Peimisine (BioDeep_00000230192)

 

Secondary id: BioDeep_00000254801

PANOMIX_OTCML-2023


代谢物信息卡片


Spiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-5(6H)-one, 1,2,3,3a,4,4,4a,5,6,6a,6b,7,7,7a,8,11,11a,11b-octadecahydro-3-hydroxy-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,4aS,6S,6aR,6bS,7aR,11aS,11bR)-

化学式: C27H41NO3 (427.3086276)
中文名称: 贝母新碱, 贝母辛
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 7.1%

分子结构信息

SMILES: CC1CC2C(C(C3(O2)CCC4C5CC(=O)C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
InChI: InChI=1S/C27H41NO3/c1-14-9-24-25(28-13-14)16(3)27(31-24)8-6-18-19(15(27)2)11-21-20(18)12-23(30)22-10-17(29)5-7-26(21,22)4/h14,16-18,20-22,24-25,28-29H,5-13H2,1-4H3/t14-,16+,17-,18+,20-,21-,22+,24+,25-,26+,27-/m0/s1

描述信息

Peimisine is an alkaloid.
Peimisine is a natural product found in Fritillaria anhuiensis, Fritillaria cirrhosa, and other organisms with data available.
Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research[1][2][3].
Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research[1][2][3].
Peimisine (Ebeiensine) is a muscarinic M receptor antagonist and angiotensin converting enzyme (ACE) inhibitor. Peimisine shows anti-tumor, anti-inflammatory, antihypertensive activities. Peimisine can induce apoptosis and be used in cough and asthma research[1][2][3].

同义名列表

13 个代谢物同义名

Spiro[9H-benzo[a]fluorene-9,2(3H)-furo[3,2-b]pyridin]-5(6H)-one, 1,2,3,3a,4,4,4a,5,6,6a,6b,7,7,7a,8,11,11a,11b-octadecahydro-3-hydroxy-3,6,10,11b-tetramethyl-, (2R,3S,3R,3aS,4aS,6S,6aR,6bS,7aR,11aS,11bR)-; (3S,3R,3aS,4aS,6S,6aR,6bS,7aR,9R,11aS,11bR)-3-hydroxy-3,6,10,11b-tetramethylspiro[1,2,3,4,4a,6,6a,6b,7,8,11,11a-dodecahydrobenzo[a]fluorene-9,2-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-5-one; (3S,3R,3aS,4aS,6S,6aR,6bS,7aR,9R,11aS,11bR)-3-hydroxy-3,6,10,11b-tetramethyl-1,2,3,3a,4,4,4a,5,5,6,6,6a,6b,7,7,7a,8,11,11a,11b-icosahydro-3H-spiro[cyclohexa[a]fluorene-9,2-furo[3,2-b]pyridin]-5-one; (3S,3R,3aS,4aS,6S,6aR,6bS,7aR,9R,11aS,11bR)-3-hydroxy-3,6,10,11b-tetramethylspiro[1,2,3,4,4a,6,6a,6b,7,8,11,11a-dodecahydrobenzo[a]luorene-9,2-3a,4,5,6,7,7a-hexahydro-3H-uro[3,2-b]pyridine]-5-one; Veratraman-6(5H)-one, 17,23-epoxy-3-hydroxy-, (3beta,5alpha,23beta)-; Veratraman-6(5H)-one, 17,23-epoxy-3-hydroxy-, (3beta)-; 3-Hydroxy-5,6-dihydro-17,23-epoxyveratraman-6-one; KYELXPJVGNZIGC-GKFGJCLESA-N; Ebeiensine; peimissine; 1ST178246; Peimisine; Pemissine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Simei Liu, Tiechui Yang, Tse Wai Ming, Tse Kathy Wai Gaun, Ting Zhou, Shu Wang, Bengui Ye. Isosteroid alkaloids with different chemical structures from Fritillariae cirrhosae bulbus alleviate LPS-induced inflammatory response in RAW 264.7 cells by MAPK signaling pathway. International immunopharmacology. 2020 Jan; 78(?):106047. doi: 10.1016/j.intimp.2019.106047. [PMID: 31816576]
  • Qiu-Yan Wang, Xin Dong, Juan Yang, Xiao-Ting Zhen, Li-Hong Ye, Chu Chu, Bin Wang, Yu-Han Hu, Hui Zheng, Jun Cao. Solid acids assisted matrix solid-phase dispersion microextraction of alkaloids by capillary electrophoresis coupled with quadrupole time-of-flight mass spectrometry. Journal of separation science. 2019 Dec; 42(23):3579-3588. doi: 10.1002/jssc.201900647. [PMID: 31617304]
  • Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang. Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jun; 1054(?):20-26. doi: 10.1016/j.jchromb.2017.03.001. [PMID: 28415020]
  • Lihua Chen, Dongxun Li, Guosong Zhang, Wei Zhang, Lihua Zhang, Yongmei Guan, Weifeng Zhu, Hongning Liu. Pharmacokinetics, tissue distribution and excretion of peimisine in rats assessed by liquid chromatography-tandem mass spectrometry. Archives of pharmacal research. 2015 Jun; 38(6):1138-46. doi: 10.1007/s12272-014-0434-1. [PMID: 25001900]
  • By Feng Pan, Xuemei Su, Bo Hu, Nan Yang, Que Chen, Wei Wu. Fusarium redolens 6WBY3, an endophytic fungus isolated from Fritillaria unibracteata var. wabuensis, produces peimisine and imperialine-3β-D-glucoside. Fitoterapia. 2015 Jun; 103(?):213-21. doi: 10.1016/j.fitote.2015.04.006. [PMID: 25869849]
  • Dongdong Wang, Yun Jiang, Ke Wu, Shu Wang, Yitao Wang. Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC complementary and alternative medicine. 2015 Feb; 15(?):29. doi: 10.1186/s12906-015-0551-5. [PMID: 25880867]
  • Shu-Yan Zheng, Hong-Sheng Tan, Jian-Sheng Tao, Zheng-Wu Shen. A convenient and efficient one-pot conversion of peimisine into cyclopamine. Fitoterapia. 2012 Oct; 83(7):1238-41. doi: 10.1016/j.fitote.2012.06.010. [PMID: 22735603]
  • Qing-Jian Zhang, Zhong-Fei Zheng, De-Quan Yu. Steroidal alkaloids from the bulbs of Fritillaria unibracteata. Journal of Asian natural products research. 2011 Dec; 13(12):1098-103. doi: 10.1080/10286020.2011.619980. [PMID: 22115033]
  • Bao-zhong Duan, Lin-fang Huang, Shi-lin Chen. [Simultaneous determination of peimisine and sipeimine in Fritillaria walujewii regel and Fritillaria pallidiflora Schrenk by UPLC-ELSD]. Yao xue xue bao = Acta pharmaceutica Sinica. 2010 Dec; 45(12):1541-4. doi: ". [PMID: 21351494]
  • Hua Yu, Yan Jiang, Ping Li, Shao-Ping Li, Yi-Tao Wang. [Study on analytical method for alkaloids in Bulbus Fritillariae cirrhosae]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2005 Apr; 30(8):572-5. doi: ". [PMID: 16011276]
  • Hyuncheol Oh, Dae-Gill Kang, Sunyoung Lee, Yunmi Lee, Ho-Sub Lee. Angiotensin converting enzyme (ACE) inhibitory alkaloids from Fritillaria ussuriensis. Planta medica. 2003 Jun; 69(6):564-5. doi: 10.1055/s-2003-40659. [PMID: 12865981]
  • D Xu, E Huang, C Li. [Alkaloid constituents of Fritillaria pallidiflora Schrenk]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1990 Sep; 15(9):551-2, 577. doi: ". [PMID: 2092715]
  • D M Xu. [Alkaloid constituents in the leaves and stems of Fritillaria ussuriensis]. Zhong yao tong bao (Beijing, China : 1981). 1986 Nov; 11(11):40-1. doi: ". [PMID: 2952324]