Dehydroandrographolide (BioDeep_00000229979)
PANOMIX_OTCML-2023
代谢物信息卡片
(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]furan-2-one
化学式: C20H28O4 (332.19874880000003)
中文名称: 脱水穿心莲内酯, 穿心莲丁素, 脱水穿心莲内酯
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 5.26%
分子结构信息
SMILES: C=C1CCC2C(C)(CO)C(O)CCC2(C)C1CC=C1C=COC1=O
InChI: InChI=1S/C20H28O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h5,9,11,15-17,21-22H,1,4,6-8,10,12H2,2-3H3/b14-5+/t15-,16-,17+,19-,20-/m0/s1
描述信息
2(3H)-Furanone, 3-(2-((1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)-, (3E)- is a natural product found in Andrographis paniculata with data available.
Dehydroandrographolide can be extracted from herbal medicine Andrographis paniculata Nees. Dehydroandrographolide reduces oxidative stress in LPS-induced acute lung injury by inactivating iNOS. Dehydroandrographolide has anti-infective activity[1][2][3].
Dehydroandrographolide can be extracted from herbal medicine Andrographis paniculata Nees. Dehydroandrographolide reduces oxidative stress in LPS-induced acute lung injury by inactivating iNOS. Dehydroandrographolide has anti-infective activity[1][2][3].
同义名列表
5 个代谢物同义名
(3E)-3-[2-[(1S,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]furan-2-one; 2(3H)-Furanone, 3-(2-((1S,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl)ethylidene)-, (3E)-; (E)-3-(2-((1S,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)furan-2(3H)-one; 14,15-Anhydroandrographolide, (1S)-; Dehydroandrographolide
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 78577438
- PubChem: 53394883
- MeSH: dehydroandrographolide
- ChemIDplus: 0134418283
- chemspider: 24540945
- CAS: 134418-28-3
- medchemexpress: HY-N0676
- PMhub: MS000105987
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 穿心莲: -
- 33090 Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yong-Guang Liu, Shan-Shan Zhang, Su-Wei Jin, Tian-Ji Xia, Yong-Hong Liao, Rui-Le Pan, Ming-Zhu Yan, Qi Chang. Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 May; 174(?):116456. doi:
10.1016/j.biopha.2024.116456. [PMID: 38552441] - Qiru Guo, Jiali Li, Zheng Wang, Xiao Wu, Zhong Jin, Song Zhu, Hongfei Li, Delai Zhang, Wangming Hu, Huan Xu, Lan Yang, Liangqin Shi, Yong Wang. Potassium dehydroandrographolide succinate regulates the MyD88/CDH13 signaling pathway to enhance vascular injury-induced pathological vascular remodeling.
Chinese journal of natural medicines.
2024 Jan; 22(1):62-74. doi:
10.1016/s1875-5364(24)60562-5. [PMID: 38278560] - Ning Kong, Huanshuai Guan, Xudong Duan, Ruomu Cao, Heng Li, Fangze Xing, Xueshan Du, Yi Zheng, Lei Zhang, Yiyang Li, Zeyu Liu, Run Tian, Kunzheng Wang, Delu Che, Pei Yang. Dehydroandrographolide alleviates rheumatoid arthritis by inhibiting neutrophil activation via LMIR3 in collagen induced arthritis rats.
Cell cycle (Georgetown, Tex.).
2024 Jan; 23(1):1-14. doi:
10.1080/15384101.2024.2304508. [PMID: 38234233] - Zhichen Pu, Bangzhi Sui, Xingwen Wang, Wusuan Wang, Lingling Li, Haitang Xie. The effects and mechanisms of the anti-COVID-19 traditional Chinese medicine, Dehydroandrographolide from Andrographis paniculata (Burm.f.) Wall, on acute lung injury by the inhibition of NLRP3-mediated pyroptosis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Pharmaceutical biology.
2022 Dec; 60(1):175-184. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2022 Jul; 38(7):977-988. doi:
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Phytotherapy research : PTR.
2022 May; 36(5):2173-2185. doi:
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Aging.
2020 07; 12(14):14050-14065. doi:
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Toxicology and applied pharmacology.
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Biochemical pharmacology.
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Fitoterapia.
2018 Jun; 127(?):226-236. doi:
10.1016/j.fitote.2018.02.021. [PMID: 29477305] - Zhiyong Weng, Yue Chi, Jing Xie, Xuefeng Liu, Jiehua Hu, Fan Yang, Lihua Li. Anti-Inflammatory Activity of Dehydroandrographolide by TLR4/NF-κB Signaling Pathway Inhibition in Bile Duct-Ligated Mice.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2018; 49(3):1083-1096. doi:
10.1159/000493292. [PMID: 30196285] - Ming-Ju Hsieh, Chiao-Wen Lin, Hui-Ling Chiou, Shun-Fa Yang, Mu-Kuan Chen. Dehydroandrographolide, an iNOS inhibitor, extracted from Andrographis paniculata (Burm.f.) Nees, induces autophagy in human oral cancer cells.
Oncotarget.
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2015 Jul; 38(7):1505-8. doi:
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Antiviral research.
2015 Jun; 118(?):82-92. doi:
10.1016/j.antiviral.2015.03.008. [PMID: 25800824] - Fang-fang Xu, Shu-jun Fu, Sheng-pan Gu, Zhi-min Wang, Zhen-zhong Wang, Xin He, Wei Xiao. Simultaneous determination of andrographolide, dehydroandrographolide and neoandrographolide in dog plasma by LC-MS/MS and its application to a dog pharmacokinetic study of Andrographis paniculata tablet.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 May; 990(?):125-31. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2015 Apr; 35(2):125-33. doi:
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Bioorganic & medicinal chemistry letters.
2014 May; 24(10):2353-9. doi:
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Toxicology and applied pharmacology.
2014 Mar; 275(2):163-75. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2014 Feb; 37(2):219-23. doi:
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Molecules (Basel, Switzerland).
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Journal of chromatographic science.
2013 Apr; 51(4):341-8. doi:
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Journal of pharmaceutical and biomedical analysis.
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2011 Jun; 79(1):191-6. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Aug; 878(24):2274-9. doi:
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Talanta.
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Se pu = Chinese journal of chromatography.
2006 May; 24(3):294-7. doi:
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Journal of pharmaceutical and biomedical analysis.
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2004 Nov; 2(6):456-8. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2002 Dec; 27(12):911-3. doi:
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