Oridonin (BioDeep_00000230051)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(1|A,6|A,7|A,14R)-1,5,6,14-Tetrahydroxy-4,4-dimethyl-8-methylenedecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-one

化学式: C20H28O6 (364.1885788)
中文名称: 冬凌草甲素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 80%

分子结构信息

SMILES: C=C1C(=O)C23C(O)C1CCC2C12COC3(O)C(O)C1C(C)(C)CCC2O
InChI: InChI=1S/C20H28O6/c1-9-10-4-5-11-18-8-26-20(25,19(11,14(9)22)15(10)23)16(24)13(18)17(2,3)7-6-12(18)21/h10-13,15-16,21,23-25H,1,4-8H2,2-3H3

描述信息

Oridonin is an organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an apoptosis inducer, an anti-asthmatic agent, a plant metabolite and an antibacterial agent. It is an organic heteropentacyclic compound, an enone, a cyclic hemiketal, a secondary alcohol and an ent-kaurane diterpenoid.
Oridonin is a natural product found in Isodon rugosus, Isodon ternifolius, and other organisms with data available.
An organic heteropentacyclic compound and ent-kaurane diterpenoid with formula C20H28O6 isolated from the leaves of the medicinal herb Rabdosia rubescens.
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.
Oridonin (NSC-250682), a diterpenoid isolated from Rabdosia rubescens, acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2; Oridonin possesses anti-tumor, anti-bacterial and anti-inflammatory effects.

同义名列表

25 个代谢物同义名

(1|A,6|A,7|A,14R)-1,5,6,14-Tetrahydroxy-4,4-dimethyl-8-methylenedecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-one; (1alpha,5beta,6beta,7alpha,8alpha,9beta,10alpha,13alpha,14R)-1,6,7,14-tetrahydroxy-7,20-epoxykaur-16-en-15-one; KAUR-16-EN-15-ONE, 7,20-EPOXY-1,6,7,14-TETRAHYDROXY-, (1.ALPHA.,6.BETA.,7.ALPHA.,14R)-; Kaur-16-en-15-one, 7,20-epoxy-1,6,7,14-tetrahydroxy-, (1alpha,6beta,7alpha,14R)-; KAUR-16-EN-15-ONE, 7.ALPHA.,20-EPOXY-1.ALPHA.,6.BETA.,7,14-TETRAHYDROXY-, (14R)-; (1-alpha,6-beta,7-alpha,14R)-7,20-Epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one; KAUR-16-EN-15-ONE, 7-alpha,20-EPOXY-1-alpha,6-beta,7,14-TETRAHYDROXY-, (14R)-; oridonin, (1alpha,5alpha,6alpha,7beta,8beta,9alpha,10beta,13beta,14S)-isomer; (1alpha,6beta,7alpha,14R)-7,20-epoxy-1,6,7,14-tetrahydroxykaur-16-en-15-one; (14R)-7-alpha,20-Epoxy-1-alpha,6-beta,7,14-tetrahydroxykaur-16-en-15-one; 7?,20-Epoxy-1?,6?,7,14-tetrahydroxykaur-16-en-15-one; oridonin, (1alpha,6beta,7alpha,11alpha)-isomer; oridonin, (1alpha,6beta,7alpha,11beta)-isomer; UNII-0APJ98UCLQ; ORIDONIN [INCI]; Rubescensin A; PURE ORIDONIN; Rubescensin; Rubescenin; 0APJ98UCLQ; Oridonine; lasidonin; ISODONOL; Oridonin; NSC-250682



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shiying Ye, Xiangyan Hu, Shaowei Sun, Bo Su, Jiye Cai, Jinhuan Jiang. Oridonin promotes RSL3-induced ferroptosis in breast cancer cells by regulating the oxidative stress signaling pathway JNK/Nrf2/HO-1. European journal of pharmacology. 2024 Jul; 974(?):176620. doi: 10.1016/j.ejphar.2024.176620. [PMID: 38685305]
  • Jing Liu, Qian Zhang, Yin Kwan Wong, Piao Luo, Junhui Chen, Lulin Xie, Jiayun Chen, Xueling He, Fei Shi, Ping Gong, Xueyan Liu, Jigang Wang. Single-Cell Transcriptomics Reveals the Ameliorative Effect of Oridonin on Septic Liver Injury. Advanced biology. 2024 Mar; 8(3):e2300542. doi: 10.1002/adbi.202300542. [PMID: 38408269]
  • Tao-Yan Lin, Jun-Shuang Jia, Wei-Ren Luo, Xiao-Lin Lin, Sheng-Jun Xiao, Jie Yang, Jia-Wei Xia, Chen Zhou, Zhi-Hao Zhou, Shu-Jun Lin, Qi-Wen Li, Zhi-Zhi Yang, Ye Lei, Wen-Qing Yang, Hong-Fen Shen, Shi-Hao Huang, Sheng-Chun Wang, Lin-Bei Chen, Yu-Lin Yang, Shu-Wen Xue, Yong-Long Li, Guan-Qi Dai, Ying Zhou, Ying-Chun Li, Fang Wei, Xiao-Xiang Rong, Xiao-Jun Luo, Bing-Xia Zhao, Wen-Hua Huang, Dong Xiao, Yan Sun. ThermomiR-377-3p-induced suppression of Cirbp expression is required for effective elimination of cancer cells and cancer stem-like cells by hyperthermia. Journal of experimental & clinical cancer research : CR. 2024 Feb; 43(1):62. doi: 10.1186/s13046-024-02983-3. [PMID: 38419081]
  • Feifan Zhang, Yang Hao, Ning Yang, Man Liu, Yage Luo, Ying Zhang, Jian Zhou, Hongjian Liu, Jitian Li. Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells. BMC cancer. 2024 Feb; 24(1):198. doi: 10.1186/s12885-024-11951-1. [PMID: 38347435]
  • Henglai Sun, Jijuan Nai, Biqi Deng, Zhen Zheng, Xuemei Chen, Chao Zhang, Huagang Sheng, Liqiao Zhu. Angelica Sinensis Polysaccharide-Based Nanoparticles for Liver-Targeted Delivery of Oridonin. Molecules (Basel, Switzerland). 2024 Feb; 29(3):. doi: 10.3390/molecules29030731. [PMID: 38338476]
  • Lifen Zhang, Yao Yu, Qi Wang, Xi Huang, Zheng Feng, Zhi Li. Oridonin loaded peptide nanovesicles alleviate nonalcoholic fatty liver disease in mice. Pharmaceutical development and technology. 2024 Feb; 29(2):123-130. doi: 10.1080/10837450.2024.2315460. [PMID: 38327230]
  • Conglong Lian, Fei Zhang, Hao Yang, Xueyu Zhang, Jinxu Lan, Bao Zhang, Xiuyu Liu, Jingfan Yang, Suiqing Chen. Multi-omics analysis of small RNA, transcriptome, and degradome to identify putative miRNAs linked to MeJA regulated and oridonin biosynthesis in Isodon rubescens. International journal of biological macromolecules. 2024 Feb; 258(Pt 2):129123. doi: 10.1016/j.ijbiomac.2023.129123. [PMID: 38163496]
  • Shuling Zhang, Annamalai Vijayalakshmi, Lingjun Meng. Oridonin attenuated human PC-3 cell activity by modulating the Wnt/β-catenin signaling. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2024 Jan; ?(?):. doi: 10.17219/acem/175519. [PMID: 38269477]
  • Ronald J Quinn, Tin Mak, Dene R Littler, Jamie Rossjohn, Miaomiao Liu. Discovery of Anti-SARS-CoV-2 Nsp9 Binders from Natural Products by a Native Mass Spectrometry Approach. Journal of natural products. 2023 12; 86(12):2630-2637. doi: 10.1021/acs.jnatprod.3c00636. [PMID: 37993134]
  • Shoudi He, Changsheng Huang, Ning Tan, Jianyong Zhang. Oridonin Promotes Apoptosis in Rheumatoid Arthritis Fibroblast-like Synoviocytes Through PERK/eIF2α/CHOP of Endoplasmic Reticulum Stress Pathway. DNA and cell biology. 2023 Dec; 42(12):711-719. doi: 10.1089/dna.2023.0244. [PMID: 37862122]
  • Ming Zhang, Lianjie Hou, Wanying Tang, Weixing Lei, Huiling Lin, Yu Wang, Haijiao Long, Shuyun Lin, Zhi Chen, Guangliang Wang, Guojun Zhao. Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling. Journal of cellular and molecular medicine. 2023 Oct; ?(?):. doi: 10.1111/jcmm.18000. [PMID: 37905351]
  • Xiangli He, Jiayan Cui, Hui Ma, Naijipu Abuduaini, Ying Huang, Lu Tang, Wanyan Wang, Yuanyuan Zhang, Yang Wang, Weiqiang Lu, Bo Feng, Jin Huang. Berberrubine is a novel and selective IMPDH2 inhibitor that impairs the growth of colorectal cancer. Biochemical pharmacology. 2023 Oct; 218(?):115868. doi: 10.1016/j.bcp.2023.115868. [PMID: 37871880]
  • Lei Wang, Xiaoqi Zhao, Jiawen Ding, Yutong Liu, Han Liu, Lei Zheng, Hongting Zhao, Zichen Sun, Kuanyu Li, Jing Cai, Tong Qiao. Oridonin attenuates the progression of atherosclerosis by inhibiting NLRP3 and activating Nrf2 in apolipoprotein E-deficient mice. Inflammopharmacology. 2023 Aug; 31(4):1993-2005. doi: 10.1007/s10787-023-01161-9. [PMID: 37155118]
  • Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye, Shenglan Yang. Oridonin promotes endoplasmic reticulum stress via TP53-repressed TCF4 transactivation in colorectal cancer. Journal of experimental & clinical cancer research : CR. 2023 Jun; 42(1):150. doi: 10.1186/s13046-023-02702-4. [PMID: 37337284]
  • Ahmed Sultan, Bassim Mohammad, Najah Hadi, Azhar Al-Shaibany, Anil Philip, Dina Jamil, Hayder Al-Aubaidy. Oridonin supplementation in rabbits may help to improve the outcome of induced atherosclerosis via autophagy induction. Acta bio-medica : Atenei Parmensis. 2023 04; 94(2):e2023015. doi: 10.23750/abm.v94i2.14003. [PMID: 37092629]
  • Xiaofei Xin, Jingjing Li, Wantao Wu, Pengbo Zhao, Yang Yang, Ying Zhu, Lianjie Ren, Chao Qin, Lifang Yin. ROS-scavenging nanomedicine for "multiple crosstalk" modulation in non-alcoholic fatty liver disease. Biomaterials science. 2023 Apr; ?(?):. doi: 10.1039/d2bm02161g. [PMID: 37039546]
  • Meng-Bing Chen, Meng-Hua Li, Li-Yuan Wu, Rong Wang, Xi Long, Liang Zhang, Wei Sun, Wei-Wei Guo, Yong Pan, Yun-Shi Zhang, Chang Lin, Xi Shi, Shi-Ming Yang. Oridonin employs interleukin 1 receptor type 2 to treat noise-induced hearing loss by blocking inner ear inflammation. Biochemical pharmacology. 2023 Feb; ?(?):115457. doi: 10.1016/j.bcp.2023.115457. [PMID: 36806583]
  • Shiying Ye, Shaowei Sun, Jiye Cai, Jinhuan Jiang. Research Progress and Future Development Potential of Oridonin in Pharmacological Activities. Current molecular pharmacology. 2023; 16(7):691-706. doi: 10.2174/1874467216666221130163634. [PMID: 36453482]
  • Guohui Wu, Yusheng Guo, Yang Liu, Xiangsheng Cai, Tanggang Deng, Tianchu Pei, Long Huang, Kai Chen, Xuan Pan. Network-Based Method to Investigate the Promoted Cell Apoptosis Mechanisms of Oridonin in OSCC through the RNA-Transcriptome. Journal of immunology research. 2023; 2023(?):5293677. doi: 10.1155/2023/5293677. [PMID: 36969496]
  • Yuwei Sun, Jie Shao, Haili Liu, Hua Wang, Guangyi Wang, Jianhua Li, Yaping Mao, Zhuo Chen, Ke Ma, Lin Xu, Yong Wang. A chromosome-level genome assembly reveals that tandem-duplicated CYP706V oxidase genes control oridonin biosynthesis in the shoot apex of Isodon rubescens. Molecular plant. 2022 Dec; ?(?):. doi: 10.1016/j.molp.2022.12.007. [PMID: 36518072]
  • Ying Zhang, Qianyu Zhang, Zheng Chu, Lin Chen, Jiayun Chen, Yang Yang, Huan Tang, Guangqing Cheng, Ang Ma, Ying Zhang, Chen Wang, Peng Gao, Fei Xia, Qiuyan Guo, Qiaoli Shi, Guang Han, Jigang Wang, Yinhua Zhu. Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells. Chemical communications (Cambridge, England). 2022 Nov; 58(95):13250-13253. doi: 10.1039/d2cc05278d. [PMID: 36367053]
  • Zhipeng Chen, Heqian Liu, Xiaoqi Zhao, Subinur Mamateli, Cheng Liu, Lei Wang, Jing Yu, Yutong Liu, Jing Cai, Tong Qiao. Oridonin attenuates low shear stress-induced endothelial cell dysfunction and oxidative stress by activating the nuclear factor erythroid 2-related factor 2 pathway. BMC complementary medicine and therapies. 2022 Jul; 22(1):180. doi: 10.1186/s12906-022-03658-2. [PMID: 35799227]
  • Xiaoqi Zhao, Yutong Liu, Lei Wang, Chaolong Yan, Han Liu, Wenxin Zhang, Hongting Zhao, Chen Cheng, Zhipeng Chen, Tianze Xu, Kuanyu Li, Jing Cai, Tong Qiao. Oridonin attenuates hind limb ischemia-reperfusion injury by modulating Nrf2-mediated oxidative stress and NLRP3-mediated inflammation. Journal of ethnopharmacology. 2022 Jun; 292(?):115206. doi: 10.1016/j.jep.2022.115206. [PMID: 35301099]
  • Yuzhou Shen, Haitao Ma. Oridonin-loaded lipid-coated calcium phosphate nanoparticles: preparation, characterization, and application in A549 lung cancer. Pharmaceutical development and technology. 2022 Jun; 27(5):598-605. doi: 10.1080/10837450.2022.2090958. [PMID: 35734959]
  • Huahong Yang, Lidong Wang, Manshi Yang, Jianqiang Hu, Erli Zhang, Liping Peng. Oridonin attenuates LPS-induced early pulmonary fibrosis by regulating impaired autophagy, oxidative stress, inflammation and EMT. European journal of pharmacology. 2022 May; 923(?):174931. doi: 10.1016/j.ejphar.2022.174931. [PMID: 35398392]
  • Xiao-Jing Zhao, Hai-Yan Zhu, Xiao-Liang Wang, Xiao-Wei Lu, Cai-Long Pan, Lu Xu, Xue Liu, Ning Xu, Zhi-Yuan Zhang. Oridonin Ameliorates Traumatic Brain Injury-Induced Neurological Damage by Improving Mitochondrial Function and Antioxidant Capacity and Suppressing Neuroinflammation through the Nrf2 Pathway. Journal of neurotrauma. 2022 04; 39(7-8):530-543. doi: 10.1089/neu.2021.0466. [PMID: 35102762]
  • Hyemin Gu, Mi-Gyeong Gwon, Jong Hyun Kim, Jaechan Leem, Sun-Jae Lee. Oridonin Attenuates Cisplatin-Induced Acute Kidney Injury via Inhibiting Oxidative Stress, Apoptosis, and Inflammation in Mice. BioMed research international. 2022; 2022(?):3002962. doi: 10.1155/2022/3002962. [PMID: 35469348]
  • Yu Zhu, Shuiliang Ruan, Heping Shen, Qiaobing Guan, Liping Zhai, Yi Yang. Oridonin regulates the polarized state of Kupffer cells to alleviate nonalcoholic fatty liver disease through ROS-NF-κB. International immunopharmacology. 2021 Dec; 101(Pt B):108290. doi: 10.1016/j.intimp.2021.108290. [PMID: 34717194]
  • Dene R Littler, Miaomiao Liu, Julie L McAuley, Shea A Lowery, Patricia T Illing, Benjamin S Gully, Anthony W Purcell, Indu R Chandrashekaran, Stanley Perlman, Damian F J Purcell, Ronald J Quinn, Jamie Rossjohn. A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein. The Journal of biological chemistry. 2021 12; 297(6):101362. doi: 10.1016/j.jbc.2021.101362. [PMID: 34756886]
  • Boning Cheng, Jianhong Jin, Dianlei Liu, Tingting Shi, Xiaoqing Fu, Chuntao Liu, Shourong Liu, Rui Wu. Oridonin interferes with simple steatosis of liver cells by regulating autophagy. Tissue & cell. 2021 Oct; 72(?):101532. doi: 10.1016/j.tice.2021.101532. [PMID: 33823340]
  • Xinglong Fan, Tian Wang, Zhongyi Ji, Qingpeng Li, Hongyu Shen, Jun Wang. Synergistic combination therapy of lung cancer using lipid-layered cisplatin and oridonin co-encapsulated nanoparticles. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111830. doi: 10.1016/j.biopha.2021.111830. [PMID: 34146851]
  • Yue Zhang, Ruirui Liu, Yaping Zhou, Simin Wang, Bianfeng Zhang, Juantao Kong, Sheng Zheng, Ning Yang. PLDα1 and GPA1 are involved in the stomatal closure induced by Oridonin in Arabidopsis thaliana. Functional plant biology : FPB. 2021 09; 48(10):1005-1016. doi: 10.1071/fp21156. [PMID: 34167638]
  • Yuqin Lei, Yuling Li, Yuping Tan, Zhiyong Qian, Qiao Zhou, Da Jia, Qingxiang Sun. Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. Journal of natural products. 2021 05; 84(5):1478-1488. doi: 10.1021/acs.jnatprod.0c01231. [PMID: 33890470]
  • Luzhou Xu, Lei Zhu, Kai Zheng, Junlou Liu, Panpan Tian, Di Hu, Qianqian Wang, Qiaoyun Zuo, Xiaosong Ouyang, Yanna Dai, Yuxian Fu, Xinyi Dai, Fang Huang, Jun Cheng. The design and synthesis of redox-responsive oridonin polymeric prodrug micelle formulation for effective gastric cancer therapy. Journal of materials chemistry. B. 2021 04; 9(13):3068-3078. doi: 10.1039/d1tb00127b. [PMID: 33885668]
  • Seiji Tanaka, Michiho Ito. Quantitative Analysis of Ent-Kaurane Diterpenoids in Isodon Herb (Enmei-So) by HPLC-UV. Chemical & pharmaceutical bulletin. 2021; 69(3):246-252. doi: 10.1248/cpb.c20-00769. [PMID: 33642472]
  • Rui-Zhi Tan, Ying Yan, Yan Yu, Hui Diao, Xia Zhong, Xiao Lin, Yi-Yi Liao, Li Wang. Renoprotective Effect of Oridonin in a Mouse Model of Acute Kidney Injury via Suppression of Macrophage Involved Inflammation. Biological & pharmaceutical bulletin. 2021; 44(5):714-723. doi: 10.1248/bpb.b21-00071. [PMID: 33952827]
  • Mu-Keng Hong, Hai-Hua Liu, Gui-Hong Chen, Jun-Qing Zhu, Song-Yuan Zheng, Di Zhao, Jianxing Diao, Hui Jia, Ding-Ding Zhang, Shi-Xian Chen, Lei Gao, Juan Li. Oridonin Alters Hepatic Urea Cycle via Gut Microbiota and Protects against Acetaminophen-Induced Liver Injury. Oxidative medicine and cellular longevity. 2021; 2021(?):3259238. doi: 10.1155/2021/3259238. [PMID: 34721757]
  • Shou-Di He, Sheng-Guang Huang, Hui-Jun Zhu, Xiao-Guang Luo, Kang-Han Liao, Jie-Yao Zhang, Ning Tan, De-Yu Li. Oridonin suppresses autophagy and survival in rheumatoid arthritis fibroblast-like synoviocytes. Pharmaceutical biology. 2020 Dec; 58(1):146-151. doi: 10.1080/13880209.2020.1711783. [PMID: 31971852]
  • Huagang Sheng, Yuanyuan Zhang, Jijuan Nai, Shaohua Wang, Mengmeng Dai, Guitao Lin, Liqiao Zhu, Qiang Zhang. Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells. Pharmaceutical biology. 2020 Dec; 58(1):518-527. doi: 10.1080/13880209.2020.1767160. [PMID: 32501184]
  • Ning Kang, Shijie Cao, Benke Jiang, Qiang Zhang, Paul Owusu Donkor, Yan Zhu, Feng Qiu, Xiumei Gao. Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells. Toxicology in vitro : an international journal published in association with BIBRA. 2020 Sep; 67(?):104885. doi: 10.1016/j.tiv.2020.104885. [PMID: 32407876]
  • Dongliang Zhu, Xiaoling Tian, Xiaoping Yin, Haidong Yan, Weihao Li. Oridonin triggers G2/M cell cycle arrest, cellular apoptosis and autophagy in human gastric cancer cells. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2020 Sep; 25(5):2308-2314. doi: ". [PMID: 33277850]
  • Yu-Chiao Yang, Chia-Sui Wang, Ming-Chi Wei. A green approach for the extraction and characterization of oridonin and ursolic and oleanolic acids from Rabdosia rubescens and its kinetic behavior. Food chemistry. 2020 Jul; 319(?):126582. doi: 10.1016/j.foodchem.2020.126582. [PMID: 32199144]
  • Dong Liu, Hailong Qin, Bixian Yang, Bin Du, Xuelin Yun. Oridonin ameliorates carbon tetrachloride-induced liver fibrosis in mice through inhibition of the NLRP3 inflammasome. Drug development research. 2020 06; 81(4):526-533. doi: 10.1002/ddr.21649. [PMID: 32219880]
  • Ying Yan, Rui-Zhi Tan, Peng Liu, Jian-Chun Li, Xia Zhong, Yuan Liao, Xiao Lin, Cong Wei, Li Wang. Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways. Medical science monitor : international medical journal of experimental and clinical research. 2020 May; 26(?):e921114. doi: 10.12659/msm.921114. [PMID: 32362652]
  • Linhao Xu, Yanli Bi, Yizhou Xu, Zhuocheng Zhang, Wenjie Xu, Sisi Zhang, Jian Chen. Oridonin inhibits the migration and epithelial-to-mesenchymal transition of small cell lung cancer cells by suppressing FAK-ERK1/2 signalling pathway. Journal of cellular and molecular medicine. 2020 04; 24(8):4480-4493. doi: 10.1111/jcmm.15106. [PMID: 32168416]
  • Yuanyuan Zhang, Shaohua Wang, Mengmeng Dai, Jijuan Nai, Liqiao Zhu, Huagang Sheng. Solubility and Bioavailability Enhancement of Oridonin: A Review. Molecules (Basel, Switzerland). 2020 Jan; 25(2):. doi: 10.3390/molecules25020332. [PMID: 31947574]
  • Qiong Yang, Wengdong Ma, Kun Yu, Qi Zhang, Zaiyuan Ye, Wenjie Xia, Shuguang Li. Oridonin Suppresses Human Gastric Cancer Growth in Vitro and in Vivo via Inhibition of VEGF, Integrin β3, and PCNA. Biological & pharmaceutical bulletin. 2020; 43(7):1035-1045. doi: 10.1248/bpb.b19-00839. [PMID: 32612067]
  • Xu Hu, Yan Wang, Xiang Gao, Shengtao Xu, Linghe Zang, Yan Xiao, Zhanlin Li, Huiming Hua, Jinyi Xu, Dahong Li. Recent Progress of Oridonin and Its Derivatives for the Treatment of Acute Myelogenous Leukemia. Mini reviews in medicinal chemistry. 2020; 20(6):483-497. doi: 10.2174/1389557519666191029121809. [PMID: 31660811]
  • Jing Liu, Ning Zhang, Na Li, Xiaocheng Fan, Ying Li. Influence of verapamil on the pharmacokinetics of oridonin in rats. Pharmaceutical biology. 2019 Dec; 57(1):787-791. doi: 10.1080/13880209.2019.1688844. [PMID: 31747844]
  • Lili Tian, Donglai Sheng, Qiushuang Li, Chenxu Guo, Guofu Zhu. Preliminary safety assessment of oridonin in zebrafish. Pharmaceutical biology. 2019 Dec; 57(1):632-640. doi: 10.1080/13880209.2019.1662457. [PMID: 31545911]
  • Xiaofei Shen, Lin Zhao, Peihao Chen, Yanqiu Gong, Dingdong Liu, Xia Zhang, Lunzhi Dai, Qingxiang Sun, Jizhong Lou, Zhong Jin, Baohua Zhang, Dawen Niu, Ceshi Chen, Xiangbing Qi, Da Jia. A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3. The Journal of biological chemistry. 2019 11; 294(46):17471-17486. doi: 10.1074/jbc.ra119.009801. [PMID: 31594861]
  • Kuan-Ho Lin, Chien-Yu Li, Yuan-Man Hsu, Chang-Hai Tsai, Fuu-Jen Tsai, Chih-Hsin Tang, Jai-Sing Yang, Zhi-Hong Wang, Mei-Chin Yin. Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP+- and kainic acid-induced injury. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019 Nov; 133(?):110765. doi: 10.1016/j.fct.2019.110765. [PMID: 31430510]
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