Anhydroicaritin (BioDeep_00000230065)

   

PANOMIX_OTCML-2023


代谢物信息卡片


4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one,9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-

化学式: C21H20O6 (368.126)
中文名称: 脱水淫羊藿素, 脱水淫羊霍素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 100%

分子结构信息

SMILES: CC1(CCC2=C(O1)C=C(C3=C2OC(=C(C3=O)O)C4=CC=C(C=C4)OC)O)C
InChI: InChI=1S/C21H20O6/c1-21(2)9-8-13-15(27-21)10-14(22)16-17(23)18(24)19(26-20(13)16)11-4-6-12(25-3)7-5-11/h4-7,10,22,24H,8-9H2,1-3H3

描述信息

beta-Anhydroicaritin is a natural product found in Epimedium brevicornu with data available.
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats[2]. β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca2+, and markedly decreases iNOS protein expression[3].

同义名列表

7 个代谢物同义名

3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydro-4h,8h-pyrano[2,3-f]chromen-4-one; 3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-9,10-dihydropyrano[2,3-h]chromen-4-one; 3,7-dimethanesulfonyl-8-prenyl-4-methoxy Chrysin; beta-Anhydroicaritin; β-Anhydroicaritin; Anhydroicaritin; 4H,8H-Benzo[1,2-b:3,4-b']dipyran-4-one,9,10-dihydro-3,5-dihydroxy-2-(4-methoxyphenyl)-8,8-dimethyl-



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Youyang Shi, Yuanyuan Wu, Feifei Li, Yang Zhang, Ciyi Hua, Jianfeng Yang, Jinzhou Zheng, Lili Chen, Zheng Wei, Haiyan Yue, Chenping Sun, Xiqiu Zhou, Sheng Liu. Identifying the anti-metastasis effect of Anhydroicaritin on breast cancer: Coupling network pharmacology with experimental validation. Journal of ethnopharmacology. 2022 Jul; 293(?):115326. doi: 10.1016/j.jep.2022.115326. [PMID: 35489659]
  • Zhenru Tao, Juan Liu, Yueming Jiang, Liang Gong, Bao Yang. Synthesis of prenylated flavonols and their potents as estrogen receptor modulator. Scientific reports. 2017 09; 7(1):12445. doi: 10.1038/s41598-017-12640-9. [PMID: 28963488]
  • Zu-Guo Zheng, Ya-Ping Zhou, Xin Zhang, Pyone Myat Thu, Zhi-Shen Xie, Chong Lu, Tao Pang, Bin Xue, Da-Qian Xu, Yan Chen, Xiao-Wei Chen, Hui-Jun Li, Xiaojun Xu. Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. Biochemical pharmacology. 2016 Dec; 122(?):42-61. doi: 10.1016/j.bcp.2016.10.016. [PMID: 27816546]
  • Yingtao Wu, Wanchun Wang, Lian Liu. Effect of β-anhydroicaritin on the expression levels of tumor necrosis factor-α and matrix metalloproteinase-3 in periodontal tissue of diabetic rats. Molecular medicine reports. 2015 Aug; 12(2):1829-37. doi: 10.3892/mmr.2015.3591. [PMID: 25847066]
  • Mi-Shan Wu, Su-Zhi Zhao, Li-Zhong Ren, Ru Wang, Xia Bai, Hong-Wei Han, Bin Li. [Experimental study on effect of anhydroicaritin phytosomes in preventing and treating bone loss and enhancing bone quality in ovariectomized osteoporosis rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Jul; 38(13):2163-8. doi: NULL. [PMID: 24079247]
  • Yanping Li, Xuehui Zhang, Hui Peng, Rongtao Li, Xuliang Deng. Effects of anhydroicaritin and 2'-hydroxy-3'-en-anhydroicaritin on the proliferation and differentiation of MC3T3-E1 osteoblasts. Natural product communications. 2012 Nov; 7(11):1461-4. doi: ". [PMID: 23285807]
  • Mario Dell'Agli, Germana V Galli, Esther Dal Cero, Federica Belluti, Riccardo Matera, Elisa Zironi, Giampiero Pagliuca, Enrica Bosisio. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. Journal of natural products. 2008 Sep; 71(9):1513-7. doi: 10.1021/np800049y. [PMID: 18778098]