. Chloroform extract and acetyl-11-keto-beta-boswellic acid from Boswellia dalzielii stem bark induce apoptosis and cell cycle blockage in AW8507 cells.
Journal of the Egyptian National Cancer Institute.
2021 Aug; 33(1):20. doi:
10.1186/s43046-021-00075-3. [PMID: 34368899] - Hippolyt L Greve, Marcel Kaiser, Pascal Mäser, Thomas J Schmidt. Boswellic Acids Show In Vitro Activity against Leishmania donovani.
Molecules (Basel, Switzerland).
2021 Jun; 26(12):. doi:
10.3390/molecules26123651. [PMID: 34203815] - Jiawei Shi, Ye Gu, Yong Wang, Jiaxiang Bai, Longbin Xiong, Yunxia Tao, Yi Xue, Yaozeng Xu, Huilin Yang, Hongwei Ye, Dechun Geng. Inhibitory effect of acetyl-11-keto-β-boswellic acid on titanium particle-induced bone loss by abrogating osteoclast formation and downregulating the ERK signaling pathway.
International immunopharmacology.
2021 May; 94(?):107459. doi:
10.1016/j.intimp.2021.107459. [PMID: 33611061] - Nathaniel C Gilbert, Jana Gerstmeier, Erin E Schexnaydre, Friedemann Börner, Ulrike Garscha, David B Neau, Oliver Werz, Marcia E Newcomer. Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products.
Nature chemical biology.
2020 07; 16(7):783-790. doi:
10.1038/s41589-020-0544-7. [PMID: 32393899] - Umair Shamraiz, Hidayat Hussain, Najeeb Ur Rehman, Sulaiman Al-Shidhani, Aasim Saeed, Husain Yar Khan, Ajmal Khan, Lucie Fischer, René Csuk, Amin Badshah, Ahmed Al-Rawahi, Javid Hussain, Ahmed Al-Harrasi. Synthesis of new boswellic acid derivatives as potential antiproliferative agents.
Natural product research.
2020 Jul; 34(13):1845-1852. doi:
10.1080/14786419.2018.1564295. [PMID: 30691289] - Tarun Sharma, Snehasis Jana. A Validated LC-MS/MS Method for Simultaneous Determination of 3-O-Acetyl-11-Keto-β-Boswellic Acid (AKBA) and its Active Metabolite Acetyl-11-Hydroxy-β-Boswellic Acid (Ac-11-OH-BA) in Rat Plasma: Application to a Pharmacokinetic Study.
Journal of chromatographic science.
2020 Jun; 58(6):485-493. doi:
10.1093/chromsci/bmaa010. [PMID: 32134105] - Xiao Huang, Muhammad Farrukh Nisar, Mei Wang, Wenhong Wang, Long Chen, Mao Lin, Wei Xu, Qingchun Diao, Julia Li Zhong. UV-responsive AKBA@ZnO nanoparticles potential for polymorphous light eruption protection and therapy.
Materials science & engineering. C, Materials for biological applications.
2020 Feb; 107(?):110254. doi:
10.1016/j.msec.2019.110254. [PMID: 31761216] - Shikang Wang, Huijun Wang, Baoyou Sun, Duanfeng Li, Jing Wu, Juan Li, Xiaona Tian, Chengkun Qin, Hong Chang, Yongqing Liu. Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo.
Fundamental & clinical pharmacology.
2020 Feb; 34(1):65-76. doi:
10.1111/fcp.12488. [PMID: 31141202] - Arezoo Rajabian, Hamid Reza Sadeghnia, Azar Hosseini, Seyed Hadi Mousavi, Mohammad Taher Boroushaki. 3-Acetyl-11-keto-β-boswellic acid attenuated oxidative glutamate toxicity in neuron-like cell lines by apoptosis inhibition.
Journal of cellular biochemistry.
2020 02; 121(2):1778-1789. doi:
10.1002/jcb.29413. [PMID: 31642100] - Saif Ahmad, Shah Alam Khan, Adam Kindelin, Tasha Mohseni, Kanchan Bhatia, Md Nasrul Hoda, Andrew F Ducruet. Acetyl-11-keto-β-boswellic acid (AKBA) Attenuates Oxidative Stress, Inflammation, Complement Activation and Cell Death in Brain Endothelial Cells Following OGD/Reperfusion.
Neuromolecular medicine.
2019 12; 21(4):505-516. doi:
10.1007/s12017-019-08569-z. [PMID: 31515728] - Ajmal Khan, Ahmed Al-Harrasi, Najeeb Ur Rehman, Rizwana Sarwar, Touqeer Ahmad, Rukhsana Ghaffar, Haroon Khan, Issa Al-Amri, Rene Csuk, Ahmed Al-Rawahi. Loading AKBA on surface of silver nanoparticles to improve their sedative-hypnotic and anti-inflammatory efficacies.
Nanomedicine (London, England).
2019 11; 14(21):2783-2798. doi:
10.2217/nnm-2019-0211. [PMID: 31617445] - Priti Bhardwaj, Manoj Kumar, Sunil Kumar Dhatwalia, Mohan Lal Garg, Devinder Kumar Dhawan. Acetyl-11-keto-β-boswellic acid modulates membrane dynamics in benzo(a)pyrene-induced lung carcinogenesis.
Molecular and cellular biochemistry.
2019 Oct; 460(1-2):17-27. doi:
10.1007/s11010-019-03566-z. [PMID: 31165316] - Erin Miscioscia, Justin Shmalberg, Karen C Scott. Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs.
BMC veterinary research.
2019 Aug; 15(1):270. doi:
10.1186/s12917-019-2021-7. [PMID: 31370899] - Muhammed Majeed, Shaheen Majeed, Narayanan K Narayanan, Kalyanam Nagabhushanam. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee.
Phytotherapy research : PTR.
2019 May; 33(5):1457-1468. doi:
10.1002/ptr.6338. [PMID: 30838706] - Minna Liu, Tianlong Liu, Peijin Shang, Yikai Zhang, Limin Liu, Ting Liu, Shiren Sun. Acetyl-11-keto-β-boswellic acid ameliorates renal interstitial fibrosis via Klotho/TGF-β/Smad signalling pathway.
Journal of cellular and molecular medicine.
2018 10; 22(10):4997-5007. doi:
10.1111/jcmm.13766. [PMID: 30054990] - Ming-Xing Wang, Jing-Xia Zhao, Yu-Jiao Meng, Ting-Ting Di, Xiao-Long Xu, Xiang-Jiang Xie, Yan Lin, Lu Zhang, Ning Wang, Ping Li, Yan Wang. Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro.
Life sciences.
2018 Aug; 207(?):90-104. doi:
10.1016/j.lfs.2018.05.044. [PMID: 29859222] - Haroon Khan, Kannan R R Rengasamy, Aini Pervaiz, Seyed Mohammad Nabavi, Atanas G Atanasov, Mohammad A Kamal. Plant-derived mPGES-1 inhibitors or suppressors: A new emerging trend in the search for small molecules to combat inflammation.
European journal of medicinal chemistry.
2018 Jun; 153(?):2-28. doi:
10.1016/j.ejmech.2017.12.059. [PMID: 29329790] - Najeeb Ur Rehman, Liaqat Ali, Ahmed Al-Harrasi, Fazal Mabood, Muhammed Al-Broumi, Abdul Latif Khan, Hidayat Hussain, Javid Hussain, René Csuk. Quantification of AKBA in Boswellia sacra Using NIRS Coupled with PLSR as an Alternative Method and Cross-Validation by HPLC.
Phytochemical analysis : PCA.
2018 Mar; 29(2):137-143. doi:
10.1002/pca.2721. [PMID: 28881407] - Sefora Conti, Akiva Vexler, Liat Edry-Botzer, Lital Kalich-Philosoph, Benjamin W Corn, Natan Shtraus, Yaron Meir, Lior Hagoel, Alexander Shtabsky, Sylvia Marmor, Gideon Earon, Shahar Lev-Ari. Combined acetyl-11-keto-β-boswellic acid and radiation treatment inhibited glioblastoma tumor cells.
PloS one.
2018; 13(7):e0198627. doi:
10.1371/journal.pone.0198627. [PMID: 29969452] - Elia Ranzato, Simona Martinotti, Andrea Volante, Aldo Tava, Maria Angela Masini, Bruno Burlando. The major Boswellia serrata active 3-acetyl-11-keto-β-boswellic acid strengthens interleukin-1α upregulation of matrix metalloproteinase-9 via JNK MAP kinase activation.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2017 Dec; 36(?):176-182. doi:
10.1016/j.phymed.2017.09.010. [PMID: 29157812] - Sonali S Niphadkar, Virendra K Rathod. Adsorption kinetics, isotherm, and thermodynamics studies of acetyl-11-keto-β-boswellic acids (AKBA) from Boswellia serrata extract using macroporous resin.
Preparative biochemistry & biotechnology.
2017 Sep; 47(8):804-812. doi:
10.1080/10826068.2017.1342263. [PMID: 28662360] - Ulf Siemoneit, Lars Tausch, Daniel Poeckel, Michael Paul, Hinnak Northoff, Andreas Koeberle, Johann Jauch, Oliver Werz. Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.
Planta medica.
2017 Aug; 83(12-13):1020-1027. doi:
10.1055/s-0043-107884. [PMID: 28403501] - Gitu Pandey, Naresh Mittapelly, Guru Raghavendra Valicherla, Ravi Prakash Shukla, Shweta Sharma, Venkatesh Teja Banala, Sandeep Urandur, Arun Kumar Jajoriya, Kalyan Mitra, D P Mishra, J R Gayen, P R Mishra. P-gp modulatory acetyl-11-keto-β-boswellic acid based nanoemulsified carrier system for augmented oral chemotherapy of docetaxel.
Colloids and surfaces. B, Biointerfaces.
2017 Jul; 155(?):276-286. doi:
10.1016/j.colsurfb.2017.04.028. [PMID: 28437753] - Xia Xue, Fang Chen, Anxin Liu, Deqing Sun, Jing Wu, Feng Kong, Yun Luan, Xianjun Qu, Rongmei Wang. Reversal of the multidrug resistance of human ileocecal adenocarcinoma cells by acetyl-11-keto-β-boswellic acid via downregulation of P-glycoprotein signals.
Bioscience trends.
2016 Nov; 10(5):392-399. doi:
10.5582/bst.2016.01115. [PMID: 27545217] - Giuseppe Mannino, Andrea Occhipinti, Massimo E Maffei. Quantitative Determination of 3-O-Acetyl-11-Keto-βBoswellic Acid (AKBA) and Other Boswellic Acids in Boswellia sacra Flueck (syn. B. carteri Birdw) and Boswellia serrata Roxb.
Molecules (Basel, Switzerland).
2016 Oct; 21(10):. doi:
10.3390/molecules21101329. [PMID: 27782055] - Yi Ding, Youbei Qiao, Min Wang, Huinan Zhang, Liang Li, Yikai Zhang, Jie Ge, Ying Song, Yuwen Li, Aidong Wen. Enhanced Neuroprotection of Acetyl-11-Keto-β-Boswellic Acid (AKBA)-Loaded O-Carboxymethyl Chitosan Nanoparticles Through Antioxidant and Anti-Inflammatory Pathways.
Molecular neurobiology.
2016 08; 53(6):3842-3853. doi:
10.1007/s12035-015-9333-9. [PMID: 26162321] - Jürgen Meins, Christian Artaria, Antonella Riva, Paolo Morazzoni, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab. Survey on the Quality of the Top-Selling European and American Botanical Dietary Supplements Containing Boswellic Acids.
Planta medica.
2016 Apr; 82(6):573-9. doi:
10.1055/s-0042-103497. [PMID: 27054914] - Christine von Rhein, Tatjana Weidner, Lisa Henß, Judith Martin, Christopher Weber, Katja Sliva, Barbara S Schnierle. Curcumin and Boswellia serrata gum resin extract inhibit chikungunya and vesicular stomatitis virus infections in vitro.
Antiviral research.
2016 Jan; 125(?):51-7. doi:
10.1016/j.antiviral.2015.11.007. [PMID: 26611396] - Khemraj Bairwa, Sanjay Madhukar Jachak. Development and optimisation of 3-Acetyl-11-keto-β-boswellic acid loaded poly-lactic-co-glycolic acid-nanoparticles with enhanced oral bioavailability and in-vivo anti-inflammatory activity in rats.
The Journal of pharmacy and pharmacology.
2015 Sep; 67(9):1188-97. doi:
10.1111/jphp.12420. [PMID: 25851251] - Ying-Ni Pan, Xiao-Xu Liang, Li-Ying Niu, Yan-Nian Wang, Xin Tong, Hui-Ming Hua, Jiang Zheng, Dong-Ya Meng, Xiao-Qiu Liu. Comparative studies of pharmacokinetics and anticoagulatory effect in rats after oral administration of Frankincense and its processed products.
Journal of ethnopharmacology.
2015 Aug; 172(?):118-23. doi:
10.1016/j.jep.2015.06.029. [PMID: 26117531] - A M Shehata, L Quintanilla-Fend, S Bettio, J Jauch, T Scior, W A Scherbaum, H P T Ammon. 11-Keto-β-Boswellic Acids Prevent Development of Autoimmune Reactions, Insulitis and Reduce Hyperglycemia During Induction of Multiple Low-Dose Streptozotocin (MLD-STZ) Diabetes in Mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2015 Jun; 47(6):463-9. doi:
10.1055/s-0035-1547293. [PMID: 25951322] - Matteo Lulli, Maurizio Cammalleri, Irene Fornaciari, Giovanni Casini, Massimo Dal Monte. Acetyl-11-keto-β-boswellic acid reduces retinal angiogenesis in a mouse model of oxygen-induced retinopathy.
Experimental eye research.
2015 Jun; 135(?):67-80. doi:
10.1016/j.exer.2015.04.011. [PMID: 25913458] - Sida Shen, Xingyu Xu, Zhulong Liu, Junhua Liu, Lihong Hu. Synthesis and structure-activity relationships of boswellic acid derivatives as potent VEGFR-2 inhibitors.
Bioorganic & medicinal chemistry.
2015 May; 23(9):1982-93. doi:
10.1016/j.bmc.2015.03.022. [PMID: 25819335] - Ryan C Bennett, Chris Brough, Dave A Miller, Kevin P O'Donnell, Justin M Keen, Justin R Hughey, Robert O Williams, James W McGinity. Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol Dispersing: approaches to enhance solubility of a poorly water-soluble gum extract.
Drug development and industrial pharmacy.
2015 Mar; 41(3):382-97. doi:
10.3109/03639045.2013.866142. [PMID: 24329130] - Dina Mahmoud Mostafa, Nagwa Mohammed Ammar, Sameh Hosam Abd El-Alim, Ahmed Alaa Kassem, Rehab Ali Hussein, Gamal Awad, Sally Abdul-Wanees El-Awdan. Boswellia carterii liquisolid systems with promoted anti-inflammatory activity.
Current drug delivery.
2015; 12(4):454-63. doi:
10.2174/1567201812666150421111627. [PMID: 25895614] - Daniela Catanzaro, Serena Rancan, Genny Orso, Stefano Dall'Acqua, Paola Brun, Maria Cecilia Giron, Maria Carrara, Ignazio Castagliuolo, Eugenio Ragazzi, Laura Caparrotta, Monica Montopoli. Boswellia serrata Preserves Intestinal Epithelial Barrier from Oxidative and Inflammatory Damage.
PloS one.
2015; 10(5):e0125375. doi:
10.1371/journal.pone.0125375. [PMID: 25955295] - Dina Mahmoud Mostafa, Nagwa Mohammed Ammar, Mona Basha, Rehab Ali Hussein, Sally El Awdan, Gamal Awad. Transdermal microemulsions of Boswellia carterii Bird: formulation, characterization and in vivo evaluation of anti-inflammatory activity.
Drug delivery.
2015; 22(6):748-56. doi:
10.3109/10717544.2014.898347. [PMID: 24725029] - Moritz Verhoff, Stefanie Seitz, Michael Paul, Stefan M Noha, Johann Jauch, Daniela Schuster, Oliver Werz. Tetra- and pentacyclic triterpene acids from the ancient anti-inflammatory remedy frankincense as inhibitors of microsomal prostaglandin E(2) synthase-1.
Journal of natural products.
2014 Jun; 77(6):1445-51. doi:
10.1021/np500198g. [PMID: 24844534] - Jian-Jun Liu, Wan Ching Toy, Sylvia Liu, Anton Cheng, Boon Khim Lim, Tavin Subramaniam, Chee Fang Sum, Su Chi Lim. Acetyl-keto-β-boswellic acid induces lipolysis in mature adipocytes.
Biochemical and biophysical research communications.
2013 Feb; 431(2):192-6. doi:
10.1016/j.bbrc.2012.12.136. [PMID: 23313487] - Jan Hüsch, Kathleen Gerbeth, Gert Fricker, Constanze Setzer, Jürgen Zirkel, Herbert Rebmann, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab. Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
Journal of natural products.
2012 Oct; 75(10):1675-82. doi:
10.1021/np300009w. [PMID: 23013292] - Vivek R Yadav, Sahdeo Prasad, Bokyung Sung, Juri G Gelovani, Sushovan Guha, Sunil Krishnan, Bharat B Aggarwal. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers.
International journal of cancer.
2012 May; 130(9):2176-84. doi:
10.1002/ijc.26251. [PMID: 21702037] - Krishanu Sengupta, Jayaprakash N Kolla, Alluri V Krishnaraju, Nandini Yalamanchili, Chirravuri V Rao, Trimurtulu Golakoti, Smriti Raychaudhuri, Siba P Raychaudhuri. Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Molecular and cellular biochemistry.
2011 Aug; 354(1-2):189-97. doi:
10.1007/s11010-011-0818-1. [PMID: 21479939] - Byoungduck Park, Bokyung Sung, Vivek R Yadav, Sung-Gook Cho, Mingyao Liu, Bharat B Aggarwal. Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression.
International journal of cancer.
2011 Jul; 129(1):23-33. doi:
10.1002/ijc.25966. [PMID: 21448932] - Alsaba F Raja, Furqan Ali, Inshad A Khan, Abdul S Shawl, Daljit S Arora, Bhahwal A Shah, Subhash C Taneja. Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata.
BMC microbiology.
2011 Mar; 11(?):54. doi:
10.1186/1471-2180-11-54. [PMID: 21406118] - A V Krishnaraju, D Sundararaju, U Vamsikrishna, R Suryachandra, G Machiraju, K Sengupta, G Trimurtulu. Safety and toxicological evaluation of Aflapin: a novel Boswellia-derived anti-inflammatory product.
Toxicology mechanisms and methods.
2010 Nov; 20(9):556-63. doi:
10.3109/15376516.2010.497978. [PMID: 20874664] - Judith M Rollinger, Denise V Kratschmar, Daniela Schuster, Petra H Pfisterer, Christel Gumy, Evelyne M Aubry, Sarah Brandstötter, Hermann Stuppner, Gerhard Wolber, Alex Odermatt. 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches.
Bioorganic & medicinal chemistry.
2010 Feb; 18(4):1507-15. doi:
10.1016/j.bmc.2010.01.010. [PMID: 20100662] - Phillip Krüger, Johanna Kanzer, Jessica Hummel, Gert Fricker, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab. Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2009 Feb; 36(2-3):275-84. doi:
10.1016/j.ejps.2008.10.005. [PMID: 19010411] - Phillip Krüger, Rambod Daneshfar, Gunter P Eckert, Jochen Klein, Dietrich A Volmer, Ute Bahr, Walter E Müller, Michael Karas, Manfred Schubert-Zsilavecz, Mona Abdel-Tawab. Metabolism of boswellic acids in vitro and in vivo.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jun; 36(6):1135-42. doi:
10.1124/dmd.107.018424. [PMID: 18356270] - Bruno Burlando, Alessandro Parodi, Andrea Volante, Anna Maria Bassi. Comparison of the irritation potentials of Boswellia serrata gum resin and of acetyl-11-keto-beta-boswellic acid by in vitro cytotoxicity tests on human skin-derived cell lines.
Toxicology letters.
2008 Mar; 177(2):144-9. doi:
10.1016/j.toxlet.2008.01.008. [PMID: 18304763] - Clarisse Cuaz-Pérolin, Ludivine Billiet, Eric Baugé, Corinne Copin, Daniel Scott-Algara, Felicitas Genze, Berhold Büchele, Tatiana Syrovets, Thomas Simmet, Mustapha Rouis. Antiinflammatory and antiatherogenic effects of the NF-kappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/- mice.
Arteriosclerosis, thrombosis, and vascular biology.
2008 Feb; 28(2):272-7. doi:
10.1161/atvbaha.107.155606. [PMID: 18032778] - Mahendra Bishnoi, C S Patil, Anil Kumar, Shrinivas K Kulkarni. Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
Pharmacology.
2007; 79(1):34-41. doi:
10.1159/000097627. [PMID: 17139192] - Olga N Pozharitskaya, Svetlana A Ivanova, Alexander N Shikov, Valery G Makarov. Separation and quantification of terpenoids of Boswellia serrata Roxb. extract by planar chromatography techniques (TLC and AMD).
Journal of separation science.
2006 Sep; 29(14):2245-50. doi:
10.1002/jssc.200600078. [PMID: 17069256] - Yasunari Takada, Haruyo Ichikawa, Vladimir Badmaev, Bharat B Aggarwal. Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.
Journal of immunology (Baltimore, Md. : 1950).
2006 Mar; 176(5):3127-40. doi:
10.4049/jimmunol.176.5.3127. [PMID: 16493072] - Berthold Büchele, Waltraud Zugmaier, Felicitas Genze, Thomas Simmet. High-performance liquid chromatographic determination of acetyl-11-keto-alpha-boswellic acid, a novel pentacyclic triterpenoid, in plasma using a fluorinated stationary phase and photodiode array detection: application in pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Dec; 829(1-2):144-8. doi:
10.1016/j.jchromb.2005.09.043. [PMID: 16266833] - M Bishnoi, C S Patil, A Kumar, S K Kulkarni. Protective effects of nimesulide (COX Inhibitor), AKBA (5-LOX Inhibitor), and their combination in aging-associated abnormalities in mice.
Methods and findings in experimental and clinical pharmacology.
2005 Sep; 27(7):465-70. doi:
10.1358/mf.2005.27.7.920929. [PMID: 16258590] - Yong Seok Park, Joung H Lee, Judy Bondar, Jyoti A Harwalkar, Hasan Safayhi, Mladen Golubic. Cytotoxic action of acetyl-11-keto-beta-boswellic acid (AKBA) on meningioma cells.
Planta medica.
2002 May; 68(5):397-401. doi:
10.1055/s-2002-32090. [PMID: 12058313] - K Krohn, M S Rao, N V Raman, M Khalilullah. High-performance thin layer chromatographic analysis of anti-inflammatory triterpenoids from Boswellia serrata Roxb.
Phytochemical analysis : PCA.
2001 Nov; 12(6):374-6. doi:
10.1002/pca.606. [PMID: 11793815] - C F Krieglstein, C Anthoni, E J Rijcken, M Laukötter, H U Spiegel, S E Boden, S Schweizer, H Safayhi, N Senninger, G Schürmann. Acetyl-11-keto-beta-boswellic acid, a constituent of a herbal medicine from Boswellia serrata resin, attenuates experimental ileitis.
International journal of colorectal disease.
2001 Apr; 16(2):88-95. doi:
10.1007/s003840100292. [PMID: 11355324] - S Schweizer, A F von Brocke, S E Boden, E Bayer, H P Ammon, H Safayhi. Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.
Journal of natural products.
2000 Aug; 63(8):1058-61. doi:
10.1021/np000069k. [PMID: 10978197]
