WLN91FAQ6Z (BioDeep_00000229986)

   

PANOMIX_OTCML-2023


代谢物信息卡片


4-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one

化学式: C20H30O4 (334.214398)
中文名称: 14-去氧穿心莲内酯, 去氧穿心莲内酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CC12CCC(C(C1CCC(=C)C2CCC3=CCOC3=O)(C)CO)O
InChI: InChI=1S/C20H30O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h9,15-17,21-22H,1,4-8,10-12H2,2-3H3/t15-,16+,17-,19+,20+/m1/s1

描述信息

14-Deoxyandrographolide is a natural product found in Andrographis paniculata and Taiwanofungus camphoratus with data available.
14-Deoxyandrographolide is a labdane diterpene with calcium channel blocking activity. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release[1][2].
14-Deoxyandrographolide is a labdane diterpene with calcium channel blocking activity. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release[1][2].

同义名列表

12 个代谢物同义名

4-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one; 3-[2-[(1R,4abeta)-2-Methylene-5alpha-(hydroxymethyl)-5,8aalpha-dimethyl-6alpha-hydroxydecalin-1alpha-yl]ethyl]-2,5-dihydrofuran-2-one; 2(5H)-Furanone, 3-(2-((1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-; 2(5H)-Furanone,3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-; 3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone; 3-(2-((1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethyl)-2(5H)-furanone; 3-(2-((1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one; Ent-3beta-hydroxy-8(17),13(14)-labdadiene-16,15-olide 14-deoxyandrographolide; 14-Deoxyandrographolide; Deoxyandrographolide; UNII-WLN91FAQ6Z; WLN91FAQ6Z



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nor Elliza Tajidin, Khozirah Shaari, Maulidiani Maulidiani, Nor Shariah Salleh, Bunga Raya Ketaren, Munirah Mohamad. Metabolite profiling of Andrographis paniculata (Burm. f.) Nees. young and mature leaves at different harvest ages using 1H NMR-based metabolomics approach. Scientific reports. 2019 11; 9(1):16766. doi: 10.1038/s41598-019-52905-z. [PMID: 31727911]
  • Xiao Zhang, Hongwei Wu, Xiankuo Yu, Hanyan Luo, Yaqi Lu, Hongjun Yang, Xin Li, Zhiyong Li, Liying Tang, Zhuju Wang. Determination of Bitterness of Andrographis Herba Based on Electronic Tongue Technology and Discovery of the Key Compounds of Bitter Substances. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123362. [PMID: 30572573]
  • Deepti Arha, Sukanya Pandeti, Akansha Mishra, Swayam Prakash Srivastava, Arvind Kumar Srivastava, Tadigoppula Narender, Akhilesh Kumar Tamrakar. Deoxyandrographolide promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo. European journal of pharmacology. 2015 Dec; 768(?):207-16. doi: 10.1016/j.ejphar.2015.10.055. [PMID: 26528798]
  • Samir Mandal, Sibabrata Mukhopadhyay, Sukdeb Bandhopadhyay, Gargi Sen, Tuli Biswas. 14-Deoxyandrographolide alleviates ethanol-induced hepatosteatosis through stimulation of AMP-activated protein kinase activity in rats. Alcohol (Fayetteville, N.Y.). 2014 Mar; 48(2):123-32. doi: 10.1016/j.alcohol.2013.11.005. [PMID: 24507479]
  • Samir Mandal, Vinod K Nelson, Sibabrata Mukhopadhyay, Sukdeb Bandhopadhyay, Lakshmi Maganti, Nanda Ghoshal, Gargi Sen, Tuli Biswas. 14-Deoxyandrographolide targets adenylate cyclase and prevents ethanol-induced liver injury through constitutive NOS dependent reduced redox signaling in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Sep; 59(?):236-48. doi: 10.1016/j.fct.2013.05.056. [PMID: 23764359]
  • Chantana Aromdee, Supawadee Suebsasana, Tipaya Ekalaksananan, Chamsai Pientong, Sasithorn Thongchai. Stage of action of naturally occurring andrographolides and their semisynthetic analogues against herpes simplex virus type 1 in vitro. Planta medica. 2011 Jun; 77(9):915-21. doi: 10.1055/s-0030-1250659. [PMID: 21259187]
  • Xiu-Lan Xin, Sha Deng, Bao-Jing Zhang, Shan-Shan Huang, Yan Tian, Xiao-Chi Ma, Lei An, Xiao-Hong Shu, Ji-Hong Yao, Xun Cui. Microbial transformation of deoxyandrographolide by Alternaria alternata AS 3.4578. Natural product communications. 2011 Jun; 6(6):781-4. doi: ". [PMID: 21815410]
  • Suresh R Naik, Amolkumar Hule. Evaluation of immunomodulatory activity of an extract of andrographolides from Andographis paniculata. Planta medica. 2009 Jun; 75(8):785-91. doi: 10.1055/s-0029-1185398. [PMID: 19263340]
  • Yun-Heng Shen, Rong-Tao Li, Wei-Lie Xiao, Gang Xu, Zhong-Wen Lin, Qin-Shi Zhao, Han-Dong Sun. ent-Labdane diterpenoids from Andrographis paniculata. Journal of natural products. 2006 Mar; 69(3):319-22. doi: 10.1021/np050160u. [PMID: 16562826]
  • Srinivas Nanduri, Vijay Kumar Nyavanandi, Siva Sanjeeva Rao Thunuguntla, Sridevi Kasu, Mahesh Kumar Pallerla, P Sai Ram, Sriram Rajagopal, R Ajaya Kumar, Rajagopalan Ramanujam, J Moses Babu, Krishnamurthi Vyas, A Sivalakshmi Devi, G Om Reddy, Venkateswarlu Akella. Synthesis and structure-activity relationships of andrographolide analogues as novel cytotoxic agents. Bioorganic & medicinal chemistry letters. 2004 Sep; 14(18):4711-7. doi: 10.1016/j.bmcl.2004.06.090. [PMID: 15324893]
  • Rafael A Burgos, Mario Loyola, María A Hidalgo, Timothy P Labranche, Juan L Hancke. Effect of 14-deoxyandrographolide on calcium-mediated rat uterine smooth muscle contractility. Phytotherapy research : PTR. 2003 Nov; 17(9):1011-5. doi: 10.1002/ptr.1275. [PMID: 14595578]