D6S8A779IY (BioDeep_00000229952)

 

Secondary id: BioDeep_00000266858

PANOMIX_OTCML-2023


代谢物信息卡片


2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-hydroxyphenyl)-, (2E)-

化学式: C20H18O4 (322.1205028)
中文名称: 异补骨脂色烯查尔酮, 异补骨脂色烯查耳酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(O)=CC=C1/C=C/C(=O)C1C(O)=C2C=CC(C)(C)OC2=CC=1
InChI: InChI=1S/C20H18O4/c1-20(2)12-11-16-18(24-20)10-8-15(19(16)23)17(22)9-5-13-3-6-14(21)7-4-13/h3-12,21,23H,1-2H3/b9-5+

描述信息

Isobavachromene is a natural product found in Millettia ferruginea, Lonchocarpus utilis, and other organisms with data available.
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities[1].
4-Hydroxylonchocarpin is a chalcone compound from an extract of Psoralea corylifolia. 4-Hydroxylonchocarpin increases phosphorylation of p38 MAPK, JNK and ERK. 4-Hydroxylonchocarpin has diverse pharmacological activities, including antibacterial, antifungal, anticancer, antireverse transcriptase, antitubercular, antimalarial, anti-inflammatory and antioxidant activities[1].
Isobavachromene is an antibacterial agent[1].
Isobavachromene is an antibacterial agent[1].

同义名列表

13 个代谢物同义名

2-Propen-1-one, 1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-hydroxyphenyl)-, (2E)-; 2-Propen-1-one,1-(5-hydroxy-2,2-dimethyl- 2H-1-benzopyran-6-yl)-3-(4-hydroxyphenyl)-; (2E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(5-hydroxy-2,2-dimethyl-chromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one; (E)-1-(5-hydroxy-2,2-dimethylchromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one; 1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxy-phenyl)-propenone; 4-hydroxylonchocarpin; Isobavachromene; UNII-D6S8A779IY; D6S8A779IY; 2-Propen-1-one,1-(5-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)-3-(4-hydroxyphenyl)-,(E)-



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yanbei Tu, Chuanhai Wu, Yunyao Kang, Qin Li, Chao Zhu, Yanfang Li. Bioactivity-guided identification of flavonoids with cholinesterase and β-amyloid peptide aggregation inhibitory effects from the seeds of Millettia pachycarpa. Bioorganic & medicinal chemistry letters. 2019 05; 29(10):1194-1198. doi: 10.1016/j.bmcl.2019.03.024. [PMID: 30910460]
  • Louis P Sandjo, Milene H de Moraes, Victor Kuete, Blaise C Kamdoum, Bonaventure T Ngadjui, Mario Steindel. Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi. Bioorganic & medicinal chemistry letters. 2016 Apr; 26(7):1772-5. doi: 10.1016/j.bmcl.2016.02.044. [PMID: 26906638]
  • Haoyu Ye, Caifeng Xie, Wenshuang Wu, Minli Xiang, Zhuowei Liu, Yanfang Li, Minghai Tang, Shucai Li, Jianhong Yang, Huan Tang, Kai Chen, Chaofeng Long, Aihua Peng, Lijuan Chen. Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/iNOS expression. The American journal of Chinese medicine. 2014; 42(4):949-65. doi: 10.1142/s0192415x14500608. [PMID: 25004885]
  • Nerilson M Lima, Jaqueline I A Andrade, Karen C S Lima, Francislane N dos Santos, Andersson Barison, Kahlil Schwanka Salomé, Takeshi Matsuura, Cecilia V Nunez. Chemical profile and biological activities of Deguelia duckeana A.M.G. Azevedo (Fabaceae). Natural product research. 2013 Mar; 27(4-5):425-32. doi: 10.1080/14786419.2012.733387. [PMID: 23092395]
  • Victor Kuete, Bathelemy Ngameni, Benjamin Wiench, Benjamin Krusche, Cindy Horwedel, Bonaventure T Ngadjui, Thomas Efferth. Cytotoxicity and mode of action of four naturally occuring flavonoids from the genus Dorstenia: gancaonin Q, 4-hydroxylonchocarpin, 6-prenylapigenin, and 6,8-diprenyleriodictyol. Planta medica. 2011 Dec; 77(18):1984-9. doi: 10.1055/s-0031-1280023. [PMID: 21800276]
  • V Kuete, B Ngameni, A T Mbaveng, B Ngadjui, J J Marion Meyer, N Lall. Evaluation of flavonoids from Dorstenia barteri for their antimycobacterial, antigonorrheal and anti-reverse transcriptase activities. Acta tropica. 2010 Oct; 116(1):100-4. doi: 10.1016/j.actatropica.2010.06.005. [PMID: 20599632]
  • Kirandeep Kaur, Meenakshi Jain, Tarandeep Kaur, Rahul Jain. Antimalarials from nature. Bioorganic & medicinal chemistry. 2009 May; 17(9):3229-56. doi: 10.1016/j.bmc.2009.02.050. [PMID: 19299148]
  • Ming Hong Lee, Jae Yeon Kim, Jae-Ha Ryu. Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells. Biological & pharmaceutical bulletin. 2005 Dec; 28(12):2253-7. doi: 10.1248/bpb.28.2253. [PMID: 16327160]
  • Tadigoppula Narender, Shweta, Suman Gupta. A convenient and biogenetic type synthesis of few naturally occurring chromeno dihydrochalcones and their in vitro antileishmanial activity. Bioorganic & medicinal chemistry letters. 2004 Aug; 14(15):3913-6. doi: 10.1016/j.bmcl.2004.05.071. [PMID: 15225696]
  • N Fang, J E Casida. New bioactive flavonoids and stilbenes in cubé resin insecticide. Journal of natural products. 1999 Feb; 62(2):205-10. doi: 10.1021/np980119+. [PMID: 10075742]