Bavachalcone (BioDeep_00000229959)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(E) -1- [ 2,4-Dihydroxy-5- (3-methyl-2-butenyl) phenyl ] -3- (4-hydroxyphenyl) -2-propen-1-one

化学式: C20H20O4 (324.13615200000004)
中文名称: 补骨脂查耳酮, 补骨脂查尔酮, 补骨脂查耳酮
谱图信息: 最多检出来源 Viridiplantae(plant) 41.18%

分子结构信息

SMILES: C1=CC(O)=CC=C1/C=C/C(=O)C1C(O)=CC(O)=C(C/C=C(\C)/C)C=1
InChI: InChI=1S/C20H20O4/c1-13(2)3-7-15-11-17(20(24)12-19(15)23)18(22)10-6-14-4-8-16(21)9-5-14/h3-6,8-12,21,23-24H,7H2,1-2H3/b10-6+

描述信息

Bavachalcone is a member of chalcones.
Bavachalcone is a natural product found in Broussonetia papyrifera, Cullen corylifolium, and Sophora prostrata with data available.
Bavachalcone is a compound isolated from psoralen. It is widely used in traditional Chinese medicine and has antibiotic and anti-cancer activities.
Bavachalcone is a compound isolated from psoralen. It is widely used in traditional Chinese medicine and has antibiotic and anti-cancer activities.

同义名列表

8 个代谢物同义名

(2E)-1-[2,4-dihydroxy-5-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-[2,4-dihydroxy-5-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(2,4-Dihydroxy-5-(3-methyl-but-2-enyl)-phenyl)-3-(4-hydroxy-phenyl)-propenone; (E)-1-[2,4-Dihydroxy-5-(3-methyl-but-2-enyl)-phenyl]-3-(4-hydroxy-phenyl)-propenone; BLZGPHNVMRXDCB-UXBLZVDNSA-N; broussochalcone B; Bavachalcone; (E) -1- [ 2,4-Dihydroxy-5- (3-methyl-2-butenyl) phenyl ] -3- (4-hydroxyphenyl) -2-propen-1-one



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peng-Chao Huo, Qing Hu, Sheng Shu, Qi-Hang Zhou, Rong-Jing He, Jie Hou, Xiao-Qing Guan, Dong-Zhu Tu, Xu-Dong Hou, Peng Liu, Nan Zhang, Zhi-Guo Liu, Guang-Bo Ge. Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors. Bioorganic & medicinal chemistry. 2021 01; 29(?):115853. doi: 10.1016/j.bmc.2020.115853. [PMID: 33214035]
  • Zhi-Xing Zhou, Li Yang, Li-Yuan Cheng, Ying-Li Yu, Lei Song, Kun Zhou, Ying-Liang Wu, Yue Zhang. Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics. Journal of separation science. 2020 Jul; 43(14):2804-2816. doi: 10.1002/jssc.202000286. [PMID: 32384213]
  • Xu-Dong Hou, Li-Lin Song, Yun-Feng Cao, Yi-Nan Wang, Qi Zhou, Sheng-Quan Fang, Da-Chang Wu, Shi-Zhu Zang, Lu Chen, Yue Bai, Guang-Bo Ge, Jie Hou. Pancreatic lipase inhibitory constituents from Fructus Psoraleae. Chinese journal of natural medicines. 2020 May; 18(5):369-378. doi: 10.1016/s1875-5364(20)30043-1. [PMID: 32451094]
  • Hae Seong Song, Sunphil Jang, Se Chan Kang. Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Feb; 40(?):37-47. doi: 10.1016/j.phymed.2017.12.030. [PMID: 29496173]
  • Dan Zhou, Lianhua An, Yan Xia, Yuanyi Wang, Xingliang Li. Quantitative bioanalysis of bavachalcone in rat plasma by LC-MS/MS and its application in a pharmacokinetics study. Biomedical chromatography : BMC. 2017 Dec; 31(12):. doi: 10.1002/bmc.4031. [PMID: 28618051]
  • Yanqi Dang, Shuang Ling, Ju Duan, Jing Ma, Rongzhen Ni, Jin-Wen Xu. Bavachalcone-induced manganese superoxide dismutase expression through the AMP-activated protein kinase pathway in human endothelial cells. Pharmacology. 2015; 95(3-4):105-10. doi: 10.1159/000375452. [PMID: 25766656]
  • Rong-Li Qiu, Lin Li, Miao-Hua Zhu, Jia Liu. [Study on the chemical constituents of Psoralea corylifolia]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2011 Aug; 34(8):1211-3. doi: . [PMID: 22233033]
  • Ming Hong Lee, Jae Yeon Kim, Jae-Ha Ryu. Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells. Biological & pharmaceutical bulletin. 2005 Dec; 28(12):2253-7. doi: 10.1248/bpb.28.2253. [PMID: 16327160]