Icartin (BioDeep_00000230062)
PANOMIX_OTCML-2023
代谢物信息卡片
4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-
化学式: C21H20O6 (368.125982)
中文名称: 去水淫羊藿黄素, 三七淫羊藿素, 淫羊藿素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=CCC1=C2C(=C(C=C1O)O)C(=O)C(=C(O2)C3=CC=C(C=C3)OC)O)C
InChI: InChI=1S/C21H20O6/c1-11(2)4-9-14-15(22)10-16(23)17-18(24)19(25)20(27-21(14)17)12-5-7-13(26-3)8-6-12/h4-8,10,22-23,25H,9H2,1-3H3
描述信息
Icaritin has been used in trials studying the treatment of Solid Tumors, Metastatic Breast Cancer, and Hepatocellular Carcinoma (HCC).
Icaritin is a natural product found in Epimedium diphyllum, Epimedium wushanense, and other organisms with data available.
Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC50 of 8 μM) and primary CML cells (IC50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis[1][2][3.
Icaritin (Anhydroicaritin) is a prenylflavonoid derivative from Epimedium brevicornuMaxim. and potently inhibits proliferation of K562 cells (IC50 of 8 μM) and primary CML cells (IC50 of 13.4 μM for CML-CP and 18 μM for CML-BC). Icaritin can regulate MAPK/ERK/JNK and JAK2/STAT3 /AKT signalings, also enhances osteogenesis[1][2][3.
同义名列表
16 个代谢物同义名
4H-1-benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-butenyl)-; 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-en-1-yl)-4H-chromen-4-one; 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-4h-chromen-4-one; 3,5,7-trihydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one; 3-hydroxy-7-o-beta-glucose-8-prenyl-4-methoxy Chrysin; 4-methoxy-3,5,7trihydroxy-8-3,3-dimethylallylflavone; TUUXBSASAQJECY-UHFFFAOYSA-N; Icaritin(Anhydroicaritin); Icaritin, >=98\\% (HPLC); ICARITIN [WHO-DD]; Cycloicaritin; Icaritin; Icartin; Anhydroicaritin
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 5318980
- DrugBank: DB12672
- ChEMBL: CHEMBL498485
- MeSH: icaritin
- ChemIDplus: 0118525409
- chemspider: 4477409
- CAS: 118525-40-9
- medchemexpress: HY-N0678
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 253612 - Epimedium acuminatum: 10.1021/NP50096A021
- 253601 - Epimedium diphyllum: 10.1016/0031-9422(88)80784-2
- 153729 - Epimedium pubescens: -
- 253611 - Epimedium wushanense: 10.1016/0031-9422(90)80206-V
- 33090 - Plants: -
- 33090 - 淫羊藿: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Piao Luo, Yehai An, Jingqian He, Xuefeng Xing, Qian Zhang, Xueying Liu, Yu Chen, Haitao Yuan, Junhui Chen, Yin-Kwan Wong, Jingnan Huang, Zipeng Gong, Qingfeng Du, Wei Xiao, Jigang Wang. Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma.
Cancer letters.
2024 Apr; 587(?):216621. doi:
10.1016/j.canlet.2024.216621. [PMID: 38242198] - Xiangyang Zhou, Di Wu, Tian Mi, Ruohan Li, Tao Guo, Wenjuan Li. Icaritin activates p53 and inhibits aerobic glycolysis in liver cancer cells.
Chemico-biological interactions.
2024 Apr; 392(?):110926. doi:
10.1016/j.cbi.2024.110926. [PMID: 38431053] - Yipeng Chen, Tiantian Zhao, Lina Cheng, Bao Yang, Lingrong Wen. Degree of methyl esterification: A key factor for the encapsulation of icaritin with pectin.
International journal of biological macromolecules.
2024 Mar; 260(Pt 1):129361. doi:
10.1016/j.ijbiomac.2024.129361. [PMID: 38218280] - Si-Qing Huang, Lei Xia, Yan-Qiu Xia, Hong-Li Huang, Li Dong. Icaritin attenuates recurrent spontaneous abortion in mice by modulating Treg/Th17 imbalance via TGF-β/SMAD signaling pathway.
Biochimica et biophysica acta. Molecular cell research.
2024 01; 1871(1):119574. doi:
10.1016/j.bbamcr.2023.119574. [PMID: 37689142] - Yipeng Chen, Yueming Jiang, Lingrong Wen, Bao Yang. Interaction between ultrasound-modified pectin and icaritin.
Food chemistry.
2023 Nov; 426(?):136618. doi:
10.1016/j.foodchem.2023.136618. [PMID: 37354572] - Feifei Yang, Han Wen, Siqi Ma, Qi Chang, Ruile Pan, Xinmin Liu, Yonghong Liao. Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells.
Molecules (Basel, Switzerland).
2023 Aug; 28(15):. doi:
10.3390/molecules28155837. [PMID: 37570807] - Jianwei Fan, Yu Miao, Yun Zhao, Yongxia Guan, Li Zhang, Lihong Pan, Qun Feng, Jingchun Yao, Chenghong Sun. Icaritin inhibits oxidative stress in murine astrocytes by binding to Orai1 to block store-operated calcium channel.
Chemical biology & drug design.
2023 04; 101(4):873-882. doi:
10.1111/cbdd.14193. [PMID: 36527176] - Dalong Wang, Jing Liu, Xiaodong Chen, Jing Chen, Tingting Zhao, Jie Du, Changyuan Wang, Qiang Meng, Huijun Sun, Fangjun Wang, Kexin Liu, Jingjing Wu. Renal transporter OAT1 and PPAR-α pathway co-contribute to icaritin-induced nephrotoxicity.
Phytotherapy research : PTR.
2023 Feb; 37(2):549-562. doi:
10.1002/ptr.7633. [PMID: 36331006] - Yunfeng Tang, Lixin Sun, Yun Zhao, Jingchun Yao, Zhong Feng, Zhong Liu, Guimin Zhang, Chenghong Sun. UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion.
PeerJ.
2023; 11(?):e14483. doi:
10.7717/peerj.14483. [PMID: 36643627] - Peng Yu, Zhen Qian, Hongmei Yang, Tianyang Xu, Yulin Dai, Laihui Song, Jinling Liang, Yuying Shi, Zhiguo Zhang, Lijing Li. Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress.
European journal of pharmacology.
2022 Dec; 937(?):175378. doi:
10.1016/j.ejphar.2022.175378. [PMID: 36372277] - Huating Zeng, Xiaoqi Li, Yuping Liu, Xia Li, Ding Qu, Yan Chen. An icaritin-loaded microemulsion based on coix oil for improved pharmacokinetics and enhanced antitumor efficacy.
Drug delivery.
2022 Dec; 29(1):3454-3466. doi:
10.1080/10717544.2022.2147601. [PMID: 36447364] - Zhangyang Bi, Wei Zhang, Xiaoyan Yan. Anti-inflammatory and immunoregulatory effects of icariin and icaritin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jul; 151(?):113180. doi:
10.1016/j.biopha.2022.113180. [PMID: 35676785] - Yalan Sun, Dandan Jia, Meng Xue, Zhihua Huang, Cheng Huang. Trifluoro-icaritin alleviates chronic inflammatory pain through α7nAChR-mediated suppression of HMGB1/NF-κB signaling in the spinal cord of rats.
Brain research bulletin.
2022 06; 183(?):13-26. doi:
10.1016/j.brainresbull.2022.02.014. [PMID: 35202753] - Shumei Tu, Dengxuan Mao, Mengxin Shi, Huangqin Zhang, Congyan Liu, Xiaoqi Li, Yang Zhao, Yan Chen, Yuping Liu. Icaritin ameliorates extracellular microparticles-induced inflammatory pre-metastatic niche via modulating the cGAS-STING signaling.
Phytotherapy research : PTR.
2022 May; 36(5):2127-2142. doi:
10.1002/ptr.7433. [PMID: 35257426] - Yi Hou, Wenbin Kuang, Wenjian Min, Ziwen Liu, Fang Zhang, Kai Yuan, Xiao Wang, Chengliang Sun, Hao Cheng, Liping Wang, Yibei Xiao, Sheban Pu, Gui-Zhong Xin, Peng Yang. Design, Synthesis, and Biological Evaluation of Icaritin Derivatives as Novel Putative DEPTOR Inhibitors for Multiple Myeloma Treatment.
Journal of medicinal chemistry.
2021 10; 64(20):14942-14954. doi:
10.1021/acs.jmedchem.1c00087. [PMID: 34644502] - Qingzhong Hua, Xiaoting Huang, Weixi Xie, Feiyan Zhao, Haipeng Cheng, Ziqiang Luo, Jianzhong Han, Zun Wang, Qian Zeng, Miao Lin, Tingting Zhou, Jialu Zhang, Can Gu, Wei Liu, Siyuan Tang. PPARγ mediates the anti-pulmonary fibrosis effect of icaritin.
Toxicology letters.
2021 Oct; 350(?):81-90. doi:
10.1016/j.toxlet.2021.06.014. [PMID: 34153405] - Jingxin Fu, Yian Wang, Haowen Li, Likang Lu, Hui Ao, Meihua Han, Yifei Guo, Xiangtao Wang. A Low Dose of Hydrous Icaritin Nano-Formulation with Remarkable Efficacy and Tumor Targeting in Cancer Therapy.
Journal of biomedical nanotechnology.
2021 Oct; 17(10):2003-2013. doi:
10.1166/jbn.2021.3176. [PMID: 34706800] - Pingping Wang, Chaojing Li, Xiaodong Li, Wenjun Huang, Yan Wang, Jiali Wang, Yanjun Zhang, Xiaoman Yang, Xing Yan, Ying Wang, Zhihua Zhou. Complete biosynthesis of the potential medicine icaritin by engineered Saccharomyces cerevisiae and Escherichia coli.
Science bulletin.
2021 09; 66(18):1906-1916. doi:
10.1016/j.scib.2021.03.002. [PMID: 36654400] - Ke-Ming Hou, Qiu-Rui Li, Qin Yang, Ke Xu, Rong Chen. [Effect of icaritin on proliferation and apoptosis of human ovarian cancer cells SKOV3].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2021 Jan; 46(1):183-189. doi:
10.19540/j.cnki.cjcmm.20200915.404. [PMID: 33645069] - Cheng-Cheng Tao, Yue Wu, Xiang Gao, Ling Qiao, Ying Yang, Fang Li, Jie Zou, Yu-Hao Wang, Shu-Yu Zhang, Chang-Long Li, Yuan-Yuan Zhang, Xiao-Dong Sun. The Antitumor Effects of Icaritin Against Breast Cancer is Related to Estrogen Receptors.
Current molecular medicine.
2021; 21(1):73-85. doi:
10.2174/1566524020666200530212440. [PMID: 32472997] - Yuyu Xu, Xiaoyan Lu, Li Zhang, Lijuan Wang, Guimin Zhang, Jingchun Yao, Chenghong Sun. Icaritin activates Nrf2/Keap1 signaling to protect neuronal cells from oxidative stress.
Chemical biology & drug design.
2021 01; 97(1):111-120. doi:
10.1111/cbdd.13765. [PMID: 32654377] - Yian Wang, Tiantian Huang, Haowen Li, Jingxin Fu, Hui Ao, Likang Lu, Meihua Han, Yifei Guo, Feng Yue, Xiangtao Wang. Hydrous icaritin nanorods with excellent stability improves the in vitro and in vivo activity against breast cancer.
Drug delivery.
2020 Dec; 27(1):228-237. doi:
10.1080/10717544.2020.1716877. [PMID: 32003229] - Haowen Li, Yijing Li, Hui Ao, Jingxin Fu, Yifei Guo, Meihua Han, Xueying Yan, Xi Chen, Xiangtao Wang. A comparative study on the in vitro and in vivo antitumor efficacy of icaritin and hydrous icaritin nanorods.
Drug delivery.
2020 Dec; 27(1):1176-1187. doi:
10.1080/10717544.2020.1801892. [PMID: 32762483] - Yi Rong, Yifan Tu, Taijun Yin, Zhiyun Meng, Guifang Dou, Ming Hu. Rapid intestinal glucuronidation and hepatic glucuronide recycling contributes significantly to the enterohepatic circulation of icaritin and its glucuronides in vivo.
Archives of toxicology.
2020 11; 94(11):3737-3749. doi:
10.1007/s00204-020-02867-3. [PMID: 32918091] - Shu-Kui Qin, Qing Li, Jian Ming Xu, Jun Liang, Ying Cheng, Ying Fan, Jun Jiang, Hao Ye, Huimin Tao, Lian Li, Limin Zheng, Zhaohui Wei, Shu Li, Kun Meng, Bin Ye, Yan Sun. Icaritin-induced immunomodulatory efficacy in advanced hepatitis B virus-related hepatocellular carcinoma: Immunodynamic biomarkers and overall survival.
Cancer science.
2020 Nov; 111(11):4218-4231. doi:
10.1111/cas.14641. [PMID: 32889778] - Romela Irene Ramos, Matias A Bustos, Jinfeng Wu, Peter Jones, Shu Ching Chang, Eiji Kiyohara, Kevin Tran, Xiaoqing Zhang, Stacey L Stern, Sivan Izraely, Orit Sagi-Assif, Isaac P Witz, Michael A Davies, Gordon B Mills, Daniel F Kelly, Reiko F Irie, Dave S B Hoon. Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis.
Molecular oncology.
2020 08; 14(8):1760-1778. doi:
10.1002/1878-0261.12702. [PMID: 32358995] - Hua-Ting Zeng, Jian Guo, Cong-Yan Liu, Ting Xu, Rui-Yun Li, Yan Chen. [Development of preparation process of icaritin-coix seed oil microemulsion based on quality by design concept].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Aug; 45(16):3844-3851. doi:
10.19540/j.cnki.cjcmm.20200522.304. [PMID: 32893579] - Zhuo Yu, Jianfeng Guo, Mengying Hu, Yueqiu Gao, Leaf Huang. Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma.
ACS nano.
2020 04; 14(4):4816-4828. doi:
10.1021/acsnano.0c00708. [PMID: 32188241] - Canjing Zhang, Xianxian Sui, Yudong Jiang, Xuanyi Wang, Songmei Wang. Antitumor effects of icaritin and the molecular mechanisms.
Discovery medicine.
2020 Jan; 29(156):5-16. doi:
. [PMID: 32598859] - Jimeng Hu, Xiaobo Wu, Chen Yang, Khalid Rashid, Chenkai Ma, Mengbo Hu, Qiang Ding, Haowen Jiang. Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2C.
Cancer medicine.
2019 12; 8(18):7833-7845. doi:
10.1002/cam4.2630. [PMID: 31646760] - Haibang Hao, Qi Zhang, Hai Zhu, Yuxiang Wen, Ding Qiu, Jian Xiong, Xiaolan Fu, Yuzhang Wu, Kun Meng, Jian Li. Icaritin promotes tumor T-cell infiltration and induces antitumor immunity in mice.
European journal of immunology.
2019 12; 49(12):2235-2244. doi:
10.1002/eji.201948225. [PMID: 31465113] - Kehuan Sun, Wenhui Mei, Shu Mo, Ling Xin, Xiaojun Lei, Mengtian Huang, Qiufang Chen, Li Han, Xiaofeng Zhu. Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells.
Chemico-biological interactions.
2019 Apr; 303(?):7-13. doi:
10.1016/j.cbi.2019.01.039. [PMID: 30731080] - Shibing Shan, Jingchun Yao, Lisa Xu, Shangcong Han, Jie Cao, Guimin Zhang, Yong Sun. Preparation of Icaritin-Loaded mPEG-PLA Micelles and Evaluation on Ischemic Brain Injury.
Journal of biomedical nanotechnology.
2019 Apr; 15(4):674-685. doi:
10.1166/jbn.2019.2721. [PMID: 30841962] - Yi Ling Teo, Wei Fun Cheong, Amaury Cazenave-Gassiot, Shanshan Ji, Susan Logan, Zhi Xing Kelvin Lee, Jun Li, Kok Yong Seng, Lawrence Soon-U Lee, Eu Leong Yong. Pharmacokinetics of Prenylflavonoids following Oral Ingestion of Standardized Epimedium Extract in Humans.
Planta medica.
2019 Mar; 85(4):347-355. doi:
10.1055/a-0806-7673. [PMID: 30522143] - Lumei Liu, Zhengxiao Zhao, Linwei Lu, Jiaqi Liu, Jing Sun, Xiao Wu, Jingcheng Dong. Icariin and icaritin ameliorated hippocampus neuroinflammation via inhibiting HMGB1-related pro-inflammatory signals in lipopolysaccharide-induced inflammation model in C57BL/6 J mice.
International immunopharmacology.
2019 Mar; 68(?):95-105. doi:
10.1016/j.intimp.2018.12.055. [PMID: 30616172] - Xiao-Jing Yang, Ya-Ming Xi, Zi-Jian Li. Icaritin: A Novel Natural Candidate for Hematological Malignancies Therapy.
BioMed research international.
2019; 2019(?):4860268. doi:
10.1155/2019/4860268. [PMID: 31032347] - Le Huang, Xinluan Wang, Huijuan Cao, Ling Li, Dick Ho-Kiu Chow, Li Tian, Heng Wu, Jiayong Zhang, Nan Wang, Lizhen Zheng, Xinsheng Yao, Zhijun Yang, Ling Qin. A bone-targeting delivery system carrying osteogenic phytomolecule icaritin prevents osteoporosis in mice.
Biomaterials.
2018 11; 182(?):58-71. doi:
10.1016/j.biomaterials.2018.07.046. [PMID: 30107270] - Yannan Li, Jing Ning, Yan Wang, Chao Wang, Chengpeng Sun, Xiaokui Huo, Zhenlong Yu, Lei Feng, Baojing Zhang, Xiangge Tian, Xiaochi Ma. Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects.
Toxicology letters.
2018 Sep; 294(?):27-36. doi:
10.1016/j.toxlet.2018.05.008. [PMID: 29753067] - Yongji Liu, Ling Shi, Yuan Liu, Peng Li, Guoping Jiang, Xiaoning Gao, Yongbin Zhang, Chuanwu Jiang, Weiping Zhu, Hongxing Han, Fang Ju. Activation of PPARγ mediates icaritin-induced cell cycle arrest and apoptosis in glioblastoma multiforme.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Apr; 100(?):358-366. doi:
10.1016/j.biopha.2018.02.006. [PMID: 29453045] - Chenghong Sun, Jian Yang, Lihong Pan, Na Guo, Bingbing Li, Jingchun Yao, Mingzhi Wang, Changpeng Qi, Guimin Zhang, Zhong Liu. Improvement of icaritin on hematopoietic function in cyclophosphamide-induced myelosuppression mice.
Immunopharmacology and immunotoxicology.
2018 Feb; 40(1):25-34. doi:
10.1080/08923973.2017.1392564. [PMID: 29077519] - Chenghong Sun, Jian Yang, Mingzhi Wang, Lihong Pan, Jingchun Yao, Shenglan Wang, Na Guo, Chunyan Li, Guimin Zhang. Icaritin Improves Antibody-Induced Thrombocytopenia in a Mouse Model by Regulating T-cell Polarization.
Planta medica.
2018 Feb; 84(3):168-175. doi:
10.1055/s-0043-119643. [PMID: 28938496] - Ke Zhang, Zhenfeng Dai, Runzhe Liu, Fang Tian, Xi Liu, Yi Sun, Xin Zhao, Xiaoping Pu. Icaritin Provokes Serum Thrombopoietin and Downregulates Thrombopoietin/MPL of the Bone Marrow in a Mouse Model of Immune Thrombocytopenia.
Mediators of inflammation.
2018; 2018(?):7235639. doi:
10.1155/2018/7235639. [PMID: 30224899] - Zhi-Yuan Li, Zhen-Jie Li, Xu Chen, Xing-Ru Huang, Zhi-Qing Fang, Jian-Guo Zhang, Jian Fang. [Icaritin Reverses Multidrug Resistance of Multiple Myeloma Cell Line KM3/BTZ].
Zhongguo shi yan xue ye xue za zhi.
2017 Dec; 25(6):1690-1695. doi:
10.7534/j.issn.1009-2137.2017.06.020. [PMID: 29262899] - Shuang-Qing Zhang, Shi-Zhong Zhang. Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q-TOF and UHPLC-MS/MS.
Drug testing and analysis.
2017 Oct; 9(10):1604-1610. doi:
10.1002/dta.2188. [PMID: 28303675] - Zhenru Tao, Juan Liu, Yueming Jiang, Liang Gong, Bao Yang. Synthesis of prenylated flavonols and their potents as estrogen receptor modulator.
Scientific reports.
2017 09; 7(1):12445. doi:
10.1038/s41598-017-12640-9. [PMID: 28963488] - Pei-Hua Lu, Min-Bin Chen, Yuan-Yuan Liu, Mian-Hua Wu, Wen-Ting Li, Mu-Xin Wei, Chao-Ying Liu, Shu-Kui Qin. Identification of sphingosine kinase 1 (SphK1) as a primary target of icaritin in hepatocellular carcinoma cells.
Oncotarget.
2017 Apr; 8(14):22800-22810. doi:
10.18632/oncotarget.15205. [PMID: 28206952] - Tao Wu, Tao Shu, Le Kang, Jinhui Wu, Jianzhou Xing, Zhiqin Lu, Shuxiang Chen, Jun Lv. Icaritin, a novel plant-derived osteoinductive agent, enhances the osteogenic differentiation of human bone marrow- and human adipose tissue-derived mesenchymal stem cells.
International journal of molecular medicine.
2017 Apr; 39(4):984-992. doi:
10.3892/ijmm.2017.2906. [PMID: 28260001] - Jian-Guang Yang, Rui Lu, Xiao-Jing Ye, Jing Zhang, Ya-Qin Tan, Gang Zhou. Icaritin Reduces Oral Squamous Cell Carcinoma Progression via the Inhibition of STAT3 Signaling.
International journal of molecular sciences.
2017 Jan; 18(1):. doi:
10.3390/ijms18010132. [PMID: 28085115] - Jinfeng Wu, Juan Du, Xiuqiong Fu, Bin Liu, Huihui Cao, Ting Li, Tao Su, Jinhua Xu, Anfernee Kai-Wing Tse, Zhi-Ling Yu. Iciartin, a novel FASN inhibitor, exerts anti-melanoma activities through IGF-1R/STAT3 signaling.
Oncotarget.
2016 Aug; 7(32):51251-51269. doi:
10.18632/oncotarget.9984. [PMID: 27323414] - Si-wen Lin, Xue-qin Li, Su-yun Liu, Jian-ming Shi, Jun-huai Xu, Long-huo Mao, Ming Yin. [Inhibition of Combination of Icaritin and Doxorubicin on Human Osteosarcoma MG-63 Cells in vitro].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2016 Jun; 36(6):729-34. doi:
". [PMID: 27491234] - Shi Shen, Shuangqing Zhang. [Identification of icaritin metabolites in rat plasma by UPLC-QTOF-MS].
Wei sheng yan jiu = Journal of hygiene research.
2016 May; 45(3):458-62. doi:
NULL. [PMID: 27459812] - Chunxian Zhou, Zhengrong Chen, Xingsheng Lu, Hao Wu, Qunying Yang, Dongfeng Xu. Icaritin activates JNK-dependent mPTP necrosis pathway in colorectal cancer cells.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2016 Mar; 37(3):3135-44. doi:
10.1007/s13277-015-4134-3. [PMID: 26427664] - Zong-Kang Zhang, Jie Li, De-Xin Yan, Wing-Nang Leung, Bao-Ting Zhang. Icaritin Inhibits Collagen Degradation-Related Factors and Facilitates Collagen Accumulation in Atherosclerotic Lesions: A Potential Action for Plaque Stabilization.
International journal of molecular sciences.
2016 Jan; 17(2):. doi:
10.3390/ijms17020169. [PMID: 26828485] - Ling Qin, Dong Yao, Lizhen Zheng, Wai-Ching Liu, Zhong Liu, Ming Lei, Le Huang, Xinhui Xie, Xinluan Wang, Yang Chen, Xinsheng Yao, Jiang Peng, He Gong, James F Griffith, Yanping Huang, Yongping Zheng, Jian Q Feng, Ying Liu, Shihui Chen, Deming Xiao, Daping Wang, Jiangyi Xiong, Duanqing Pei, Peng Zhang, Xiaohua Pan, Xiaohong Wang, Kwong-Man Lee, Chun-Yiu Cheng. Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits.
Biomaterials.
2015 Aug; 59(?):125-43. doi:
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European journal of medicinal chemistry.
2015 Jul; 100(?):139-50. doi:
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Wei sheng yan jiu = Journal of hygiene research.
2015 Jul; 44(4):692-4. doi:
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Cell biochemistry and biophysics.
2015 Jun; 72(2):533-42. doi:
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Oncotarget.
2015 Apr; 6(12):10460-72. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2015 Apr; 22(4):487-97. doi:
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Molecular medicine reports.
2015 Apr; 11(4):3094-100. doi:
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Drug testing and analysis.
2015 Apr; 7(4):309-19. doi:
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International journal of nanomedicine.
2015; 10(?):2377-89. doi:
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The American journal of Chinese medicine.
2015; 43(6):1083-97. doi:
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Wei sheng yan jiu = Journal of hygiene research.
2015 Jan; 44(1):91-4. doi:
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Molecules (Basel, Switzerland).
2014 Nov; 19(11):18690-704. doi:
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Wei sheng yan jiu = Journal of hygiene research.
2014 Nov; 43(6):986-9, 997. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Oct; 21(12):1633-7. doi:
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International journal of molecular medicine.
2014 Jun; 33(6):1627-34. doi:
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Die Pharmazie.
2014 Apr; 69(4):301-5. doi:
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Planta medica.
2014 Jan; 80(1):22-8. doi:
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Molecular medicine reports.
2013 Dec; 8(6):1883-7. doi:
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Behavioural brain research.
2013 Nov; 256(?):602-8. doi:
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PloS one.
2013; 8(12):e81657. doi:
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Aug; 19(11):1024-8. doi:
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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Aug; 50(8):2751-9. doi:
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International immunopharmacology.
2012 May; 13(1):1-7. doi:
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Journal of ethnopharmacology.
2011 Sep; 137(1):714-23. doi:
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Molecular bioSystems.
2011 Jul; 7(7):2128-38. doi:
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2009 Oct; 44(10):1140-4. doi:
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Bone.
2009 Feb; 44(2):345-56. doi:
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Journal of natural products.
2008 Sep; 71(9):1513-7. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 857(1):47-52. doi:
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Neuroscience.
2007 Mar; 145(3):911-22. doi:
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