Sauchinone (BioDeep_00000230036)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C20H20O6 (356.125982)
中文名称: 三白草酮, 三白草酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3C(C1C)C4=CC5=C(C=C4OC36C(=CC2=O)OCO6)OCO5
InChI: InChI=1S/C20H20O6/c1-9-3-11-13(21)5-17-20(25-8-24-17)19(11)18(10(9)2)12-4-15-16(23-7-22-15)6-14(12)26-20/h4-6,9-11,18-19H,3,7-8H2,1-2H3/t9-,10+,11+,18+,19+,20+/m1/s1
描述信息
Sauchinone is a natural product found in Saururus chinensis with data available.
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].
Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 11725801
- MeSH: sauchinone
- chemspider: 9900517
- CAS: 177931-17-8
- medchemexpress: HY-N0613
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yiping Lu, Miao Yu, Jinsheng Ye, Yankai Liang, Jianxin Gao, Zhen Ji, Jie Wang. Sauchinone inhibits the proliferation and immune invasion capacity of colorectal cancer cells through the suppression of PD-L1 and MMP2/MM9.
Anti-cancer agents in medicinal chemistry.
2023 Mar; ?(?):. doi:
10.2174/1871520623666230320125406. [PMID: 36941807] - Qinghao Jin, Jin Woo Lee, Jun Gu Kim, Dongho Lee, Jin Tae Hong, Youngsoo Kim, Mi Kyeong Lee, Bang Yeon Hwang. Lignans from Saururus chinensis with Inhibitory Effects on Nitric Oxide Production.
Journal of natural products.
2019 11; 82(11):3002-3009. doi:
10.1021/acs.jnatprod.9b00520. [PMID: 31642320] - Hee-Sung Chae, Byoung Hoon You, Dong-Yeop Kim, Hankyu Lee, Hyuk Wan Ko, Hyun-Jeong Ko, Young Hee Choi, Sun Shim Choi, Young-Won Chin. Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network.
Scientific reports.
2018 04; 8(1):6737. doi:
10.1038/s41598-018-24935-6. [PMID: 29712938] - Eun Chae Gong, Satya Chea, Anand Balupuri, Nam Sook Kang, Young-Won Chin, Young Hee Choi. Enzyme Kinetics and Molecular Docking Studies on Cytochrome 2B6, 2C19, 2E1, and 3A4 Activities by Sauchinone.
Molecules (Basel, Switzerland).
2018 Mar; 23(3):. doi:
10.3390/molecules23030555. [PMID: 29498658] - Byoung Hoon You, Eun Chae Gong, Young Hee Choi. Inhibitory Effect of Sauchinone on UDP-Glucuronosyltransferase (UGT) 2B7 Activity.
Molecules (Basel, Switzerland).
2018 Feb; 23(2):. doi:
10.3390/molecules23020366. [PMID: 29425147] - Xue Meng, Inhye Kim, Yong Joon Jeong, Young Mi Cho, Se Chan Kang. Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1.
Experimental biology and medicine (Maywood, N.J.).
2016 Feb; 241(4):396-408. doi:
10.1177/1535370215614657. [PMID: 26553125] - You-Jin Kim, Seung Yon Han, Jun Su Seo, Young-Won Chin, Young Hee Choi. Pharmacokinetics, tissue distribution, and tentative metabolite identification of sauchinone in mice by microsampling and HPLC-MS/MS methods.
Biological & pharmaceutical bulletin.
2015; 38(2):218-27. doi:
10.1248/bpb.b14-00524. [PMID: 25747980] - Wei-Jern Tsai, Chien-Chang Shen, Tung-Hu Tsai, Lie-Chwen Lin. Lignans from the aerial parts of Saururus chinensis: isolation, structural characterization, and their effects on platelet aggregation.
Journal of natural products.
2014 Jan; 77(1):125-31. doi:
10.1021/np400772h. [PMID: 24387347] - Bin Li, Yun Jung Lee, Youn Chul Kim, Jung Joo Yoon, So Min Lee, Yong Pyo Lee, Dae Gill Kang, Ho Sub Lee. Sauchinone from Saururus chinensis protects vascular inflammation by heme oxygenase-1 induction in human umbilical vein endothelial cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Jan; 21(2):101-8. doi:
10.1016/j.phymed.2013.08.009. [PMID: 24035224] - Xiu Gao, Juan He, Xing-De Wu, Li-Yan Peng, Liao-Bin Dong, Xu Deng, Yan Li, Xiao Cheng, Qin-Shi Zhao. Further lignans from Saururus chinensis.
Planta medica.
2013 Dec; 79(18):1720-3. doi:
10.1055/s-0033-1351053. [PMID: 24356870] - Chun-lei Xu, Jian-wei Chen, Wen-zheng Ju, Shi-jia Liu, Yong Chen, Zhi-peng Chen, Ping Xue, Hong-jiang Chen, Xiang Li. Quantitative determination of sauchinone in rat plasma by liquid chromatography-mass spectrometry.
Biomedical chromatography : BMC.
2012 Oct; 26(10):1210-4. doi:
10.1002/bmc.2681. [PMID: 22222773] - Hee Yeon Kay, Young Woo Kim, Da Hye Ryu, Sang Hyun Sung, Se Jin Hwang, Sang Geon Kim. Nrf2-mediated liver protection by sauchinone, an antioxidant lignan, from acetaminophen toxicity through the PKCδ-GSK3β pathway.
British journal of pharmacology.
2011 Aug; 163(8):1653-65. doi:
10.1111/j.1476-5381.2010.01095.x. [PMID: 21039417] - Min-Ho Jung, Min-Cheol Song, Kiho Bae, Han Sung Kim, Seung Hyun Kim, Sang Hyun Sung, Sang Kyu Ye, Kwang Ho Lee, Yeo-Pyo Yun, Tack-Joong Kim. Sauchinone attenuates oxidative stress-induced skeletal muscle myoblast damage through the down-regulation of ceramide.
Biological & pharmaceutical bulletin.
2011; 34(4):575-9. doi:
10.1248/bpb.34.575. [PMID: 21467649] - Bin Li, Dong-Sung Lee, Hyun-Gyu Choi, Kyoung-Su Kim, Dae-Gil Kang, Ho-Sub Lee, Gil-Saeng Jeong, Youn-Chul Kim. Sauchinone suppresses pro-inflammatory mediators by inducing heme oxygenase-1 in RAW264.7 macrophages.
Biological & pharmaceutical bulletin.
2011; 34(10):1566-71. doi:
10.1248/bpb.34.1566. [PMID: 21963496] - Gil-Saeng Jeong, Dong-Sung Lee, Bin Li, Erisa Byun, Dong-Yeul Kwon, Hyun Park, Youn-Chul Kim. Protective effect of sauchinone by upregulating heme oxygenase-1 via the P38 MAPK and Nrf2/ARE pathways in HepG2 cells.
Planta medica.
2010 Jan; 76(1):41-7. doi:
10.1055/s-0029-1185906. [PMID: 19591088] - Young Woo Kim, Sung Min Lee, Sang Mi Shin, Se Jin Hwang, Janie S Brooks, Hee Eun Kang, Myung Gull Lee, Sang Chan Kim, Sang Geon Kim. Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury.
Free radical biology & medicine.
2009 Oct; 47(7):1082-92. doi:
10.1016/j.freeradbiomed.2009.07.018. [PMID: 19616619] - Bang Yeon Hwang, Jeong-Hyung Lee, Haeng Sun Jung, Kyung-Sook Kim, Jeong Beom Nam, Young Soo Hong, Sang-Gi Paik, Jung Joon Lee. Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB.
Planta medica.
2003 Dec; 69(12):1096-101. doi:
10.1055/s-2003-45189. [PMID: 14750024] - S H Sung, E J Lee, J H Cho, H S Kim, Y C Kim. Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes.
Biological & pharmaceutical bulletin.
2000 May; 23(5):666-8. doi:
10.1248/bpb.23.666. [PMID: 10823687]