Taurocholic Acid (BioDeep_00000229624)
Main id: BioDeep_00000002590
human metabolite PANOMIX_OTCML-2023 Bile acids BioNovoGene_Lab2019 Volatile Flavor Compounds
代谢物信息卡片
N-(3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oyl)-taurine
化学式: C26H45NO7S (515.291658)
中文名称: 牛磺胆酸, 牛磺胆酸盐, 牛黄胆酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C1(C(CC3C2C(CC4C3(CCC(C4)O)C)O)O)C
InChI: InChI=1S/C26H45NO7S/c1-15(4-7-23(31)27-10-11-35(32,33)34)18-5-6-19-24-20(14-22(30)26(18,19)3)25(2)9-8-17(28)12-16(25)13-21(24)29/h15-22,24,28-30H,4-14H2,1-3H3,(H,27,31)(H,32,33,34)/t15-,16+,17-,18-,19+,20+,21-,22+,24+,25+,26-/m1/s1
描述信息
D005765 - Gastrointestinal Agents > D002756 - Cholagogues and Choleretics
D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids
D013501 - Surface-Active Agents > D003902 - Detergents
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:28865
- KEGG: C05122
- PubChem: 46783527
- PubChem: 6675
- HMDB: HMDB00036
- DrugBank: DB04348
- ChEMBL: CHEMBL224867
- LipidMAPS: LMST05040001
- MeSH: Taurocholic Acid
- CAS: 81-24-3
- MoNA: MT000116
- ChEBI: CHEBI:181348
- PubChem: 7544
- PDB-CCD: TCH
- 3DMET: B04981
- NIKKAJI: J8.603G
- RefMet: Taurocholic acid
- medchemexpress: HY-B1788
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-818
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-966
- KNApSAcK: 181348
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
6 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 32046 - Synechococcus elongatus: 10.1111/1462-2920.12899
- 5691 - Trypanosoma brucei: 10.1128/AAC.00044-13
- 9642 - Ursus thibetanus: 10.1248/CPB.57.528
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ying Li, Ya-Nan Gao, Ying-Bao Zhu, Wen-Fang Lu, Jia-Yue Yu, Yuan-Yuan Dong, Meng-Yue Xu, Bo Peng, Jun-Zhe Wu, Qing Su, Juan Bai, Xiao-Lian Shi, Yu-Ming Kang, Hong-Bao Li, Meng-Lu Xu. Taurocholic acid ameliorates hypertension through the activation of TGR5 in the hypothalamic paraventricular nucleus.
Food & function.
2024 May; 15(9):5088-5102. doi:
10.1039/d4fo00808a. [PMID: 38666497] - Ana Clara Sabbione, María Cristina Añón, Adriana Scilingo. Characterization and Bile Acid Binding Capacity of Dietary Fiber Obtained from Three Different Amaranth Products.
Plant foods for human nutrition (Dordrecht, Netherlands).
2024 Mar; 79(1):38-47. doi:
10.1007/s11130-023-01116-z. [PMID: 37938455] - Zehui Qin, Minhua Li, Juanjuan Cheng, Ziwei Huang, Gaoxiang Ai, Chang Qu, Youliang Xie, Yucui Li, Huijun Liao, Jianhui Xie, Ziren Su. Self-Assembled nanoparticles Combining Berberine and Sodium Taurocholate for Enhanced Anti-Hyperuricemia Effect.
International journal of nanomedicine.
2023; 18(?):4101-4120. doi:
10.2147/ijn.s409513. [PMID: 37525694] - Zongmei Zheng, Jiao Wei, Xinxin Hou, Fengjing Jia, Zhaozhou Zhang, Haidong Guo, Fuwen Yuan, Feng He, Zunji Ke, Yan Wang, Ling Zhao. A High Hepatic Uptake of Conjugated Bile Acids Promotes Colorectal Cancer-Associated Liver Metastasis.
Cells.
2022 Nov; 11(23):. doi:
10.3390/cells11233810. [PMID: 36497071] - Tien S Dong, Jonathan P Jacobs, Vatche Agopian, Joseph R Pisegna, Walid Ayoub, Francisco Durazo, Pedram Enayati, Vinay Sundaram, Jihane N Benhammou, Mazen Noureddin, Gina Choi, Venu Lagishetty, Oliver Fiehn, Marc T Goodman, David Elashoff, Shehnaz K Hussain. Duodenal Microbiome and Serum Metabolites Predict Hepatocellular Carcinoma in a Multicenter Cohort of Patients with Cirrhosis.
Digestive diseases and sciences.
2022 08; 67(8):3831-3841. doi:
10.1007/s10620-021-07299-2. [PMID: 34799768] - Jessica Y Idowu, Bruno Hagenbuch. Free Cholesterol Affects the Function and Localization of Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1).
International journal of molecular sciences.
2022 Jul; 23(15):. doi:
10.3390/ijms23158457. [PMID: 35955590] - Dariusz Zakrzewicz, Regina Leidolf, Sebastian Kunz, Simon Franz Müller, Anita Neubauer, Silke Leiting, Nora Goldmann, Felix Lehmann, Dieter Glebe, Joachim Geyer. Tyrosine 146 of the Human Na+/Taurocholate Cotransporting Polypeptide (NTCP) Is Essential for Its Hepatitis B Virus (HBV) Receptor Function and HBV Entry into Hepatocytes.
Viruses.
2022 06; 14(6):. doi:
10.3390/v14061259. [PMID: 35746730] - Jian Wu, Yanping Xu, Yubao Cui, Mariza Bortolanza, Minjie Wang, Bin Jiang, Meina Yan, Wei Liang, Yiwen Yao, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Dawei Wang, Hongcui Cao, Lanjuan Li. Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection.
Journal of medical virology.
2022 06; 94(6):2714-2726. doi:
10.1002/jmv.27669. [PMID: 35199373] - Daisuke Watase, Shuichi Setoguchi, Nami Nagata-Akaho, Shotaro Goto, Hirofumi Yamakawa, Ayano Yamada, Mitsuhisa Koga, Yoshiharu Karube, Kazuhisa Matsunaga, Jiro Takata. Cationic N,N-Dimethylglycine Ester Prodrug of 2R-α-Tocotrienol Promotes Intestinal Absorption via Efficient Self-Micellization with Intrinsic Bile Acid Anion.
Molecules (Basel, Switzerland).
2022 Apr; 27(9):. doi:
10.3390/molecules27092727. [PMID: 35566078] - Jia Xu, Shiwei Xie, Shuyan Chi, Shuang Zhang, Junming Cao, Beiping Tan. Protective effects of taurocholic acid on excessive hepatic lipid accumulation via regulation of bile acid metabolism in grouper.
Food & function.
2022 Mar; 13(5):3050-3062. doi:
10.1039/d1fo04085e. [PMID: 35199809] - Ana Virseda-Berdices, David Rojo, Isidoro Martínez, Juan Berenguer, Juan González-García, Oscar Brochado-Kith, Amanda Fernández-Rodríguez, Cristina Díez, Víctor Hontañon, Leire Pérez-Latorre, Rafael Micán, Coral Barbas, Salvador Resino, María Angeles Jiménez-Sousa. Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Mar; 147(?):112623. doi:
10.1016/j.biopha.2022.112623. [PMID: 35032770] - A L Schneider, H Köhler, B Röthlisberger, R Grobholz, V A McLin. Sodium taurocholate co-transporting polypeptide deficiency.
Clinics and research in hepatology and gastroenterology.
2022 03; 46(3):101824. doi:
10.1016/j.clinre.2021.101824. [PMID: 34757153] - Yun Wang, Yanjing Li, Shaojingya Gao, Xi Yu, Yu Chen, Yunfeng Lin. Tetrahedral Framework Nucleic Acids Can Alleviate Taurocholate-Induced Severe Acute Pancreatitis and Its Subsequent Multiorgan Injury in Mice.
Nano letters.
2022 02; 22(4):1759-1768. doi:
10.1021/acs.nanolett.1c05003. [PMID: 35138113] - Anne-Margarethe Enge, Florian Kaltner, Christoph Gottschalk, Angelina Kin, Michael Kirstgen, Joachim Geyer, Anja These, Helen Hammer, Oliver Pötz, Albert Braeuning, Stefanie Hessel-Pras. Organic Cation Transporter I and Na+ /taurocholate Co-Transporting Polypeptide are Involved in Retrorsine- and Senecionine-Induced Hepatotoxicity in HepaRG cells.
Molecular nutrition & food research.
2022 01; 66(2):e2100800. doi:
10.1002/mnfr.202100800. [PMID: 34826203] - L Liu, Y Yang, W Li, Y Li, X Jiang, L Wang. Tanshinone IIA alleviate rifampicin-induced cholestasis by regulating the expression and function of bile salt export pump.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221097365. doi:
10.1177/09603271221097365. [PMID: 35544702] - Yishuang Tang, Jing Kong, Bingduo Zhou, Xiaosu Wang, Xiaowen Liu, Yi Wang, Shengliang Zhu. Mesenteric Lymph Duct Ligation Alleviates Acute Lung Injury Caused by Severe Acute Pancreatitis Through Inhibition of High Mobility Group Box 1-Induced Inflammation in Rats.
Digestive diseases and sciences.
2021 12; 66(12):4344-4353. doi:
10.1007/s10620-020-06801-6. [PMID: 33433807] - Liga Skarda, Julia Kowal, Kaspar P Locher. Structure of the Human Cholesterol Transporter ABCG1.
Journal of molecular biology.
2021 10; 433(21):167218. doi:
10.1016/j.jmb.2021.167218. [PMID: 34461069] - Xuan Qin, Yuanjin Zhang, Jian Lu, Shengbo Huang, Zongjun Liu, Xin Wang. CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.
Toxicology and applied pharmacology.
2021 10; 429(?):115703. doi:
10.1016/j.taap.2021.115703. [PMID: 34461081] - Suzhen Lei, Lu Liu, Linyu Ding, Yi Zhang, Hongliang Zeng. Lotus seed resistant starch affects the conversion of sodium taurocholate by regulating the intestinal microbiota.
International journal of biological macromolecules.
2021 Sep; 186(?):227-236. doi:
10.1016/j.ijbiomac.2021.07.031. [PMID: 34245735] - Yuki Takashima, Kazuki Ishikawa, Rina Miyawaki, Mana Ogawa, Takeshi Ishii, Takumi Misaka, Shoko Kobayashi. Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity.
Journal of agricultural and food chemistry.
2021 Aug; 69(33):9585-9596. doi:
10.1021/acs.jafc.1c03483. [PMID: 34346218] - Anders Ø Petersen, Hanna Julienne, Tuulia Hyötyläinen, Partho Sen, Yong Fan, Helle Krogh Pedersen, Sirkku Jäntti, Tue H Hansen, Trine Nielsen, Torben Jørgensen, Torben Hansen, Pernille Neve Myers, H Bjørn Nielsen, S Dusko Ehrlich, Matej Orešič, Oluf Pedersen. Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species.
Scientific reports.
2021 06; 11(1):13252. doi:
10.1038/s41598-021-91482-y. [PMID: 34168163] - Shengchuan Chen, Jingfei Zhu, Li-Qiong Sun, Siying Liu, Tan Zhang, Yuepeng Jin, Chaohao Huang, Dapei Li, Haiping Yao, Jian Huang, Yanghua Qin, Mengtao Zhou, Gang Chen, Qiyu Zhang, Feng Ma. LincRNA-EPS alleviates severe acute pancreatitis by suppressing HMGB1-triggered inflammation in pancreatic macrophages.
Immunology.
2021 06; 163(2):201-219. doi:
10.1111/imm.13313. [PMID: 33512718] - Hao-Wei Chang, Nathan P McNulty, Matthew C Hibberd, David O'Donnell, Jiye Cheng, Vincent Lombard, Bernard Henrissat, Olga Ilkayeva, Michael J Muehlbauer, Christopher B Newgard, Michael J Barratt, Xi Lin, Jack Odle, Jeffrey I Gordon. Gut microbiome contributions to altered metabolism in a pig model of undernutrition.
Proceedings of the National Academy of Sciences of the United States of America.
2021 05; 118(21):. doi:
10.1073/pnas.2024446118. [PMID: 34001614] - Qiuju Tian, Ruiyuan Yang, Yan Wang, Jimin Liu, Aileen Wee, Romil Saxena, Lan Wang, Min Li, Liwei Liu, Shan Shan, Yuanyuan Kong, Hong Ma, Xiaojuan Ou, Hong You, Xinyan Zhao, Jidong Jia. A High Serum Level of Taurocholic Acid Is Correlated With the Severity and Resolution of Drug-induced Liver Injury.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2021 05; 19(5):1009-1019.e11. doi:
10.1016/j.cgh.2020.06.067. [PMID: 32634627] - Nikolaos N Koliakos, Georgios Renieris, Dimitrios Sotiropoulos, Kalliopi Pavlou, Dionysia-Eirini Droggiti, Theologia Gkavogianni, Anestis Charalampopoulos, Evangelos J Giamarellos-Bourboulis. Immunomodulation Through Beta-D-glucan in Chemically-induced Necrotizing Pancreatitis.
The Journal of surgical research.
2021 05; 261(?):74-84. doi:
10.1016/j.jss.2020.12.020. [PMID: 33421796] - Toshihide Takagi, Takato Masada, Keiko Minami, Makoto Kataoka, Ken-Ichi Izutsu, Kazuki Matsui, Shinji Yamashita. In Vitro Sensitivity Analysis of the Gastrointestinal Dissolution Profile of Weakly Basic Drugs in the Stomach-to-Intestine Fluid Changing System: Explanation for Variable Plasma Exposure after Oral Administration.
Molecular pharmaceutics.
2021 04; 18(4):1711-1719. doi:
10.1021/acs.molpharmaceut.0c01207. [PMID: 33629861] - Deliang Ma, Chang Li, Pengling Jiang, Yingjian Jiang, Jiang Wang, Dianliang Zhang. Inhibition of Ferroptosis Attenuates Acute Kidney Injury in Rats with Severe Acute Pancreatitis.
Digestive diseases and sciences.
2021 02; 66(2):483-492. doi:
10.1007/s10620-020-06225-2. [PMID: 32219613] - Christine Wu, Maria-Elisabeth Smet, Susan Heath, Jennifer Curnow, Ming-Wei Lin, Jacob George, Thushari I Alahakoon. Pregnancy complicated by refractory severe hypercholanaemia from sodium taurocholate co-transporting polypeptide deficiency.
The journal of obstetrics and gynaecology research.
2021 Feb; 47(2):822-826. doi:
10.1111/jog.14568. [PMID: 33174277] - Zhen Xun, Jinpiao Lin, Qingqing Yu, Can Liu, Jinlan Huang, Hongyan Shang, Jianhui Guo, Yuchen Ye, Wennan Wu, Yongbin Zeng, Songhang Wu, Siyi Xu, Tianbin Chen, Jing Chen, Qishui Ou. Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function.
Cellular & molecular immunology.
2021 02; 18(2):461-471. doi:
10.1038/s41423-020-00601-8. [PMID: 33432062] - Shuo Wang, Jiang Chen, Hongyu Li, Xingshun Qi, Xu Liu, Xiaozhong Guo. Metabolomic Detection Between Pancreatic Cancer and Liver Metastasis Nude Mouse Models Constructed by Using the PANC1-KAI1/CD82 Cell Line.
Technology in cancer research & treatment.
2021 Jan; 20(?):15330338211045204. doi:
10.1177/15330338211045204. [PMID: 34605330] - Lauren E Hughes, Clare Ford, Matthew J Brookes, Rousseau Gama. Bile acid diarrhoea: Current and potential methods of diagnosis.
Annals of clinical biochemistry.
2021 01; 58(1):22-28. doi:
10.1177/0004563220966139. [PMID: 32998535] - Chongyan Zhao, Fang Yang, Feng Lin, Qingsong Qu, Zhixun Li, Xing Liu, Lu Han, Xinyuan Shi. Process optimization in ginseng fermentation by Monascus ruber and study on bile acid-binding ability of fermentation products in vitro.
Preparative biochemistry & biotechnology.
2021; 51(2):120-126. doi:
10.1080/10826068.2020.1799389. [PMID: 33342390] - Kai Wang, Martin Yan-Chun Chan, Jian Xu, Pik-Shan Li, Xing Liu, Angus Yiu-Fai Lee, Susanna Sau-Tuen Lee, Wing-Tai Cheung. Male-biased fasting-induced changes in hepatic tauro-cholic acid and plasma cholesterol in Sult2a8-haplodeficient mice.
Transgenic research.
2020 12; 29(5-6):499-510. doi:
10.1007/s11248-020-00215-w. [PMID: 33029720] - Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey, Ibrahim Elsayed. Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency.
Drug delivery.
2020 Dec; 27(1):996-1009. doi:
10.1080/10717544.2020.1787557. [PMID: 32611266] - Michael Camilleri, Priya Vijayvargiya. The Role of Bile Acids in Chronic Diarrhea.
The American journal of gastroenterology.
2020 10; 115(10):1596-1603. doi:
10.14309/ajg.0000000000000696. [PMID: 32558690] - Zhifu Xie, Haowen Jiang, Wei Liu, Xinwen Zhang, Dakai Chen, Shuimei Sun, Chendong Zhou, Jia Liu, Sheng Bao, Xiachang Wang, Yinan Zhang, Jia Li, Lihong Hu, Jingya Li. The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling.
Cell death & disease.
2020 09; 11(9):770. doi:
10.1038/s41419-020-02974-0. [PMID: 32943612] - Iván L Csanaky, Andrew J Lickteig, Youcai Zhang, Curtis D Klaassen. Effects of patent ductus venosus on bile acid homeostasis in aryl hydrocarbon receptor (AhR)-null mice.
Toxicology and applied pharmacology.
2020 09; 403(?):115136. doi:
10.1016/j.taap.2020.115136. [PMID: 32679164] - Tomokazu Tokoro, Isamu Makino, Shinichi Harada, Koichi Okamoto, Shinichi Nakanuma, Seisho Sakai, Jun Kinoshita, Keishi Nakamura, Tomoharu Miyashita, Hidehiro Tajima, Itasu Ninomiya, Sachio Fushida, Tetsuo Ohta. Interactions Between Neutrophils and Platelets in the Progression of Acute Pancreatitis.
Pancreas.
2020 07; 49(6):830-836. doi:
10.1097/mpa.0000000000001585. [PMID: 32541639] - Salma Alavi, Jonathan D Mitchell, Jennifer Y Cho, Rui Liu, John C Macbeth, Ansel Hsiao. Interpersonal Gut Microbiome Variation Drives Susceptibility and Resistance to Cholera Infection.
Cell.
2020 06; 181(7):1533-1546.e13. doi:
10.1016/j.cell.2020.05.036. [PMID: 32631492] - Weiguo Sui, Qing Gan, Fuhua Liu, Minglin Ou, Bingguo Wang, Songbai Liao, Liusheng Lai, Huaizhou Chen, Ming Yang, Yong Dai. Dynamic Metabolomics Study of the Bile Acid Pathway During Perioperative Primary Hepatic Carcinoma Following Liver Transplantation.
Annals of transplantation.
2020 Jun; 25(?):e921844. doi:
10.12659/aot.921844. [PMID: 32572018] - Monique D Appelman, Marion J D Robin, Esther W M Vogels, Christie Wolzak, Winnie G Vos, Harmjan R Vos, Robert M Van Es, Boudewijn M T Burgering, Stan F J Van de Graaf. The Lipid Raft Component Stomatin Interacts with the Na+ Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake.
Cells.
2020 04; 9(4):. doi:
10.3390/cells9040986. [PMID: 32316189] - Laura E Russell, Yitian Zhou, Volker M Lauschke, Richard B Kim. In Vitro Functional Characterization and in Silico Prediction of Rare Genetic Variation in the Bile Acid and Drug Transporter, Na+-Taurocholate Cotransporting Polypeptide (NTCP, SLC10A1).
Molecular pharmaceutics.
2020 04; 17(4):1170-1181. doi:
10.1021/acs.molpharmaceut.9b01200. [PMID: 32101444] - Sarah Farr, Bogdan Stankovic, Simon Hoffman, Hassan Masoudpoor, Chris Baker, Jennifer Taher, Angela E Dean, Sayeepriyadarshini Anakk, Khosrow Adeli. Bile acid treatment and FXR agonism lower postprandial lipemia in mice.
American journal of physiology. Gastrointestinal and liver physiology.
2020 04; 318(4):G682-G693. doi:
10.1152/ajpgi.00386.2018. [PMID: 32003602] - Cassandra Warden, Joshua M Barnett, Milam A Brantley. Taurocholic acid inhibits features of age-related macular degeneration in vitro.
Experimental eye research.
2020 04; 193(?):107974. doi:
10.1016/j.exer.2020.107974. [PMID: 32067977] - Chen Luo, Qilin Huang, Xiaohui Yuan, Yi Yang, Bing Wang, Zhu Huang, Lijun Tang, Hongyu Sun. Abdominal paracentesis drainage attenuates severe acute pancreatitis by enhancing cell apoptosis via PI3K/AKT signaling pathway.
Apoptosis : an international journal on programmed cell death.
2020 04; 25(3-4):290-303. doi:
10.1007/s10495-020-01597-2. [PMID: 32100210] - Lilong Sun, Zhicheng Le, Shuran He, Jingyan Liu, Lixin Liu, Kam W Leong, Hai-Quan Mao, Zhijia Liu, Yongming Chen. Flash Fabrication of Orally Targeted Nanocomplexes for Improved Transport of Salmon Calcitonin across the Intestine.
Molecular pharmaceutics.
2020 03; 17(3):757-768. doi:
10.1021/acs.molpharmaceut.9b00827. [PMID: 32011888] - Ian B Jeffery, Anubhav Das, Eileen O'Herlihy, Simone Coughlan, Katryna Cisek, Michael Moore, Fintan Bradley, Tom Carty, Meenakshi Pradhan, Chinmay Dwibedi, Fergus Shanahan, Paul W O'Toole. Differences in Fecal Microbiomes and Metabolomes of People With vs Without Irritable Bowel Syndrome and Bile Acid Malabsorption.
Gastroenterology.
2020 03; 158(4):1016-1028.e8. doi:
10.1053/j.gastro.2019.11.301. [PMID: 31843589] - Ana Ferrero-Andrés, Arnau Panisello-Roselló, Anna Serafín, Joan Roselló-Catafau, Emma Folch-Puy. Polyethylene Glycol 35 (PEG35) Protects against Inflammation in Experimental Acute Necrotizing Pancreatitis and Associated Lung Injury.
International journal of molecular sciences.
2020 Jan; 21(3):. doi:
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World journal of gastroenterology.
2020 Jan; 26(1):35-54. doi:
10.3748/wjg.v26.i1.35. [PMID: 31933513] - Lu Li, Wang-Wei Fu, Rui-Ting Wu, Ye-Hao Song, Wen-Ying Wu, Shu-Hua Yin, Wen-Juan Li, Ming-Yong Xie. Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics.
International journal of biological macromolecules.
2020 Jan; 142(?):693-704. doi:
10.1016/j.ijbiomac.2019.10.010. [PMID: 31739063] - Xiaoyu Zhang, Guang Xin, Shiyi Li, Zeliang Wei, Yue Ming, Jiyan Yuan, E Wen, Zhihua Xing, Kui Yu, Youping Li, Junhua Zhang, Boli Zhang, Hai Niu, Wen Huang. Dehydrocholic Acid Ameliorates Sodium Taurocholate-Induced Acute Biliary Pancreatitis in Mice.
Biological & pharmaceutical bulletin.
2020; 43(6):985-993. doi:
10.1248/bpb.b20-00021. [PMID: 32475920] - A Jiménez-Alesanco, M Marcuello, M Pastor-Jiménez, L López-Puerto, L Bonjoch, M Gironella, M Carrascal, J Abian, E de-Madaria, D Closa. Acute pancreatitis promotes the generation of two different exosome populations.
Scientific reports.
2019 12; 9(1):19887. doi:
10.1038/s41598-019-56220-5. [PMID: 31882721] - Olivia Pabois, Christian D Lorenz, Richard D Harvey, Isabelle Grillo, Myriam M-L Grundy, Peter J Wilde, Yuri Gerelli, Cécile A Dreiss. Molecular insights into the behaviour of bile salts at interfaces: a key to their role in lipid digestion.
Journal of colloid and interface science.
2019 Nov; 556(?):266-277. doi:
10.1016/j.jcis.2019.08.010. [PMID: 31450021] - Ivan Lyutakov, Francesco Ursini, Plamen Penchev, Giacomo Caio, Antonio Carroccio, Umberto Volta, Roberto De Giorgio. Methods for diagnosing bile acid malabsorption: a systematic review.
BMC gastroenterology.
2019 Nov; 19(1):185. doi:
10.1186/s12876-019-1102-1. [PMID: 31726982] - M-Z Qin, M-B Qin, Z-H Liang, G-D Tang. Effect of SOCS3 on lung injury in rats with severe acute pancreatitis through regulating JAK2/STAT3 signaling pathway.
European review for medical and pharmacological sciences.
2019 Nov; 23(22):10123-10131. doi:
10.26355/eurrev_201911_19582. [PMID: 31799684] - Jin-Seok Park, Seok Jeong, Joon Mee Kim, Bum Hei Lee, Jae Min Kim, Don Haeng Lee. Development of an acute pancreatitis porcine model based on endoscopic retrograde infusion of contrast medium or sodium taurocholate.
The Korean journal of internal medicine.
2019 Nov; 34(6):1244-1251. doi:
10.3904/kjim.2017.367. [PMID: 30428647] - A Baena García, F Partida Palma, S García Martínez, M de Bonilla Candau, M Pajares Vinardell. 75Se-Homocholic acid taurine scintigraphy (75SeHCAT®), a standard benchmark test in bile acid malabsorption?.
Revista espanola de medicina nuclear e imagen molecular.
2019 Sep; 38(5):305-311. doi:
10.1016/j.remn.2018.12.005. [PMID: 30745130] - Raed Madhi, Milladur Rahman, Matthias Mörgelin, Henrik Thorlacius. c-Abl kinase regulates neutrophil extracellular trap formation, inflammation, and tissue damage in severe acute pancreatitis.
Journal of leukocyte biology.
2019 08; 106(2):455-466. doi:
10.1002/jlb.3a0618-222rr. [PMID: 30861207] - You-Dong Wan, Rui-Xue Zhu, Zhong-Zheng Bian, Xin-Ting Pan. Improvement of Gut Microbiota by Inhibition of P38 Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Rats with Severe Acute Pancreatitis.
Medical science monitor : international medical journal of experimental and clinical research.
2019 06; 25(?):4609-4616. doi:
10.12659/msm.914538. [PMID: 31226101] - Yun-Dong You, Wen-Hong Deng, Wen-Yi Guo, Liang Zhao, Fang-Chao Mei, Yu-Pu Hong, Yu Zhou, Jia Yu, Sheng Xu, Wei-Xing Wang. 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.
Digestive diseases and sciences.
2019 06; 64(6):1535-1547. doi:
10.1007/s10620-018-5437-1. [PMID: 30607691] - S Li, H-Z Cui, C-M Xu, Z-W Sun, Z-K Tang, H-L Chen. RUNX3 protects against acute lung injury by inhibiting the JAK2/STAT3 pathway in rats with severe acute pancreatitis.
European review for medical and pharmacological sciences.
2019 Jun; 23(12):5382-5391. doi:
10.26355/eurrev_201906_18207. [PMID: 31298391] - Guang Zhao, Yu-Zhen Zhuo, Li-Hua Cui, Cai-Xia Li, Sha-Yan Chen, Dan Li, Jun-Hong Liu, Di-Hua Li, Nai-Qiang Cui, Shu-Kun Zhang. Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ injury in severe acute pancreatitis rats.
Chinese journal of natural medicines.
2019 May; 17(5):355-362. doi:
10.1016/s1875-5364(19)30041-x. [PMID: 31171270] - Kristen E Syring, Travis J Cyphert, Thomas C Beck, Charles R Flynn, Nicholas A Mignemi, Owen P McGuinness. Systemic bile acids induce insulin resistance in a TGR5-independent manner.
American journal of physiology. Endocrinology and metabolism.
2019 05; 316(5):E782-E793. doi:
10.1152/ajpendo.00362.2018. [PMID: 30779633] - Karl M Weigand, Tom J J Schirris, Megan Houweling, Jeroen J M W van den Heuvel, Jan B Koenderink, Anita C A Dankers, Frans G M Russel, Rick Greupink. Uremic solutes modulate hepatic bile acid handling and induce mitochondrial toxicity.
Toxicology in vitro : an international journal published in association with BIBRA.
2019 Apr; 56(?):52-61. doi:
10.1016/j.tiv.2019.01.003. [PMID: 30639138] - Mehmet Ali Kosekli, Özkan Herek, Özlem Ozmen, Sima Sahinduran. Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats.
Revista da Associacao Medica Brasileira (1992).
2019 Feb; 65(2):204-210. doi:
10.1590/1806-9282.65.2.204. [PMID: 30892445] - Yuan Tian, Jingwei Cai, Wei Gui, Robert G Nichols, Imhoi Koo, Jingtao Zhang, Mallappa Anitha, Andrew D Patterson. Berberine Directly Affects the Gut Microbiota to Promote Intestinal Farnesoid X Receptor Activation.
Drug metabolism and disposition: the biological fate of chemicals.
2019 02; 47(2):86-93. doi:
10.1124/dmd.118.083691. [PMID: 30409838] - Xuehua Piao, Yanping Zou, Xiaodan Sui, Baohai Liu, Fanji Meng, Shuangdi Li, Qingyu Zhang, Chi Ma, Tong Wu. Hydrostatin-SN10 Ameliorates Pancreatitis-Induced Lung Injury by Affecting IL-6-Induced JAK2/STAT3-Associated Inflammation and Oxidative Stress.
Oxidative medicine and cellular longevity.
2019; 2019(?):9659757. doi:
10.1155/2019/9659757. [PMID: 31827715] - Yuecheng Guo, Chunlan Huang, Liyan Liu, Xinyuan Fu, Yingying Lu, Junyuan Zheng, Qixiang Mei, Zehua Huang, Junjie Fan, Lungen Lu, Yue Zeng. Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet.
Mediators of inflammation.
2019; 2019(?):8474523. doi:
10.1155/2019/8474523. [PMID: 31827383] - Patrick G K Mayer, Natalia Qvartskhava, Annika Sommerfeld, Boris Görg, Dieter Häussinger. Regulation of Plasma Membrane Localization of the Na⁺-Taurocholate Co-Transporting Polypeptide by Glycochenodeoxycholate and Tauroursodeoxycholate.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 52(6):1427-1445. doi:
10.33594/000000100. [PMID: 31088037] - Cadi Davies, Aidan J Taylor, Abdi Elmi, Jody Winter, Janie Liaw, Anna D Grabowska, Ozan Gundogdu, Brendan W Wren, David J Kelly, Nick Dorrell. Sodium Taurocholate Stimulates Campylobacter jejuni Outer Membrane Vesicle Production via Down-Regulation of the Maintenance of Lipid Asymmetry Pathway.
Frontiers in cellular and infection microbiology.
2019; 9(?):177. doi:
10.3389/fcimb.2019.00177. [PMID: 31192166] - Qingkai Zhang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Hailong Li, Dong Shang. Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.
Oncology reports.
2019 Jan; 41(1):270-278. doi:
10.3892/or.2018.6844. [PMID: 30542707] - Reika Yoshitsugu, Keidai Kikuchi, Hitoshi Iwaya, Nobuyuki Fujii, Shota Hori, Dong Geun Lee, Satoshi Ishizuka. Alteration of Bile Acid Metabolism by a High-Fat Diet Is Associated with Plasma Transaminase Activities and Glucose Intolerance in Rats.
Journal of nutritional science and vitaminology.
2019; 65(1):45-51. doi:
10.3177/jnsv.65.45. [PMID: 30814411] - Ola Winsö, Josef Kral, Wanzhong Wang, Ivana Kralova, Pernilla Abrahamsson, Göran Johansson, Per-Jonas Blind. Thoracic epidural anaesthesia reduces insulin resistance and inflammatory response in experimental acute pancreatitis.
Upsala journal of medical sciences.
2018 Dec; 123(4):207-215. doi:
10.1080/03009734.2018.1539054. [PMID: 30468105] - Chenyuan Shi, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Yunpeng Peng, Min Tu, Qiang Li, Yi Miao. SRT1720 ameliorates sodium taurocholate-induced severe acute pancreatitis in rats by suppressing NF-κB signalling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Dec; 108(?):50-57. doi:
10.1016/j.biopha.2018.09.035. [PMID: 30216799] - Shogo Takahashi, Naoki Tanaka, Tatsuki Fukami, Cen Xie, Tomoki Yagai, Donghwan Kim, Thomas J Velenosi, Tingting Yan, Kristopher W Krausz, Moshe Levi, Frank J Gonzalez. Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development.
Hepatology communications.
2018 Dec; 2(12):1567-1582. doi:
10.1002/hep4.1263. [PMID: 30556042] - Yongtao Xiao, Kejun Zhou, Ying Lu, Weihui Yan, Wei Cai, Ying Wang. Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling.
Experimental & molecular medicine.
2018 11; 50(12):1-14. doi:
10.1038/s12276-018-0181-3. [PMID: 30504803] - Chen-Yang Wang, Liang Zhao, Yu-Pu Hong, Fang-Chao Mei, Yu Zhou, Qiao Shi, Wen-Yi Guo, Wen-Hong Deng, Chen Chen, Jia Yu, Wei-Xing Wang. Serum thyroid hormones levels are significantly decreased in pregnant rats with acute pancreatitis.
Biochemical and biophysical research communications.
2018 11; 505(3):657-663. doi:
10.1016/j.bbrc.2018.09.180. [PMID: 30286956] - Tao Wang, Lihua Jiang, Xiaoyong Wei, Bo Liu, Junbo Zhao, Peilin Xie, Bo Yang, Lijuan Wang. MiR-21-3p aggravates injury in rats with acute hemorrhagic necrotizing pancreatitis by activating TRP signaling pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Nov; 107(?):1744-1753. doi:
10.1016/j.biopha.2018.08.164. [PMID: 30257393] - Zhiqiang Cheng, Guozhi Liu, Xiang Zhang, Dongsong Bi, Sanyuan Hu. Improvement of Glucose Metabolism Following Long-Term Taurocholic Acid Gavage in a Diabetic Rat Model.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Oct; 24(?):7206-7212. doi:
10.12659/msm.912429. [PMID: 30298865] - Liang Sun, Yuanhua Li, Huayou Luo, Kunhua Wang, Li Li, Yujian Zeng. Effects of Toll‑like receptor 9 and CpG oligodeoxynucleotides 1826 on sodium taurocholate‑induced acute pancreatitis rats.
Molecular medicine reports.
2018 Oct; 18(4):3818-3824. doi:
10.3892/mmr.2018.9346. [PMID: 30106134] - Zheng Junyuan, Xu Hui, Huang Chunlan, Fan Junjie, Mei Qixiang, Lu Yingying, Lou Lihong, Wang Xingpeng, Zeng Yue. Quercetin protects against intestinal barrier disruption and inflammation in acute necrotizing pancreatitis through TLR4/MyD88/p38 MAPK and ERS inhibition.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2018 Oct; 18(7):742-752. doi:
10.1016/j.pan.2018.08.001. [PMID: 30115563] - Yongtao Xiao, Weihui Yan, Ying Lu, Kejun Zhou, Wei Cai. Neurotensin contributes to pediatric intestinal failure-associated liver disease via regulating intestinal bile acids uptake.
EBioMedicine.
2018 Sep; 35(?):133-141. doi:
10.1016/j.ebiom.2018.08.006. [PMID: 30104181] - Jack Guinan, Shankar Thangamani. Antibiotic-induced alterations in taurocholic acid levels promote gastrointestinal colonization of Candida albicans.
FEMS microbiology letters.
2018 09; 365(18):. doi:
10.1093/femsle/fny196. [PMID: 30137306] - Zhimin Liu, Zhifeng Zhang, Mei Huang, Xiaoping Sun, Bojia Liu, Qiyang Guo, Qingshan Chang, Zhijun Duan. Taurocholic acid is an active promoting factor, not just a biomarker of progression of liver cirrhosis: evidence from a human metabolomic study and in vitro experiments.
BMC gastroenterology.
2018 Jul; 18(1):112. doi:
10.1186/s12876-018-0842-7. [PMID: 29996772] - Evelyn Zöhrer, Katharina Meinel, Günter Fauler, Victor Aguiriano Moser, Theresa Greimel, Joachim Zobl, Axel Schlagenhauf, Jörg Jahnel. Neonatal sepsis leads to early rise of rare serum bile acid tauro-omega-muricholic acid (TOMCA).
Pediatric research.
2018 07; 84(1):66-70. doi:
10.1038/s41390-018-0007-y. [PMID: 29795204] - Lei Li, Zhongwei Sun, Caiming Xu, Jun Wu, Geliang Liu, Hongzhang Cui, Hailong Chen. Adenovirus-mediated overexpression of sST2 attenuates cardiac injury in the rat with severe acute pancreatitis.
Life sciences.
2018 Jun; 202(?):167-174. doi:
10.1016/j.lfs.2018.04.008. [PMID: 29653119] - Charles Desmarchelier, Véronique Rosilio, David Chapron, Ali Makky, Damien P Prévéraud, Estelle Devillard, Véronique Legrand-Defretin, Patrick Borel. Molecular interactions governing the incorporation of cholecalciferol and retinyl-palmitate in mixed taurocholate-lipid micelles.
Food chemistry.
2018 Jun; 250(?):221-229. doi:
10.1016/j.foodchem.2018.01.063. [PMID: 29412915] - Shuo Yu, Min Wang, Xingjun Guo, Renyi Qin. Curcumin Attenuates Inflammation in a Severe Acute Pancreatitis Animal Model by Regulating TRAF1/ASK1 Signaling.
Medical science monitor : international medical journal of experimental and clinical research.
2018 Apr; 24(?):2280-2286. doi:
10.12659/msm.909557. [PMID: 29657313] - Yina Chen, Qian Zhao, Qinfen Chen, Yuxue Zhang, Bule Shao, Yin Jin, Jiansheng Wu. Melatonin attenuated inflammatory reaction by inhibiting the activation of p38 and NF‑κB in taurocholate‑induced acute pancreatitis.
Molecular medicine reports.
2018 04; 17(4):5934-5939. doi:
10.3892/mmr.2018.8614. [PMID: 29484391] - Fangchao Mei, Teng Zuo, Liang Zhao, Qiao Shi, Mingwei Xiang, Yupu Hong, Man Li, Weixing Wang. Differential JNK, p38 and ERK response to renal injury in a rat model of acute pancreatitis in pregnancy.
Archives of gynecology and obstetrics.
2018 04; 297(4):933-942. doi:
10.1007/s00404-018-4668-x. [PMID: 29349553] - Ying Xu, Ping-Ping Zhong, Yan-Yan Tao. Metabolic profiling of endogenous bile acids: a novel method to assess hepatoprotective effect of Tanreqing capsule on carbon-tetrachloride-induced liver injury in rats.
Chinese journal of natural medicines.
2018 Apr; 16(4):271-283. doi:
10.1016/s1875-5364(18)30057-8. [PMID: 29703327] - Priya Vijayvargiya, Michael Camilleri. Update on Bile Acid Malabsorption: Finally Ready for Prime Time?.
Current gastroenterology reports.
2018 Mar; 20(3):10. doi:
10.1007/s11894-018-0615-z. [PMID: 29582208] - Iván L Csanaky, Andrew J Lickteig, Curtis D Klaassen. Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice.
Toxicology and applied pharmacology.
2018 03; 343(?):48-61. doi:
10.1016/j.taap.2018.02.005. [PMID: 29452137] - Abdi Elmi, Amber Dorey, Eleanor Watson, Heena Jagatia, Neil F Inglis, Ozan Gundogdu, Mona Bajaj-Elliott, Brendan W Wren, David G E Smith, Nick Dorrell. The bile salt sodium taurocholate induces Campylobacter jejuni outer membrane vesicle production and increases OMV-associated proteolytic activity.
Cellular microbiology.
2018 03; 20(3):. doi:
10.1111/cmi.12814. [PMID: 29205766] - Ming-Wei Liu, Rui Wei, Mei-Xian Su, Hui Li, Tian-Wen Fang, Wei Zhang. Effects of Panax notoginseng saponins on severe acute pancreatitis through the regulation of mTOR/Akt and caspase-3 signaling pathway by upregulating miR-181b expression in rats.
BMC complementary and alternative medicine.
2018 Feb; 18(1):51. doi:
10.1186/s12906-018-2118-8. [PMID: 29402262] - Zhen Lu, Cuiping Bu, Weicheng Hu, Hui Zhang, Mengrui Liu, Meiqi Lu, Guangxi Zhai. Preparation and in vitro and in vivo evaluation of quercetin-loaded mixed micelles for oral delivery.
Bioscience, biotechnology, and biochemistry.
2018 Feb; 82(2):238-246. doi:
10.1080/09168451.2017.1419852. [PMID: 29327653] - Jun Li, Rui Zhou, Bei-Bei Bie, Na Huang, Ying Guo, Hai-Yan Chen, Meng-Jiao Shi, Jun Yang, Jian Zhang, Zong-Fang Li. Emodin and baicalein inhibit sodium taurocholate-induced vacuole formation in pancreatic acinar cells.
World journal of gastroenterology.
2018 Jan; 24(1):35-45. doi:
10.3748/wjg.v24.i1.35. [PMID: 29358880] - Youcai Zhang, Andrew J Lickteig, Iván L Csanaky, Curtis D Klaassen. Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion.
Toxicology and applied pharmacology.
2018 01; 338(?):112-123. doi:
10.1016/j.taap.2017.11.014. [PMID: 29175453] - Jibiao Li, Benjamin L Woolbright, Wen Zhao, Yifeng Wang, David Matye, Bruno Hagenbuch, Hartmut Jaeschke, Tiangang Li. Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice.
Toxicological sciences : an official journal of the Society of Toxicology.
2018 01; 161(1):34-47. doi:
10.1093/toxsci/kfx078. [PMID: 28453831]