29MRT0H4CE (BioDeep_00000230096)

 

Secondary id: BioDeep_00000618917

PANOMIX_OTCML-2023


代谢物信息卡片


1H-5,10c-Ethanonaphtho(1,2-c:7,8-c)difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cs)-

化学式: C24H28O4 (380.19874880000003)
中文名称: 洋川芎内酯O, 欧当归内酯A
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CCCC=C1C2=C(C3C(CC2)C4CCC35C(=C4)C(=O)OC5=CCCC)C(=O)O1
InChI: InChI=1S/C24H28O4/c1-3-5-7-18-16-10-9-15-14-11-12-24(21(15)20(16)23(26)27-18)17(13-14)22(25)28-19(24)8-6-4-2/h7-8,13-15,21H,3-6,9-12H2,1-2H3/b18-7-,19-8-/t14-,15+,21-,24+/m1/s1

描述信息

(Z)-6,6,7,3a-Diligustilide is a butenolide. It has a role as a metabolite.
Levistilide A is a natural product found in Ligusticum striatum, Angelica sinensis, and other organisms with data available.
See also: Angelica sinensis root oil (part of).
A natural product found in Ligusticum porteri.
Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. Levistolide A can induce apoptosis via ROS-mediated ER stress pathway[1].
Levistolide A (LA), a natural compound isolated from the traditional Chinese herb Ligusticum chuanxiong Hort, is used for treating cancer. Levistolide A can induce apoptosis via ROS-mediated ER stress pathway[1].

同义名列表

20 个代谢物同义名

1H-5,10c-Ethanonaphtho(1,2-c:7,8-c)difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (1Z,5S,5aS,8Z,10bS,10cs)-; (1S,2S,6Z,10S,11S,16Z)-6,16-di(butylidene)-5,15-dioxapentacyclo[9.5.2.01,13.02,10.03,7]octadeca-3(7),12-diene-4,14-dione; (1Z,5S,5aS,8Z,10bS,10cS)-1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-1H-5,10c-ethanonaphtho(1,2-c:7,8-c)difuran-3,10-dione; 1H-5,10c-Ethanonaphtho(1,2-c:7,8-c)difuran-3,10-dione, 1,8-dibutylidene-5,5a,6,7,8,10b-hexahydro-, (5S,8Z,10cS)-; (Z,Z)-di(butylidene)[?]dione; E,Z-6,6,7,3a-diligustilide; (Z)-6,6,7,3a-Diligustilide; Z,Z-6,6,7,3a-Diligustilide; LEVISTOLIDE A [INCI]; (Z,Z)-Diligustilide; UNII-29MRT0H4CE; Senkyunolide O; Diligustilide; Levistolide A; levistilide A; Levistilide-A; LevistilideA; Levistolid A; Levistilide; 29MRT0H4CE



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mingjie Zhang, Congyan Duan, Weifang Lin, Honghua Wu, Lu Chen, Hong Guo, Minyu Yu, Qi Liu, Yaling Nie, Hong Wang, Shaoxia Wang. Levistilide A Exerts a Neuroprotective Effect by Suppressing Glucose Metabolism Reprogramming and Preventing Microglia Polarization Shift: Implications for Parkinson's Disease. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040912. [PMID: 38398662]
  • Shu Li, Wei Zhao, Zhimin Zhao, Binbin Cheng, Shuang Li, Chenghai Liu. Levistilide A reverses rat hepatic fibrosis by suppressing angiotensin II‑induced hepatic stellate cells activation. Molecular medicine reports. 2020 09; 22(3):2191-2198. doi: 10.3892/mmr.2020.11326. [PMID: 32705207]
  • Tao Guo, Zu-Long Liu, Qiang Zhao, Zhi-Min Zhao, Cheng-Hai Liu. A combination of astragaloside I, levistilide A and calycosin exerts anti-liver fibrosis effects in vitro and in vivo. Acta pharmacologica Sinica. 2018 Sep; 39(9):1483-1492. doi: 10.1038/aps.2017.175. [PMID: 29849130]
  • Huining Guo, Li Sun, Shuang Ling, Jin-Wen Xu. Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats. Mediators of inflammation. 2018; 2018(?):7304096. doi: 10.1155/2018/7304096. [PMID: 30158835]
  • Hyun Gyu Choi, In-Gyu Je, Geum Jin Kim, Joo-Won Nam, Sang Hee Shim, Sang-Hyun Kim, Hyukjae Choi. Chemical Constituents of the Root of Angelica tenuissima and their Anti-allergic Inflammatory Activity. Natural product communications. 2017 May; 12(5):779-780. doi: . [PMID: 30496664]
  • Zhi-Min Zhao, Hong-Liang Liu, Xin Sun, Tao Guo, Li Shen, Yan-Yan Tao, Cheng-Hai Liu. Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway. Experimental biology and medicine (Maywood, N.J.). 2017 05; 242(9):974-985. doi: 10.1177/1535370217701005. [PMID: 28440736]
  • Ting-Fang Lee, Yun-Lian Lin, Yi-Tsau Huang. Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta medica. 2007 Jun; 73(6):527-34. doi: 10.1055/s-2007-981520. [PMID: 17520522]