Kinsenoside (BioDeep_00000229855)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one

化学式: C10H16O8 (264.0845136)
中文名称: 金线莲苷
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.46%

分子结构信息

SMILES: C1C(COC1=O)OC2C(C(C(C(O2)CO)O)O)O
InChI: InChI=1S/C10H16O8/c11-2-5-7(13)8(14)9(15)10(18-5)17-4-1-6(12)16-3-4/h4-5,7-11,13-15H,1-3H2/t4-,5-,7-,8+,9-,10-/m1/s1

描述信息

(3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside is a glycoside.
Kinsenoside is a natural product found in Anoectochilus formosanus, Anoectochilus koshunensis, and Crocus sativus with data available.
Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects[1]. Kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxidative stress and protects against apoptosis, senescence and mitochondrial dysfunction in a Nrf2-dependent way[2].
Kinsenoside is a main active component isolated from plants of the genus Anoectochilus, and exhibits many biological activities and pharmacological effects[1]. Kinsenoside rescues the nucleus pulposus cells (NPCs) viability under oxidative stress and protects against apoptosis, senescence and mitochondrial dysfunction in a Nrf2-dependent way[2].

同义名列表

11 个代谢物同义名

(R)-4-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)dihydrofuran-2(3H)-one; (4R)-4-{[(2R,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]OXY}OXOLAN-2-ONE; (4R)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-one; 2(3H)-Furanone, 4-(.beta.-D-glucopyranosyloxy)dihydro-, (R)-; 2(3H)-Furanone, 4-(b-D-glucopyranosyloxy)dihydro-,(4R)-; (3R)-5-Oxotetrahydro-3-furanyl beta-D-glucopyranoside; 3-(r)-beta-d-glucopyranosyloxybutanolide; 3-glucopyranosyloxybutanolide; Kinsenoside;(+)-Kinsenoside; (+)-Kinsenoside; Kinsenoside



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yu Xiao, Changsong Duan, Pushuang Gong, Qi Zhao, Xin Hui Wang, Fang Geng, Jin Zeng, Tianfeng Luo, Yisha Xu, Junning Zhao. Kinsenoside from Anoectochilus roxburghii (Wall.) Lindl. suppressed oxidative stress to attenuate aging-related learning and memory impairment via ERK/Nrf2 pathway. Journal of ethnopharmacology. 2023 Sep; 319(Pt 1):117152. doi: 10.1016/j.jep.2023.117152. [PMID: 37689328]
  • Pensiri Buacheen, Jirarat Karinchai, Natchapon Kammasit, Piya Temviriyanukul, Chutikarn Butkinaree, Santi Watthana, Ariyaphong Wongnoppavich, Arisa Imsumran, Pornsiri Pitchakarn. Protective effect of Anoectochilus burmannicus extracts and its active compound, kinsenoside on adipocyte differentiation induced by benzyl butyl phthalate and bisphenol A. Scientific reports. 2023 Feb; 13(1):2939. doi: 10.1038/s41598-023-30227-5. [PMID: 36806746]
  • Yan-Fang Deng, Qian-Qian Xu, Tian-Qi Chen, Jia-Xiong Ming, Ya-Fen Wang, Li-Na Mao, Jia-Jun Zhou, Wei-Guang Sun, Qun Zhou, Hong Ren, Yong-Hui Zhang. Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 104(?):154241. doi: 10.1016/j.phymed.2022.154241. [PMID: 35749827]
  • Ming Xiang, Tingting Liu, Cheng Tian, Kun Ma, Jing Gou, Rongrong Huang, Senlin Li, Qing Li, Chuanrui Xu, Lei Li, Chih-Hao Lee, Yonghui Zhang. Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway. Pharmacological research. 2022 03; 177(?):106092. doi: 10.1016/j.phrs.2022.106092. [PMID: 35066108]
  • Yue Yang, Zhen-Tong Zhong, Yong-Guang Xiao, Hong-Bin Chen. The Activation of AMPK/NRF2 Pathway in Lung Epithelial Cells Is Involved in the Protective Effects of Kinsenoside on Lipopolysaccharide-Induced Acute Lung Injury. Oxidative medicine and cellular longevity. 2022; 2022(?):3589277. doi: 10.1155/2022/3589277. [PMID: 35340214]
  • Biyun Yang, Mengyuan Zhang, Haiyong Weng, Yong Xu, Lihui Zeng. Optimization of Ultrasound Assisted Extraction (UAE) of Kinsenoside Compound from Anoectochilus roxburghii (Wall.) Lindl by Response Surface Methodology (RSM). Molecules (Basel, Switzerland). 2020 Jan; 25(1):. doi: 10.3390/molecules25010193. [PMID: 31906599]
  • Yuan-Chii G Lee, Yuh-Mou Sue, Ching-Kuo Lee, Huei-Mei Huang, Jhin-Jyun He, Yu-Shiou Wang, Shu-Hui Juan. Synergistic effects of cAMP-dependent protein kinase A and AMP-activated protein kinase on lipolysis in kinsenoside-treated C3H10T1/2 adipocytes. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Mar; 55(?):255-263. doi: 10.1016/j.phymed.2018.06.043. [PMID: 30668437]
  • Ming Xiang, Tingting Liu, Wanyue Tan, Hongyu Ren, Hua Li, Junjun Liu, Hui Cao, Qi Cheng, Xiulan Liu, Hucheng Zhu, Yali Tuo, Jianping Wang, Yonghui Zhang. Effects of kinsenoside, a potential immunosuppressive drug for autoimmune hepatitis, on dendritic cells/CD8+ T cells communication in mice. Hepatology (Baltimore, Md.). 2016 12; 64(6):2135-2150. doi: 10.1002/hep.28825. [PMID: 27639182]
  • Qiao Han, Wang Bing, Yin Di, Li Hua, Li Shi-He, Zheng Yu-Hua, Han Xiu-Guo, Wang Yu-Gang, Fan Qi-Ming, Yang Shih-Mo, Tang Ting-Ting. Kinsenoside screening with a microfluidic chip attenuates gouty arthritis through inactivating NF-κB signaling in macrophages and protecting endothelial cells. Cell death & disease. 2016 09; 7(9):e2350. doi: 10.1038/cddis.2016.255. [PMID: 27584788]
  • Shaheed Ur Rehman, Min Sun Choi, In Sook Kim, Zengwei Luo, Yongbo Xue, Guangming Yao, Yonghui Zhang, Hye Hyun Yoo. In Vitro Assessment of CYP-Mediated Drug Interactions for Kinsenoside, an Antihyperlipidemic Candidate. Molecules (Basel, Switzerland). 2016 Jun; 21(6):. doi: 10.3390/molecules21060800. [PMID: 27322236]
  • Hung-Bo Hsiao, Chang-Chi Hsieh, Jin-Bin Wu, Ho Lin, Wen-Chuan Lin. Kinsenoside inhibits the inflammatory mediator release in a type-II collagen induced arthritis mouse model by regulating the T cells responses. BMC complementary and alternative medicine. 2016 Feb; 16(?):80. doi: 10.1186/s12906-016-1054-8. [PMID: 26916550]
  • Shaheed Ur Rehman, In Sook Kim, Min Sun Choi, Zengwei Luo, Guangming Yao, Yongbo Xue, Yonghui Zhang, Hye Hyun Yoo. Development of a hydrophilic interaction liquid chromatography-tandem mass spectrometric method for the determination of kinsenoside, an antihyperlipidemic candidate, in rat plasma and its application to pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2016 Feb; 120(?):19-24. doi: 10.1016/j.jpba.2015.12.003. [PMID: 26686829]
  • Fu-sheng Zhang, Ya-li Lv, Yue Zhao, Shun-xing Guo. Promoting role of an endophyte on the growth and contents of kinsenosides and flavonoids of Anoectochilus formosanus Hayata, a rare and threatened medicinal Orchidaceae plant. Journal of Zhejiang University. Science. B. 2013 Sep; 14(9):785-92. doi: 10.1631/jzus.b1300056. [PMID: 24009198]
  • H-B Hsiao, H Lin, J-B Wu, W-C Lin. Kinsenoside prevents ovariectomy-induced bone loss and suppresses osteoclastogenesis by regulating classical NF-κB pathways. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2013 May; 24(5):1663-76. doi: 10.1007/s00198-012-2199-z. [PMID: 23143538]
  • Wen-Tsong Hsieh, Chia-Tzu Tsai, Jin-Bin Wu, Hung-Bo Hsiao, Li-Chan Yang, Wen-Chuan Lin. Kinsenoside, a high yielding constituent from Anoectochilus formosanus, inhibits carbon tetrachloride induced Kupffer cells mediated liver damage. Journal of ethnopharmacology. 2011 May; 135(2):440-9. doi: 10.1016/j.jep.2011.03.040. [PMID: 21470577]
  • Hung-Bo Hsiao, Jin-Bin Wu, Ho Lin, Wen-Chuan Lin. Kinsenoside isolated from Anoectochilus formosanus suppresses LPS-stimulated inflammatory reactions in macrophages and endotoxin shock in mice. Shock (Augusta, Ga.). 2011 Feb; 35(2):184-90. doi: 10.1097/shk.0b013e3181f0e7a3. [PMID: 20661184]
  • Xiao-Ming Du, Nobuto Irino, Norihiro Furusho, Jun Hayashi, Yukihiro Shoyama. Pharmacologically active compounds in the Anoectochilus and Goodyera species. Journal of natural medicines. 2008 Apr; 62(2):132-48. doi: 10.1007/s11418-007-0169-0. [PMID: 18404313]
  • Jin-Bin Wu, Wei-Lii Lin, Chang-Chi Hsieh, Hui-Ya Ho, Hsin-Sheng Tsay, Wen-Chuan Lin. The hepatoprotective activity of kinsenoside from Anoectochilus formosanus. Phytotherapy research : PTR. 2007 Jan; 21(1):58-61. doi: 10.1002/ptr.2025. [PMID: 17078107]
  • T Wasada. [The changes in serum levels of FSH, LH, LHalpha and beta-subunit, and prolactin and their responses to synthetic LH-RH and TRH in normal subjects with aging (author's transl)]. Fukuoka igaku zasshi = Hukuoka acta medica. 1978 Dec; 69(12):506-18. doi: NULL. [PMID: 104911]