Nuciferine (BioDeep_00000229898)

 

Secondary id: BioDeep_00000865587

PANOMIX_OTCML-2023


代谢物信息卡片


4H-DIBENZO(DE,G)QUINOLINE, 5,6,6A,7-TETRAHYDRO-1,2-DIMETHOXY-6-METHYL-, (6AR)-

化学式: C19H21NO2 (295.1572206)
中文名称: 荷叶碱, 荷叶碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 9.9%

分子结构信息

SMILES: CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)OC
InChI: InChI=1S/C19H21NO2/c1-20-9-8-13-11-16(21-2)19(22-3)18-14-7-5-4-6-12(14)10-15(20)17(13)18/h4-7,11,15H,8-10H2,1-3H3/t15-/m1/s1

描述信息

CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2317
Nuciferine is a natural product found in Cissampelos pareira, Paliurus hemsleyanus, and other organisms with data available.
Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.
Nuciferine is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.

同义名列表

24 个代谢物同义名

(-)-nuciferine; Nuciferine; 4H-DIBENZO(DE,G)QUINOLINE, 5,6,6A,7-TETRAHYDRO-1,2-DIMETHOXY-6-METHYL-, (6AR)-; 4H-Dibenzo(de,g)quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-, (R)-; (6ar)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline; (R)-1,2-dimethoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline; 6a-.beta.-Aporphine, 1,2-dimethoxy-; 6a-beta-APORPHINE, 1,2-DIMETHOXY-; 1,2-DIMETHOXY-6A.BETA.-APORPHINE; 1,2-Dimethoxy-6abeta-aporphine; ORJVQPIHKOARKV-OAHLLOKOSA-N; (R)-1,2-Dimethoxyaporphine; 1-5, 6-Dimethoxyaporphine; l-5,6-dimethoxyaporphine; nuciferine, (+-)-isomer; nuciferine, (S)-isomer; D-(-)-NUCIFERINE; (-)-Nucipherine; UNII-W26UEB90B7; (R)-NUCIFERINE; Sanjoinine E; l-Nuciferine; W26UEB90B7; Nuciferin



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xinshui Ren, Hua Chen, Haibo Wang, Yue Wang, Chuanjun Huang, Hongzhi Pan. Advances in the pharmacological effects and mechanisms of Nelumbo nucifera gaertn. Extract nuciferine. Journal of ethnopharmacology. 2024 Sep; 331(?):118262. doi: 10.1016/j.jep.2024.118262. [PMID: 38670406]
  • Hao Wang, Xiaolong Geng, Fangbin Ai, Zhilun Yu, Yan Zhang, Beibei Zhang, Cheng Lv, Ruiyang Gao, Bei Yue, Wei Dou. Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance. Chinese journal of natural medicines. 2024 Apr; 22(4):341-355. doi: 10.1016/s1875-5364(24)60622-9. [PMID: 38658097]
  • Ramanathan Bharathi, Ganesh Harini, Aravind Sankaranarayanan, Abinaya Shanmugavadivu, Mariappanadar Vairamani, Nagarajan Selvamurugan. Nuciferine-loaded chitosan hydrogel-integrated 3D-printed polylactic acid scaffolds for bone tissue engineering: A combinatorial approach. International journal of biological macromolecules. 2023 Dec; 253(Pt 7):127492. doi: 10.1016/j.ijbiomac.2023.127492. [PMID: 37858655]
  • Xiangyang Zhu, Fan Si, Rili Hao, Jingjie Zheng, Chen Zhang. Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects. Journal of agricultural and food chemistry. 2023 Dec; 71(48):18769-18779. doi: 10.1021/acs.jafc.3c05735. [PMID: 38006352]
  • Yi-Ju Lee, Sin-Rong Chen, Ping-En Ko, Mon-Yuan Yang, Meng-Hsuin Yu, Chau-Jong Wang, Huei-Jane Lee. Quercetin-3-O-β-d-glucuronide in the Nuciferine Leaf Polyphenol Extract Promotes Neurogenesis Involving the Upregulation of the Tropomyosin Receptor Kinase (Trk) Receptor and AKT/Phosphoinositide 3-Kinase Signaling Pathway. Journal of agricultural and food chemistry. 2023 Oct; ?(?):. doi: 10.1021/acs.jafc.3c03894. [PMID: 37819167]
  • Tong Zhao, Yuchen Zhu, Rui Zhao, Shiyi Xiong, Jing Sun, Juntao Zhang, Daidi Fan, Jianjun Deng, Haixia Yang. Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases. Pharmacological research. 2023 07; 193(?):106820. doi: 10.1016/j.phrs.2023.106820. [PMID: 37315822]
  • Feng Li, Xiaojuan Zhao, Fengyu Xie, Zixuan Wang, Hong Ding, Wanru Wang, Ruiqing Jiao, Ying Pan, Lingdong Kong. Nuciferine blocks MIB2-mediated CARD6 polyubiquitination and degradation in the amelioration of high fructose-induced liver lipid accumulation. Food & function. 2023 May; 14(10):4706-4721. doi: 10.1039/d2fo03622c. [PMID: 37186242]
  • Kaikai Xue, Guojian Zhang, Yiwei Zhou, Kangyan Wang, Zhe Yao, Jinghao Chen, Yu Zhang, Zihao Li, Zi Li, Zimin Zheng, Yongzeng Feng, Cong Mao, Cai Lin, Weidong Xia. Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway. International immunopharmacology. 2023 Apr; 119(?):110204. doi: 10.1016/j.intimp.2023.110204. [PMID: 37126988]
  • Uttam Kulhari, Sourav Kundu, Madhav Nilakanth Mugale, Bidya Dhar Sahu. Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro. International immunopharmacology. 2023 Feb; 115(?):109613. doi: 10.1016/j.intimp.2022.109613. [PMID: 36577154]
  • Jinxia Li, Chenchen Zhao, Menglin Liu, Linfang Chen, Yiwei Zhu, Wenwen Gao, Xiliang Du, Yuxiang Song, Xinwei Li, Guowen Liu, Lin Lei, Haihua Feng. Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway. Journal of agricultural and food chemistry. 2023 Jan; 71(1):443-456. doi: 10.1021/acs.jafc.2c06133. [PMID: 36573646]
  • Jingyue Sun, Jiemin Fan, Tingting Li, Xiaoxue Yan, Yihong Jiang. Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats. Journal of agricultural and food chemistry. 2022 Sep; 70(38):12014-12028. doi: 10.1021/acs.jafc.2c04817. [PMID: 36106619]
  • Yu-Kai Zhang, Jia-Shu Chen, Min-Min Wang, Chuan-Zeng Wang, Mu-Xuan Wang, Zhen Wang, Qin-Liang Yang, Bin Sun, Jin-Yue Sun, Yu-Fa Liu, Chao Liu. Synthesis and bioactivity evaluation of novel nuciferine derivatives with antihyperuricemia and nephroprotective effects. Bioorganic chemistry. 2022 09; 126(?):105916. doi: 10.1016/j.bioorg.2022.105916. [PMID: 35687986]
  • Mengdie Wu, Feifan Qi, Ren Qiu, Jing Feng, Xinshui Ren, Shengzhong Rong, Hongkun Ma, Hongzhi Pan, Dong Chang. Electrochemical Detection of Nuciferine in the Lotus Leaf Based on Efficient Catalysis by Zirconium-MOFs. Journal of AOAC International. 2022 Jun; 105(4):1175-1182. doi: 10.1093/jaoacint/qsac024. [PMID: 35167658]
  • Rajendran HarishKumar, Chinnadurai Immanuel Selvaraj. Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol-induced myocardial infarction in Wistar rats. Biotechnology and applied biochemistry. 2022 Jun; 69(3):1176-1189. doi: 10.1002/bab.2194. [PMID: 33998037]
  • Xuan Yu, Mei-Ling Chen, Yi Liu, Cheng-Hao Li, Xi-Long Qiu, Xiao-Liang Ren, Meng Wang, De-Qin Zhang. An eco-friendly extraction and purification method of nuciferine from Folium nelumbinis with p-sulfonatocalix[6]arenes. Phytochemical analysis : PCA. 2022 Jun; 33(4):543-553. doi: 10.1002/pca.3108. [PMID: 35098593]
  • Yeqing Ruan, Jiahuan Xu, Jianbo Chu, Jing Shi, Qiyuan Shi. Processing tactics for low-cost production of pure nuciferine from lotus leaf. Ultrasonics sonochemistry. 2022 May; 86(?):106026. doi: 10.1016/j.ultsonch.2022.106026. [PMID: 35537315]
  • Hanyuan Xu, Xiaorui Lyu, Xiaonan Guo, Hongbo Yang, Lian Duan, Huijuan Zhu, Hui Pan, Fengying Gong, Linjie Wang. Distinct AMPK-Mediated FAS/HSL Pathway Is Implicated in the Alleviating Effect of Nuciferine on Obesity and Hepatic Steatosis in HFD-Fed Mice. Nutrients. 2022 Apr; 14(9):. doi: 10.3390/nu14091898. [PMID: 35565866]
  • Yan Wan, Jia Xia, Jin-Feng Xu, Lu Chen, Yu Yang, Jiao-Jiao Wu, Fei Tang, Hui Ao, Cheng Peng. Nuciferine, an active ingredient derived from lotus leaf, lights up the way for the potential treatment of obesity and obesity-related diseases. Pharmacological research. 2022 01; 175(?):106002. doi: 10.1016/j.phrs.2021.106002. [PMID: 34826599]
  • Zhuohong Tang, Ting Luo, Peng Huang, Mi Luo, Jianghua Zhu, Xing Wang, Qingmei Lin, Zihao He, Pingming Gao, Shuwen Liu. Nuciferine administration in C57BL/6J mice with gestational diabetes mellitus induced by a high-fat diet: the improvement of glycolipid disorders and intestinal dysbacteriosis. Food & function. 2021 Nov; 12(22):11174-11189. doi: 10.1039/d1fo02714j. [PMID: 34636388]
  • Rajendran Harishkumar, Johnsamuel Godwin Christopher, Rajan Ravindran, Chinnadurai Immanuel Selvaraj. Nuciferine Attenuates Doxorubicin-Induced Cardiotoxicity: An In Vitro and In Vivo Study. Cardiovascular toxicology. 2021 11; 21(11):947-963. doi: 10.1007/s12012-021-09689-4. [PMID: 34401977]
  • Wan-Tao Xiong, Jia-Bao Liao, Zhi-Xia Yang, Huan-Tian Cui, Zhai-Yi Zhang, Wei-Bo Wen, Hong-Wu Wang. [Effect of nuciferine on gut microbiota and inflammatory response in obese model mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Apr; 46(8):2104-2111. doi: 10.19540/j.cnki.cjcmm.20201207.401. [PMID: 33982526]
  • Danyu Li, Bing Liu, Yumei Fan, Ming Liu, Bihui Han, Yanxiu Meng, Xiao Xu, Zhiyuan Song, Xiaopeng Liu, Qiang Hao, Xianglin Duan, Akira Nakai, Yanzhong Chang, Pengxiu Cao, Ke Tan. Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis. British journal of pharmacology. 2021 03; 178(5):1182-1199. doi: 10.1111/bph.15364. [PMID: 33450067]
  • Yue Yu, Juan Lu, Le Sun, Xinkai Lyu, Xin-Yue Chang, Xiao Mi, Mei-Geng Hu, Chongming Wu, Xi Chen. Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):111014. doi: 10.1016/j.biopha.2020.111014. [PMID: 33246225]
  • Yu Wang, Weifan Yao, Bo Li, Shiyun Qian, Binbin Wei, Shiqiang Gong, Jing Wang, Mingyan Liu, Minjie Wei. Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats. Experimental & molecular medicine. 2020 12; 52(12):1959-1975. doi: 10.1038/s12276-020-00534-2. [PMID: 33262480]
  • Yingying Zhou, Zhanghan Chen, Qiumin Lin, Yang Yang, Yunzhen Hang, Xinni Zhou, Changbiao Wu, Zhenglu Xie. Nuciferine reduced fat deposition by controlling triglyceride and cholesterol concentration in broiler chickens. Poultry science. 2020 Dec; 99(12):7101-7108. doi: 10.1016/j.psj.2020.09.013. [PMID: 33248627]
  • Rui-Ming Liu, Peng Xu, Qi Chen, Sen-Ling Feng, Ying Xie. A multiple-targets alkaloid nuciferine overcomes paclitaxel-induced drug resistance in vitro and in vivo. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Dec; 79(?):153342. doi: 10.1016/j.phymed.2020.153342. [PMID: 32992085]
  • Li-Ming Wang, Piao Wang, Tekleab Teka, You-Cai Zhang, Wen-Zhi Yang, Yi Zhang, Tao Wang, Lai-Xing Liu, Li-Feng Han, Cai-Xiang Liu. 1H NMR and UHPLC/Q-Orbitrap-MS-Based Metabolomics Combined with 16S rRNA Gut Microbiota Analysis Revealed the Potential Regulation Mechanism of Nuciferine in Hyperuricemia Rats. Journal of agricultural and food chemistry. 2020 Nov; 68(47):14059-14070. doi: 10.1021/acs.jafc.0c04985. [PMID: 33146009]
  • Xiao-Tian Liu, Tian-Tian Liu, Hui-Long Xu, Qing-Xi Chen, Qin Wang. Inhibitory kinetics and bioactivities of Nuciferine and Methyl Ganoderate on Mucor miehei lipase and 3T3-L1 preadipocytes. International journal of biological macromolecules. 2020 Nov; 163(?):1719-1728. doi: 10.1016/j.ijbiomac.2020.09.127. [PMID: 32971170]
  • Michelle R Peace, Mika E Smith, Justin L Poklis. The analysis of commercially available natural products recommended for use in electronic cigarettes. Rapid communications in mass spectrometry : RCM. 2020 Jun; 34(11):e8771. doi: 10.1002/rcm.8771. [PMID: 32110843]
  • Huanhuan Li, Xuexiao Cao, Yanan Liu, Tingting Liu, Meng Wang, Xiaoliang Ren, Zhiying Dou. Establishment of modified biopharmaceutics classification system absorption model for oral Traditional Chinese Medicine (Sanye Tablet). Journal of ethnopharmacology. 2019 Nov; 244(?):112148. doi: 10.1016/j.jep.2019.112148. [PMID: 31400507]
  • Ling Zhou, Qiaoyun Wang, Han Zhang, Youjie Li, Shuyang Xie, Maolei Xu. YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine. Biomolecules. 2019 10; 9(10):. doi: 10.3390/biom9100620. [PMID: 31627466]
  • Chao Zhang, Jianjun Deng, Dan Liu, Xingxia Tuo, Lei Xiao, Baochang Lai, Qinyu Yao, Jia Liu, Haixia Yang, Nanping Wang. Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. British journal of pharmacology. 2018 11; 175(22):4218-4228. doi: 10.1111/bph.14482. [PMID: 30129056]
  • Liping Li, Hongmei Lei, Wei Wang, Weijuan Du, Jingqun Yuan, Meijuan Tu, Hui Zhou, Su Zeng, Huidi Jiang. Co-administration of nuciferine reduces the concentration of metformin in liver via differential inhibition of hepatic drug transporter OCT1 and MATE1. Biopharmaceutics & drug disposition. 2018 Nov; 39(9):411-419. doi: 10.1002/bdd.2158. [PMID: 30294927]
  • Fugang Wang, Juan Cao, Xueqin Hou, Zhiyong Li, Xiaolan Qu. Pharmacokinetics, tissue distribution, bioavailability, and excretion of nuciferine, an alkaloid from lotus, in rats by LC/MS/MS. Drug development and industrial pharmacy. 2018 Sep; 44(9):1557-1562. doi: 10.1080/03639045.2018.1483399. [PMID: 29909691]
  • Ziqiang Li, Jia Liu, Yazhuo Li, Xi Du, Yanfen Li, Ruihua Wang, Chunxiao Lv, Xin He, Baohe Wang, Yuhong Huang, Deqin Zhang. Identify super quality markers from prototype-based pharmacokinetic markers of Tangzhiqing tablet (TZQ) based on in vitro dissolution/ permeation and in vivo absorption correlations. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):59-67. doi: 10.1016/j.phymed.2018.04.001. [PMID: 29685365]
  • Ziqiang Li, Jia Liu, Deqin Zhang, Xi Du, Lifeng Han, Chunxiao Lv, Yanfen Li, Ruihua Wang, Baohe Wang, Yuhong Huang. Nuciferine and paeoniflorin can be quality markers of Tangzhiqing tablet, a Chinese traditional patent medicine, based on the qualitative, quantitative and dose-exposure-response analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):155-163. doi: 10.1016/j.phymed.2018.02.006. [PMID: 29519686]
  • Jun-Rui Zhao, Xiao-Liang Ren, Meng Wang. [Biopharmaceuticals classification system(BCS) of nuciferin in Nelumbinis Folium]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2018 Feb; 43(3):511-519. doi: 10.19540/j.cnki.cjcmm.20171023.001. [PMID: 29600615]
  • Xiao Yang, Meng-Fei Yu, Jun Lei, Yong-Bo Peng, Ping Zhao, Lu Xue, Weiwei Chen, Li-Qun Ma, Qing-Hua Liu, Jinhua Shen. Nuciferine Relaxes Tracheal Rings via the Blockade of VDLCC and NSCC Channels. Planta medica. 2018 Jan; 84(2):83-90. doi: 10.1055/s-0043-118178. [PMID: 28817840]
  • Nan Wu, Huihui Xie, Yingtong Fang, Yuanyuan Liu, Xingjun Xi, Qiao Chu, Genlai Dong, Tao Lan, Yun Wei. Isolation and purification of alkaloids from lotus leaves by ionic-liquid-modified high-speed countercurrent chromatography. Journal of separation science. 2018 Jan; 41(2):571-577. doi: 10.1002/jssc.201700851. [PMID: 29087605]
  • Ying Liu, Xin Wu, Yushuai Mi, Bimeng Zhang, Shengying Gu, Gaolin Liu, Xiaoyu Li. PLGA nanoparticles for the oral delivery of nuciferine: preparation, physicochemical characterization and in vitro/in vivo studies. Drug delivery. 2017 Nov; 24(1):443-451. doi: 10.1080/10717544.2016.1261381. [PMID: 28165858]
  • Justin L Poklis, Haley A Mulder, Matthew S Halquist, Carl E Wolf, Alphonse Poklis, Michelle R Peace. The Blue Lotus Flower (Nymphea caerulea) Resin Used in a New Type of Electronic Cigarette, the Re-Buildable Dripping Atomizer. Journal of psychoactive drugs. 2017 Jul; 49(3):175-181. doi: 10.1080/02791072.2017.1290304. [PMID: 28266899]
  • Xiao-Lei Wu, Ming-Jiang Wu, Xin-Ze Chen, Hao-Ling Ma, Li-Qin Ding, Feng Qiu, Qin Pan, De-Qin Zhang. Metabolic profiling of nuciferine in rat urine, plasma, bile and feces after oral administration using ultra-high performance liquid chromatography-diode array detection-quadrupole time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2017 Jun; 140(?):71-80. doi: 10.1016/j.jpba.2017.03.022. [PMID: 28342305]
  • Lin-Hu Ye, Bing-Xin Xiao, Yong-Hong Liao, Xin-Min Liu, Rui-Le Pan, Qi Chang. Metabolism profiles of nuciferine in rats using ultrafast liquid chromatography with tandem mass spectrometry. Biomedical chromatography : BMC. 2016 Aug; 30(8):1216-22. doi: 10.1002/bmc.3670. [PMID: 26682724]
  • Quan Qi, Rui Li, Hui-Ying Li, Yu-Bing Cao, Ming Bai, Xiao-Jing Fan, Shu-Yan Wang, Bo Zhang, Shao Li. Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach. Acta pharmacologica Sinica. 2016 Jul; 37(7):963-72. doi: 10.1038/aps.2016.53. [PMID: 27180984]
  • Pei-Fang Wu, Chien-Chih Chiu, Chung-Yi Chen, Hui-Min David Wang. 7-Hydroxydehydronuciferine induces human melanoma death via triggering autophagy and apoptosis. Experimental dermatology. 2015 Dec; 24(12):930-5. doi: 10.1111/exd.12805. [PMID: 26174122]
  • Chengjun Ma, Gang Li, Yanfeng He, Bo Xu, Xiangquan Mi, Honglun Wang, Zhenhua Wang. Pronuciferine and nuciferine inhibit lipogenesis in 3T3-L1 adipocytes by activating the AMPK signaling pathway. Life sciences. 2015 Sep; 136(?):120-5. doi: 10.1016/j.lfs.2015.07.001. [PMID: 26164185]
  • Wei Liu, Dan-Dan Yi, Jian-Li Guo, Zhu-Xing Xiang, Lin-Feng Deng, Lei He. Nuciferine, extracted from Nelumbo nucifera Gaertn, inhibits tumor-promoting effect of nicotine involving Wnt/β-catenin signaling in non-small cell lung cancer. Journal of ethnopharmacology. 2015 May; 165(?):83-93. doi: 10.1016/j.jep.2015.02.015. [PMID: 25698245]
  • Ming-Xing Wang, Yang-Liu Liu, Ying Yang, Dong-Mei Zhang, Ling-Dong Kong. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. European journal of pharmacology. 2015 Jan; 747(?):59-70. doi: 10.1016/j.ejphar.2014.11.035. [PMID: 25499818]
  • Shengying Gu, Guanhua Zhu, Yuzhu Wang, Qin Li, Xin Wu, Jigang Zhang, Gaolin Liu, Xiaoyu Li. A sensitive liquid chromatography-tandem mass spectrometry method for pharmacokinetics and tissue distribution of nuciferine in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jun; 961(?):20-8. doi: 10.1016/j.jchromb.2014.04.038. [PMID: 24854711]
  • Seikou Nakamura, Souichi Nakashima, Genzo Tanabe, Yoshimi Oda, Nami Yokota, Katsuyoshi Fujimoto, Takahiro Matsumoto, Rika Sakuma, Tomoe Ohta, Keiko Ogawa, Shino Nishida, Hisako Miki, Hisashi Matsuda, Osamu Muraoka, Masayuki Yoshikawa. Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells. Bioorganic & medicinal chemistry. 2013 Feb; 21(3):779-87. doi: 10.1016/j.bmc.2012.11.038. [PMID: 23270663]
  • Fuchuan Guo, Xue Yang, Xiaoxia Li, Rennan Feng, Chunmei Guan, Yanwen Wang, Ying Li, Changhao Sun. Nuciferine prevents hepatic steatosis and injury induced by a high-fat diet in hamsters. PloS one. 2013; 8(5):e63770. doi: 10.1371/journal.pone.0063770. [PMID: 23691094]
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