TIIAS (BioDeep_00000230127)
Secondary id: BioDeep_00000396305
PANOMIX_OTCML-2023
代谢物信息卡片
Phenanthro(1,2-b)furan-2-sulfonic acid, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-, sodium salt
化学式: C19H17O6S-.Na+ (396.06435020000004)
中文名称: 丹参酮IIA-磺酸钠, 丹参酮IIA磺酸钠, 丹参酮IIA-磺酸钠
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 3.17%
分子结构信息
SMILES: CC1=C(OC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C)S(=O)(=O)[O-].[Na+]
InChI: /q
描述信息
同义名列表
22 个代谢物同义名
Phenanthro(1,2-b)furan-2-sulfonic acid, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-, sodium salt; Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate; sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate; Sodium Tanshinone IIA sulfonate;Tanshinone IIA sodium sulfonate; TANSHINONE IIA SODIUM SULFONATE [WHO-DD]; Tanshinone IIA sulfonate (sodium); Tanshinone II-A sodium sulfonate; tanshinone II A sodium sulfonate; sodium tanshinone II A sulfonate; TANSHINONE IIA SULFONATE SODIUM; sodium tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate; TANSHINONE IIA-SULFONIC SODIUM; TANSHINONEIIASULFONATESODIUM; SULFOTANSHINONE SODIUM II-A; Sulfotanshinone IIA Sodium; tanshinone IIA sulfonate; Sulfotanshinone Sodium; UNII-IVJ88KQ4XN; TanshinoneIIA; IVJ88KQ4XN; TIIAS
数据库引用编号
4 个数据库交叉引用编号
- PubChem: 23669322
- MeSH: tanshinone II A sodium sulfonate
- ChemIDplus: 0069659809
- CAS: 69659-80-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jie Zeng, Wei-Wei Gao, Hao Yang, Ya-Nang Wang, Yang Mei, Ting-Ting Liu, Min Wang, Li Tang, Dong-Chuan Ma, Wei Li. Sodium tanshinone IIA sulfonate suppresses microglia polarization and neuroinflammation possibly via regulating miR-125b-5p/STAT3 axis to ameliorate neuropathic pain.
European journal of pharmacology.
2024 Jun; 972(?):176523. doi:
10.1016/j.ejphar.2024.176523. [PMID: 38552937] - Huikai Shao, Fei Yu, Dongsheng Xu, Chunyan Fang, Rongsheng Tong, Lingguo Zhao. A systematic review and meta-analysis on sodium tanshinone IIA sulfonate injection for the adjunctive therapy of pulmonary heart disease.
BMC complementary medicine and therapies.
2024 Apr; 24(1):151. doi:
10.1186/s12906-024-04434-0. [PMID: 38580972] - Lufeng Peng, Maoxia Fan, Junhai Li, Wenqiang Chen. Evidence quality assessment of sodium tanshinone IIA sulfonate injection intervention coronary heart disease angina pectoris: An overview of systematic reviews and meta-analyses.
Medicine.
2023 Nov; 102(44):e35509. doi:
10.1097/md.0000000000035509. [PMID: 37933033] - Ya-Qin Song, Wei-Ji Lin, Hong-Jie Hu, Shu-Hui Wu, Liang Jing, Qing Lu, Wei Zhu. Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis.
International immunopharmacology.
2023 Apr; 118(?):110111. doi:
10.1016/j.intimp.2023.110111. [PMID: 37028275] - Zhong-Yan Zhou, Wen-Ting Shi, Jing Zhang, Wai-Rong Zhao, Ying Xiao, Kai-Yu Zhang, Jie Ma, Jing-Yi Tang, Yu Wang. Sodium tanshinone IIA sulfonate protects against hyperhomocysteine-induced vascular endothelial injury via activation of NNMT/SIRT1-mediated NRF2/HO-1 and AKT/MAPKs signaling in human umbilical vascular endothelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 158(?):114137. doi:
10.1016/j.biopha.2022.114137. [PMID: 36525817] - Xiaoqi Wu, Maoxia Fan, Sining Wei, Dong Guo. The efficacy and safety of sodium tanshinone ⅡA sulfonate injection in the treatment of unstable angina pectoris: A systematic review and meta-analysis.
PloS one.
2023; 18(8):e0290841. doi:
10.1371/journal.pone.0290841. [PMID: 37651454] - Teng Ma, Li-Ting Mu, Xin-Tong Tian, Ji Yang, Ying-Qiang Zhao. [Systematic review and sequential analysis of Tanshinone Ⅱ_A Sodium Sulfonate Injection combined with enalapril in treatment of acute exacerbation of pulmonary heart disease].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Dec; 47(24):6794-6802. doi:
10.19540/j.cnki.cjcmm.20220830.501. [PMID: 36604928] - Bu Wang, Xin Gu, Bao-Li Xiang, Jian-Qing Zhao, Chang-Hong Zhang, Pan-Deng Huang, Zhi-Hua Zhang. eEF-2K knockdown synergizes with STS treatment to inhibit cell proliferation, migration, and invasion via the TG2/ERK pathway in A549 cells.
Journal of biochemical and molecular toxicology.
2022 Oct; 36(10):e23158. doi:
10.1002/jbt.23158. [PMID: 35844142] - Shuo Liu, Xi-Yun Zhao, Jin-Feng Li, Zeng-Peng Lu, Xiao-Gang Zhang. [Network Meta-analysis of Chinese medicine injections in treatment of rheumatoid arthritis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(20):5627-5641. doi:
10.19540/j.cnki.cjcmm.20220727.501. [PMID: 36471981] - Jian Wang, Wenyan Liu, Wenju Lu, Xiaoyun Luo, Yongrui Lin, Shiyun Liu, Jing Qian, Chenting Zhang, Haixia Chen, Yi Li, Xiang Li, Jiyuan Chen, Yuqin Chen, Qian Jiang, Chunli Liu, Cheng Hong, Tao Wang, Haiyang Tang, Nanshan Zhong, Jun Yang, Kai Yang, Dejun Sun. Sodium tanshinone IIA sulfonate enhances the BMP9-BMPR2-Smad1/5/9 signaling pathway in rat pulmonary microvascular endothelial cells and human embryonic stem cell-derived endothelial cells.
Biochemical pharmacology.
2022 05; 199(?):114986. doi:
10.1016/j.bcp.2022.114986. [PMID: 35276216] - Dan Luo, Xing Li, Yonghui Hou, Yu Hou, Jiyao Luan, Jiaxian Weng, Jiheng Zhan, Dingkun Lin. Sodium tanshinone IIA sulfonate promotes spinal cord injury repair by inhibiting blood spinal cord barrier disruption in vitro and in vivo.
Drug development research.
2022 05; 83(3):669-679. doi:
10.1002/ddr.21898. [PMID: 34842291] - Jiao Lan, Ke Li, Austin Gresham, Jifei Miao. Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-κB into the nucleus.
European journal of pharmacology.
2022 Jan; 914(?):174693. doi:
10.1016/j.ejphar.2021.174693. [PMID: 34896110] - Huikai Shao, Chuanyan Fang, Yang Huang, Yulong Ye, Rongsheng Tong. Sodium tanshinone ⅡA sulfonate injection as adjunctive therapy for the treatment of heart failure: A systematic review and meta-analysis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jan; 95(?):153879. doi:
10.1016/j.phymed.2021.153879. [PMID: 34906894] - Baoli Zhang, Peng Yu, Enyong Su, Jianguo Jia, Chunyu Zhang, Shiyao Xie, Zhenhui Huang, Ying Dong, Jinguo Ding, Yunzeng Zou, Hong Jiang, Junbo Ge. Sodium Tanshinone IIA Sulfonate Improves Adverse Ventricular Remodeling Post-MI by Reducing Myocardial Necrosis, Modulating Inflammation, and Promoting Angiogenesis.
Current pharmaceutical design.
2022; 28(9):751-759. doi:
10.2174/1381612828666211224152440. [PMID: 34951571] - Yunxia Xu, Ke Chen, Juanli Pan, Yingshou Lei, Danting Zhang, Lipei Fang, Jinle Tang, Xin Chen, Yanhong Ma, Yi Zheng, Bao Zhang, Yaoqi Zhou, Jian Zhan, Wei Xu. Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease.
International journal of biological macromolecules.
2021 Oct; 188(?):137-146. doi:
10.1016/j.ijbiomac.2021.07.184. [PMID: 34364941] - Baotao Lian, Ruixiang Zeng, Yuanfang Chen, Pengda Liao, Liheng Guo, Minzhou Zhang. Sodium Tanshinone IIA sulfonate for acute myocardial infarction: a systematic review and Meta-analysis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2021 02; 41(1):26-35. doi:
10.19852/j.cnki.jtcm.2021.01.004. [PMID: 33522194] - Shouqian Dai, Xiu Shi, Rongqing Qin, Xing Zhang, Feng Xu, Huilin Yang. Sodium Tanshinone IIA Sulfonate Ameliorates Injury-Induced Oxidative Stress and Intervertebral Disc Degeneration in Rats by Inhibiting p38 MAPK Signaling Pathway.
Oxidative medicine and cellular longevity.
2021; 2021(?):5556122. doi:
10.1155/2021/5556122. [PMID: 34122723] - Zhonghui Zhu, Qiuyue Li, Chunjie Xu, Jing Zhao, Siling Li, Yan Wang, Lin Tian. Sodium tanshinone IIA sulfonate attenuates silica-induced pulmonary fibrosis in rats via activation of the Nrf2 and thioredoxin system.
Environmental toxicology and pharmacology.
2020 Nov; 80(?):103461. doi:
10.1016/j.etap.2020.103461. [PMID: 32738294] - Min Luo, Xianjun Cai, Dingmin Yan, Xishi Liu, Sun-Wei Guo. Sodium tanshinone IIA sulfonate restrains fibrogenesis through induction of senescence in mice with induced deep endometriosis.
Reproductive biomedicine online.
2020 Sep; 41(3):373-384. doi:
10.1016/j.rbmo.2020.04.006. [PMID: 32651107] - Xiao-Qi Liu, Ya-Xiang Deng, Zhao Dai, Tian Hu, Wei-Wu Cai, Hao-Fei Liu, Han Li, Wen-Li Zhu, Ben-Yue Li, Qi Wang, Shi-Jie Zhang. Sodium tanshinone IIA sulfonate protects against Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells.
International journal of biological macromolecules.
2020 May; 151(?):47-55. doi:
10.1016/j.ijbiomac.2020.02.040. [PMID: 32035959] - Xiao-Bin Zhang, Xiao-Yang Chen, Peng Sun, Xiao-Man Su, Hui-Qing Zeng, Yi-Ming Zeng, Miao Wang, Xiongbiao Luo. Sodium Tanshinone IIA Sulfonate Attenuates Tumor Oxidative Stress and Promotes Apoptosis in an Intermittent Hypoxia Mouse Model.
Technology in cancer research & treatment.
2020 Jan; 19(?):1533033820928073. doi:
10.1177/1533033820928073. [PMID: 32431212] - Liren Zhong, Wei Ding, Qingyu Zeng, Binglin He, Haibo Zhang, Li Wang, Junhong Fan, Shuhua He, Yuanyuan Zhang, Anyang Wei. Sodium Tanshinone IIA Sulfonate Attenuates Erectile Dysfunction in Rats with Hyperlipidemia.
Oxidative medicine and cellular longevity.
2020; 2020(?):7286958. doi:
10.1155/2020/7286958. [PMID: 32215177] - Zhong-Yan Zhou, Wai-Rong Zhao, Jing Zhang, Xin-Lin Chen, Jing-Yi Tang. Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Oct; 118(?):109362. doi:
10.1016/j.biopha.2019.109362. [PMID: 31545252] - Xiao-Xiao Li, Xin-Yi Lu, Shi-Jie Zhang, Amy P Chiu, Lilian H Lo, David A Largaespada, Qu-Bo Chen, Vincent W Keng. Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Mar; 111(?):68-75. doi:
10.1016/j.biopha.2018.12.019. [PMID: 30576936] - Wei-Wei Qin, Li Wang, Zheng Jiao, Bin Wang, Cheng-Yu Wang, Li-Xuan Qian, Wei-Lin Qi, Ming-Kang Zhong. Lower clearance of sodium tanshinone IIA sulfonate in coronary heart disease patients and the effect of total bilirubin: a population pharmacokinetics analysis.
Chinese journal of natural medicines.
2019 Mar; 17(3):218-226. doi:
10.1016/s1875-5364(19)30024-x. [PMID: 30910058] - Ding Qu, Lixiang Wang, Yue Qin, Mengfei Guo, Jian Guo, Mengmeng Huang, Yuping Liu, Congyan Liu, Hui Li, Yan Chen. Non-triggered sequential-release liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion.
Biomaterials science.
2018 Nov; 6(12):3284-3299. doi:
10.1039/c8bm00796a. [PMID: 30346001] - Zheng-Jie Meng, Chao Wang, Ling-Tong Meng, Bei-Hua Bao, Jin-Hui Wu, Yi-Qiao Hu. Sodium tanshinone IIA sulfonate attenuates cardiac dysfunction and improves survival of rats with cecal ligation and puncture-induced sepsis.
Chinese journal of natural medicines.
2018 Nov; 16(11):846-855. doi:
10.1016/s1875-5364(18)30126-2. [PMID: 30502766] - Zhong-Yan Zhou, Bin Huang, Shang Li, Xiao-Hui Huang, Jing-Yi Tang, Yiu Wa Kwan, Pui Man Hoi, Simon Ming-Yuen Lee. Sodium tanshinone IIA sulfonate promotes endothelial integrity via regulating VE-cadherin dynamics and RhoA/ROCK-mediated cellular contractility and prevents atorvastatin-induced intracerebral hemorrhage in zebrafish.
Toxicology and applied pharmacology.
2018 07; 350(?):32-42. doi:
10.1016/j.taap.2018.04.037. [PMID: 29730311] - Shaolei Ma, Xian Wang, Yujie Wang, Xiangrong Zuo. Sodium Tanshinone IIA Sulfonate Improves Hemodynamic Parameters, Cytokine Release, and Multi-Organ Damage in Endotoxemia Rabbits.
Medical science monitor : international medical journal of experimental and clinical research.
2018 May; 24(?):2975-2982. doi:
10.12659/msm.909996. [PMID: 29735976] - Zi-Jian Li, Ying-Ru Huang, Huan-Huan Zeng, Xiong Deng, Yi Wang, Song Zhang. [Effects of tanshinone ⅡA sulfonate on nerve regeneration after cryopreserved sciatic nerve allograft in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 May; 43(9):1907-1914. doi:
10.19540/j.cnki.cjcmm.20180228.003. [PMID: 29902904] - Di Tan, Jia-Rui Wu, Xiao-Meng Zhang, Shi Liu, Bing Zhang. Sodium Tanshinone II A Sulfonate Injection as Adjuvant Treatment for Unstable Angina Pectoris: A Meta-Analysis of 17 Randomized Controlled Trials.
Chinese journal of integrative medicine.
2018 Feb; 24(2):156-160. doi:
10.1007/s11655-017-2424-x. [PMID: 29181731] - Ji Zhu, Yingling Xu, Guangyan Ren, Xiao Hu, Cui Wang, Zhen Yang, Zhuoyu Li, Wei Mao, Dezhao Lu. Tanshinone IIA Sodium sulfonate regulates antioxidant system, inflammation, and endothelial dysfunction in atherosclerosis by downregulation of CLIC1.
European journal of pharmacology.
2017 Nov; 815(?):427-436. doi:
10.1016/j.ejphar.2017.09.047. [PMID: 28970012] - Fang Chen, Huimin Li, Guoguo Zhu, Xiaojuan Chen, Zhongzhi Tang. Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.
Molecular medicine reports.
2017 Jul; 16(1):87-94. doi:
10.3892/mmr.2017.6573. [PMID: 28498471] - WeiWei Qin, Bin Wang, XiaoPei Lu, HaiMing Liu, Li Wang, WeiLin Qi. Determination of Sodium Tanshinone IIA Sulfonate in human plasma by LC-MS/MS and its application to a clinical pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2016 Mar; 121(?):204-208. doi:
10.1016/j.jpba.2016.01.026. [PMID: 26812478] - Qinghua Hu, Bo Wei, Linlin Wei, Kai Hua, Xing Yu, Huanqiu Li, Hui Ji. Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome.
International journal of cardiology.
2015 Oct; 196(?):183-92. doi:
10.1016/j.ijcard.2015.05.152. [PMID: 26143630] - Jude S Morton, Anita Quon, Po-Yin Cheung, Tatsuya Sawamura, Sandra T Davidge. Effect of sodium tanshinone IIA sulfonate treatment in a rat model of preeclampsia.
American journal of physiology. Regulatory, integrative and comparative physiology.
2015 Feb; 308(3):R163-72. doi:
10.1152/ajpregu.00222.2014. [PMID: 25477421] - Jude S Morton, Irene J Andersson, Po-Yin Cheung, Philip Baker, Sandra T Davidge. The vascular effects of sodium tanshinone IIA sulphonate in rodent and human pregnancy.
PloS one.
2015; 10(3):e0121897. doi:
10.1371/journal.pone.0121897. [PMID: 25811628] - Jing Gu, Hai-Long Li, Hong-Yan Wu, Mei Gu, Ying-Dong Li, Xiao-Gang Wang, Hai-Xia Ming, Xiao-Li Dong, Kai Liu. Sodium tanshinone IIA sulfonate attenuates radiation-induced fibrosis damage in cardiac fibroblasts.
Journal of Asian natural products research.
2014; 16(9):941-52. doi:
10.1080/10286020.2014.935769. [PMID: 25135631] - Hai-Chen Liu, Hai-Huan Liu. [Adverse reactions of tanshinone II(A) sodium sulfonate injection in treating 18 cases: an analysis of clinical features].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2013 Sep; 33(9):1287-9. doi:
". [PMID: 24273991] - Bo Wei, Mei-Gui You, Jing-Jing Ling, Lin-Lin Wei, Kai Wang, Wen-Wen Li, Tong Chen, Qian-Ming Du, Hui Ji. Regulation of antioxidant system, lipids and fatty acid β-oxidation contributes to the cardioprotective effect of sodium tanshinone IIA sulphonate in isoproterenol-induced myocardial infarction in rats.
Atherosclerosis.
2013 Sep; 230(1):148-56. doi:
10.1016/j.atherosclerosis.2013.07.005. [PMID: 23958267] - Xue-Hua Niu, Hai-Yong Hua, Wen-Jian Guo, Yu Zhang, Min Liu, Ye Hong, Peng-Fei Wu, Ping Lu, Hai-Fang Zhang. [Clinical efficiency of tanshinone IIA-sulfonate in treatment of liver fibrosis of advanced schistosomiasis].
Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control.
2013 Apr; 25(2):137-40. doi:
NULL. [PMID: 23894832] - M Jason Hatfield, Lyudmila G Tsurkan, Janice L Hyatt, Carol C Edwards, Andrew Lemoff, Cynthia Jeffries, Bing Yan, Philip M Potter. Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ('Danshen').
Journal of natural products.
2013 Jan; 76(1):36-44. doi:
10.1021/np300628a. [PMID: 23286284] - Li Zhang, Guo-Yao An, Wen-Guang Zhang, Kai Chen. [Effects of tanshinone- II A sulfonate on expression of nuclear factor-kappaB, vascular cell adhesion molecule-1 and hemorrheology during spinal cord ischemia reperfusion injury].
Zhongguo gu shang = China journal of orthopaedics and traumatology.
2012 Dec; 25(12):1016-20. doi:
NULL. [PMID: 23627149] - Liang-Cai Wu, Xi Lin, Hao Sun. Tanshinone IIA protects rabbits against LPS-induced disseminated intravascular coagulation (DIC).
Acta pharmacologica Sinica.
2012 Oct; 33(10):1254-9. doi:
10.1038/aps.2012.84. [PMID: 22983394] - Liping Zeng, Dingfang Wu, Shihua Wu. A novel protocol for the preparation of sodium tanshinone sulphonates by direct ultrasound-assisted sulphonation of the crude extract of the roots of Salvia miltiorrhiza Bunge and following counter-current chromatography purification.
Phytochemical analysis : PCA.
2011 Sep; 22(5):424-31. doi:
10.1002/pca.1298. [PMID: 21465597] - Xuan Liu, Yingchun Wang, Chao Ma, Lin Zhang, Wanying Wu, Shuhong Guan, Min Yang, Junchen Wang, Baohong Jiang, De-An Guo. Proteomic assessment of tanshinone IIA sodium sulfonate on doxorubicin induced nephropathy.
The American journal of Chinese medicine.
2011; 39(2):395-409. doi:
10.1142/s0192415x11008907. [PMID: 21476214] - Yanwu Liu, Lingjuan Wang, Xinkui Li, Changwei Lv, Dapeng Feng, Zhuojing Luo. Tanshinone IIA improves impaired nerve functions in experimental diabetic rats.
Biochemical and biophysical research communications.
2010 Aug; 399(1):49-54. doi:
10.1016/j.bbrc.2010.07.037. [PMID: 20637731] - Jiangqin Liu, Jude Morton, Margaret Miedzyblocki, Tze Fun Lee, David L Bigam, Tai Fai Fok, Chao Chen, Shoo K Lee, Sandra T Davidge, Po-Yin Cheung. Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets.
American journal of physiology. Heart and circulatory physiology.
2009 Oct; 297(4):H1217-24. doi:
10.1152/ajpheart.00477.2009. [PMID: 19617411] - Baohong Jiang, Lin Zhang, Yingchun Wang, Ming Li, Wanying Wu, Shuhong Guan, Xuan Liu, Min Yang, Junchen Wang, De-an Guo. Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2009 Jul; 47(7):1538-44. doi:
10.1016/j.fct.2009.03.038. [PMID: 19358873] - Y Chen, J-H Tu, Y-J He, W Zhang, G Wang, Z-R Tan, G Zhou, L Fan, H-H Zhou. Effect of sodium tanshinone II A sulfonate on the activity of CYP1A2 in healthy volunteers.
Xenobiotica; the fate of foreign compounds in biological systems.
2009 Jul; 39(7):508-13. doi:
10.1080/00498250902951763. [PMID: 19534587] - Yan Yang, Fang Cai, Peng-Yun Li, Miao-Ling Li, Jun Chen, Gui-Lan Chen, Zhi-Fei Liu, Xiao-Rong Zeng. Activation of high conductance Ca(2+)-activated K(+) channels by sodium tanshinoneII-A sulfonate (DS-201) in porcine coronary artery smooth muscle cells.
European journal of pharmacology.
2008 Nov; 598(1-3):9-15. doi:
10.1016/j.ejphar.2008.09.013. [PMID: 18831973] - Yan Xu, Dechun Feng, Ying Wang, Shuting Lin, Lingyun Xu. Sodium tanshinone IIA sulfonate protects mice from ConA-induced hepatitis via inhibiting NF-kappaB and IFN-gamma/STAT1 pathways.
Journal of clinical immunology.
2008 Sep; 28(5):512-9. doi:
10.1007/s10875-008-9206-3. [PMID: 18498044] - Haiping Hao, Guangji Wang, Nan Cui, Jing Li, Zuoqi Ding. Determination of sodium tanshinone IIA sulfonate in plasma by liquid chromatography-electrospray ionisation-tandem mass spectrometry.
Biomedical chromatography : BMC.
2007 Nov; 21(11):1172-9. doi:
10.1002/bmc.871. [PMID: 17630641] - John W Ho, Meng Jie. Pharmacological activity of cardiovascular agents from herbal medicine.
Cardiovascular & hematological agents in medicinal chemistry.
2007 Oct; 5(4):273-7. doi:
10.2174/187152507782109854. [PMID: 17979689] - ShengJun Mao, Hui Jin, YueQi Bi, Zhen Liang, Hui Li, ShiXiang Hou. Ion-pair reversed-phase HPLC method for determination of sodium tanshinone IIA sulfonate in biological samples and its pharmacokinetics and biodistribution in mice.
Chemical & pharmaceutical bulletin.
2007 May; 55(5):753-6. doi:
10.1248/cpb.55.753. [PMID: 17473462] - S J Mao, S X Hou, Z Liang, Y Q Bi, Y Wu, H Li, H Jin. Ion-pair reversed-phase HPLC: assay validation of sodium tanshinone IIA sulfonate in mouse plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 831(1-2):163-8. doi:
10.1016/j.jchromb.2005.11.045. [PMID: 16406380] - C M Wang, Q Z He, R X Zhang. [Effects of tanshionone to bleomycin induced pulmonary fibrosis of rats on histological changes and production of lipid peroxides and hydroxyproline].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
1994 Oct; 17(5):308-10, 320. doi:
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